Details of the Target

General Information of Target

Target ID LDTP07283
Target Name E3 ubiquitin-protein ligase RNF213 (RNF213)
Gene Name RNF213
Gene ID 57674
Synonyms
ALO17; C17orf27; KIAA1554; KIAA1618; MYSTR; E3 ubiquitin-protein ligase RNF213; EC 2.3.2.27; EC 3.6.4.-; ALK lymphoma oligomerization partner on chromosome 17; E3 ubiquitin-lipopolysaccharide ligase RNF213; EC 2.3.2.-; Mysterin; RING finger protein 213
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG
PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHL
TLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG
EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQE
LLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPP
ATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN
QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICEL
HYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCL
FIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI
LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVP
LPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHR
DLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA
ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEH
LGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEAL
SPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ
TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGD
MEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYS
DLRKFGIVLSAVITKSWPRTADNFNDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKR
LIAVADSVLTKVVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEQCAVEEAL
DWRREELLLLKKEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTVTVRLS
TSSNSQRATHYHLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEP
EEESERHILELEEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSE
LKIMCTVDHQDQRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLN
FTDNFDDFRRETLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINE
LKVFVDLASISAGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALD
KDQYLPRKLCDSARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPD
TVLHLILPESPGSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLS
QAFIDLHSAGNMLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQM
EHFLDSWKRFVTQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRD
VLRASVGCGSEAARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLE
TLGHCLAHLAGMGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYD
EVLLCTPATTFEEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQH
REDYQLVMVCDGDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVF
NDRLCVGIVASERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALL
PFLDAQYQKVPVLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEIL
ERRTSVPSRSSSALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFC
SETFQRPYQYLRRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFAR
FLNYQLRDCEASLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVT
MDGVREEDLAPFSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKV
IKRDVMTRDLYQGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNM
LKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMI
YSRVREAENVAFANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHI
IAACNPYRKHSEEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVW
DFGQLSDVAEKLYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRD
VERCVKVFRWFHEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKK
DSYRKAIARFFPKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIE
LKIPLFLVGKPGSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIIS
TFRQCARFQQGKDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVG
FVGISNWALDPAKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYE
TVCKRQDKEFFGLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFL
ANLPEAKCSEEVSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFF
EGDQQPEIIFGSGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYY
VHLGGQKYVDLGLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVL
EKWQKSIVEELCAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPR
ALTEELHQKVSEEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFL
QAHLHTADLERHAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLK
EVRNCLTNTAKCKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKL
SRVGRGTAYVGFHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHR
AEDGHEEAMETEASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCV
QSAVGMLRDQNESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHP
LEWLAREACNQDALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPW
ARDLWMFIFSDTMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLE
ELWVQAQYITDAEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVST
EEELKFLQMALWSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLH
SLMEARWNHELAGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDE
HMQGSGSLAQAVIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLR
ENSDVKTHGPFEAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRC
LRAWFASEQMICPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKD
NAPPEKEVIESLLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLK
YSFHDVKDYIQEYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEE
EGRFLKAYSPASRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYL
QQVKQFCIRVENDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDH
PGQMDRYLVYGDEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVA
ILYRSHNASLHPTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLD
GTVTEMAIHAAAVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERV
HWYTCPNGHPCSVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLG
NPQRRDVVTCDRGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHI
LKDLEQLAKMLGHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKE
IAAVISPELEHLDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKI
WSCRKRITVEYLQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQN
VQQVEYSSIRGFLSKHSSDGLRQLLHNRITVFLSTWNKLRRSLETNGEINLPKDYCSTDL
DLDTEFEILLPRRRGLGLCATALVSYLIRLHNEIVYAVEKLSKENNSYSVDAAEVTELHV
ISYEVERDLTPLILSNCQYQVEEGRETVQEFDLEKIQRQIVSRFLQGKPRLSLKGIPTLV
YRHDWNYEHLFMDIKNKMAQDSLPSSVISAISGQLQSYSDACEVLSVVEVTLGFLSTAGG
DPNMQLNVYTQDILQMGDQTIHVLKALNRCQLKHTIALWQFLSAHKSEQLLRLHKEPFGE
ISSRYKADLSPENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRD
TLVSYMQTKESEILPEMASQFPEEILLASCVSVWKTAAVLKWNREMR
Target Bioclass
Enzyme
Family
AAA ATPase family
Subcellular location
Cytoplasm, cytosol
Function
Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity. Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS. Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains. Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader. Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process. Also regulates lipotoxicity by inhibiting desaturation of fatty acids. Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins. Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression. Also has ATPase activity; ATPase activity is required for ubiquitination of LPS.
Uniprot ID
Q63HN8
Ensemble ID
ENST00000319921.4
HGNC ID
HGNC:14539

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.90  LDD0402  [2]
C-Sul
 Probe Info  		14.42  LDD0066  [3]
STPyne
 Probe Info  		K1151(10.00); K1404(2.12); K1508(8.33); K2367(0.74)  LDD0277  [4]
Probe 1
 Probe Info  		Y475(40.47); Y4225(16.23); Y4327(17.23); Y4806(14.48)  LDD3495  [5]
BTD
 Probe Info  		C2132(2.64)  LDD1700  [6]
AHL-Pu-1
 Probe Info  		C614(2.05)  LDD0168  [7]
DBIA
 Probe Info  		CAmbiguous(26.23); C3084(14.51); C2536(5.58); C3330(4.31)  LDD0209  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1748(0.00); C4348(0.00); C2943(0.00); C1881(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C1748(0.00); C4348(0.00); C3008(0.00); C1156(0.00)  LDD0036  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C4348(0.00); C2943(0.00); C1881(0.00); C3008(0.00)  LDD0037  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
TFBX
 Probe Info  		C614(0.00); C3261(0.00)  LDD0027  [12]
WYneN
 Probe Info  		C1748(0.00); C3084(0.00); C1156(0.00); C3609(0.00)  LDD0021  [14]
WYneO
 Probe Info  		C4111(0.00); C3330(0.00); C2943(0.00); C614(0.00)  LDD0022  [14]
Compound 10
 Probe Info  		C1510(0.00); C1748(0.00); C3008(0.00); C614(0.00)  LDD2216  [15]
Compound 11
 Probe Info  		C1510(0.00); C1748(0.00); C3008(0.00); C614(0.00)  LDD2213  [15]
ENE
 Probe Info  		C3554(0.00); C614(0.00)  LDD0006  [14]
IPM
 Probe Info  		N.A.  LDD0005  [14]
PF-06672131
 Probe Info  		C614(0.00); C4348(0.00)  LDD0017  [16]
Acrolein
 Probe Info  		C3609(0.00); C3330(0.00); C856(0.00); C3261(0.00)  LDD0217  [17]
Crotonaldehyde
 Probe Info  		C1748(0.00); C1614(0.00); C3261(0.00)  LDD0219  [17]
Methacrolein
 Probe Info  		C310(0.00); C3261(0.00); C856(0.00); C1748(0.00)  LDD0218  [17]
W1
 Probe Info  		C614(0.00); C680(0.00); C3554(0.00); C310(0.00)  LDD0236  [18]
AOyne
 Probe Info  		12.30  LDD0443  [19]
NAIA_5
 Probe Info  		C4348(0.00); C5190(0.00); C310(0.00); C1643(0.00)  LDD2223  [13]
HHS-482
 Probe Info  		Y2792(1.47); Y3273(0.96); Y4806(1.05)  LDD2239  [20]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C174
 Probe Info  		4.99  LDD1854  [21]
Alk-rapa
 Probe Info  		9.93  LDD0213  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1510(0.91)  LDD2112  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C1748(0.99)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C856(0.89); C1748(0.97); C1510(0.82); C2132(0.83)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C856(1.03); C1510(1.20); C2132(1.05)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1510(0.86)  LDD2103  [6]
 LDCM0025  4SU-RNA HEK-293T C614(2.05)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C614(4.49); C310(2.27)  LDD0169  [7]
 LDCM0214  AC1 HEK-293T C2536(1.04); C3554(0.91); C310(1.05); C1748(1.01)  LDD1507  [23]
 LDCM0215  AC10 HEK-293T C2536(1.01); C3554(0.97); C310(1.02); C1748(1.15)  LDD1508  [23]
 LDCM0226  AC11 HEK-293T C2536(1.03); C3554(1.03); C310(1.00); C1748(1.08)  LDD1509  [23]
 LDCM0237  AC12 HEK-293T C2536(1.06); C3554(0.93); C310(1.01); C1748(1.05)  LDD1510  [23]
 LDCM0259  AC14 HEK-293T C2536(0.94); C3554(1.26); C310(0.90); C1748(0.94)  LDD1512  [23]
 LDCM0270  AC15 HEK-293T C2536(0.89); C3554(0.89); C310(1.07); C1748(1.03)  LDD1513  [23]
 LDCM0276  AC17 HEK-293T C2536(1.04); C3554(0.85); C310(1.10); C1748(1.25)  LDD1515  [23]
 LDCM0277  AC18 HEK-293T C2536(0.88); C3554(1.04); C310(1.07); C1748(0.94)  LDD1516  [23]
 LDCM0278  AC19 HEK-293T C2536(1.13); C3554(1.01); C310(1.02); C1748(1.03)  LDD1517  [23]
 LDCM0279  AC2 HEK-293T C2536(0.99); C3554(0.97); C310(1.06); C1748(0.97)  LDD1518  [23]
 LDCM0280  AC20 HEK-293T C2536(1.01); C3554(1.00); C310(1.03); C1748(0.96)  LDD1519  [23]
 LDCM0281  AC21 HEK-293T C2536(1.00); C3554(0.89); C310(0.98); C1748(1.03)  LDD1520  [23]
 LDCM0282  AC22 HEK-293T C2536(0.93); C3554(1.18); C310(0.94); C1748(0.92)  LDD1521  [23]
 LDCM0283  AC23 HEK-293T C2536(0.97); C3554(1.05); C310(1.04); C1748(1.02)  LDD1522  [23]
 LDCM0284  AC24 HEK-293T C2536(0.86); C3554(0.93); C310(0.95); C1748(1.02)  LDD1523  [23]
 LDCM0285  AC25 HEK-293T C2536(1.02); C3554(0.89); C310(1.05); C1748(1.09)  LDD1524  [23]
 LDCM0286  AC26 HEK-293T C2536(0.95); C3554(1.09); C310(1.01); C1748(1.03)  LDD1525  [23]
 LDCM0287  AC27 HEK-293T C2536(1.01); C3554(0.90); C310(1.00); C1748(0.94)  LDD1526  [23]
 LDCM0288  AC28 HEK-293T C2536(0.98); C3554(1.08); C310(0.99); C1748(0.94)  LDD1527  [23]
 LDCM0289  AC29 HEK-293T C2536(1.12); C3554(1.07); C310(1.00); C1748(1.02)  LDD1528  [23]
 LDCM0290  AC3 HEK-293T C2536(0.88); C3554(1.20); C310(0.98); C1748(1.02)  LDD1529  [23]
 LDCM0291  AC30 HEK-293T C2536(0.96); C3554(1.12); C310(0.94); C1748(0.93)  LDD1530  [23]
 LDCM0292  AC31 HEK-293T C2536(1.02); C3554(1.09); C310(1.00); C1748(1.10)  LDD1531  [23]
 LDCM0293  AC32 HEK-293T C2536(0.88); C3554(0.88); C310(1.02); C1748(1.03)  LDD1532  [23]
 LDCM0294  AC33 HEK-293T C2536(1.03); C3554(0.85); C310(1.14); C1748(0.94)  LDD1533  [23]
 LDCM0295  AC34 HEK-293T C2536(0.97); C3554(0.97); C310(1.05); C1748(0.94)  LDD1534  [23]
 LDCM0296  AC35 HEK-293T C2536(1.01); C3554(0.99); C310(0.99); C1748(1.12)  LDD1535  [23]
 LDCM0297  AC36 HEK-293T C2536(1.04); C3554(0.95); C310(0.95); C1748(1.01)  LDD1536  [23]
 LDCM0298  AC37 HEK-293T C2536(0.90); C3554(1.08); C310(0.92); C1748(1.12)  LDD1537  [23]
 LDCM0299  AC38 HEK-293T C2536(0.90); C3554(1.01); C310(0.91); C1748(0.93)  LDD1538  [23]
 LDCM0300  AC39 HEK-293T C2536(1.02); C3554(0.99); C310(0.97); C1748(1.03)  LDD1539  [23]
 LDCM0301  AC4 HEK-293T C2536(1.07); C3554(0.96); C310(1.01); C1748(0.98)  LDD1540  [23]
 LDCM0302  AC40 HEK-293T C2536(0.91); C3554(0.93); C310(0.97); C1748(0.93)  LDD1541  [23]
 LDCM0303  AC41 HEK-293T C2536(1.00); C3554(0.89); C310(1.14); C1748(1.09)  LDD1542  [23]
 LDCM0304  AC42 HEK-293T C2536(0.96); C3554(1.19); C310(1.06); C1748(1.04)  LDD1543  [23]
 LDCM0305  AC43 HEK-293T C2536(1.11); C3554(0.98); C310(1.02); C1748(1.07)  LDD1544  [23]
 LDCM0306  AC44 HEK-293T C2536(0.97); C3554(0.95); C310(0.97); C1748(1.03)  LDD1545  [23]
 LDCM0307  AC45 HEK-293T C2536(1.08); C3554(1.04); C310(0.99); C1748(1.13)  LDD1546  [23]
 LDCM0308  AC46 HEK-293T C2536(1.10); C3554(1.15); C310(0.89); C1748(1.01)  LDD1547  [23]
 LDCM0309  AC47 HEK-293T C2536(1.12); C3554(1.10); C310(1.05); C1748(1.00)  LDD1548  [23]
 LDCM0310  AC48 HEK-293T C2536(0.95); C3554(1.02); C310(0.95); C1748(0.93)  LDD1549  [23]
 LDCM0311  AC49 HEK-293T C2536(1.13); C3554(0.85); C310(1.21); C1748(0.95)  LDD1550  [23]
 LDCM0312  AC5 HEK-293T C2536(1.01); C3554(0.98); C310(0.94); C1748(1.05)  LDD1551  [23]
 LDCM0313  AC50 HEK-293T C2536(1.05); C3554(1.02); C310(1.00); C1748(1.04)  LDD1552  [23]
 LDCM0314  AC51 HEK-293T C2536(0.98); C3554(1.08); C310(1.02); C1748(1.06)  LDD1553  [23]
 LDCM0315  AC52 HEK-293T C2536(1.04); C3554(1.00); C310(0.96); C1748(1.00)  LDD1554  [23]
 LDCM0316  AC53 HEK-293T C2536(1.29); C3554(1.02); C310(1.00); C1748(1.10)  LDD1555  [23]
 LDCM0317  AC54 HEK-293T C2536(0.98); C3554(0.94); C310(0.97); C1748(1.00)  LDD1556  [23]
 LDCM0318  AC55 HEK-293T C2536(0.90); C3554(1.02); C310(0.98); C1748(0.96)  LDD1557  [23]
 LDCM0319  AC56 HEK-293T C2536(0.85); C3554(1.02); C310(0.96); C1748(0.94)  LDD1558  [23]
 LDCM0320  AC57 HEK-293T C2536(1.00); C3554(1.02); C310(1.10); C1748(1.08)  LDD1559  [23]
 LDCM0321  AC58 HEK-293T C2536(0.96); C3554(0.98); C310(0.99); C1748(1.02)  LDD1560  [23]
 LDCM0322  AC59 HEK-293T C2536(0.96); C3554(1.13); C310(1.00); C1748(1.08)  LDD1561  [23]
 LDCM0323  AC6 HEK-293T C2536(0.97); C3554(1.11); C310(0.97); C1748(0.91)  LDD1562  [23]
 LDCM0324  AC60 HEK-293T C2536(1.05); C3554(1.07); C310(0.95); C1748(0.97)  LDD1563  [23]
 LDCM0325  AC61 HEK-293T C2536(1.11); C3554(1.06); C310(0.97); C1748(1.09)  LDD1564  [23]
 LDCM0326  AC62 HEK-293T C2536(1.05); C3554(1.25); C310(0.92); C1748(1.03)  LDD1565  [23]
 LDCM0327  AC63 HEK-293T C2536(1.02); C3554(0.94); C310(1.02); C1748(1.03)  LDD1566  [23]
 LDCM0328  AC64 HEK-293T C2536(0.89); C3554(0.95); C310(1.00); C1748(1.04)  LDD1567  [23]
 LDCM0334  AC7 HEK-293T C2536(0.94); C3554(1.00); C310(0.96); C1748(0.94)  LDD1568  [23]
 LDCM0345  AC8 HEK-293T C2536(0.87); C3554(1.06); C310(0.97); C1748(1.02)  LDD1569  [23]
 LDCM0248  AKOS034007472 HEK-293T C2536(1.05); C3554(0.90); C310(0.94); C1748(1.09)  LDD1511  [23]
 LDCM0356  AKOS034007680 HEK-293T C2536(1.07); C3554(0.89); C310(1.21); C1748(1.09)  LDD1570  [23]
 LDCM0275  AKOS034007705 HEK-293T C2536(0.91); C3554(1.04); C310(0.96); C1748(0.94)  LDD1514  [23]
 LDCM0498  BS-3668 MDA-MB-231 C856(0.89)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C3330(0.00); C1748(0.00); C1614(0.00); C2633(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C1748(20.00); C2620(20.00); C310(0.94)  LDD2227  [13]
 LDCM0367  CL1 HEK-293T C2536(1.00); C3554(1.02); C310(0.97); C1748(1.03)  LDD1571  [23]
 LDCM0368  CL10 HEK-293T C2536(1.20); C3554(1.49); C310(0.87); C1748(1.01)  LDD1572  [23]
 LDCM0369  CL100 HEK-293T C2536(0.82); C3554(0.72); C1748(1.06); C2132(1.02)  LDD1573  [23]
 LDCM0370  CL101 HEK-293T C2536(0.97); C3554(1.03); C310(1.10); C1748(1.03)  LDD1574  [23]
 LDCM0371  CL102 HEK-293T C2536(1.12); C3554(0.96); C310(0.97); C1748(1.08)  LDD1575  [23]
 LDCM0372  CL103 HEK-293T C2536(0.96); C3554(1.02); C310(1.04); C1748(1.10)  LDD1576  [23]
 LDCM0373  CL104 HEK-293T C2536(0.94); C3554(0.88); C1748(1.08); C2132(1.00)  LDD1577  [23]
 LDCM0374  CL105 HEK-293T C2536(0.93); C3554(1.02); C310(1.07); C1748(0.99)  LDD1578  [23]
 LDCM0375  CL106 HEK-293T C2536(0.92); C3554(1.22); C310(1.06); C1748(1.04)  LDD1579  [23]
 LDCM0376  CL107 HEK-293T C2536(0.83); C3554(1.00); C310(1.01); C1748(0.96)  LDD1580  [23]
 LDCM0377  CL108 HEK-293T C2536(0.94); C3554(0.88); C1748(1.00); C2132(0.85)  LDD1581  [23]
 LDCM0378  CL109 HEK-293T C2536(1.01); C3554(0.87); C310(1.03); C1748(1.03)  LDD1582  [23]
 LDCM0379  CL11 HEK-293T C2536(1.10); C3554(1.25); C310(0.94); C1748(1.05)  LDD1583  [23]
 LDCM0380  CL110 HEK-293T C2536(1.19); C3554(1.10); C310(0.99); C1748(1.06)  LDD1584  [23]
 LDCM0381  CL111 HEK-293T C2536(0.99); C3554(1.26); C310(1.00); C1748(1.05)  LDD1585  [23]
 LDCM0382  CL112 HEK-293T C2536(0.94); C3554(0.92); C1748(1.08); C2132(0.97)  LDD1586  [23]
 LDCM0383  CL113 HEK-293T C2536(1.09); C3554(0.95); C310(1.05); C1748(1.03)  LDD1587  [23]
 LDCM0384  CL114 HEK-293T C2536(1.09); C3554(1.08); C310(0.90); C1748(1.11)  LDD1588  [23]
 LDCM0385  CL115 HEK-293T C2536(0.97); C3554(1.02); C310(1.05); C1748(1.08)  LDD1589  [23]
 LDCM0386  CL116 HEK-293T C2536(0.80); C3554(0.77); C1748(1.07); C2132(1.00)  LDD1590  [23]
 LDCM0387  CL117 HEK-293T C2536(0.99); C3554(0.89); C310(1.05); C1748(1.04)  LDD1591  [23]
 LDCM0388  CL118 HEK-293T C2536(1.10); C3554(0.86); C310(0.99); C1748(1.00)  LDD1592  [23]
 LDCM0389  CL119 HEK-293T C2536(0.91); C3554(1.03); C310(1.06); C1748(1.05)  LDD1593  [23]
 LDCM0390  CL12 HEK-293T C2536(0.94); C3554(1.14); C310(0.91); C1748(0.98)  LDD1594  [23]
 LDCM0391  CL120 HEK-293T C2536(1.08); C3554(0.76); C1748(1.06); C2132(1.10)  LDD1595  [23]
 LDCM0392  CL121 HEK-293T C2536(1.01); C3554(1.12); C310(0.97); C1748(1.00)  LDD1596  [23]
 LDCM0393  CL122 HEK-293T C2536(1.24); C3554(0.96); C310(1.00); C1748(1.08)  LDD1597  [23]
 LDCM0394  CL123 HEK-293T C2536(0.93); C3554(1.63); C310(0.97); C1748(1.05)  LDD1598  [23]
 LDCM0395  CL124 HEK-293T C2536(1.61); C3554(1.31); C1748(0.98); C2132(0.95)  LDD1599  [23]
 LDCM0396  CL125 HEK-293T C2536(0.95); C3554(0.93); C310(1.00); C1748(0.97)  LDD1600  [23]
 LDCM0397  CL126 HEK-293T C2536(0.93); C3554(1.04); C310(0.95); C1748(1.02)  LDD1601  [23]
 LDCM0398  CL127 HEK-293T C2536(0.97); C3554(1.07); C310(1.17); C1748(1.06)  LDD1602  [23]
 LDCM0399  CL128 HEK-293T C2536(0.81); C3554(0.93); C1748(0.94); C2132(0.97)  LDD1603  [23]
 LDCM0400  CL13 HEK-293T C2536(1.00); C3554(0.97); C310(1.05); C1748(0.94)  LDD1604  [23]
 LDCM0401  CL14 HEK-293T C2536(0.87); C3554(0.93); C310(0.92); C1748(0.93)  LDD1605  [23]
 LDCM0402  CL15 HEK-293T C2536(0.97); C3554(1.44); C310(0.94); C1748(1.11)  LDD1606  [23]
 LDCM0403  CL16 HEK-293T C2536(0.76); C3554(0.83); C1748(0.99); C2132(1.07)  LDD1607  [23]
 LDCM0404  CL17 HEK-293T C2536(0.99); C3554(1.26); C310(1.02); C1748(0.94)  LDD1608  [23]
 LDCM0405  CL18 HEK-293T C2536(0.92); C3554(0.95); C310(1.02); C1748(1.04)  LDD1609  [23]
 LDCM0406  CL19 HEK-293T C2536(1.05); C3554(1.07); C310(1.02); C1748(1.18)  LDD1610  [23]
 LDCM0407  CL2 HEK-293T C2536(0.95); C3554(1.06); C310(0.97); C1748(0.98)  LDD1611  [23]
 LDCM0408  CL20 HEK-293T C2536(1.17); C3554(1.09); C310(0.98); C1748(1.04)  LDD1612  [23]
 LDCM0409  CL21 HEK-293T C2536(1.02); C3554(1.50); C310(0.89); C1748(1.24)  LDD1613  [23]
 LDCM0410  CL22 HEK-293T C2536(1.08); C3554(1.39); C310(1.14); C1748(0.87)  LDD1614  [23]
 LDCM0411  CL23 HEK-293T C2536(1.11); C3554(1.16); C310(1.02); C1748(1.09)  LDD1615  [23]
 LDCM0412  CL24 HEK-293T C2536(0.92); C3554(1.08); C310(0.96); C1748(1.03)  LDD1616  [23]
 LDCM0413  CL25 HEK-293T C2536(0.84); C3554(1.30); C310(0.95); C1748(1.09)  LDD1617  [23]
 LDCM0414  CL26 HEK-293T C2536(0.88); C3554(0.99); C310(0.99); C1748(1.01)  LDD1618  [23]
 LDCM0415  CL27 HEK-293T C2536(0.94); C3554(1.12); C310(0.93); C1748(1.07)  LDD1619  [23]
 LDCM0416  CL28 HEK-293T C2536(0.77); C3554(0.74); C1748(1.02); C2132(0.98)  LDD1620  [23]
 LDCM0417  CL29 HEK-293T C2536(1.13); C3554(0.80); C310(1.01); C1748(1.01)  LDD1621  [23]
 LDCM0418  CL3 HEK-293T C2536(1.00); C3554(1.07); C310(1.09); C1748(1.03)  LDD1622  [23]
 LDCM0419  CL30 HEK-293T C2536(0.92); C3554(1.01); C310(1.00); C1748(1.08)  LDD1623  [23]
 LDCM0420  CL31 HEK-293T C2536(0.96); C3554(1.08); C310(1.05); C1748(1.08)  LDD1624  [23]
 LDCM0421  CL32 HEK-293T C2536(1.06); C3554(1.22); C310(1.02); C1748(1.04)  LDD1625  [23]
 LDCM0422  CL33 HEK-293T C2536(1.36); C3554(1.15); C310(0.80); C1748(1.19)  LDD1626  [23]
 LDCM0423  CL34 HEK-293T C2536(1.02); C3554(1.22); C310(0.97); C1748(0.98)  LDD1627  [23]
 LDCM0424  CL35 HEK-293T C2536(1.18); C3554(0.95); C310(1.10); C1748(1.11)  LDD1628  [23]
 LDCM0425  CL36 HEK-293T C2536(0.97); C3554(1.18); C310(0.95); C1748(1.18)  LDD1629  [23]
 LDCM0426  CL37 HEK-293T C2536(0.94); C3554(0.95); C310(0.96); C1748(0.94)  LDD1630  [23]
 LDCM0428  CL39 HEK-293T C2536(0.96); C3554(0.95); C310(0.97); C1748(1.05)  LDD1632  [23]
 LDCM0429  CL4 HEK-293T C2536(0.90); C3554(1.29); C1748(1.02); C2132(1.05)  LDD1633  [23]
 LDCM0430  CL40 HEK-293T C2536(0.89); C3554(0.76); C1748(1.08); C2132(0.95)  LDD1634  [23]
 LDCM0431  CL41 HEK-293T C2536(1.03); C3554(1.03); C310(1.14); C1748(0.93)  LDD1635  [23]
 LDCM0432  CL42 HEK-293T C2536(0.93); C3554(1.16); C310(1.00); C1748(0.96)  LDD1636  [23]
 LDCM0433  CL43 HEK-293T C2536(0.98); C3554(1.09); C310(1.01); C1748(1.10)  LDD1637  [23]
 LDCM0434  CL44 HEK-293T C2536(1.02); C3554(1.09); C310(1.02); C1748(1.03)  LDD1638  [23]
 LDCM0435  CL45 HEK-293T C2536(1.17); C3554(0.88); C310(1.04); C1748(1.11)  LDD1639  [23]
 LDCM0436  CL46 HEK-293T C2536(1.11); C3554(1.16); C310(0.92); C1748(1.17)  LDD1640  [23]
 LDCM0437  CL47 HEK-293T C2536(1.11); C3554(0.99); C310(1.18); C1748(1.10)  LDD1641  [23]
 LDCM0438  CL48 HEK-293T C2536(1.02); C3554(1.17); C310(0.95); C1748(1.29)  LDD1642  [23]
 LDCM0439  CL49 HEK-293T C2536(0.91); C3554(1.03); C310(0.96); C1748(1.13)  LDD1643  [23]
 LDCM0440  CL5 HEK-293T C2536(1.07); C3554(0.93); C310(1.23); C1748(0.86)  LDD1644  [23]
 LDCM0441  CL50 HEK-293T C2536(1.05); C3554(1.21); C310(0.96); C1748(1.01)  LDD1645  [23]
 LDCM0443  CL52 HEK-293T C2536(0.77); C3554(0.96); C1748(1.06); C2132(1.06)  LDD1646  [23]
 LDCM0444  CL53 HEK-293T C2536(1.01); C3554(0.95); C310(1.09); C1748(1.06)  LDD1647  [23]
 LDCM0445  CL54 HEK-293T C2536(1.08); C3554(1.16); C310(0.96); C1748(1.00)  LDD1648  [23]
 LDCM0446  CL55 HEK-293T C2536(1.01); C3554(1.02); C310(1.00); C1748(1.12)  LDD1649  [23]
 LDCM0447  CL56 HEK-293T C2536(1.08); C3554(1.02); C310(0.99); C1748(1.12)  LDD1650  [23]
 LDCM0448  CL57 HEK-293T C2536(1.24); C3554(0.74); C310(0.89); C1748(1.31)  LDD1651  [23]
 LDCM0449  CL58 HEK-293T C2536(1.11); C3554(1.36); C310(0.89); C1748(1.03)  LDD1652  [23]
 LDCM0450  CL59 HEK-293T C2536(1.04); C3554(1.06); C310(0.98); C1748(1.09)  LDD1653  [23]
 LDCM0451  CL6 HEK-293T C2536(1.02); C3554(1.24); C310(1.01); C1748(1.02)  LDD1654  [23]
 LDCM0452  CL60 HEK-293T C2536(0.87); C3554(1.27); C310(0.92); C1748(0.96)  LDD1655  [23]
 LDCM0453  CL61 HEK-293T C2536(1.01); C3554(1.05); C310(0.99); C1748(1.00)  LDD1656  [23]
 LDCM0454  CL62 HEK-293T C2536(1.68); C3554(0.81); C310(0.99); C1748(1.04)  LDD1657  [23]
 LDCM0455  CL63 HEK-293T C2536(1.02); C3554(1.01); C310(1.06); C1748(1.10)  LDD1658  [23]
 LDCM0456  CL64 HEK-293T C2536(0.92); C3554(1.12); C1748(1.10); C2132(1.13)  LDD1659  [23]
 LDCM0457  CL65 HEK-293T C2536(1.05); C3554(0.91); C310(1.20); C1748(1.08)  LDD1660  [23]
 LDCM0458  CL66 HEK-293T C2536(1.08); C3554(1.03); C310(0.99); C1748(1.02)  LDD1661  [23]
 LDCM0459  CL67 HEK-293T C2536(1.14); C3554(1.08); C310(0.97); C1748(1.13)  LDD1662  [23]
 LDCM0460  CL68 HEK-293T C2536(1.10); C3554(1.14); C310(0.97); C1748(1.04)  LDD1663  [23]
 LDCM0461  CL69 HEK-293T C2536(1.24); C3554(0.98); C310(0.97); C1748(1.16)  LDD1664  [23]
 LDCM0462  CL7 HEK-293T C2536(1.04); C3554(0.97); C310(0.98); C1748(1.15)  LDD1665  [23]
 LDCM0463  CL70 HEK-293T C2536(1.02); C3554(1.31); C310(0.91); C1748(0.94)  LDD1666  [23]
 LDCM0464  CL71 HEK-293T C2536(1.07); C3554(1.10); C310(0.99); C1748(1.12)  LDD1667  [23]
 LDCM0465  CL72 HEK-293T C2536(0.95); C3554(1.05); C310(0.95); C1748(1.17)  LDD1668  [23]
 LDCM0466  CL73 HEK-293T C2536(0.89); C3554(1.12); C310(0.98); C1748(1.01)  LDD1669  [23]
 LDCM0467  CL74 HEK-293T C2536(0.90); C3554(1.09); C310(0.97); C1748(1.01)  LDD1670  [23]
 LDCM0469  CL76 HEK-293T C2536(0.80); C3554(1.07); C1748(0.98); C2132(1.09)  LDD1672  [23]
 LDCM0470  CL77 HEK-293T C2536(1.04); C3554(0.95); C310(1.08); C1748(0.93)  LDD1673  [23]
 LDCM0471  CL78 HEK-293T C2536(0.87); C3554(1.17); C310(1.02); C1748(1.24)  LDD1674  [23]
 LDCM0472  CL79 HEK-293T C2536(1.04); C3554(0.92); C310(0.98); C1748(1.14)  LDD1675  [23]
 LDCM0473  CL8 HEK-293T C2536(1.33); C3554(1.65); C310(0.69); C1748(1.16)  LDD1676  [23]
 LDCM0474  CL80 HEK-293T C2536(0.94); C3554(0.97); C310(0.99); C1748(1.01)  LDD1677  [23]
 LDCM0475  CL81 HEK-293T C2536(1.32); C3554(1.01); C310(1.02); C1748(1.27)  LDD1678  [23]
 LDCM0476  CL82 HEK-293T C2536(1.02); C3554(0.99); C310(0.89); C1748(0.92)  LDD1679  [23]
 LDCM0477  CL83 HEK-293T C2536(0.97); C3554(1.29); C310(1.01); C1748(1.08)  LDD1680  [23]
 LDCM0478  CL84 HEK-293T C2536(0.93); C3554(1.14); C310(0.91); C1748(1.02)  LDD1681  [23]
 LDCM0479  CL85 HEK-293T C2536(0.92); C3554(0.90); C310(1.01); C1748(0.95)  LDD1682  [23]
 LDCM0480  CL86 HEK-293T C2536(0.82); C3554(0.93); C310(0.92); C1748(1.00)  LDD1683  [23]
 LDCM0481  CL87 HEK-293T C2536(0.95); C3554(1.10); C310(1.04); C1748(0.99)  LDD1684  [23]
 LDCM0482  CL88 HEK-293T C2536(0.90); C3554(1.34); C1748(1.03); C2132(0.96)  LDD1685  [23]
 LDCM0483  CL89 HEK-293T C2536(1.00); C3554(1.03); C310(1.09); C1748(1.03)  LDD1686  [23]
 LDCM0484  CL9 HEK-293T C2536(1.33); C3554(1.01); C310(0.90); C1748(1.12)  LDD1687  [23]
 LDCM0485  CL90 HEK-293T C2536(1.16); C3554(1.33); C310(0.81); C1748(1.21)  LDD1688  [23]
 LDCM0486  CL91 HEK-293T C2536(1.08); C3554(0.93); C310(0.94); C1748(1.10)  LDD1689  [23]
 LDCM0487  CL92 HEK-293T C2536(1.07); C3554(1.48); C310(0.95); C1748(1.07)  LDD1690  [23]
 LDCM0488  CL93 HEK-293T C2536(1.07); C3554(1.05); C310(0.89); C1748(1.27)  LDD1691  [23]
 LDCM0489  CL94 HEK-293T C2536(1.03); C3554(1.37); C310(0.91); C1748(1.02)  LDD1692  [23]
 LDCM0490  CL95 HEK-293T C2536(1.19); C3554(1.48); C310(0.95); C1748(1.53)  LDD1693  [23]
 LDCM0491  CL96 HEK-293T C2536(0.93); C3554(1.33); C310(0.93); C1748(1.18)  LDD1694  [23]
 LDCM0492  CL97 HEK-293T C2536(1.01); C3554(0.97); C310(1.09); C1748(1.02)  LDD1695  [23]
 LDCM0493  CL98 HEK-293T C2536(1.05); C3554(1.12); C310(0.99); C1748(0.97)  LDD1696  [23]
 LDCM0494  CL99 HEK-293T C2536(0.91); C3554(1.06); C310(1.05); C1748(1.04)  LDD1697  [23]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C4407(4.11)  LDD0513  [24]
 LDCM0495  E2913 HEK-293T C2536(0.95); C3554(1.06); C310(1.09); C1748(1.10)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C4348(4.45); C1881(2.44)  LDD1702  [6]
 LDCM0203  EV-96 T cell C614(5.01)  LDD0523  [24]
 LDCM0205  EV-98 T cell C4407(4.78)  LDD0519  [24]
 LDCM0625  F8 Ramos C1748(1.23); C3261(0.50)  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C1748(0.84); C3261(0.66); C3609(0.96)  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C3261(0.78)  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C1748(0.85); C3261(0.87)  LDD2191  [25]
 LDCM0575  Fragment13 Ramos C1748(0.80); C3261(0.92); C3609(0.72)  LDD2192  [25]
 LDCM0576  Fragment14 Ramos C1748(1.51)  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C1748(0.78)  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C1748(0.88); C3261(0.85); C3609(1.05)  LDD2195  [25]
 LDCM0582  Fragment23 Ramos C1748(0.68)  LDD2196  [25]
 LDCM0578  Fragment27 Ramos C1748(0.93); C3261(0.87); C3609(0.98)  LDD2197  [25]
 LDCM0586  Fragment28 Ramos C1748(0.52); C3261(0.42); C3609(1.06)  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C1748(1.01); C3261(0.65); C3609(1.04)  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C1748(0.93); C3261(0.88); C3609(0.66)  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C1748(0.87); C3609(0.76)  LDD2201  [25]
 LDCM0468  Fragment33 HEK-293T C2536(0.93); C3554(1.01); C310(1.07); C1748(1.07)  LDD1671  [23]
 LDCM0596  Fragment38 Ramos C1748(0.81); C3261(0.78); C3609(1.18)  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C1748(0.97); C3609(0.93)  LDD2184  [25]
 LDCM0427  Fragment51 HEK-293T C2536(0.90); C3554(0.86); C310(0.95); C1748(1.02)  LDD1631  [23]
 LDCM0610  Fragment52 Ramos C1748(1.52); C3261(0.88)  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C1748(1.52)  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C1748(0.93); C3261(0.76); C3609(1.01)  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C1748(1.10)  LDD2188  [25]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 HEK-293T C3554(0.84); C310(1.01); C2536(0.90); C1748(0.90)  LDD1492  [23]
 LDCM0023  KB03 Jurkat CAmbiguous(26.23); C3084(14.51); C2536(5.58); C3330(4.31)  LDD0209  [8]
 LDCM0024  KB05 G361 C1797(5.94); C2992(3.68); C3603(3.28); C1478(3.62)  LDD3311  [26]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1510(1.22)  LDD2102  [6]
 LDCM0109  NEM HeLa N.A.  LDD0224  [17]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C1510(0.83)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1510(0.88)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C856(1.16); C1510(1.10)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C1510(0.87)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1510(1.20)  LDD2096  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1510(1.08)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C856(1.00); C1748(0.89); C1510(0.60); C2132(1.01)  LDD2099  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1510(0.93)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1510(1.44)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C856(0.91); C1748(0.86); C1510(0.92); C2132(1.06)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C856(0.81); C1748(0.74); C2132(0.89)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C856(0.84); C1748(0.93)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1510(0.63)  LDD2114  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C856(0.90); C2132(0.84); C614(1.27)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C856(0.91); C1748(0.68); C1510(0.90); C2132(0.83)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C856(0.86); C1748(0.77); C2132(1.04)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C856(1.36)  LDD2129  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C856(1.22); C1748(1.29); C2132(0.88); C1736(0.94)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C856(0.66); C1748(1.02)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C2132(2.64)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1510(0.71); C2132(0.75)  LDD2140  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1510(0.85); C2132(0.89)  LDD2146  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C856(1.28); C1510(0.59)  LDD2150  [6]
 LDCM0131  RA190 MM1.R C78(1.46)  LDD0304  [27]
 LDCM0090  Rapamycin JHH-7 9.93  LDD0213  [22]
 LDCM0112  W16 Hep-G2 C614(0.64)  LDD0239  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proto-oncogene c-Rel (REL) . Q04864
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
UBX domain-containing protein 11 (UBXN11) . Q5T124

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
27 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.