Details of the Target

General Information of Target

Target ID LDTP12040
Target Name Prostaglandin E synthase 2 (PTGES2)
Gene Name PTGES2
Gene ID 80142
Synonyms
C9orf15; PGES2; Prostaglandin E synthase 2; EC 5.3.99.3; Membrane-associated prostaglandin E synthase-2; mPGE synthase-2; Microsomal prostaglandin E synthase 2; mPGES-2; Prostaglandin-H(2) E-isomerase) [Cleaved into: Prostaglandin E synthase 2 truncated form]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAQGAAAAVAAGTSGVAGEGEPGPGENAAAEGTAPSPGRVSPPTPARGEPEVTVEIGET
YLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQ
KNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVD
KIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEI
YRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVG
YFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLS
YRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPK
LVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK
Target Bioclass
Enzyme
Family
GST superfamily
Subcellular location
Cytoplasm, perinuclear region; Golgi apparatus membrane
Function
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate. In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA).
TTD ID
T01037
Uniprot ID
Q9H7Z7
DrugMap ID
TTWU04I
Ensemble ID
ENST00000338961.11
HGNC ID
HGNC:17822
ChEMBL ID
CHEMBL4411

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
EN219-alkyne
 Probe Info  		5.03  LDD0297  [1]
AZ-9
 Probe Info  		7.23  LDD0393  [2]
TH211
 Probe Info  		Y222(9.83)  LDD0260  [3]
FBP2
 Probe Info  		26.00  LDD0317  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
BTD
 Probe Info  		C110(1.11)  LDD1699  [6]
OPA-S-S-alkyne
 Probe Info  		K225(1.93); K233(2.07)  LDD3494  [7]
Probe 1
 Probe Info  		Y222(74.68); Y308(25.38)  LDD3495  [8]
IA-alkyne
 Probe Info  		C110(1.15)  LDD0304  [9]
m-APA
 Probe Info  		10.14  LDD0403  [10]
Alkylaryl probe 3
 Probe Info  		14.64  LDD0282  [11]
CCW36
 Probe Info  		2.35  LDD2215  [12]
Johansson_61
 Probe Info  		_(20.00)  LDD1485  [13]
YY4-yne
 Probe Info  		7.73  LDD0400  [14]
HPAP
 Probe Info  		4.88  LDD0063  [15]
BDBM50514113
 Probe Info  		110.67  LDD0041  [16]
DBIA
 Probe Info  		C110(1.45)  LDD0078  [17]
5E-2FA
 Probe Info  		N.A.  LDD2235  [18]
IPM
 Probe Info  		N.A.  LDD0005  [19]
NHS
 Probe Info  		K225(0.00); K200(0.00)  LDD0010  [19]
SF
 Probe Info  		N.A.  LDD0028  [20]
STPyne
 Probe Info  		K141(0.00); K200(0.00)  LDD0009  [19]
Phosphinate-6
 Probe Info  		C110(0.00); C113(0.00)  LDD0018  [21]
1c-yne
 Probe Info  		N.A.  LDD0228  [22]
Acrolein
 Probe Info  		N.A.  LDD0217  [23]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [23]
MPP-AC
 Probe Info  		N.A.  LDD0428  [24]
TER-AC
 Probe Info  		N.A.  LDD0426  [24]
TPP-AC
 Probe Info  		N.A.  LDD0427  [24]
PAL-AfBPP Probe
Click To Hide/Show 65 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C010
 Probe Info  		6.32  LDD1719  [25]
C017
 Probe Info  		6.41  LDD1725  [25]
C027
 Probe Info  		6.77  LDD1733  [25]
C028
 Probe Info  		44.02  LDD1734  [25]
C040
 Probe Info  		15.45  LDD1740  [25]
C041
 Probe Info  		8.75  LDD1741  [25]
C055
 Probe Info  		12.30  LDD1752  [25]
C056
 Probe Info  		19.43  LDD1753  [25]
C063
 Probe Info  		11.39  LDD1760  [25]
C071
 Probe Info  		8.11  LDD1767  [25]
C087
 Probe Info  		7.16  LDD1779  [25]
C091
 Probe Info  		15.78  LDD1782  [25]
C092
 Probe Info  		21.11  LDD1783  [25]
C094
 Probe Info  		60.55  LDD1785  [25]
C106
 Probe Info  		17.75  LDD1793  [25]
C112
 Probe Info  		22.16  LDD1799  [25]
C141
 Probe Info  		9.06  LDD1823  [25]
C143
 Probe Info  		17.03  LDD1825  [25]
C153
 Probe Info  		15.67  LDD1834  [25]
C158
 Probe Info  		9.99  LDD1838  [25]
C159
 Probe Info  		7.46  LDD1839  [25]
C161
 Probe Info  		12.91  LDD1841  [25]
C166
 Probe Info  		7.67  LDD1846  [25]
C177
 Probe Info  		78.79  LDD1856  [25]
C196
 Probe Info  		11.79  LDD1872  [25]
C199
 Probe Info  		5.86  LDD1875  [25]
C201
 Probe Info  		28.44  LDD1877  [25]
C206
 Probe Info  		16.34  LDD1881  [25]
C218
 Probe Info  		10.70  LDD1892  [25]
C228
 Probe Info  		20.25  LDD1901  [25]
C232
 Probe Info  		33.82  LDD1905  [25]
C234
 Probe Info  		8.63  LDD1907  [25]
C235
 Probe Info  		36.00  LDD1908  [25]
C240
 Probe Info  		13.74  LDD1913  [25]
C246
 Probe Info  		12.82  LDD1919  [25]
C251
 Probe Info  		25.81  LDD1924  [25]
C252
 Probe Info  		8.69  LDD1925  [25]
C266
 Probe Info  		10.56  LDD1937  [25]
C275
 Probe Info  		19.56  LDD1945  [25]
C285
 Probe Info  		19.16  LDD1955  [25]
C289
 Probe Info  		33.82  LDD1959  [25]
C299
 Probe Info  		6.28  LDD1968  [25]
C338
 Probe Info  		15.89  LDD2001  [25]
C339
 Probe Info  		6.54  LDD2002  [25]
C349
 Probe Info  		9.71  LDD2010  [25]
C350
 Probe Info  		41.36  LDD2011  [25]
C355
 Probe Info  		27.47  LDD2016  [25]
C356
 Probe Info  		8.22  LDD2017  [25]
C361
 Probe Info  		23.26  LDD2022  [25]
C362
 Probe Info  		39.67  LDD2023  [25]
C364
 Probe Info  		16.45  LDD2025  [25]
C373
 Probe Info  		8.00  LDD2033  [25]
C388
 Probe Info  		52.71  LDD2047  [25]
C390
 Probe Info  		27.47  LDD2049  [25]
C407
 Probe Info  		11.63  LDD2064  [25]
C409
 Probe Info  		7.36  LDD2066  [25]
C426
 Probe Info  		17.88  LDD2081  [25]
C431
 Probe Info  		16.00  LDD2086  [25]
FFF probe14
 Probe Info  		20.00  LDD0477  [26]
FFF probe3
 Probe Info  		20.00  LDD0464  [26]
JN0003
 Probe Info  		20.00  LDD0469  [26]
STS-1
 Probe Info  		N.A.  LDD0137  [27]
A-DA
 Probe Info  		2.74  LDD0145  [28]
DA-2
 Probe Info  		N.A.  LDD0072  [29]
OEA-DA
 Probe Info  		16.61  LDD0046  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C110(0.98)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C110(1.88)  LDD2112  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C110(0.95)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C110(0.78)  LDD2152  [6]
 LDCM0214  AC1 HCT 116 C110(0.95); C113(0.60)  LDD0531  [17]
 LDCM0215  AC10 HCT 116 C110(5.73); C113(7.12)  LDD0532  [17]
 LDCM0216  AC100 HCT 116 C110(0.93); C113(0.97)  LDD0533  [17]
 LDCM0217  AC101 HCT 116 C110(0.82); C113(0.81)  LDD0534  [17]
 LDCM0218  AC102 HCT 116 C110(0.88); C113(0.88)  LDD0535  [17]
 LDCM0219  AC103 HCT 116 C110(0.73); C113(0.74)  LDD0536  [17]
 LDCM0220  AC104 HCT 116 C110(0.84); C113(0.87)  LDD0537  [17]
 LDCM0221  AC105 HCT 116 C110(0.79); C113(0.82)  LDD0538  [17]
 LDCM0222  AC106 HCT 116 C110(0.77); C113(0.79)  LDD0539  [17]
 LDCM0223  AC107 HCT 116 C110(0.79); C113(0.81)  LDD0540  [17]
 LDCM0224  AC108 HCT 116 C110(0.87); C113(0.89)  LDD0541  [17]
 LDCM0225  AC109 HCT 116 C110(0.88); C113(0.94)  LDD0542  [17]
 LDCM0226  AC11 HCT 116 C110(1.24); C113(1.50)  LDD0543  [17]
 LDCM0227  AC110 HCT 116 C110(0.89); C113(0.91)  LDD0544  [17]
 LDCM0228  AC111 HCT 116 C110(0.91); C113(0.92)  LDD0545  [17]
 LDCM0229  AC112 HCT 116 C110(0.82); C113(0.80)  LDD0546  [17]
 LDCM0230  AC113 HCT 116 C110(1.10); C113(1.02); C16(0.85)  LDD0547  [17]
 LDCM0231  AC114 HCT 116 C110(1.16); C113(0.96); C16(1.02)  LDD0548  [17]
 LDCM0232  AC115 HCT 116 C110(1.22); C113(0.96); C16(0.94)  LDD0549  [17]
 LDCM0233  AC116 HCT 116 C110(1.28); C113(0.93); C16(0.99)  LDD0550  [17]
 LDCM0234  AC117 HCT 116 C110(1.13); C113(0.86); C16(0.77)  LDD0551  [17]
 LDCM0235  AC118 HCT 116 C110(1.02); C113(0.92); C16(0.91)  LDD0552  [17]
 LDCM0236  AC119 HCT 116 C110(1.03); C113(0.92); C16(0.82)  LDD0553  [17]
 LDCM0237  AC12 HCT 116 C110(1.16); C113(1.15)  LDD0554  [17]
 LDCM0238  AC120 HCT 116 C110(1.14); C113(1.04); C16(0.98)  LDD0555  [17]
 LDCM0239  AC121 HCT 116 C110(1.01); C113(0.92); C16(0.79)  LDD0556  [17]
 LDCM0240  AC122 HCT 116 C110(1.05); C113(0.98); C16(1.03)  LDD0557  [17]
 LDCM0241  AC123 HCT 116 C110(1.20); C113(0.93); C16(0.68)  LDD0558  [17]
 LDCM0242  AC124 HCT 116 C110(0.97); C113(0.85); C16(0.82)  LDD0559  [17]
 LDCM0243  AC125 HCT 116 C110(1.15); C113(1.01); C16(0.97)  LDD0560  [17]
 LDCM0244  AC126 HCT 116 C110(1.17); C113(1.01); C16(0.92)  LDD0561  [17]
 LDCM0245  AC127 HCT 116 C110(1.22); C113(0.99); C16(0.93)  LDD0562  [17]
 LDCM0246  AC128 HCT 116 C110(1.35); C113(1.35)  LDD0563  [17]
 LDCM0247  AC129 HCT 116 C110(1.48); C113(1.48)  LDD0564  [17]
 LDCM0249  AC130 HCT 116 C110(1.53); C113(1.53)  LDD0566  [17]
 LDCM0250  AC131 HCT 116 C110(1.36); C113(1.36)  LDD0567  [17]
 LDCM0251  AC132 HCT 116 C110(1.20); C113(1.20)  LDD0568  [17]
 LDCM0252  AC133 HCT 116 C110(1.23); C113(1.23)  LDD0569  [17]
 LDCM0253  AC134 HCT 116 C110(1.21); C113(1.21)  LDD0570  [17]
 LDCM0254  AC135 HCT 116 C110(1.30); C113(1.30)  LDD0571  [17]
 LDCM0255  AC136 HCT 116 C110(1.25); C113(1.25)  LDD0572  [17]
 LDCM0256  AC137 HCT 116 C110(1.28); C113(1.28)  LDD0573  [17]
 LDCM0257  AC138 HCT 116 C110(1.12); C113(1.12)  LDD0574  [17]
 LDCM0258  AC139 HCT 116 C110(1.12); C113(1.12)  LDD0575  [17]
 LDCM0259  AC14 HCT 116 C110(1.04); C113(1.06)  LDD0576  [17]
 LDCM0260  AC140 HCT 116 C110(1.06); C113(1.06)  LDD0577  [17]
 LDCM0261  AC141 HCT 116 C110(1.03); C113(1.03)  LDD0578  [17]
 LDCM0262  AC142 HCT 116 C110(1.10); C113(1.10)  LDD0579  [17]
 LDCM0263  AC143 HCT 116 C110(1.02); C113(1.02); C16(1.00)  LDD0580  [17]
 LDCM0264  AC144 HCT 116 C16(1.04); C113(1.10); C110(1.10)  LDD0581  [17]
 LDCM0265  AC145 HCT 116 C110(1.12); C113(1.17); C16(1.19)  LDD0582  [17]
 LDCM0266  AC146 HCT 116 C113(0.99); C110(1.01); C16(1.20)  LDD0583  [17]
 LDCM0267  AC147 HCT 116 C113(1.12); C110(1.13); C16(1.35)  LDD0584  [17]
 LDCM0268  AC148 HCT 116 C113(0.96); C110(1.09); C16(1.64)  LDD0585  [17]
 LDCM0269  AC149 HCT 116 C113(1.05); C110(1.09); C16(1.41)  LDD0586  [17]
 LDCM0270  AC15 HCT 116 C113(1.00); C110(1.06)  LDD0587  [17]
 LDCM0271  AC150 HCT 116 C110(1.06); C113(1.11); C16(1.15)  LDD0588  [17]
 LDCM0272  AC151 HCT 116 C113(1.03); C110(1.05); C16(1.21)  LDD0589  [17]
 LDCM0273  AC152 HCT 116 C113(1.01); C110(1.05); C16(1.31)  LDD0590  [17]
 LDCM0274  AC153 HCT 116 C113(0.84); C110(1.08); C16(1.72)  LDD0591  [17]
 LDCM0621  AC154 HCT 116 C110(0.99); C113(0.98); C16(1.39)  LDD2158  [17]
 LDCM0622  AC155 HCT 116 C110(1.01); C113(1.05); C16(1.16)  LDD2159  [17]
 LDCM0623  AC156 HCT 116 C110(1.00); C113(1.04); C16(1.15)  LDD2160  [17]
 LDCM0624  AC157 HCT 116 C110(0.98); C113(1.05); C16(1.01)  LDD2161  [17]
 LDCM0276  AC17 HCT 116 C16(1.04); C110(1.06); C113(1.10)  LDD0593  [17]
 LDCM0277  AC18 HCT 116 C16(0.81); C113(1.01); C110(1.01)  LDD0594  [17]
 LDCM0278  AC19 HCT 116 C16(1.05); C110(1.06); C113(1.07)  LDD0595  [17]
 LDCM0279  AC2 HCT 116 C113(0.74); C110(1.06)  LDD0596  [17]
 LDCM0280  AC20 HCT 116 C16(1.08); C110(1.11); C113(1.20)  LDD0597  [17]
 LDCM0281  AC21 HCT 116 C110(0.97); C113(0.97); C16(1.04)  LDD0598  [17]
 LDCM0282  AC22 HCT 116 C110(1.01); C113(1.08); C16(1.19)  LDD0599  [17]
 LDCM0283  AC23 HCT 116 C16(0.90); C110(1.24); C113(1.43)  LDD0600  [17]
 LDCM0284  AC24 HCT 116 C110(1.13); C16(1.17); C113(1.21)  LDD0601  [17]
 LDCM0285  AC25 HCT 116 C113(1.13); C110(1.14)  LDD0602  [17]
 LDCM0286  AC26 HCT 116 C113(0.94); C110(1.17)  LDD0603  [17]
 LDCM0287  AC27 HCT 116 C113(0.99); C110(1.06)  LDD0604  [17]
 LDCM0288  AC28 HCT 116 C113(0.99); C110(1.12)  LDD0605  [17]
 LDCM0289  AC29 HCT 116 C113(0.82); C110(1.08)  LDD0606  [17]
 LDCM0290  AC3 HCT 116 C113(0.74); C110(0.93)  LDD0607  [17]
 LDCM0291  AC30 HCT 116 C113(0.83); C110(1.17)  LDD0608  [17]
 LDCM0292  AC31 HCT 116 C113(0.94); C110(1.18)  LDD0609  [17]
 LDCM0293  AC32 HCT 116 C113(0.83); C110(1.46)  LDD0610  [17]
 LDCM0294  AC33 HCT 116 C113(1.00); C110(1.29)  LDD0611  [17]
 LDCM0295  AC34 HCT 116 C113(1.10); C110(1.59)  LDD0612  [17]
 LDCM0296  AC35 HCT 116 C113(1.03); C110(1.05)  LDD0613  [17]
 LDCM0297  AC36 HCT 116 C113(0.91); C110(0.95)  LDD0614  [17]
 LDCM0298  AC37 HCT 116 C113(0.94); C110(0.99)  LDD0615  [17]
 LDCM0299  AC38 HCT 116 C113(0.83); C110(0.95)  LDD0616  [17]
 LDCM0300  AC39 HCT 116 C113(0.93); C110(1.15)  LDD0617  [17]
 LDCM0301  AC4 HCT 116 C113(0.72); C110(0.98)  LDD0618  [17]
 LDCM0302  AC40 HCT 116 C113(0.83); C110(1.08)  LDD0619  [17]
 LDCM0303  AC41 HCT 116 C113(0.92); C110(1.15)  LDD0620  [17]
 LDCM0304  AC42 HCT 116 C113(0.93); C110(1.19)  LDD0621  [17]
 LDCM0305  AC43 HCT 116 C113(0.78); C110(1.09)  LDD0622  [17]
 LDCM0306  AC44 HCT 116 C113(0.86); C110(1.05)  LDD0623  [17]
 LDCM0307  AC45 HCT 116 C113(0.90); C110(1.17)  LDD0624  [17]
 LDCM0308  AC46 HCT 116 C113(0.87); C110(1.01)  LDD0625  [17]
 LDCM0309  AC47 HCT 116 C113(0.99); C110(1.03)  LDD0626  [17]
 LDCM0310  AC48 HCT 116 C113(0.90); C110(0.99)  LDD0627  [17]
 LDCM0311  AC49 HCT 116 C113(0.80); C110(1.15)  LDD0628  [17]
 LDCM0312  AC5 HCT 116 C113(0.78); C110(1.05)  LDD0629  [17]
 LDCM0313  AC50 HCT 116 C113(0.99); C110(1.23)  LDD0630  [17]
 LDCM0314  AC51 HCT 116 C113(0.90); C110(1.24)  LDD0631  [17]
 LDCM0315  AC52 HCT 116 C113(0.96); C110(1.17)  LDD0632  [17]
 LDCM0316  AC53 HCT 116 C113(0.83); C110(0.92)  LDD0633  [17]
 LDCM0317  AC54 HCT 116 C113(0.91); C110(0.99)  LDD0634  [17]
 LDCM0318  AC55 HCT 116 C113(0.82); C110(0.93)  LDD0635  [17]
 LDCM0319  AC56 HCT 116 C113(0.91); C110(1.11)  LDD0636  [17]
 LDCM0320  AC57 HCT 116 C113(1.10); C110(1.34)  LDD0637  [17]
 LDCM0321  AC58 HCT 116 C113(0.82); C110(1.11)  LDD0638  [17]
 LDCM0322  AC59 HCT 116 C113(0.93); C110(1.20)  LDD0639  [17]
 LDCM0323  AC6 HCT 116 C110(5.89); C113(6.12)  LDD0640  [17]
 LDCM0324  AC60 HCT 116 C113(0.80); C110(1.11)  LDD0641  [17]
 LDCM0325  AC61 HCT 116 C113(0.88); C110(1.12)  LDD0642  [17]
 LDCM0326  AC62 HCT 116 C113(0.97); C110(1.24)  LDD0643  [17]
 LDCM0327  AC63 HCT 116 C113(1.27); C110(1.49)  LDD0644  [17]
 LDCM0328  AC64 HCT 116 C113(0.83); C110(1.15)  LDD0645  [17]
 LDCM0329  AC65 HCT 116 C113(1.00); C110(1.23)  LDD0646  [17]
 LDCM0330  AC66 HCT 116 C113(0.90); C110(1.12)  LDD0647  [17]
 LDCM0331  AC67 HCT 116 C113(0.76); C110(1.09)  LDD0648  [17]
 LDCM0332  AC68 HCT 116 C110(1.17); C113(1.32)  LDD0649  [17]
 LDCM0333  AC69 HCT 116 C113(1.06); C110(1.11)  LDD0650  [17]
 LDCM0334  AC7 HCT 116 C110(12.93); C113(13.71)  LDD0651  [17]
 LDCM0335  AC70 HCT 116 C110(0.89); C113(0.89)  LDD0652  [17]
 LDCM0336  AC71 HCT 116 C110(1.22); C113(1.30)  LDD0653  [17]
 LDCM0337  AC72 HCT 116 C110(1.07); C113(1.12)  LDD0654  [17]
 LDCM0338  AC73 HCT 116 C113(0.93); C110(1.05)  LDD0655  [17]
 LDCM0339  AC74 HCT 116 C113(1.04); C110(1.18)  LDD0656  [17]
 LDCM0340  AC75 HCT 116 C113(0.98); C110(1.16)  LDD0657  [17]
 LDCM0341  AC76 HCT 116 C110(1.19); C113(1.42)  LDD0658  [17]
 LDCM0342  AC77 HCT 116 C110(1.22); C113(1.33)  LDD0659  [17]
 LDCM0343  AC78 HCT 116 C113(1.11); C110(1.12)  LDD0660  [17]
 LDCM0344  AC79 HCT 116 C110(1.44); C113(1.76)  LDD0661  [17]
 LDCM0345  AC8 HCT 116 C110(5.31); C113(5.94)  LDD0662  [17]
 LDCM0346  AC80 HCT 116 C110(1.01); C113(1.02)  LDD0663  [17]
 LDCM0347  AC81 HCT 116 C113(1.09); C110(1.10)  LDD0664  [17]
 LDCM0348  AC82 HCT 116 C113(0.97); C110(1.10)  LDD0665  [17]
 LDCM0349  AC83 HCT 116 C113(0.79); C110(0.84); C16(1.13)  LDD0666  [17]
 LDCM0350  AC84 HCT 116 C113(0.82); C110(0.91); C16(1.10)  LDD0667  [17]
 LDCM0351  AC85 HCT 116 C113(0.86); C110(0.94); C16(1.08)  LDD0668  [17]
 LDCM0352  AC86 HCT 116 C16(0.87); C113(1.10); C110(1.14)  LDD0669  [17]
 LDCM0353  AC87 HCT 116 C113(0.84); C110(0.86); C16(0.94)  LDD0670  [17]
 LDCM0354  AC88 HCT 116 C110(0.84); C113(0.84); C16(0.98)  LDD0671  [17]
 LDCM0355  AC89 HCT 116 C113(0.71); C110(0.74); C16(0.98)  LDD0672  [17]
 LDCM0357  AC90 HCT 116 C113(0.75); C110(0.76); C16(0.87)  LDD0674  [17]
 LDCM0358  AC91 HCT 116 C113(0.77); C110(0.84); C16(1.15)  LDD0675  [17]
 LDCM0359  AC92 HCT 116 C113(1.02); C110(1.06); C16(1.09)  LDD0676  [17]
 LDCM0360  AC93 HCT 116 C113(0.83); C110(0.88); C16(1.09)  LDD0677  [17]
 LDCM0361  AC94 HCT 116 C113(0.90); C110(0.95); C16(1.06)  LDD0678  [17]
 LDCM0362  AC95 HCT 116 C113(0.74); C110(0.76); C16(0.96)  LDD0679  [17]
 LDCM0363  AC96 HCT 116 C16(0.98); C113(1.56); C110(1.86)  LDD0680  [17]
 LDCM0364  AC97 HCT 116 C16(0.93); C113(2.31); C110(2.39)  LDD0681  [17]
 LDCM0365  AC98 HCT 116 C113(0.50); C110(0.54)  LDD0682  [17]
 LDCM0366  AC99 HCT 116 C110(0.83); C113(0.83)  LDD0683  [17]
 LDCM0520  AKOS000195272 MDA-MB-231 C110(0.55)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C110(0.95); C113(1.04)  LDD0565  [17]
 LDCM0356  AKOS034007680 HCT 116 C110(4.06); C113(4.86)  LDD0673  [17]
 LDCM0275  AKOS034007705 HCT 116 C113(0.94); C110(1.21)  LDD0592  [17]
 LDCM0156  Aniline NCI-H1299 10.14  LDD0403  [10]
 LDCM0020  ARS-1620 HCC44 C110(1.45)  LDD0078  [17]
 LDCM0199  BPK-21 T cell C110(15.24)  LDD0517  [31]
 LDCM0200  BPK-25 T cell C110(9.96)  LDD0516  [31]
 LDCM0631  CCW16 231MFP 2.35  LDD2215  [12]
 LDCM0108  Chloroacetamide HeLa C113(0.00); H377(0.00)  LDD0222  [23]
 LDCM0367  CL1 HCT 116 C113(5.42); C110(7.81)  LDD0684  [17]
 LDCM0368  CL10 HCT 116 C113(2.83); C110(6.27)  LDD0685  [17]
 LDCM0369  CL100 HCT 116 C113(0.88); C110(1.32)  LDD0686  [17]
 LDCM0370  CL101 HCT 116 C110(6.40); C113(6.95)  LDD0687  [17]
 LDCM0371  CL102 HCT 116 C110(7.78); C113(9.16)  LDD0688  [17]
 LDCM0372  CL103 HCT 116 C110(2.37); C113(2.71)  LDD0689  [17]
 LDCM0373  CL104 HCT 116 C110(5.90); C113(6.77)  LDD0690  [17]
 LDCM0374  CL105 HCT 116 C16(0.95); C113(2.84); C110(3.36)  LDD0691  [17]
 LDCM0375  CL106 HCT 116 C16(1.19); C113(2.96); C110(3.25)  LDD0692  [17]
 LDCM0376  CL107 HCT 116 C113(1.12); C16(1.13); C110(1.20)  LDD0693  [17]
 LDCM0377  CL108 HCT 116 C16(1.24); C113(2.19); C110(2.24)  LDD0694  [17]
 LDCM0378  CL109 HCT 116 C16(1.23); C113(4.11); C110(8.50)  LDD0695  [17]
 LDCM0379  CL11 HCT 116 C113(4.30); C110(9.35)  LDD0696  [17]
 LDCM0380  CL110 HCT 116 C16(1.08); C110(5.83); C113(6.04)  LDD0697  [17]
 LDCM0381  CL111 HCT 116 C16(1.19); C113(5.10); C110(7.64)  LDD0698  [17]
 LDCM0382  CL112 HCT 116 C110(1.30); C113(1.32)  LDD0699  [17]
 LDCM0383  CL113 HCT 116 C113(0.99); C110(1.50)  LDD0700  [17]
 LDCM0384  CL114 HCT 116 C113(9.25); C110(11.43)  LDD0701  [17]
 LDCM0385  CL115 HCT 116 C113(2.50); C110(4.09)  LDD0702  [17]
 LDCM0386  CL116 HCT 116 C113(1.34); C110(1.76)  LDD0703  [17]
 LDCM0387  CL117 HCT 116 C110(6.36); C113(9.36)  LDD0704  [17]
 LDCM0388  CL118 HCT 116 C110(1.78); C113(1.99)  LDD0705  [17]
 LDCM0389  CL119 HCT 116 C113(1.19); C110(1.31)  LDD0706  [17]
 LDCM0390  CL12 HCT 116 C113(1.62); C110(3.02)  LDD0707  [17]
 LDCM0391  CL120 HCT 116 C113(1.34); C110(1.42)  LDD0708  [17]
 LDCM0392  CL121 HCT 116 C110(1.46); C113(1.52)  LDD0709  [17]
 LDCM0393  CL122 HCT 116 C110(4.67); C113(6.26)  LDD0710  [17]
 LDCM0394  CL123 HCT 116 C110(4.92); C113(6.97)  LDD0711  [17]
 LDCM0395  CL124 HCT 116 C110(3.83); C113(4.27)  LDD0712  [17]
 LDCM0396  CL125 HCT 116 C110(1.32); C113(1.38)  LDD0713  [17]
 LDCM0397  CL126 HCT 116 C110(8.70); C113(11.70)  LDD0714  [17]
 LDCM0398  CL127 HCT 116 C110(6.73); C113(8.67)  LDD0715  [17]
 LDCM0399  CL128 HCT 116 C113(1.08); C110(1.19)  LDD0716  [17]
 LDCM0400  CL13 HCT 116 C113(3.85); C110(6.66)  LDD0717  [17]
 LDCM0401  CL14 HCT 116 C113(2.87); C110(4.03)  LDD0718  [17]
 LDCM0402  CL15 HCT 116 C113(5.43); C110(8.08)  LDD0719  [17]
 LDCM0403  CL16 HCT 116 C110(5.18); C113(7.68)  LDD0720  [17]
 LDCM0404  CL17 HCT 116 C110(13.94); C113(16.27)  LDD0721  [17]
 LDCM0405  CL18 HCT 116 C113(0.96); C110(1.03)  LDD0722  [17]
 LDCM0406  CL19 HCT 116 C110(1.42); C113(1.45)  LDD0723  [17]
 LDCM0407  CL2 HCT 116 C113(4.19); C110(6.64)  LDD0724  [17]
 LDCM0408  CL20 HCT 116 C113(1.20); C110(1.35)  LDD0725  [17]
 LDCM0409  CL21 HCT 116 C110(10.95); C113(12.02)  LDD0726  [17]
 LDCM0410  CL22 HCT 116 C110(6.33); C113(7.22)  LDD0727  [17]
 LDCM0411  CL23 HCT 116 C110(5.42); C113(5.87)  LDD0728  [17]
 LDCM0412  CL24 HCT 116 C113(1.07); C110(1.16)  LDD0729  [17]
 LDCM0413  CL25 HCT 116 C110(7.77); C113(7.42)  LDD0730  [17]
 LDCM0414  CL26 HCT 116 C110(2.03); C113(1.65)  LDD0731  [17]
 LDCM0415  CL27 HCT 116 C110(4.30); C113(4.40)  LDD0732  [17]
 LDCM0416  CL28 HCT 116 C110(11.00); C113(10.03)  LDD0733  [17]
 LDCM0417  CL29 HCT 116 C110(1.04); C113(0.96)  LDD0734  [17]
 LDCM0418  CL3 HCT 116 C110(6.30); C113(4.60)  LDD0735  [17]
 LDCM0419  CL30 HCT 116 C110(1.23); C113(1.26)  LDD0736  [17]
 LDCM0420  CL31 HCT 116 C110(7.17); C113(1.32)  LDD0737  [17]
 LDCM0421  CL32 HCT 116 C110(6.03); C113(4.55)  LDD0738  [17]
 LDCM0422  CL33 HCT 116 C110(9.38); C113(20.00)  LDD0739  [17]
 LDCM0423  CL34 HCT 116 C110(6.23); C113(7.42)  LDD0740  [17]
 LDCM0424  CL35 HCT 116 C110(2.05); C113(1.76)  LDD0741  [17]
 LDCM0425  CL36 HCT 116 C110(8.02); C113(8.02)  LDD0742  [17]
 LDCM0426  CL37 HCT 116 C110(3.54); C113(0.66)  LDD0743  [17]
 LDCM0428  CL39 HCT 116 C110(7.91); C113(14.34)  LDD0745  [17]
 LDCM0429  CL4 HCT 116 C110(7.40); C113(4.13)  LDD0746  [17]
 LDCM0430  CL40 HCT 116 C110(1.45); C113(6.40)  LDD0747  [17]
 LDCM0431  CL41 HCT 116 C110(3.79); C113(10.12)  LDD0748  [17]
 LDCM0432  CL42 HCT 116 C110(5.48); C113(0.99)  LDD0749  [17]
 LDCM0433  CL43 HCT 116 C110(6.14); C113(0.88)  LDD0750  [17]
 LDCM0434  CL44 HCT 116 C110(3.35); C113(1.19)  LDD0751  [17]
 LDCM0435  CL45 HCT 116 C110(5.01); C113(2.58)  LDD0752  [17]
 LDCM0436  CL46 HCT 116 C110(6.36); C113(2.38)  LDD0753  [17]
 LDCM0437  CL47 HCT 116 C110(3.24); C113(3.71)  LDD0754  [17]
 LDCM0438  CL48 HCT 116 C110(2.65); C113(2.65)  LDD0755  [17]
 LDCM0439  CL49 HCT 116 C110(2.31); C113(1.91)  LDD0756  [17]
 LDCM0440  CL5 HCT 116 C110(1.38); C113(1.74)  LDD0757  [17]
 LDCM0441  CL50 HCT 116 C110(2.21); C113(2.25)  LDD0758  [17]
 LDCM0442  CL51 HCT 116 C110(2.47); C113(2.54)  LDD0759  [17]
 LDCM0443  CL52 HCT 116 C110(3.02); C113(3.14)  LDD0760  [17]
 LDCM0444  CL53 HCT 116 C110(4.83); C113(4.67)  LDD0761  [17]
 LDCM0445  CL54 HCT 116 C110(8.05); C113(7.76)  LDD0762  [17]
 LDCM0446  CL55 HCT 116 C110(6.00); C113(6.06)  LDD0763  [17]
 LDCM0447  CL56 HCT 116 C110(2.82); C113(2.98)  LDD0764  [17]
 LDCM0448  CL57 HCT 116 C110(5.41); C113(5.63)  LDD0765  [17]
 LDCM0449  CL58 HCT 116 C110(2.04); C113(2.46)  LDD0766  [17]
 LDCM0450  CL59 HCT 116 C110(2.10); C113(2.30)  LDD0767  [17]
 LDCM0451  CL6 HCT 116 C110(6.96); C113(5.64)  LDD0768  [17]
 LDCM0452  CL60 HCT 116 C110(4.28); C113(4.18)  LDD0769  [17]
 LDCM0453  CL61 HCT 116 C110(1.82); C113(1.04)  LDD0770  [17]
 LDCM0454  CL62 HCT 116 C110(2.91); C113(3.36)  LDD0771  [17]
 LDCM0455  CL63 HCT 116 C110(3.28); C113(1.30)  LDD0772  [17]
 LDCM0456  CL64 HCT 116 C110(3.64); C113(5.86)  LDD0773  [17]
 LDCM0457  CL65 HCT 116 C110(2.14); C113(1.69)  LDD0774  [17]
 LDCM0458  CL66 HCT 116 C110(5.63); C113(7.47)  LDD0775  [17]
 LDCM0459  CL67 HCT 116 C110(2.01); C113(0.98)  LDD0776  [17]
 LDCM0460  CL68 HCT 116 C110(4.66); C113(6.20)  LDD0777  [17]
 LDCM0461  CL69 HCT 116 C110(5.42); C113(5.40)  LDD0778  [17]
 LDCM0462  CL7 HCT 116 C110(4.20); C113(3.41)  LDD0779  [17]
 LDCM0463  CL70 HCT 116 C110(2.94); C113(3.07)  LDD0780  [17]
 LDCM0464  CL71 HCT 116 C110(4.24); C113(4.96)  LDD0781  [17]
 LDCM0465  CL72 HCT 116 C110(1.83); C113(1.17)  LDD0782  [17]
 LDCM0466  CL73 HCT 116 C110(3.70); C113(5.08)  LDD0783  [17]
 LDCM0467  CL74 HCT 116 C110(1.70); C113(1.09)  LDD0784  [17]
 LDCM0469  CL76 HCT 116 C110(2.77); C113(2.04)  LDD0786  [17]
 LDCM0470  CL77 HCT 116 C110(7.62); C113(4.25)  LDD0787  [17]
 LDCM0471  CL78 HCT 116 C110(1.40); C113(1.29)  LDD0788  [17]
 LDCM0472  CL79 HCT 116 C110(2.04); C113(1.10)  LDD0789  [17]
 LDCM0473  CL8 HCT 116 C110(6.22); C113(4.66)  LDD0790  [17]
 LDCM0474  CL80 HCT 116 C110(1.40); C113(1.09)  LDD0791  [17]
 LDCM0475  CL81 HCT 116 C110(2.96); C113(1.98)  LDD0792  [17]
 LDCM0476  CL82 HCT 116 C110(2.61); C113(1.37)  LDD0793  [17]
 LDCM0477  CL83 HCT 116 C110(11.09); C113(1.98)  LDD0794  [17]
 LDCM0478  CL84 HCT 116 C110(6.40); C113(2.39)  LDD0795  [17]
 LDCM0479  CL85 HCT 116 C110(6.00); C113(4.03)  LDD0796  [17]
 LDCM0480  CL86 HCT 116 C110(9.15); C113(2.19)  LDD0797  [17]
 LDCM0481  CL87 HCT 116 C110(10.23); C113(2.03)  LDD0798  [17]
 LDCM0482  CL88 HCT 116 C110(5.52); C113(3.26)  LDD0799  [17]
 LDCM0483  CL89 HCT 116 C110(5.11); C113(2.16)  LDD0800  [17]
 LDCM0484  CL9 HCT 116 C110(5.84); C113(4.05)  LDD0801  [17]
 LDCM0485  CL90 HCT 116 C110(13.03); C113(19.04)  LDD0802  [17]
 LDCM0486  CL91 HCT 116 C110(4.72); C113(4.66)  LDD0803  [17]
 LDCM0487  CL92 HCT 116 C110(7.25); C113(9.92)  LDD0804  [17]
 LDCM0488  CL93 HCT 116 C110(6.01); C113(5.50)  LDD0805  [17]
 LDCM0489  CL94 HCT 116 C110(5.93); C113(5.82)  LDD0806  [17]
 LDCM0490  CL95 HCT 116 C110(6.21); C113(6.15)  LDD0807  [17]
 LDCM0491  CL96 HCT 116 C110(2.14); C113(1.77)  LDD0808  [17]
 LDCM0492  CL97 HCT 116 C110(5.81); C113(5.45)  LDD0809  [17]
 LDCM0493  CL98 HCT 116 C110(5.39); C113(4.63)  LDD0810  [17]
 LDCM0494  CL99 HCT 116 C110(5.14); C113(5.13)  LDD0811  [17]
 LDCM0495  E2913 HEK-293T C110(5.84)  LDD1698  [32]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C110(1.11)  LDD1702  [6]
 LDCM0100  EN219 231MFP 5.35  LDD0298  [1]
 LDCM0201  EV-3 T cell C110(8.54)  LDD0515  [31]
 LDCM0203  EV-96 T cell C110(7.75)  LDD0522  [31]
 LDCM0204  EV-97 T cell C110(20.00)  LDD0524  [31]
 LDCM0205  EV-98 T cell C110(20.00)  LDD0518  [31]
 LDCM0206  EV-99 T cell C110(10.58)  LDD0521  [31]
 LDCM0625  F8 Ramos 13.22  LDD2187  [33]
 LDCM0573  Fragment11 Ramos C110(0.17)  LDD2190  [33]
 LDCM0574  Fragment12 Ramos C110(3.98)  LDD2191  [33]
 LDCM0576  Fragment14 Ramos 0.87  LDD2193  [33]
 LDCM0582  Fragment23 Ramos 1.12  LDD2196  [33]
 LDCM0578  Fragment27 Ramos C110(2.08); 9.33  LDD2197  [33]
 LDCM0586  Fragment28 Ramos 20.00  LDD2198  [33]
 LDCM0588  Fragment30 Ramos C110(2.66)  LDD2199  [33]
 LDCM0589  Fragment31 Ramos C110(0.66); 1.46  LDD2200  [33]
 LDCM0590  Fragment32 Ramos C110(0.92)  LDD2201  [33]
 LDCM0468  Fragment33 HCT 116 C110(3.85); C113(5.27)  LDD0785  [17]
 LDCM0596  Fragment38 Ramos 0.72  LDD2203  [33]
 LDCM0427  Fragment51 HCT 116 C110(6.84); C113(5.58)  LDD0744  [17]
 LDCM0610  Fragment52 Ramos 6.15  LDD2204  [33]
 LDCM0614  Fragment56 Ramos C110(0.90); 1.20  LDD2205  [33]
 LDCM0616  Fragment61 Jurkat _(20.00)  LDD1489  [13]
 LDCM0615  Fragment63-R Jurkat _(20.00)  LDD1487  [13]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [13]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [13]
 LDCM0107  IAA HeLa N.A.  LDD0221  [23]
 LDCM0022  KB02 HCT 116 C110(9.45)  LDD0080  [17]
 LDCM0023  KB03 HCT 116 C110(8.73)  LDD0081  [17]
 LDCM0024  KB05 HCT 116 C110(1.33)  LDD0082  [17]
 LDCM0169  KB63 Ramos 20.00  LDD0432  [34]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C110(1.22)  LDD2102  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [23]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C110(1.23)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C110(0.76)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C110(1.08); C113(0.93)  LDD2093  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C110(0.78)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C110(0.74)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C110(1.51)  LDD2098  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C110(1.11); C113(0.51)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C110(0.31)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C110(0.73)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C110(1.80)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C110(0.87)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C110(0.88)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C110(0.59)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C110(0.85)  LDD2109  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C110(0.97)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C110(0.68)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C110(1.05)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C110(1.07)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C110(2.74)  LDD2119  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C110(1.25)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C110(0.72)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C113(0.69)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C110(0.55)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C110(0.56)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C110(0.68)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C110(0.47)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C110(0.80); C113(1.16)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C110(0.65)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C110(0.81)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C110(0.64)  LDD2140  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C110(2.67)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C110(0.97)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C110(0.85)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C110(0.90)  LDD2149  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C110(3.65)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C110(2.40)  LDD2153  [6]
 LDCM0014  Panhematin K562 4.88  LDD0063  [15]
 LDCM0099  Phenelzine HEK-293T 14.64  LDD0282  [11]
 LDCM0131  RA190 MM1.R C110(1.15)  LDD0304  [9]
 LDCM0084  Ro 48-8071 A-549 2.74  LDD0145  [28]
 LDCM0021  THZ1 HCT 116 C110(0.99)  LDD2173  [17]
 LDCM0002  Ward_cp1 U2OS 110.67  LDD0041  [16]
 LDCM0154  YY4 T cell 7.73  LDD0400  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cilia- and flagella-associated protein 141 (CFAP141) . Q5VU69

References

1 Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28(4):559-566.e15. doi: 10.1016/j.chembiol.2021.01.005. Epub 2021 Jan 28.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
10 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
11 Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets. ACS Cent Sci. 2021 Sep 22;7(9):1524-1534. doi: 10.1021/acscentsci.1c00616. Epub 2021 Aug 19.
12 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
13 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
14 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
15 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
16 Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells. ACS Chem Biol. 2016 Dec 16;11(12):3268-3272. doi: 10.1021/acschembio.6b00766. Epub 2016 Oct 31.
17 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
18 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
25 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
28 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
29 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
30 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
31 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
32 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
33 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
34 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.