Details of the Target

General Information of Target

Target ID LDTP08030
Target Name Autophagy-related protein 9A (ATG9A)
Gene Name ATG9A
Gene ID 79065
Synonyms
APG9L1; Autophagy-related protein 9A; APG9-like 1; mATG9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQFDTEYQRLEASYSDSPPGEEDLLVHVAEGSKSPWHHIENLDLFFSRVYNLHQKNGFT
CMLIGEIFELMQFLFVVAFTTFLVSCVDYDILFANKMVNHSLHPTEPVKVTLPDAFLPAQ
VCSARIQENGSLITILVIAGVFWIHRLIKFIYNICCYWEIHSFYLHALRIPMSALPYCTW
QEVQARIVQTQKEHQICIHKRELTELDIYHRILRFQNYMVALVNKSLLPLRFRLPGLGEA
VFFTRGLKYNFELILFWGPGSLFLNEWSLKAEYKRGGQRLELAQRLSNRILWIGIANFLL
CPLILIWQILYAFFSYAEVLKREPGALGARCWSLYGRCYLRHFNELEHELQSRLNRGYKP
ASKYMNCFLSPLLTLLAKNGAFFAGSILAVLIALTIYDEDVLAVEHVLTTVTLLGVTVTV
CRSFIPDQHMVFCPEQLLRVILAHIHYMPDHWQGNAHRSQTRDEFAQLFQYKAVFILEEL
LSPIVTPLILIFCLRPRALEIIDFFRNFTVEVVGVGDTCSFAQMDVRQHGHPQWLSAGQT
EASVYQQAEDGKTELSLMHFAITNPGWQPPRESTAFLGFLKEQVQRDGAAASLAQGGLLP
ENALFTSIQSLQSESEPLSLIANVVAGSSCRGPPLPRDLQGSRHRAEVASALRSFSPLQP
GQAPTGRAHSTMTGSGVDARTASSGSSVWEGQLQSLVLSEYASTEMSLHALYMHQLHKQQ
AQAEPERHVWHRRESDESGESAPDEGGEGARAPQSIPRSASYPCAAPRPGAPETTALHGG
FQRRYGGITDPGTVPRVPSHFSRLPLGGWAEDGQSASRHPEPVPEEGSEDELPPQVHKV
Target Bioclass
Transporter and channel
Family
ATG9 family
Subcellular location
Preautophagosomal structure membrane
Function
Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1. In addition to autophagy, also plays a role in necrotic cell death.
Uniprot ID
Q7Z3C6
Ensemble ID
ENST00000361242.9
HGNC ID
HGNC:22408

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
Ishikawa (Heraklio) 02 ER SNV: p.M430T .
JURKAT SNV: p.G357V .
KYSE510 SNV: p.P434S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.57  LDD0402  [1]
CHEMBL5175495
 Probe Info  		8.88  LDD0196  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
BTD
 Probe Info  		C764(0.88)  LDD2127  [4]
BDBM50514113
 Probe Info  		1.78  LDD0041  [5]
DBIA
 Probe Info  		C433(0.96); C764(1.79); C197(0.92)  LDD0531  [6]
W1
 Probe Info  		C764(0.92)  LDD0238  [7]
IA-alkyne
 Probe Info  		C331(0.00); C764(0.00)  LDD0162  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
ENE
 Probe Info  		N.A.  LDD0006  [10]
IPM
 Probe Info  		C331(0.00); C433(0.00)  LDD0005  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
Crotonaldehyde
 Probe Info  		H669(0.00); C197(0.00)  LDD0219  [12]
Methacrolein
 Probe Info  		C197(0.00); C764(0.00)  LDD0218  [12]
AOyne
 Probe Info  		14.60  LDD0443  [13]
NAIA_5
 Probe Info  		C519(0.00); C764(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C091
 Probe Info  		11.24  LDD1782  [14]
C092
 Probe Info  		17.75  LDD1783  [14]
C170
 Probe Info  		7.52  LDD1850  [14]
C201
 Probe Info  		26.54  LDD1877  [14]
C228
 Probe Info  		15.03  LDD1901  [14]
C231
 Probe Info  		15.03  LDD1904  [14]
C246
 Probe Info  		14.62  LDD1919  [14]
C252
 Probe Info  		8.51  LDD1925  [14]
C355
 Probe Info  		23.92  LDD2016  [14]
C356
 Probe Info  		10.06  LDD2017  [14]
C362
 Probe Info  		39.95  LDD2023  [14]
C363
 Probe Info  		16.34  LDD2024  [14]
C407
 Probe Info  		11.16  LDD2064  [14]
FFF probe11
 Probe Info  		20.00  LDD0471  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C433(0.96); C764(1.79); C197(0.92)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C178(0.80); C197(0.77); C331(1.10)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C433(0.83); C764(0.93); C178(1.17); C197(0.77)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C433(0.97); C764(0.97); C178(1.00); C197(0.82)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C433(0.79); C764(0.83); C178(1.16); C197(0.90)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C433(0.69); C764(0.91); C178(0.88); C197(0.93)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C433(0.80); C764(0.80); C178(1.30); C197(0.91)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C433(0.80); C764(1.00); C178(1.18); C197(0.89)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C433(0.81); C764(1.08); C178(0.99); C197(0.94)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C433(0.80); C764(0.76); C178(1.19); C197(1.19)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C433(0.79); C764(1.03); C178(1.04); C197(0.90)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C433(0.93); C764(0.98); C178(1.20); C197(0.89)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C178(0.84); C197(0.72); C331(1.10)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C433(0.78); C764(1.09); C178(0.87); C197(0.98)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C433(1.03); C764(0.89); C178(1.10); C197(0.81)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C433(0.85); C764(0.97); C178(0.89); C197(1.16)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C764(1.48); C178(0.98); C197(0.99); C331(1.23)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C764(0.84); C178(1.10); C197(1.01); C331(1.07)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C764(1.02); C178(1.12); C197(0.89); C331(1.11)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C764(0.78); C178(0.83); C197(1.06); C331(1.31)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C764(0.82); C178(1.16); C197(0.94); C331(0.86)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C764(0.81); C178(1.10); C197(1.18); C331(0.89)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C764(0.85); C178(0.85); C197(1.00); C331(0.70)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C178(0.96); C197(0.65); C331(0.99)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C764(0.95); C178(1.09); C197(1.20); C331(1.77)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C764(0.59); C178(1.13); C197(0.94); C331(1.48)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C764(0.77); C178(0.80); C197(1.19); C331(0.35)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C764(0.53); C178(1.05); C197(1.00); C331(0.83)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C764(0.97); C178(0.95); C197(1.07); C331(0.52)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C764(0.92); C178(1.03); C197(1.09); C331(0.92)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C764(0.89); C178(1.02); C197(1.12); C331(0.65)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C764(0.72); C178(1.13); C197(1.11); C331(0.82)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C433(1.31); C197(1.29)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C433(1.63); C197(0.91)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C433(1.35); C197(1.03)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C433(1.17); C197(1.00)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C433(1.28); C197(1.24)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C433(1.16); C197(1.28)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C433(1.36); C197(1.22)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C433(1.35); C197(1.39)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C433(1.10); C197(1.37)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C433(1.26); C197(1.45)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C433(1.29); C197(1.43)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C433(1.20); C197(1.29)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C178(0.78); C197(0.75); C331(0.80)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C433(1.46); C197(1.44)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C433(1.33); C197(1.29)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C433(1.15); C197(1.31)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C433(1.18); C764(1.53); C197(0.98)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C197(1.01); C433(1.17); C764(1.73)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C197(0.84); C433(1.23); C764(1.46)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C197(0.83); C433(1.32); C764(1.41)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C197(0.82); C764(1.23); C433(1.24)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C197(0.77); C433(2.00); C764(2.13)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C197(0.86); C433(1.86); C764(1.94)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C178(0.75); C197(0.76); C331(1.12)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C197(1.04); C764(1.20); C433(1.41)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C764(1.05); C433(1.10); C197(1.17)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C197(0.83); C764(1.51); C433(1.51)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C197(0.88); C764(1.22); C433(1.89)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C433(1.40); C764(1.24); C197(0.94)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C433(1.22); C764(1.47); C197(1.06)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C433(0.86); C764(0.94); C197(0.82)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C433(1.10); C764(1.17); C197(0.76)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C331(0.70); C764(0.74); C178(0.93); C197(0.96)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C764(0.64); C197(0.76); C331(0.82); C178(0.94)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C331(0.61); C764(0.64); C197(0.71); C178(0.92)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C197(0.93); C433(1.11); C764(3.24)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C331(0.57); C764(0.75); C197(0.79); C178(0.90)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C764(0.56); C331(0.63); C197(0.66); C178(0.91)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C764(0.62); C197(0.68); C331(0.82); C433(0.95)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C764(0.65); C331(0.69); C197(0.69); C178(0.99)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C764(0.39); C331(0.71); C197(0.87); C178(0.95)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C331(0.68); C178(1.02); C197(1.04); C433(1.27)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C331(0.78); C178(0.99); C197(1.18); C433(1.24)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C331(0.88); C178(0.92); C197(1.07); C433(1.43)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C178(0.85); C331(0.88); C197(1.11); C433(1.34)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C178(0.99); C331(1.07); C197(1.15); C433(1.43)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C197(0.96); C433(1.03); C764(1.40)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C331(1.00); C197(1.01); C178(1.12); C433(1.73)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C331(0.98); C197(1.01); C178(1.26); C433(1.50)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C178(0.93); C197(1.07); C331(1.18); C433(1.26)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C331(0.79); C197(0.90); C178(1.00); C433(1.57)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C331(0.49); C197(0.99); C178(0.99); C433(1.37)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C197(0.82); C178(0.99)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C197(0.92); C178(0.95)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C197(0.79); C178(1.15)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C197(0.89); C178(1.29)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C178(0.80); C197(0.88)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C197(0.97); C433(1.04); C764(1.29)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C197(0.91); C178(1.04)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C197(0.80); C178(0.94)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C197(0.87); C178(1.44)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C197(0.97); C178(1.12)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C197(0.75); C178(0.96)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C197(0.81); C178(0.97)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C197(0.99)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C197(1.02)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C197(0.96)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C197(1.28)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C197(1.01); C433(1.14); C764(1.29)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C197(1.08)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C197(0.91)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C197(0.96)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C197(1.00)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C197(1.05)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C197(1.05)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C197(1.18)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C178(0.70); C331(1.23); C197(1.74)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C178(1.07); C331(1.24); C197(1.39)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C178(0.76); C331(1.30); C197(1.68)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C178(0.79); C331(0.87); C197(0.94)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C178(0.80); C331(1.16); C197(1.75)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C178(0.99); C197(1.49); C331(1.75)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C331(0.73); C178(0.75); C197(1.72)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C178(0.86); C331(1.22); C197(1.60)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C178(0.74); C331(0.97); C197(1.56)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C178(0.97); C331(0.97); C197(2.25)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C178(0.85); C331(1.03); C197(1.96)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C178(0.76); C331(1.07); C197(2.24)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C331(0.98); C178(1.07)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C331(0.84); C178(0.85)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C178(0.70); C197(0.84); C331(1.06)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C178(0.87); C331(0.99)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C331(1.01); C178(1.12)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C331(0.99); C178(1.06)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C331(0.93); C178(1.00)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C331(0.78); C178(1.08)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C178(0.91); C331(1.00)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C178(0.96); C331(0.98)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C331(0.66); C178(1.05)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C331(0.89); C178(0.92)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C331(0.85); C178(1.03)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C178(0.77); C197(0.80); C331(1.00)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C331(0.83); C178(1.12)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C331(0.83); C178(0.96)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C331(0.80); C178(1.04)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C331(0.88)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C331(1.34)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C331(1.14)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C331(1.02)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C331(1.31)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C331(1.26)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C331(1.30)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C331(1.00)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C331(1.08)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C331(0.37)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C331(0.83)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C331(0.56)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C331(0.61)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C331(0.57)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C331(0.61)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C178(0.93); C433(0.94); C764(1.09); C197(1.10)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C197(0.77); C433(0.91); C764(1.03); C178(1.07)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C197(0.43)  LDD2138  [4]
 LDCM0248  AKOS034007472 HCT 116 C178(0.94); C197(0.78); C331(0.90)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C197(0.78); C178(0.98); C331(0.99)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C178(0.68); C197(0.81); C331(1.23)  LDD0592  [6]
 LDCM0630  CCW28-3 231MFP C630(1.24)  LDD2214  [16]
 LDCM0108  Chloroacetamide HeLa C197(0.00); C764(0.00)  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C197(20.00)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C764(0.81); C197(1.04); C178(1.56)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C178(0.68); C764(0.69); C197(1.10)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C197(0.85); C433(1.25); C764(1.44)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C178(0.77); C331(0.86); C197(0.96)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C197(0.67); C331(0.87); C178(0.88)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C197(0.77); C331(1.04); C178(1.15)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C197(0.76); C331(1.02); C178(1.11)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C764(0.64); C331(0.69); C178(0.93); C197(0.96)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C331(0.64); C764(0.73); C197(0.86); C178(0.90)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C331(0.74); C197(0.82); C764(0.87); C178(0.95)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C331(0.80); C178(0.90); C197(0.93); C764(1.15)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C764(0.63); C197(0.71); C331(0.77); C178(0.81)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C764(0.68); C178(0.73); C197(1.85)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C764(0.69); C331(0.71); C178(0.78); C197(0.87)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C764(0.54); C178(0.80); C331(0.82); C197(0.93)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C331(0.76); C433(1.00); C197(1.02); C178(1.09)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C331(0.69); C178(0.86); C197(0.92); C433(1.30)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C178(0.81); C331(0.94); C197(0.96); C433(1.57)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C178(0.91); C197(0.93); C331(0.99); C433(1.62)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C331(0.74); C178(0.84); C197(0.97); C433(1.09)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C197(0.86); C178(1.04)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C197(0.78); C178(0.90)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C197(0.87); C178(0.99)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C764(0.53); C197(1.16); C178(1.20)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C178(0.76); C197(0.83)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C197(0.86)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C197(0.99)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C197(1.18)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C197(1.00)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C178(0.67); C197(1.42); C331(1.44)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C178(1.08); C197(1.34); C331(1.60)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C178(0.75); C331(1.23); C197(1.26)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C178(0.97); C331(1.28); C197(1.43)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C764(0.59); C197(0.88); C178(0.97)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C764(0.67); C197(1.01); C178(1.16)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C764(0.66); C178(0.91); C197(1.02)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C764(0.99); C197(1.14); C433(1.26)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C764(0.80); C178(0.83); C197(1.10); C331(1.15)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C764(0.85); C178(0.93); C331(1.03); C197(1.06)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C178(0.78); C764(0.94); C197(1.13); C433(1.22)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C764(0.69); C197(0.98); C178(1.00)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C178(0.83); C433(1.03); C331(1.06); C197(1.08)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C764(0.74); C178(0.81); C331(0.87); C197(1.10)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C764(0.90); C197(0.96); C178(1.31); C331(1.35)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C331(0.92); C178(0.97); C433(1.02); C197(1.04)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C764(0.89); C178(0.90); C197(0.94); C331(1.19)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C433(7.79); C764(1.07); C178(1.10); C197(1.05)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C433(1.69); C764(1.47); C178(1.08); C197(1.06)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C433(1.27); C764(0.95); C178(1.09); C197(0.95)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C433(3.81); C764(1.30); C178(0.85); C197(0.95)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C433(1.16); C764(1.05); C178(1.07); C197(1.05)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C764(0.73); C178(1.16); C197(0.93)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C433(0.94); C764(1.48); C178(1.28); C197(0.92)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C178(0.95); C197(1.03); C331(0.69)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C764(1.06); C197(1.02)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C764(1.33); C197(1.02)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C764(1.31); C197(1.26)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C764(1.02); C197(1.14)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C764(1.37); C197(0.99)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C764(0.82); C197(1.23)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C764(1.17); C197(1.07)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C764(0.53); C178(1.14); C197(0.95)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C764(0.58); C197(0.99)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C764(1.00); C197(1.18)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C764(1.63); C197(1.20)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C764(0.71); C197(1.14)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C764(1.09); C197(1.14)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C764(0.95); C197(1.18)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C433(1.76); C178(1.19); C197(1.06); C331(0.79)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C433(2.07); C178(1.32); C197(1.04); C331(1.55)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C433(1.04); C178(1.52); C197(0.96); C331(1.00)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C433(1.57); C178(1.15); C197(1.05); C331(0.80)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C764(0.39); C178(0.93); C197(0.98)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C433(1.60); C178(0.91); C197(0.92); C331(1.03)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C433(0.87); C178(1.17); C197(0.96); C331(0.82)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C433(0.91); C178(1.10); C197(0.84); C331(0.86)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C433(2.15); C178(1.33); C197(0.80); C331(1.16)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C433(2.57); C178(1.03); C197(0.90); C331(0.78)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C433(0.90); C178(1.21); C197(0.88); C331(0.72)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C433(2.21); C178(1.01); C197(0.77); C331(1.06)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C433(3.55); C178(1.05); C197(0.90); C331(0.98)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C433(0.90); C178(1.08); C197(0.98); C331(0.74)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C433(0.97); C178(1.10); C197(0.87); C331(1.54)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C764(0.58); C178(0.78); C197(0.93)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C433(2.49); C178(1.19); C197(0.89); C331(0.82)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C764(1.04); C178(0.79); C197(1.09); C331(1.14)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C764(1.14); C178(1.04); C197(1.14); C331(0.91)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C764(1.00); C178(0.52); C197(0.95); C331(0.90)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C764(0.67); C178(0.71); C197(1.13); C331(1.20)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C764(0.83); C178(1.04); C197(1.02); C331(0.86)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C764(1.14); C178(0.61); C197(1.22); C331(0.95)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C764(1.04); C178(1.10); C197(1.22); C331(0.89)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C764(1.00); C178(0.52); C197(1.00); C331(0.72)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C764(1.32); C178(0.84); C197(0.97); C331(0.89)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C764(0.56); C178(0.76); C197(1.12)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C764(1.42); C178(1.02); C197(1.01); C331(0.59)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C764(1.11); C178(0.97); C197(0.97); C331(0.79)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C764(1.06); C178(0.85); C197(0.99); C331(0.84)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C764(1.14); C178(0.88); C197(1.03); C331(0.61)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C764(1.32); C178(0.81); C197(0.94); C331(0.64)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C197(1.11); C331(1.15)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C197(1.04); C331(0.68)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C197(1.02); C331(0.64)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C197(1.07); C331(1.04)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C764(0.65); C178(0.92); C197(2.30)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C197(1.01); C331(1.19)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C197(1.02); C331(0.98)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C197(1.02); C331(1.31)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C197(0.98); C331(0.97)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C197(0.99); C331(1.39)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C197(0.95); C331(1.60)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C197(0.89); C331(1.82)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C197(0.99); C331(1.33)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C197(0.94); C331(1.04)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C197(0.96); C331(0.67)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C764(0.42); C178(0.93); C197(0.94)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C197(1.32); C331(0.66)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C433(1.63); C764(1.05); C197(1.26)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C433(1.58); C764(1.03); C197(1.03)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C433(1.55); C764(1.44); C197(0.95)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C433(1.83); C764(1.95); C197(1.01)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C433(2.34); C764(1.23); C197(1.08)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C433(1.75); C764(1.06); C197(1.07)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C433(1.57); C764(1.24); C197(1.08)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C433(1.41); C764(5.01); C197(1.12)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C433(1.37); C764(1.68); C197(1.24)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C197(0.92); C433(1.61); C178(0.97); C764(1.04)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C764(1.90)  LDD1702  [4]
 LDCM0625  F8 Ramos C764(1.44)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C764(1.81)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C764(0.94)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C764(1.51)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C764(1.07)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C764(1.12)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C764(2.00)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C764(1.21)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C764(1.08)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C764(0.93)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C764(0.89)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C764(1.46)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C764(0.99)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C764(2.03)  LDD2201  [18]
 LDCM0468  Fragment33 HCT 116 C764(0.97); C178(0.89); C197(1.05); C331(1.08)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C764(1.04)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C764(1.26)  LDD2184  [18]
 LDCM0427  Fragment51 HCT 116 C764(1.08); C197(1.27)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C764(1.24)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C764(1.32)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C764(1.95)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C764(1.80)  LDD2188  [18]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HEK-293T C764(0.97); C197(0.96); C331(0.79); C433(0.95)  LDD1492  [17]
 LDCM0023  KB03 Jurkat C197(10.15)  LDD0315  [8]
 LDCM0024  KB05 COLO792 C331(2.52)  LDD3310  [19]
 LDCM0109  NEM HeLa N.A.  LDD0224  [12]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C764(0.88)  LDD2127  [4]
 LDCM0628  OTUB2-COV-1 HEK-293T C764(1.23)  LDD2207  [20]
 LDCM0111  W14 Hep-G2 C764(0.92)  LDD0238  [7]
 LDCM0112  W16 Hep-G2 C764(0.57)  LDD0239  [7]
 LDCM0113  W17 Hep-G2 C764(1.23)  LDD0240  [7]
 LDCM0002  Ward_cp1 U2OS 1.78  LDD0041  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase 1 beta subcomplex subunit 7 (NDUFB7) Complex I NDUFB7 subunit family P17568
Inactive glycosyltransferase 25 family member 3 (CERCAM) Glycosyltransferase 25 family Q5T4B2
Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) HAD-like hydrolase superfamily Q9BSH5
Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) Glyoxalase II family O95571
Serine/threonine-protein kinase TBK1 (TBK1) Ser/Thr protein kinase family Q9UHD2
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-2 complex subunit mu (AP2M1) Adaptor complexes medium subunit family Q96CW1
Autophagy-related protein 2 homolog A (ATG2A) ATG2 family Q2TAZ0
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Zinc finger and BTB domain-containing protein 42 (ZBTB42) Krueppel C2H2-type zinc-finger protein family B2RXF5
Homeobox protein MOX-1 (MEOX1) . P50221
Proto-oncogene c-Rel (REL) . Q04864
Zinc finger protein 581 (ZNF581) . Q9P0T4
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Oxoeicosanoid receptor 1 (OXER1) G-protein coupled receptor 1 family Q8TDS5
Other
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cilia- and flagella-associated protein 68 (CFAP68) CFAP68 family Q9H5F2
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cuticular Ha5 (KRT35) Intermediate filament family Q92764
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 19-1 (KRTAP19-1) KRTAP type 19 family Q8IUB9
Keratin-associated protein 3-2 (KRTAP3-2) KRTAP type 3 family Q9BYR7
Keratin-associated protein 3-3 (KRTAP3-3) KRTAP type 3 family Q9BYR6
Keratin-associated protein 4-2 (KRTAP4-2) KRTAP type 4 family Q9BYR5
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Keratin-associated protein 11-1 (KRTAP11-1) PMG family Q8IUC1
Keratin-associated protein 13-3 (KRTAP13-3) PMG family Q3SY46
Calcium and integrin-binding family member 4 (CIB4) . A0PJX0
Keratinocyte proline-rich protein (KPRP) . Q5T749

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells. ACS Chem Biol. 2016 Dec 16;11(12):3268-3272. doi: 10.1021/acschembio.6b00766. Epub 2016 Oct 31.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.