Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
TMT
Competitor Name EV-98  Competitor Info 
Competitor Concentration 20 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cell lysate (T cell)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11617  Myotubularin-related protein 12 (MTMR12) C152 20.0
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) C110 18.4
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 9.9
 LDTP13219  GTPase IMAP family member 2 (GIMAP2) C261 9.2
 LDTP03540  Heme oxygenase 2 (HMOX2) C282 8.6
 LDTP00577  Dihydroxyacetone phosphate acyltransferase (GNPAT) C54 4.9
 LDTP07283  E3 ubiquitin-protein ligase RNF213 (RNF213) C4407 4.8
Transporter and channel
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10378  Nuclear envelope pore membrane protein POM 121 (POM121) C28 4.3
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP19380  Zinc finger MYM-type protein 1 (ZMYM1) C989 15.3
Other
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10140  Calcineurin B homologous protein 3 (TESC) C213 7.8
 LDTP09794  Engulfment and cell motility protein 1 (ELMO1) C438 7.3

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.