Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C228  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 195 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00697  Cytochrome b5 type B (CYB5B) 99.7
 LDTP02359  Heme oxygenase 1 (HMOX1) 99.7
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 99.7
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 99.7
 LDTP03540  Heme oxygenase 2 (HMOX2) 92.4
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 79.3
 LDTP00844  Maleylacetoacetate isomerase (GSTZ1) 69.6
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 68.1
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 65.3
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 60.1
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 58.5
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 57.3
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 57.3
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 56.5
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 50.9
 LDTP03145  Catechol O-methyltransferase (COMT) 48.5
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 48.5
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 47.8
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 45.3
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 45.3
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 45.3
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 44.9
 LDTP12415  Adenosine 5'-monophosphoramidase HINT3 (HINT3) 44.3
 LDTP12586  Phenylalanine--tRNA ligase beta subunit (FARSB) 44.3
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 41.9
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 41.9
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 41.9
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 41.9
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 41.4
 LDTP03787  Choline kinase alpha (CHKA) 41.1
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 40.2
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 37.3
 LDTP10329  Ceramide synthase 2 (CERS2) 36.8
 LDTP11852  Presenilin-associated rhomboid-like protein, mitochondrial (PARL) 36.3
 LDTP01300  Cartilage-associated protein (CRTAP) 36.0
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 36.0
 LDTP07931  Heme A synthase COX15 (COX15) 36.0
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 35.3
 LDTP11867  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) 33.6
 LDTP10020  Ras-related protein Rab-24 (RAB24) 33.4
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 33.1
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 32.9
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 32.9
 LDTP10163  m7GpppX diphosphatase (DCPS) 32.2
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 30.9
 LDTP04247  Protein farnesyltransferase subunit beta (FNTB) 30.3
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 30.1
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 29.9
 LDTP03842  Squalene synthase (FDFT1) 29.9
 LDTP13220  Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) 29.7
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 29.7
 LDTP04531  Hexokinase-2 (HK2) 29.4
 LDTP11127  ADP-dependent glucokinase (ADPGK) 29.2
 LDTP09666  Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) 28.8
 LDTP03394  Ceramide synthase 1 (CERS1) 28.2
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 28.2
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 28.1
 LDTP18087  Dephospho-CoA kinase domain-containing protein (DCAKD) 28.1
 LDTP01769  Dihydrofolate reductase (DHFR) 27.9
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 27.7
 LDTP12293  Adipocyte plasma membrane-associated protein (APMAP) 27.3
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 27.3
 LDTP13486  Long-chain-fatty-acid--CoA ligase 6 (ACSL6) 27.1
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 26.4
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 26.2
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 26.2
 LDTP13408  Cell division cycle protein 23 homolog (CDC23) 25.8
 LDTP06977  GPI ethanolamine phosphate transferase 2 (PIGG) 25.8
 LDTP04581  Holocytochrome c-type synthase (HCCS) 25.8
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 25.8
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 25.5
 LDTP14264  Choline/ethanolaminephosphotransferase 1 (CEPT1) 25.5
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 25.5
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 25.5
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 25.3
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) 25.3
 LDTP01640  CCR4-NOT transcription complex subunit 4 (CNOT4) 25.3
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 25.3
 LDTP01389  Delta(14)-sterol reductase TM7SF2 (TM7SF2) 24.8
 LDTP09061  Retinol dehydrogenase 13 (RDH13) 24.8
 LDTP09095  Diacylglycerol lipase-beta (DAGLB) 24.3
 LDTP05905  Acid ceramidase (ASAH1) 24.1
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 24.1
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 23.9
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 23.8
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 23.8
 LDTP07756  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (HACD2) 23.6
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 23.3
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 22.9
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 22.9
 LDTP12470  GTP-binding protein SAR1a (SAR1A) 22.8
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 22.6
 LDTP00645  Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) 22.5
 LDTP11259  Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12) 22.2
 LDTP01335  Protein SCO1 homolog, mitochondrial (SCO1) 22.2
 LDTP02942  ADP-ribosylation factor 4 (ARF4) 22.0
 LDTP07620  Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (PAOX) 22.0
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 22.0
 LDTP09251  Atlastin-2 (ATL2) 21.9
 LDTP12639  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) 21.6
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 21.6
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) 21.4
 LDTP04494  NADH dehydrogenase 1 alpha subcomplex subunit 8 (NDUFA8) 21.3
 LDTP00032  2-hydroxyacyl-CoA lyase 2 (ILVBL) 21.0
 LDTP08859  Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) 20.8
 LDTP15480  Prenylcysteine oxidase-like (PCYOX1L) 20.8
 LDTP12490  Sphingosine kinase 2 (SPHK2) 20.8
 LDTP14231  GTP-binding protein SAR1b (SAR1B) 20.7
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 20.3
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 20.3
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 20.3
 LDTP11318  ADP-ribose pyrophosphatase, mitochondrial (NUDT9) 20.1
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 20.1
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 20.1
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 20.0
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 19.8
 LDTP12732  Hypoxia-inducible factor 1-alpha inhibitor (HIF1AN) 19.8
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 19.7
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 19.7
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 19.7
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 19.6
 LDTP12318  Calcium-independent phospholipase A2-gamma (PNPLA8) 19.4
 LDTP03779  Copper-transporting ATPase 2 (ATP7B) 19.4
 LDTP14427  Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7A2L) 19.4
 LDTP12679  Trimethyllysine dioxygenase, mitochondrial (TMLHE) 19.4
 LDTP04248  Deoxyhypusine synthase (DHPS) 19.3
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 19.3
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 19.0
 LDTP01743  NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) 19.0
 LDTP02837  Beta-galactosidase (GLB1) 18.9
 LDTP03769  Sterol O-acyltransferase 1 (SOAT1) 18.9
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 18.6
 LDTP09031  Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) 18.6
 LDTP06142  Squalene monooxygenase (SQLE) 18.6
 LDTP14050  E3 SUMO-protein ligase ZNF451 (ZNF451) 18.5
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 18.5
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 18.5
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 18.4
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 18.3
 LDTP00877  Protein SCO2 homolog, mitochondrial (SCO2) 18.3
 LDTP11437  Peroxisomal trans-2-enoyl-CoA reductase (PECR) 18.1
 LDTP15155  Thiol S-methyltransferase TMT1B (TMT1B) 18.1
 LDTP10930  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) 17.9
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 17.6
 LDTP09578  Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1) 17.6
 LDTP13986  Vesicle transport protein GOT1B (GOLT1B) 17.6
 LDTP01562  Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) 17.4
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 17.1
 LDTP07504  Lysophospholipid acyltransferase 5 (LPCAT3) 17.1
 LDTP00400  Torsin-1B (TOR1B) 17.1
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 17.0
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 17.0
 LDTP15097  All-trans-retinol 13,14-reductase (RETSAT) 16.9
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A) 16.9
 LDTP00836  ATPase GET3 (GET3) 16.8
 LDTP04119  Glycogenin-1 (GYG1) 16.7
 LDTP00325  Pirin (PIR) 16.7
 LDTP04895  Ras-related protein Rab-10 (RAB10) 16.7
 LDTP09814  Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (LPGAT1) 16.4
 LDTP10432  ATP synthase membrane subunit K, mitochondrial (ATP5MK) 16.4
 LDTP04892  Ras-related protein Rab-2A (RAB2A) 16.4
 LDTP12610  Obg-like ATPase 1 (OLA1) 16.3
 LDTP03900  ADP-ribosylation factor-like protein 1 (ARL1) 16.2
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 16.1
 LDTP05228  Calcium-transporting ATPase type 2C member 1 (ATP2C1) 16.1
 LDTP00575  Glutathione S-transferase A4 (GSTA4) 16.1
 LDTP06810  Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50) 15.9
 LDTP07154  ATPase family AAA domain-containing protein 3B (ATAD3B) 15.8
 LDTP01329  Lathosterol oxidase (SC5D) 15.7
 LDTP05006  Ras-related protein Rab-1A (RAB1A) 15.6
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 15.6
 LDTP02721  Farnesyl pyrophosphate synthase (FDPS) 15.5
 LDTP08530  Mitofusin-1 (MFN1) 15.5
 LDTP09495  Probable glutathione peroxidase 8 (GPX8) 15.5
 LDTP11535  Ras-related protein Rab-34 (RAB34) 15.5
 LDTP06455  Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) 15.5
 LDTP00950  Dynamin-like 120 kDa protein, mitochondrial (OPA1) 15.3
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 15.2
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 15.2
 LDTP04737  DNA polymerase epsilon subunit 2 (POLE2) 15.1
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 15.1
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 14.9
 LDTP10471  Protein disulfide-isomerase TMX3 (TMX3) 14.9
 LDTP00654  Synaptobrevin homolog YKT6 (YKT6) 14.9
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 14.9
 LDTP06905  Acylglycerol kinase, mitochondrial (AGK) 14.8
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 14.8
 LDTP06720  Peroxisomal leader peptide-processing protease (TYSND1) 14.8
 LDTP06645  Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) 14.7
 LDTP17587  Catechol O-methyltransferase domain-containing protein 1 (COMTD1) 14.6
 LDTP15879  Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) 14.6
 LDTP10981  Mitochondrial intermediate peptidase (MIPEP) 14.6
 LDTP01219  NADH dehydrogenase 1 beta subcomplex subunit 1 (NDUFB1) 14.6
 LDTP04203  Phosphatidylserine synthase 1 (PTDSS1) 14.6
 LDTP12180  Retinol dehydrogenase 14 (RDH14) 14.6
Transporter and channel
Click to Show/Hide to Show 136 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01804  ATP synthase subunit a (MT-ATP6) 99.7
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 99.7
 LDTP11927  Essential MCU regulator, mitochondrial (SMDT1) 99.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 99.7
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 99.7
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 99.7
 LDTP15948  Transmembrane protein 126A (TMEM126A) 99.7
 LDTP15648  BRI3-binding protein (BRI3BP) 94.4
 LDTP16813  Tetraspanin-3 (TSPAN3) 77.2
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 72.5
 LDTP20002  Transmembrane protein 160 (TMEM160) 72.0
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 58.5
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 56.9
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 55.3
 LDTP08279  Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42) 53.8
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 49.2
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 48.8
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 48.2
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 47.8
 LDTP16190  Protein FAM8A1 (FAM8A1) 46.2
 LDTP15481  Transmembrane protein 87A (TMEM87A) 45.3
 LDTP11615  Protein tweety homolog 3 (TTYH3) 44.9
 LDTP10065  Transmembrane protein 230 (TMEM230) 44.9
 LDTP11245  Derlin-1 (DERL1) 43.7
 LDTP15979  Transmembrane protein 245 (TMEM245) 43.7
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 43.4
 LDTP04789  Synaptojanin-2-binding protein (SYNJ2BP) 43.4
 LDTP15967  Tetraspanin-10 (TSPAN10) 42.2
 LDTP11250  MICOS complex subunit MIC26 (APOO) 41.6
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 41.4
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 40.2
 LDTP07236  Protein GPR107 (GPR107) 39.9
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 39.7
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 38.1
 LDTP02215  Prosaposin (PSAP) 37.5
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 37.0
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 35.8
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 35.3
 LDTP07439  Mitochondrial adenyl nucleotide antiporter SLC25A25 (SLC25A25) 34.3
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 34.3
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 34.1
 LDTP01060  PRA1 family protein 2 (PRAF2) 33.4
 LDTP00592  Surfeit locus protein 4 (SURF4) 33.4
 LDTP08469  Complex I assembly factor TMEM126B, mitochondrial (TMEM126B) 31.8
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 31.6
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 31.3
 LDTP08881  Transmembrane protein 199 (TMEM199) 30.7
 LDTP09180  Zinc transporter 7 (SLC30A7) 30.5
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 30.3
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 29.4
 LDTP09028  Mitoguardin 1 (MIGA1) 29.2
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 28.4
 LDTP02655  Lysosome-associated membrane glycoprotein 2 (LAMP2) 28.2
 LDTP12210  Mitochondrial thiamine pyrophosphate carrier (SLC25A19) 27.9
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 27.3
 LDTP02609  ADP/ATP translocase 3 (SLC25A6) 26.9
 LDTP12704  Anoctamin-10 (ANO10) 26.2
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) 26.0
 LDTP05900  Metaxin-1 (MTX1) 26.0
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 25.8
 LDTP07583  Transmembrane protein 65 (TMEM65) 25.3
 LDTP12979  Transmembrane protein 14C (TMEM14C) 25.1
 LDTP04787  Transmembrane protein 33 (TMEM33) 25.1
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 24.9
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 24.8
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 24.4
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 24.4
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 23.9
 LDTP01574  Importin-7 (IPO7) 23.8
 LDTP13953  Endophilin-B1 (SH3GLB1) 23.6
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 23.6
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 23.3
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 23.3
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 22.9
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 22.5
 LDTP00872  Peroxisomal membrane protein PMP34 (SLC25A17) 22.5
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 22.5
 LDTP12451  Integral membrane protein 2C (ITM2C) 22.3
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 22.3
 LDTP12383  Protein GPR108 (GPR108) 22.2
 LDTP18053  Probable mitochondrial glutathione transporter SLC25A40 (SLC25A40) 22.0
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 21.4
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 21.3
 LDTP11213  Nucleoporin NDC1 (NDC1) 20.8
 LDTP07667  Transmembrane protein 205 (TMEM205) 20.8
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 20.7
 LDTP09788  Sorting nexin-19 (SNX19) 20.5
 LDTP00590  Protein RER1 (RER1) 19.8
 LDTP11229  Transmembrane protein 70, mitochondrial (TMEM70) 19.4
 LDTP10804  Chloride channel CLIC-like protein 1 (CLCC1) 19.3
 LDTP00630  Importin-8 (IPO8) 19.3
 LDTP11844  Protein spinster homolog 1 (SPNS1) 19.2
 LDTP07058  Transmembrane protein 201 (TMEM201) 19.0
 LDTP10081  Leucine-rich repeat-containing protein 59 (LRRC59) 18.8
 LDTP13943  Thioredoxin-related transmembrane protein 2 (TMX2) 18.6
 LDTP11406  Transmembrane protein 59 (TMEM59) 18.6
 LDTP01380  Wolframin (WFS1) 18.6
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) 18.5
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 18.5
 LDTP10036  BOS complex subunit NCLN (NCLN) 18.4
 LDTP07531  Sideroflexin-4 (SFXN4) 18.4
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 18.1
 LDTP06633  Reticulon-1 (RTN1) 18.1
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 18.0
 LDTP07477  Transmembrane protein 214 (TMEM214) 17.9
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 17.6
 LDTP10769  Intermembrane lipid transfer protein VPS13A (VPS13A) 17.6
 LDTP04293  Transmembrane emp24 domain-containing protein 10 (TMED10) 17.6
 LDTP01748  Mitochondrial import receptor subunit TOM40 homolog (TOMM40) 17.5
 LDTP07472  Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) 17.4
 LDTP11116  45 kDa calcium-binding protein (SDF4) 17.1
 LDTP10343  Vacuole membrane protein 1 (VMP1) 16.9
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 16.4
 LDTP02068  Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1) 16.4
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 16.1
 LDTP09333  Golgin subfamily A member 5 (GOLGA5) 16.0
 LDTP04749  Peroxisomal biogenesis factor 3 (PEX3) 16.0
 LDTP01180  Programmed cell death protein 6 (PDCD6) 16.0
 LDTP01601  Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) 15.9
 LDTP09651  Choline transporter-like protein 1 (SLC44A1) 15.9
 LDTP06293  Metal cation symporter ZIP14 (SLC39A14) 15.7
 LDTP10513  Exocyst complex component 2 (EXOC2) 15.6
 LDTP09789  Transmembrane 9 superfamily member 4 (TM9SF4) 15.6
 LDTP11732  Magnesium transporter protein 1 (MAGT1) 15.5
 LDTP09204  Nucleoporin NUP35 (NUP35) 15.5
 LDTP09949  Transportin-1 (TNPO1) 15.5
 LDTP14084  Sorting and assembly machinery component 50 homolog (SAMM50) 15.3
 LDTP13256  SUN domain-containing protein 2 (SUN2) 15.3
 LDTP11281  Voltage-gated monoatomic cation channel TMEM109 (TMEM109) 15.2
 LDTP08030  Autophagy-related protein 9A (ATG9A) 15.0
 LDTP04426  B-cell receptor-associated protein 31 (BCAP31) 15.0
 LDTP05384  Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) 15.0
 LDTP15845  Transmembrane 9 superfamily member 2 (TM9SF2) 15.0
 LDTP12331  Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) 14.8
 LDTP13369  Rab5 GDP/GTP exchange factor (RABGEF1) 14.7
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 14.6
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 25.1
 LDTP12471  DNA polymerase epsilon subunit 4 (POLE4) 17.3
GPCR
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15303  Membrane progestin receptor alpha (PAQR7) 28.4
Immunoglobulin
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05572  Leukocyte surface antigen CD47 (CD47) 24.6
 LDTP04720  IgG receptor FcRn large subunit p51 (FCGRT) 20.1
 LDTP03772  Basigin (BSG) 16.9
Other
Click to Show/Hide to Show 141 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 99.7
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 99.7
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 99.7
 LDTP01522  Reticulon-3 (RTN3) 99.7
 LDTP05160  Nucleobindin-2 (NUCB2) 98.4
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 91.1
 LDTP08796  Protein SYS1 homolog (SYS1) 85.6
 LDTP18883  Protein CEBPZOS (CEBPZOS) 79.3
 LDTP10056  Protein FAM162A (FAM162A) 75.1
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 72.0
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) 68.1
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 65.8
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 65.3
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 59.3
 LDTP12412  Reticulon-4 (RTN4) 58.1
 LDTP18467  LYR motif-containing protein 2 (LYRM2) 54.6
 LDTP16080  Protein FAM114A2 (FAM114A2) 49.9
 LDTP05375  Nucleobindin-1 (NUCB1) 49.2
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 46.9
 LDTP08606  Nurim (NRM) 42.2
 LDTP13086  Syntaxin-18 (STX18) 41.9
 LDTP14939  Membralin (TMEM259) 40.5
 LDTP16006  Optic atrophy 3 protein (OPA3) 39.7
 LDTP08224  Protein LYRIC (MTDH) 39.1
 LDTP14458  Tetraspanin-6 (TSPAN6) 38.3
 LDTP04974  Small ribosomal subunit protein uS15 (RPS13) 36.5
 LDTP05868  Protein unc-119 homolog A (UNC119) 35.8
 LDTP18462  COX assembly mitochondrial protein 2 homolog (CMC2) 35.0
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) 34.8
 LDTP15095  Receptor expression-enhancing protein 3 (REEP3) 34.5
 LDTP09813  CCR4-NOT transcription complex subunit 9 (CNOT9) 32.7
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 32.4
 LDTP06404  Surfeit locus protein 1 (SURF1) 32.4
 LDTP12623  Zinc finger CCHC domain-containing protein 3 (ZCCHC3) 32.4
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 32.2
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 31.6
 LDTP12025  UPF0488 protein C8orf33 (C8orf33) 30.7
 LDTP19963  TraB domain-containing protein (TRABD) 30.3
 LDTP01494  Protein YIF1A (YIF1A) 30.1
 LDTP15434  ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL6IP6) 29.9
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 29.9
 LDTP06097  Reticulocalbin-2 (RCN2) 29.9
 LDTP01167  Reticulon-2 (RTN2) 29.4
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 29.0
 LDTP10116  Lipid droplet assembly factor 1 (LDAF1) 28.6
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 28.4
 LDTP13802  DNA replication complex GINS protein PSF2 (GINS2) 28.2
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 28.2
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 28.2
 LDTP11981  Receptor expression-enhancing protein 4 (REEP4) 28.1
 LDTP03729  General transcription factor IIF subunit 1 (GTF2F1) 26.7
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 26.2
 LDTP08000  Dymeclin (DYM) 23.9
 LDTP16156  Protein PALS2 (PALS2) 23.6
 LDTP01163  Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9) 23.6
 LDTP05715  Vesicle transport protein SEC20 (BNIP1) 23.4
 LDTP12379  Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) 23.1
 LDTP08594  Negative elongation factor C/D (NELFCD) 23.1
 LDTP04356  Emerin (EMD) 22.8
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 22.5
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 22.5
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 22.3
 LDTP11389  Bcl-2-like protein 13 (BCL2L13) 22.2
 LDTP11825  Phosducin-like protein 3 (PDCL3) 22.2
 LDTP13967  Transmembrane emp24 domain-containing protein 5 (TMED5) 21.7
 LDTP11113  Receptor expression-enhancing protein 2 (REEP2) 21.4
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 21.3
 LDTP06128  RNA-binding protein 39 (RBM39) 21.3
 LDTP03352  Splicing factor U2AF 65 kDa subunit (U2AF2) 21.3
 LDTP06068  MAGUK p55 subfamily member 2 (MPP2) 21.1
 LDTP13922  Tudor and KH domain-containing protein (TDRKH) 21.1
 LDTP03926  Centrin-2 (CETN2) 21.0
 LDTP17214  Protein odr-4 homolog (ODR4) 21.0
 LDTP10409  Splicing factor 45 (RBM17) 20.8
 LDTP07192  Intermembrane lipid transfer protein VPS13D (VPS13D) 20.3
 LDTP07718  MICOS complex subunit MIC27 (APOOL) 20.1
 LDTP00071  Vacuolar protein sorting-associated protein 37C (VPS37C) 20.1
 LDTP02927  Ganglioside GM2 activator (GM2A) 20.0
 LDTP12729  Required for meiotic nuclear division protein 1 homolog (RMND1) 19.8
 LDTP02297  Vimentin (VIM) 19.8
 LDTP16577  DENN domain-containing protein 11 (DENND11) 19.7
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 19.4
 LDTP11326  FUN14 domain-containing protein 2 (FUNDC2) 19.2
 LDTP19005  SLC35A4 upstream open reading frame protein (SLC35A4) 19.2
 LDTP04425  Translocon-associated protein subunit delta (SSR4) 19.0
 LDTP06291  ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) 18.5
 LDTP05530  Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) 18.5
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 18.3
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 18.3
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) 18.3
 LDTP15398  Protein FAM177A1 (FAM177A1) 18.1
 LDTP14277  Cytochrome c oxidase assembly protein COX11, mitochondrial (COX11) 18.0
 LDTP12192  Kinetochore protein Spc25 (SPC25) 18.0
 LDTP16099  p53 and DNA damage-regulated protein 1 (PDRG1) 18.0
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 17.9
 LDTP14263  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) 17.3
 LDTP10924  Prohibitin-2 (PHB2) 17.1
 LDTP04917  Proteasome activator complex subunit 3 (PSME3) 17.1
 LDTP15634  Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) 17.0
 LDTP13093  Neurochondrin (NCDN) 16.7
 LDTP02736  Myosin light chain 6B (MYL6B) 16.6
 LDTP18575  C2 domain-containing protein 2 (C2CD2) 16.4
 LDTP01359  Dynactin subunit 3 (DCTN3) 16.4
 LDTP00859  Synaptogyrin-2 (SYNGR2) 16.4
 LDTP05960  Trophoblast glycoprotein (TPBG) 16.4
 LDTP05277  Protein SET (SET) 16.3
 LDTP12762  Transmembrane protein 161A (TMEM161A) 16.3
 LDTP15976  Large ribosomal subunit protein mL46 (MRPL46) 16.2
 LDTP09644  m-AAA protease-interacting protein 1, mitochondrial (MAIP1) 16.2
 LDTP11906  Phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU) 16.2
 LDTP09839  Centromere protein I (CENPI) 16.1
 LDTP11065  Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT) 16.1
 LDTP19924  Protein PBDC1 (PBDC1) 16.1
 LDTP10403  DDRGK domain-containing protein 1 (DDRGK1) 16.0
 LDTP00417  Programmed cell death protein 5 (PDCD5) 16.0
 LDTP09773  Protein FAM3C (FAM3C) 16.0
 LDTP01259  Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA) 15.8
 LDTP17808  SHC SH2 domain-binding protein 1 (SHCBP1) 15.8
 LDTP15840  Tetratricopeptide repeat protein 1 (TTC1) 15.8
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 15.7
 LDTP15623  Neuferricin (CYB5D2) 15.6
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 15.6
 LDTP13402  Dynactin subunit 4 (DCTN4) 15.3
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 15.3
 LDTP05685  Transmembrane protein 115 (TMEM115) 15.3
 LDTP04703  Tumor protein D52 (TPD52) 15.3
 LDTP00887  Calumenin (CALU) 15.2
 LDTP16322  Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) 15.2
 LDTP14126  Mitochondrial import inner membrane translocase subunit Tim9 (TIMM9) 15.2
 LDTP10209  Regulator of microtubule dynamics protein 1 (RMDN1) 15.2
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 15.1
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 15.0
 LDTP02443  Calmodulin-3 (CALM3) 15.0
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 15.0
 LDTP18561  Small ribosomal subunit protein mS33 (MRPS33) 14.9
 LDTP16285  Transducin beta-like protein 2 (TBL2) 14.9
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 14.7
 LDTP08300  Reticulophagy regulator 3 (RETREG3) 14.7
 LDTP11210  Transmembrane protein 43 (TMEM43) 14.7
 LDTP11312  DET1- and DDB1-associated protein 1 (DDA1) 14.6
 LDTP10046  Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ERGIC1) 14.6

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587