Details of the Competitor

General Information of Competitor

Competitor ID
LDCM0111
Competitor Name
W14
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 161.164
Lipid-water partition coefficient (xlogp) 1.371
Rotatable Bond Count (rotbonds) 1
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C8H7N3O
Canonical SMILES
ON=Cc1cnc2[nH]ccc2c1
InChI
InChI=1S/C8H7N3O/c12-11-5-6-3-7-1-2-9-8(7)10-4-6/h1-5,12H,(H,9,10)/b11-5+
InChIKey
DOBDQTLRJUIUPD-VZUCSPMQSA-N

The Competitor Interaction Atlas

Probe(s) Related This Competitor

ABPP Probe
Click To Hide/Show 1 Probe Related to This Competitor
Probe Name Structure Concentration Cell-system Ref
W1
 Probe Info  		500 uM Human hepatoblastoma cells (Hep-G2) [1]

Target(s) List of this Competitor

67 Enzyme Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) LDTP02356 5.18  LDD0238 
6-phosphogluconate dehydrogenase, decarboxylating (PGD) LDTP04499 0.96  LDD0238 
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 0.83  LDD0238 
Actin, alpha skeletal muscle (ACTA1) LDTP05073 2.19  LDD0238 
Actin, cytoplasmic 2 (ACTG1) LDTP05059 1.13; 1.43; 1.75 ...  LDD0238 
Adenosylhomocysteinase (AHCY) LDTP03242 0.61  LDD0238 
Aldo-keto reductase family 1 member C2 (AKR1C2) LDTP04543 0.73; 1.75; 1.78 ...  LDD0238 
Aldo-keto reductase family 1 member C3 (AKR1C3) LDTP03976 0.91; 0.93; 1.02 ...  LDD0238 
All-trans-retinol 13,14-reductase (RETSAT) LDTP15097 11.42  LDD0238 
ATP synthase subunit beta, mitochondrial (ATP5F1B) LDTP02150 0.52  LDD0238 
ATP-dependent DNA helicase Q1 (RECQL) LDTP04083 14.50  LDD0238 
Carbonyl reductase [NADPH] 1 (CBR1) LDTP02831 26.65  LDD0238 
Casein kinase II subunit alpha' (CSNK2A2) LDTP03011 0.52  LDD0238 
Cathepsin B (CTSB) LDTP02223 0.73  LDD0238 
Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) LDTP03610 0.69  LDD0238 
Cytochrome b5 type B (CYB5B) LDTP00697 18.23  LDD0238 
D-3-phosphoglycerate dehydrogenase (PHGDH) LDTP00701 8.68  LDD0238 
Dehydrogenase/reductase SDR family member 1 (DHRS1) LDTP10550 0.85  LDD0238 
Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2) LDTP05809 0.61; 1.52  LDD0238 
Dihydropyrimidinase-related protein 5 (DPYSL5) LDTP11035 1.54  LDD0238 
DNA replication licensing factor MCM3 (MCM3) LDTP03316 21.94  LDD0238 
Double-stranded RNA-specific adenosine deaminase (ADAR) LDTP04690 2.60; 4.37  LDD0238 
E3 ubiquitin-protein ligase HUWE1 (HUWE1) LDTP08135 1.10  LDD0238 
Elongation factor 2 (EEF2) LDTP02672 0.57; 10.97  LDD0238 
Fatty acid synthase (FASN) LDTP04243 1.15; 1.17; 1.19 ...  LDD0238 
Fructosamine-3-kinase (FN3K) LDTP11904 27.44  LDD0238 
Fructose-bisphosphate aldolase A (ALDOA) LDTP02008 3.64  LDD0238 
Glucose-6-phosphate 1-dehydrogenase (G6PD) LDTP02569 13.79  LDD0238 
Glutamate dehydrogenase 1, mitochondrial (GLUD1) LDTP01768 0.87; 0.94  LDD0238 
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (GFPT1) LDTP05481 4.14  LDD0238 
Glutathione S-transferase omega-1 (GSTO1) LDTP05128 2.08; 21.16  LDD0238 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) LDTP02038 35.40  LDD0238 
Glycerol-3-phosphate phosphatase (PGP) LDTP00089 17.39  LDD0238 
GMP synthase [glutamine-hydrolyzing] (GMPS) LDTP04333 20.82  LDD0238 
GTP-binding nuclear protein Ran (RAN) LDTP05007 0.92  LDD0238 
Guanidino acid hydrolase, mitochondrial (AGMAT) LDTP15873 0.81  LDD0238 
Heat shock protein HSP 90-alpha (HSP90AA1) LDTP02225 0.91  LDD0238 
Heme oxygenase 2 (HMOX2) LDTP03540 13.04  LDD0238 
Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL) LDTP03794 17.25  LDD0238 
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) LDTP01333 0.69  LDD0238 
Lysine-specific demethylase 5B (KDM5B) LDTP13233 0.51; 0.51; 0.51  LDD0238 
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1) LDTP03677 0.73  LDD0238 
Microsomal glutathione S-transferase 1 (MGST1) LDTP02506 5.10  LDD0238 
Nucleolar RNA helicase 2 (DDX21) LDTP12469 1.18; 1.45  LDD0238 
Peroxiredoxin-6 (PRDX6) LDTP03510 0.70; 0.83; 3.28  LDD0238 
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2) LDTP06638 3.30  LDD0238 
Probable ATP-dependent RNA helicase DDX5 (DDX5) LDTP02924 0.50; 2.29  LDD0238 
Prostaglandin E synthase 3 (PTGES3) LDTP06338 0.62  LDD0238 
Protein disulfide-isomerase A3 (PDIA3) LDTP03521 0.65; 0.69  LDD0238 
Pyruvate carboxylase, mitochondrial (PC) LDTP02576 16.72  LDD0238 
Ras-related protein Rab-5B (RAB5B) LDTP04893 0.59  LDD0238 
Rho-associated protein kinase 2 (ROCK2) LDTP01127 12.02  LDD0238 
Ribosomal protein S6 kinase alpha-3 (RPS6KA3) LDTP04471 14.34  LDD0238 
S-phase kinase-associated protein 1 (SKP1) LDTP05052 28.53  LDD0238 
Serine/threonine-protein phosphatase CPPED1 (CPPED1) LDTP11107 26.94  LDD0238 
Small ribosomal subunit protein uS3 (RPS3) LDTP03223 0.59  LDD0238 
Squalene synthase (FDFT1) LDTP03842 6.80  LDD0238 
Sulfotransferase 1A4 (SULT1A4) LDTP02431 39.98  LDD0238 
Transforming protein RhoA (RHOA) LDTP04927 0.53  LDD0238 
Transitional endoplasmic reticulum ATPase (VCP) LDTP04665 1.08  LDD0238 
Triosephosphate isomerase (TPI1) LDTP04851 1.36  LDD0238 
Tubulin alpha-1B chain (TUBA1B) LDTP05074 1.30; 1.70  LDD0238 
Tubulin alpha-1C chain (TUBA1C) LDTP11074 0.70  LDD0238 
U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200) LDTP01283 1.19  LDD0238 
Ubiquitin-like modifier-activating enzyme 1 (UBA1) LDTP03166 6.77  LDD0238 
V-type proton ATPase catalytic subunit A (ATP6V1A) LDTP03859 30.32  LDD0238 
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL) LDTP04289 18.46  LDD0238 
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⏷ Show the Full List of 67 Enzyme
32 Transporter and channel Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
14-3-3 protein theta (YWHAQ) LDTP03385 0.61; 1.34  LDD0238 
Annexin A5 (ANXA5) LDTP02307 0.54  LDD0238 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 2.44  LDD0238 
ATP synthase subunit alpha, mitochondrial (ATP5F1A) LDTP03327 0.61  LDD0238 
ATP synthase subunit gamma, mitochondrial (ATP5F1C) LDTP03810 0.86  LDD0238 
Autophagy-related protein 9A (ATG9A) LDTP08030 0.92  LDD0238 
Calnexin (CANX) LDTP03405 0.65; 0.69  LDD0238 
Catenin delta-1 (CTNND1) LDTP01037 7.97  LDD0238 
Chloride intracellular channel protein 4 (CLIC4) LDTP14222 22.64  LDD0238 
Clathrin heavy chain 1 (CLTC) LDTP05252 23.05  LDD0238 
Dihydropyrimidinase-related protein 2 (DPYSL2) LDTP06554 7.25  LDD0238 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) LDTP02057 2.04  LDD0238 
Eukaryotic translation initiation factor 5A-2 (EIF5A2) LDTP11657 0.65  LDD0238 
Filamin-A (FLNA) LDTP03107 6.92; 21.49  LDD0238 
Heat shock protein HSP 90-beta (HSP90AB1) LDTP02262 0.79  LDD0238 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 3.16  LDD0238 
Nuclear pore complex protein Nup93 (NUP93) LDTP08769 15.40  LDD0238 
Oligosaccharyltransferase complex subunit OSTC (OSTC) LDTP12526 0.61  LDD0238 
PAT complex subunit CCDC47 (CCDC47) LDTP10059 1.62  LDD0238 
Pericentriolar material 1 protein (PCM1) LDTP06331 10.48  LDD0238 
Pinin (PNN) LDTP11855 0.65  LDD0238 
Protein SEC13 homolog (SEC13) LDTP04707 2.24  LDD0238 
Protein transport protein Sec61 subunit beta (SEC61B) LDTP04866 11.79  LDD0238 
Signal recognition particle 9 kDa protein (SRP9) LDTP04259 0.96  LDD0238 
Small ribosomal subunit protein RACK1 (RACK1) LDTP05057 0.50  LDD0238 
Spectrin beta chain, non-erythrocytic 1 (SPTBN1) LDTP05273 4.45  LDD0238 
Thioredoxin domain-containing protein 17 (TXNDC17) LDTP11103 8.37  LDD0238 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 1.32  LDD0238 
Transmembrane protein 199 (TMEM199) LDTP08881 5.32  LDD0238 
Tricarboxylate transport protein, mitochondrial (SLC25A1) LDTP04553 2.32  LDD0238 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 0.73  LDD0238 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 13.39  LDD0238 
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⏷ Show the Full List of 32 Transporter and channel
80 Other Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
14-3-3 protein beta/alpha (YWHAB) LDTP03617 0.69  LDD0238 
Acyl-CoA-binding protein (DBI) LDTP02177 3.86  LDD0238 
Alpha-1-antitrypsin (SERPINA1) LDTP01811 4.76  LDD0238 
Alpha-actinin-4 (ACTN4) LDTP00843 8.91  LDD0238 
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) LDTP05770 12.12  LDD0238 
CCHC-type zinc finger nucleic acid binding protein (CNBP) LDTP04995 1.60  LDD0238 
Coatomer subunit beta (COPB1) LDTP04570 6.92  LDD0238 
Cofilin-1 (CFL1) LDTP03244 37.25  LDD0238 
Coronin-7 (CORO7) LDTP04798 11.82  LDD0238 
Double-stranded RNA-binding protein Staufen homolog 1 (STAU1) LDTP01677 8.90  LDD0238 
Elongation factor 1-gamma (EEF1G) LDTP03367 0.65  LDD0238 
Endoplasmin (HSP90B1) LDTP02734 0.59  LDD0238 
Epiplakin (EPPK1) LDTP04809 0.65  LDD0238 
Eukaryotic translation initiation factor 3 subunit B (EIF3B) LDTP04718 0.57  LDD0238 
F-actin-capping protein subunit beta (CAPZB) LDTP04127 12.03  LDD0238 
Fatty acid-binding protein, liver (FABP1) LDTP02178 4.87; 7.35  LDD0238 
Glypican-3 (GPC3) LDTP04439 0.51; 7.82  LDD0238 
GrpE protein homolog 1, mitochondrial (GRPEL1) LDTP12144 8.14  LDD0238 
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) LDTP02364 0.58; 0.60  LDD0238 
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) LDTP04514 1.60; 26.30  LDD0238 
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) LDTP03615 23.99  LDD0238 
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) LDTP04714 0.72; 0.73  LDD0238 
Heterogeneous nuclear ribonucleoprotein L (HNRNPL) LDTP02750 0.89  LDD0238 
Heterogeneous nuclear ribonucleoprotein M (HNRNPM) LDTP04500 1.44; 1.44; 1.46  LDD0238 
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) LDTP05259 0.55; 1.01  LDD0238 
Histone H1.4 (H1-4) LDTP02494 0.50; 0.58  LDD0238 
Histone H2A type 1-C (H2AC6) LDTP09974 0.58  LDD0238 
Histone H2A type 1-J (H2AC14) LDTP10999 1.11  LDD0238 
Histone H2B type 1-C/E/F/G/I (H2BC4; H2BC6; H2BC7; H2BC8; H2BC10) LDTP05005 0.59; 0.95; 1.16 ...  LDD0238 
Histone H2B type 1-L (H2BC13) LDTP11001 0.96; 1.14  LDD0238 
Histone H3.2 (H3C15; H3C14; H3C13) LDTP07899 0.52; 0.98; 1.16 ...  LDD0238 
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) LDTP05004 0.65; 1.02; 1.15 ...  LDD0238 
Interleukin enhancer-binding factor 3 (ILF3) LDTP05689 1.05; 1.13  LDD0238 
Ladinin-1 (LAD1) LDTP14421 23.04  LDD0238 
Lamina-associated polypeptide 2, isoform alpha (TMPO) LDTP03967 0.89; 4.03  LDD0238 
Large ribosomal subunit protein eL18 (RPL18) LDTP05509 0.72  LDD0238 
Large ribosomal subunit protein eL20 (RPL18A) LDTP05360 0.76  LDD0238 
Large ribosomal subunit protein eL22 (RPL22) LDTP03728 0.58; 0.85  LDD0238 
Large ribosomal subunit protein eL34 (RPL34) LDTP04233 1.11; 33.47  LDD0238 
Large ribosomal subunit protein uL15 (RPL27A) LDTP04105 1.13  LDD0238 
Large ribosomal subunit protein uL22 (RPL17) LDTP02961 0.51  LDD0238 
Large ribosomal subunit protein uL3 (RPL3) LDTP03865 0.82; 0.87  LDD0238 
Large ribosomal subunit protein uL30 (RPL7) LDTP02944 0.69  LDD0238 
Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) LDTP03658 0.52  LDD0238 
Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) LDTP03997 8.73  LDD0238 
Lupus La protein (SSB) LDTP02116 28.05  LDD0238 
Matrin-3 (MATR3) LDTP04027 1.10  LDD0238 
Myb-binding protein 1A (MYBBP1A) LDTP11079 1.24  LDD0238 
Nucleolar protein 10 (NOL10) LDTP18301 6.02  LDD0238 
Nucleolar protein 58 (NOP58) LDTP13925 20.46  LDD0238 
Nucleophosmin (NPM1) LDTP02164 2.32  LDD0238 
Perilipin-3 (PLIN3) LDTP01021 4.06  LDD0238 
Poly(rC)-binding protein 1 (PCBP1) LDTP06366 9.72; 16.70  LDD0238 
Poly(rC)-binding protein 2 (PCBP2) LDTP06367 12.19  LDD0238 
Prelamin-A/C (LMNA) LDTP01932 6.98; 22.34  LDD0238 
Protein THEM6 (THEM6) LDTP19831 2.47  LDD0238 
Receptor expression-enhancing protein 5 (REEP5) LDTP05257 10.85  LDD0238 
Reticulon-4 (RTN4) LDTP12412 12.24  LDD0238 
Ribosomal L1 domain-containing protein 1 (RSL1D1) LDTP01379 1.67  LDD0238 
Ribosome-binding protein 1 (RRBP1) LDTP13044 0.58; 1.77; 5.91  LDD0238 
Scaffold attachment factor B2 (SAFB2) LDTP06054 16.98  LDD0238 
Serine/arginine-rich splicing factor 3 (SRSF3) LDTP05197 9.36  LDD0238 
Serine/arginine-rich splicing factor 7 (SRSF7) LDTP06583 1.36  LDD0238 
Shootin-1 (SHTN1) LDTP00019 14.04  LDD0238 
Small ribosomal subunit protein eS12 (RPS12) LDTP03321 3.01; 3.01  LDD0238 
Small ribosomal subunit protein eS4, Y isoform 1 (RPS4Y1) LDTP14653 0.77  LDD0238 
Small ribosomal subunit protein uS10 (RPS20) LDTP04880 14.47; 15.69  LDD0238 
Small ribosomal subunit protein uS17 (RPS11) LDTP04975 0.54  LDD0238 
Small ribosomal subunit protein uS4 (RPS9) LDTP04109 0.53; 0.59  LDD0238 
Small ribosomal subunit protein uS7 (RPS5) LDTP04110 1.13  LDD0238 
SPATS2-like protein (SPATS2L) LDTP16102 13.11; 20.61  LDD0238 
Src substrate cortactin (CTTN) LDTP06094 24.30  LDD0238 
Stress-induced-phosphoprotein 1 (STIP1) LDTP03619 1.19; 8.48  LDD0238 
T-complex protein 1 subunit epsilon (CCT5) LDTP04201 1.44; 1.83  LDD0238 
T-complex protein 1 subunit gamma (CCT3) LDTP04249 1.42  LDD0238 
T-complex protein 1 subunit theta (CCT8) LDTP04390 1.96  LDD0238 
Tektin-1 (TEKT1) LDTP10037 7.24  LDD0238 
Tubulin beta chain (TUBB) LDTP02205 0.53  LDD0238 
U3 small nucleolar RNA-associated protein 15 homolog (UTP15) LDTP09494 0.60  LDD0238 
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) LDTP05033 1.33  LDD0238 
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⏷ Show the Full List of 80 Other

Full Information of The Labelling Profiles of This Competitor

Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 500 uM
Quantitative Method SILAC
Competitor Name W14
Competitor Concentration 500 uM
In Vitro Experiment Model Model Type
Living cell
Derived Tissue
Liver
Disease Model Hepatoblastoma [ICD-11:DB91]
Model Name Human hepatoblastoma cells (Hep-G2)
Interaction Atlas ID  LDD0238  Download The Altas

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.