Details of the Target

General Information of Target

Target ID LDTP06331
Target Name Pericentriolar material 1 protein (PCM1)
Gene Name PCM1
Gene ID 5108
Synonyms
Pericentriolar material 1 protein; PCM-1; hPCM-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRV
TNDISPESSPGVGRRRTKTPHTFPHSRYMSQMSVPEQAELEKLKQRINFSDLDQRSIGSD
SQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTNPPNRETIGSAQCKELFASALS
NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLT
HLIDHLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQ
AALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA
VPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTL
RDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESEN
EGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHE
NSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPS
LDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKIN
RLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKT
QKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASV
GNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRR
KQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDE
EGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFS
ADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQEQINQLKKQLDFSVSICQTL
MQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQMLN
ELMRQQNQHPEKPGGKERGSSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMN
FSPLFPSNFGDFSQNISTPSEQQQPLAQNSSGKTEYMAFPKPFESSSSIGAEKPRNKKLP
EEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRRQFDEESLES
FSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIRYESAS
MSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSETGSDFSMFEA
LRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEK
GENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSS
NFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVN
NLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQL
LTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVL
FNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDK
DKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESEGCPVSINLSKAETQALTNYGSGE
DENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLEREATS
KNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKE
VKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYSEAD
LRKKMVEEEQKNHLSGEICEMQTEELAGNSETLKEPETVGAQSI
Target Bioclass
Transporter and channel
Family
PCM1 family
Subcellular location
Cytoplasm, cytoskeleton
Function
Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites. Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites.
Uniprot ID
Q15154
Ensemble ID
ENST00000325083.13
HGNC ID
HGNC:8727

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TG42
 Probe Info  		5.00  LDD0043  [2]
STPyne
 Probe Info  		K1076(9.17); K1602(10.00); K1707(10.00); K284(4.52)  LDD0277  [3]
ONAyne
 Probe Info  		K738(10.00)  LDD0275  [3]
BTD
 Probe Info  		C957(0.43)  LDD2096  [4]
DA-P3
 Probe Info  		4.23  LDD0181  [5]
AHL-Pu-1
 Probe Info  		C957(5.58); C876(2.42); C783(4.71); C187(2.78)  LDD0168  [6]
HHS-475
 Probe Info  		Y1176(0.94)  LDD0265  [7]
DBIA
 Probe Info  		C582(1.17); C568(1.16); C1325(1.15); C1328(1.15)  LDD0078  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C171(0.00); C1717(0.00); C957(0.00); C568(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C1585(0.00); C582(0.00); C1616(0.00); C171(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C1616(0.00); C171(0.00); C1717(0.00); C957(0.00)  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
NAIA_4
 Probe Info  		C187(0.00); C1585(0.00); C1717(0.00)  LDD2226  [11]
NAIA_5
 Probe Info  		C568(0.00); C876(0.00); C171(0.00); C582(0.00)  LDD2224  [11]
TFBX
 Probe Info  		C582(0.00); C1585(0.00)  LDD0027  [10]
WYneN
 Probe Info  		C582(0.00); C876(0.00)  LDD0021  [12]
WYneO
 Probe Info  		C1717(0.00); C582(0.00)  LDD0022  [12]
Compound 10
 Probe Info  		C1585(0.00); C171(0.00); C1717(0.00); C1872(0.00)  LDD2216  [13]
Compound 11
 Probe Info  		C1585(0.00); C171(0.00); C1872(0.00); C568(0.00)  LDD2213  [13]
ENE
 Probe Info  		N.A.  LDD0006  [12]
IPM
 Probe Info  		C1585(0.00); C171(0.00)  LDD0005  [12]
VSF
 Probe Info  		C1717(0.00); C770(0.00); C582(0.00); C783(0.00)  LDD0007  [12]
Phosphinate-6
 Probe Info  		C582(0.00); C783(0.00); C957(0.00)  LDD0018  [14]
Acrolein
 Probe Info  		C1585(0.00); C582(0.00); C957(0.00); H1334(0.00)  LDD0217  [15]
Crotonaldehyde
 Probe Info  		C582(0.00); C1585(0.00)  LDD0219  [15]
Methacrolein
 Probe Info  		C582(0.00); C876(0.00); C1585(0.00)  LDD0218  [15]
W1
 Probe Info  		C171(0.00); C582(0.00); C1585(0.00)  LDD0236  [16]
AOyne
 Probe Info  		12.50  LDD0443  [17]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C107
 Probe Info  		5.50  LDD1794  [18]
C219
 Probe Info  		5.28  LDD1893  [18]
C383
 Probe Info  		11.08  LDD2042  [18]
C388
 Probe Info  		35.75  LDD2047  [18]
C407
 Probe Info  		11.79  LDD2064  [18]
FFF probe11
 Probe Info  		20.00  LDD0472  [19]
FFF probe13
 Probe Info  		20.00  LDD0476  [19]
FFF probe14
 Probe Info  		20.00  LDD0477  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C171(0.99)  LDD2117  [4]
 LDCM0025  4SU-RNA HEK-293T C957(5.58); C876(2.42); C783(4.71); C187(2.78)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C957(3.50); C876(2.53); C783(3.25); C770(2.00)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C770(0.84); C783(0.84); C1585(0.96); C1867(0.87)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C770(1.05); C783(1.05); C1585(1.09); C957(1.06)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C770(1.02); C783(1.02); C1585(1.00); C957(1.05)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C770(1.18); C783(1.18); C1585(1.08); C957(1.12)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C770(1.29); C783(1.29); C1585(1.12); C957(0.97)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C770(1.54); C783(1.54); C1585(1.31); C957(1.40)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C770(1.42); C783(1.42); C1585(1.16); C957(1.23)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C770(1.38); C783(1.38); C1585(1.39); C957(1.13)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C770(1.41); C783(1.41); C1585(1.14); C957(1.13)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C770(1.05); C783(1.36); C1585(1.30); C957(1.19)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C770(0.89); C783(0.97); C1585(1.06); C957(0.87)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C770(0.94); C783(1.00); C1585(1.04); C957(0.95)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C770(1.20); C783(1.20); C1585(1.13); C957(1.07)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C770(1.09); C783(1.13); C1585(1.09); C957(1.13)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C770(1.02); C783(1.12); C1585(1.04); C957(1.03)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C770(1.23); C783(1.46); C1585(1.12); C957(1.16)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C770(1.00); C783(1.00); C1585(1.00); C582(0.96)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C770(1.23); C783(1.23); C1585(1.07); C582(1.18)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C770(1.51); C783(1.51); C1585(1.13); C582(1.73)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C770(1.40); C783(1.40); C1585(1.21); C582(1.30)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C770(1.12); C783(1.12); C1585(1.06); C582(1.16)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C770(1.03); C783(1.03); C1585(1.05); C582(1.31)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C770(1.29); C783(1.29); C1585(1.04); C582(1.24)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C770(0.96); C783(0.96); C1585(1.08); C957(0.75)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C770(1.26); C783(1.26); C1585(0.96); C582(1.18)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C770(1.03); C783(1.03); C1585(0.99); C582(1.38)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C770(1.09); C783(1.09); C1585(0.95); C582(1.45)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C770(1.20); C783(1.20); C1585(0.88); C582(1.14)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C770(1.15); C783(1.15); C1585(0.95); C582(1.25)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C770(1.03); C783(1.03); C1585(0.95); C582(1.20)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C770(1.41); C783(1.41); C1585(1.26); C582(1.74)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C770(1.47); C783(1.47); C1585(1.18); C582(1.35)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C770(0.81); C783(0.81); C1585(0.63); C582(0.17)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C770(0.61); C783(0.61); C1585(0.57); C582(0.17)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C770(0.65); C783(0.65); C1585(0.59); C582(0.19)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C770(0.76); C783(0.76); C1585(0.67); C582(0.20)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C770(0.48); C783(0.48); C1585(0.78); C582(0.22)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C770(0.58); C783(0.58); C1585(0.69); C582(0.22)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C770(0.80); C783(0.80); C1585(0.85); C582(0.23)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C770(0.56); C783(0.56); C1585(0.74); C582(0.27)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C770(0.62); C783(0.62); C1585(0.72); C582(0.25)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C770(0.60); C783(0.60); C1585(0.70); C582(0.21)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C770(0.77); C783(0.77); C1585(0.84); C582(0.23)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C770(0.61); C783(0.61); C1585(0.80); C582(0.23)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C770(0.96); C783(0.96); C1585(1.11); C957(0.83)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C770(0.71); C783(0.71); C1585(1.01); C582(0.23)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C770(0.70); C783(0.70); C1585(0.85); C582(0.24)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C770(0.53); C783(0.53); C1585(0.82); C582(0.22)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C770(1.11); C783(1.11); C1585(1.30); C1867(0.87)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C1325(0.83); C1328(0.83); C876(0.97); C1585(0.99)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C1325(0.71); C1328(0.71); C1717(0.93); C582(0.93)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C1325(0.80); C1328(0.80); C876(0.84); C1717(1.03)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C1325(0.72); C1328(0.72); C1717(0.82); C1585(1.05)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C1717(0.80); C1325(0.91); C1328(0.91); C876(0.97)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C876(0.83); C1717(0.94); C1325(1.01); C1328(1.01)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C1717(0.71); C876(0.81); C957(0.81); C770(1.02)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C1325(0.82); C1328(0.82); C876(0.95); C1717(0.98)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C1717(0.81); C1325(0.81); C1328(0.81); C876(0.85)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C1325(0.77); C1328(0.77); C876(0.87); C1717(0.98)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C876(0.66); C1325(0.73); C1328(0.73); C1717(1.29)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C770(1.30); C783(1.30); C1585(1.13); C1867(2.55)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C770(1.65); C783(1.65); C1585(1.16); C1867(1.97)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C770(1.12); C783(1.12); C1585(1.22); C1867(1.44)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C770(1.43); C783(1.43); C1585(1.10); C1867(1.68)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C582(0.52); C957(0.92); C1585(1.02); C876(1.05)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C582(0.56); C876(0.84); C1585(0.90); C568(0.90)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C582(0.54); C876(0.96); C1585(0.98); C957(1.06)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C770(0.80); C783(0.80); C957(0.82); C876(0.83)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C582(0.52); C1585(1.05); C171(1.07); C876(1.16)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C582(0.48); C1585(0.97); C876(1.12); C171(1.25)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C582(0.46); C568(0.95); C171(1.02); C1585(1.03)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C582(0.45); C876(0.83); C1585(0.93); C171(1.00)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C582(0.36); C876(0.96); C957(1.00); C171(1.03)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C568(0.86); C957(0.89); C876(1.07); C1585(1.08)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C568(0.89); C957(1.08); C1325(1.08); C1328(1.08)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C568(0.97); C957(1.10); C1585(1.20); C876(1.23)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C568(0.90); C957(0.97); C1325(1.21); C1328(1.21)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C568(1.05); C957(1.23); C1585(1.26); C876(1.35)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C957(0.74); C770(0.75); C783(0.75); C876(0.78)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C568(1.08); C957(1.09); C1325(1.23); C1328(1.23)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C568(0.94); C957(1.03); C171(1.24); C770(1.27)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C568(1.12); C957(1.19); C1585(1.32); C1325(1.33)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C568(1.04); C957(1.19); C876(1.35); C1585(1.38)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C568(0.92); C876(1.18); C1585(1.21); C957(1.38)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C876(0.71); C770(0.84); C783(0.84); C171(0.85)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C770(0.76); C783(0.76); C876(0.76); C1585(0.83)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C770(0.78); C783(0.78); C171(0.82); C1585(0.82)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C876(0.78); C770(0.86); C783(0.86); C1585(1.01)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C770(0.90); C783(0.90); C1585(1.04); C876(1.06)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C876(0.64); C582(0.82); C770(0.82); C783(0.82)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C1585(0.94); C770(1.01); C783(1.01); C1325(1.14)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C876(0.77); C1585(0.88); C770(0.90); C783(0.90)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C876(0.89); C770(0.92); C783(0.92); C1585(1.10)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C876(0.88); C1585(1.01); C770(1.05); C783(1.05)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C770(0.84); C783(0.84); C1585(0.89); C876(0.93)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C1585(0.95); C770(1.11); C783(1.11); C568(1.12)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C171(1.06); C770(1.11); C783(1.11); C1325(1.24)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C171(1.08); C1585(1.14); C770(1.19); C783(1.19)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C770(1.04); C783(1.04); C171(1.07); C1325(1.13)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C957(1.07); C171(1.33); C1325(1.39); C1328(1.39)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C876(0.49); C770(0.68); C783(0.68); C957(0.76)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C957(1.13); C1325(1.17); C1328(1.17); C171(1.35)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C171(0.82); C770(0.93); C783(0.93); C1325(1.20)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C171(0.88); C770(1.14); C783(1.14); C957(1.15)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C171(1.28); C1585(1.29); C876(1.31); C770(1.42)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C171(1.10); C1585(1.32); C770(1.43); C783(1.43)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C1585(1.20); C171(1.41); C876(1.54); C957(1.72)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C1585(1.30); C957(1.30); C171(1.71); C1325(2.15)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C568(0.55); C1585(0.88); C770(1.11); C783(1.11)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C568(0.81); C1585(0.99); C957(1.12); C770(1.27)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C568(0.83); C1585(1.03); C770(1.28); C783(1.28)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C1717(0.88); C876(0.97); C957(1.02); C1585(1.05)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C568(0.66); C1585(0.98); C770(1.15); C783(1.15)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C568(0.68); C770(1.03); C783(1.03); C957(1.06)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C568(0.53); C1585(0.83); C957(1.14); C171(1.24)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C568(0.50); C1585(0.84); C876(1.21); C770(1.32)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C568(0.54); C1585(0.76); C770(1.16); C783(1.16)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C568(0.65); C770(0.79); C783(0.79); C876(0.80)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C568(0.69); C876(0.77); C770(0.84); C783(0.84)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C568(0.63); C1585(0.86); C770(0.91); C783(0.91)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C957(0.79); C1328(1.03); C582(1.05); C568(1.09)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C957(1.00); C568(1.01); C171(1.08); C876(1.23)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C876(0.85); C1717(0.88); C568(0.94); C770(0.94)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C171(1.12); C957(1.13); C1328(1.15); C568(1.15)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C568(0.78); C957(0.94); C582(1.01); C1328(1.09)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C568(1.06); C957(1.17); C171(1.22); C1328(1.26)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C568(0.93); C957(1.19); C1585(1.74); C171(1.78)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C568(0.83); C1585(1.27); C957(1.35); C876(1.49)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C568(0.96); C957(1.34); C1585(1.82); C171(1.88)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C568(0.71); C957(0.90); C1328(1.28); C171(1.32)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C957(1.09); C568(1.09); C171(1.33); C1328(1.49)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C568(0.79); C171(1.06); C957(1.14); C1328(1.19)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C957(0.97); C568(1.05); C876(1.15); C582(1.18)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C1717(0.76); C876(0.81); C957(0.93); C568(0.96)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C568(0.83); C957(0.83); C1585(1.17); C171(1.21)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C568(0.89); C957(0.99); C171(1.07); C876(1.16)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C568(1.07); C957(1.11); C1585(1.24); C1328(1.94)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C582(1.41); C1585(1.59); C568(1.64); C1325(1.65)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C1325(1.29); C1328(1.29); C582(1.36); C957(1.42)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C1325(1.03); C1328(1.03); C568(1.17); C957(1.28)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C568(1.13); C1585(1.15); C1325(1.33); C1328(1.33)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C582(0.98); C1325(1.00); C1328(1.00); C568(1.01)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C568(1.20); C1325(1.27); C1328(1.27); C171(1.27)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C1585(1.23); C171(1.35); C957(1.39); C568(1.56)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C957(0.81); C568(0.97); C171(1.04); C582(1.09)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C1325(1.64); C1328(1.64); C568(1.67); C876(1.68)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C1585(1.55); C957(1.57); C1325(1.60); C1328(1.60)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C568(1.18); C957(1.22); C876(1.26); C1585(1.30)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C1325(1.08); C1328(1.08); C1585(1.14); C568(1.35)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C1585(1.16); C568(1.19); C876(1.24); C1325(1.26)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C1325(1.33); C1328(1.33); C1585(1.36); C957(1.40)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C1585(1.44); C568(1.55); C957(1.63); C876(1.72)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C568(1.11); C1325(1.22); C957(1.52); C1585(1.60)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C1585(0.87); C957(0.93); C568(0.98); C1717(1.03)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C770(0.84); C783(0.84); C1585(1.10); C957(0.85)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C957(0.98); C770(1.00); C783(1.00); C568(1.03)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C1717(0.79); C876(0.85); C957(1.25); C1585(1.31)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 11.60  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C582(1.17); C568(1.16); C1325(1.15); C1328(1.15)  LDD0078  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C1717(3.33); C171(1.46); C1717(1.41); C957(0.78)  LDD2227  [11]
 LDCM0367  CL1 HCT 116 C876(0.86); C1867(0.94); C582(1.00); C171(1.08)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C957(0.89); C1867(1.02); C1585(1.06); C582(1.15)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C876(0.72); C582(0.85); C957(0.88); C171(0.91)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C1717(0.73); C876(0.78); C957(0.89); C770(1.15)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C876(0.68); C1717(0.86); C568(0.94); C171(1.07)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C876(0.74); C1717(0.76); C957(0.95); C1585(0.99)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C1717(0.79); C876(0.89); C957(0.97); C171(1.03)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C582(0.59); C1585(0.89); C876(1.00); C568(1.05)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C582(0.50); C1585(0.85); C568(1.22); C876(1.25)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C582(0.44); C1585(0.88); C957(0.90); C876(1.07)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C582(0.40); C1585(0.95); C957(1.03); C876(1.21)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C582(0.92); C1585(1.05); C876(1.10); C957(1.29)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C1867(0.81); C582(0.91); C568(0.95); C876(1.24)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C582(0.47); C1585(0.97); C876(1.15); C957(1.27)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C582(0.45); C1585(0.85); C876(0.95); C568(1.15)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C568(0.77); C876(0.94); C957(0.95); C171(1.07)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C568(1.01); C876(1.23); C1585(1.23); C957(1.24)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C568(1.03); C876(1.13); C1325(1.19); C1328(1.19)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C568(1.11); C1325(1.19); C1328(1.19); C876(1.22)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C568(0.99); C876(1.06); C1325(1.11); C1328(1.11)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C568(1.12); C1325(1.35); C1328(1.35); C1585(1.48)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C770(0.93); C783(0.93); C876(0.95); C1585(1.00)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C1585(1.09); C876(1.10); C770(1.10); C783(1.10)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C957(0.82); C582(0.84); C568(0.93); C1585(0.97)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C770(0.96); C783(0.96); C171(0.96); C1585(1.04)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C171(0.88); C1585(1.08); C876(1.10); C1325(1.66)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C171(1.08); C770(1.16); C783(1.16); C1585(1.30)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C876(1.19); C1585(1.43); C171(1.49); C957(1.74)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C171(1.28); C957(1.30); C1585(1.37); C770(1.62)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C568(0.55); C171(0.81); C876(0.86); C770(0.87)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C568(0.70); C876(0.89); C770(0.95); C783(0.95)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C568(0.70); C770(0.86); C783(0.86); C171(0.96)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C568(0.59); C957(1.00); C1585(1.08); C770(1.23)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C1585(0.85); C568(0.87); C1867(1.01); C582(1.03)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C1585(0.93); C957(1.09); C568(1.10); C876(1.13)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C1867(0.90); C568(0.96); C582(1.02); C1585(1.25)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C582(0.86); C171(0.95); C1717(1.02); C957(1.03)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C1717(0.82); C568(0.82); C1325(1.03); C1328(1.03)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C957(0.95); C1325(0.98); C1328(0.98); C568(1.04)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C1325(0.83); C1328(0.83); C1717(0.90); C957(1.00)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C568(0.79); C876(0.89); C1867(0.92); C770(1.00)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C1325(0.85); C1328(0.85); C957(1.04); C1717(1.05)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C1325(0.86); C1328(0.86); C1717(0.89); C568(1.05)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C1325(0.69); C1328(0.69); C1717(0.90); C568(1.13)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C568(0.67); C957(0.86); C1325(0.96); C1328(0.96)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C957(0.86); C1325(0.89); C1328(0.89); C171(1.02)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C770(3.14); C783(3.14); C1585(1.73); C957(0.93)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C770(1.66); C783(1.66); C1585(1.14); C957(1.05)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C770(1.51); C783(1.51); C1585(1.20); C957(0.90)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C770(2.04); C783(2.04); C1585(1.24); C957(1.23)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C770(1.73); C783(1.73); C1585(1.20); C957(1.07)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C770(1.11); C783(1.11); C1585(1.23); C1867(1.02)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C770(1.45); C783(1.45); C1585(1.15); C957(0.86)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C770(1.31); C783(1.31); C1585(1.10); C582(0.83)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C770(1.32); C783(1.32); C1585(0.99); C582(0.86)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C770(4.64); C783(4.64); C1585(2.78); C582(0.88)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C770(1.78); C783(1.78); C1585(1.45); C582(0.93)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C770(1.88); C783(1.88); C1585(1.08); C582(1.07)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C770(1.73); C783(1.73); C1585(1.05); C582(0.99)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C770(2.04); C783(2.04); C1585(1.53); C582(1.16)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C770(2.06); C783(2.06); C1585(1.26); C582(0.97)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C770(1.89); C783(1.89); C1585(1.06); C1867(0.92)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C770(2.32); C783(2.32); C1585(1.44); C582(0.87)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C770(1.61); C783(1.61); C1585(1.18); C582(0.90)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C770(3.50); C783(3.50); C1585(1.86); C582(0.80)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C770(2.41); C783(2.41); C1585(1.22); C582(0.89)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C770(2.14); C783(2.14); C1585(1.49); C582(0.98)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C770(2.79); C783(2.79); C1585(1.62); C582(0.87)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C770(1.12); C783(1.12); C1585(1.11); C582(0.95)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C770(0.94); C783(0.94); C1585(1.00); C582(0.95)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C770(1.03); C783(1.03); C1585(1.09); C582(1.05)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C770(1.47); C783(1.47); C1585(0.97); C582(0.95)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C770(1.12); C783(1.12); C1585(0.95); C1867(0.98)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C770(1.17); C783(1.17); C1585(1.10); C582(1.01)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C770(1.02); C783(1.02); C1585(1.12); C582(1.09)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C770(1.09); C783(1.09); C1585(1.23); C582(1.07)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C770(1.26); C783(1.26); C1585(1.19); C582(1.19)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C770(1.40); C783(1.40); C1585(1.24); C582(0.88)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C770(1.19); C783(1.19); C1585(0.98); C582(0.67)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C770(1.05); C783(1.05); C1585(0.99); C582(1.10)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C770(1.21); C783(1.21); C1585(1.18); C582(0.95)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C770(1.09); C783(1.09); C1585(1.01); C582(0.99)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C770(1.06); C783(1.06); C1585(1.01); C582(0.85)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C770(1.61); C783(1.61); C1585(1.07); C1867(1.18)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C770(1.12); C783(1.12); C1585(1.07); C582(1.09)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C770(0.96); C783(0.96); C1585(0.90); C1867(1.36)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C770(1.09); C783(1.09); C1585(0.79); C1867(1.44)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C770(1.18); C783(1.18); C1585(0.93); C1867(1.36)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C770(1.63); C783(1.63); C1585(0.87); C1867(0.92)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C770(0.93); C783(0.93); C1585(0.85); C1867(1.29)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C770(1.52); C783(1.52); C1585(0.87); C1867(1.22)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C770(1.34); C783(1.34); C1585(0.84); C1867(1.44)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C770(1.35); C783(1.35); C1585(0.86); C1867(1.39)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C770(1.52); C783(1.52); C1585(0.82); C1867(1.43)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C770(1.32); C783(1.32); C1585(0.83); C1867(1.09)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C770(1.20); C783(1.20); C1585(0.86); C1867(1.37)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C770(1.47); C783(1.47); C1585(0.84); C1867(1.23)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C770(1.17); C783(1.17); C1585(0.84); C1867(1.21)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C770(1.32); C783(1.32); C1585(0.87); C1867(1.36)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C770(1.41); C783(1.41); C1585(0.88); C1867(1.67)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C770(0.90); C783(0.90); C1585(1.26); C582(1.44)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C770(0.99); C783(0.99); C1585(1.04); C582(0.70)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C770(1.15); C783(1.15); C1585(1.08); C582(1.62)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C770(0.92); C783(0.92); C1585(1.19); C582(1.44)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C770(8.44); C783(8.44); C1585(4.68); C1867(0.99)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C770(0.94); C783(0.94); C1585(0.88); C582(1.09)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C770(0.88); C783(0.88); C1585(1.36); C582(1.78)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C770(0.74); C783(0.74); C1585(1.74); C582(3.07)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C770(1.49); C783(1.49); C1585(1.81); C582(1.68)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C770(1.37); C783(1.37); C1585(1.68); C582(2.13)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C770(1.26); C783(1.26); C1585(0.90); C582(0.91)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C770(1.09); C783(1.09); C1585(0.73); C582(0.50)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C770(1.46); C783(1.46); C1585(1.10); C582(0.91)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C770(1.04); C783(1.04); C1585(1.26); C582(1.57)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C770(1.08); C783(1.08); C1585(1.94); C582(2.91)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C770(1.42); C783(1.42); C1585(0.95); C1867(0.83)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C770(3.10); C783(3.10); C1585(1.58); C582(1.08)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C770(0.98); C783(0.98); C1585(0.95); C1867(0.81)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C770(1.33); C783(1.33); C1585(1.11); C1867(0.79)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C770(0.97); C783(0.97); C1585(0.93); C1867(0.82)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C770(1.50); C783(1.50); C1585(1.03); C1867(1.11)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C770(1.58); C783(1.58); C1585(1.26); C1867(0.91)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C770(1.01); C783(1.01); C1585(0.95); C1867(0.98)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C770(0.95); C783(0.95); C1585(1.08); C1867(1.11)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C770(0.97); C783(0.97); C1585(1.13); C1867(0.97)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C770(0.93); C783(0.93); C1585(0.93); C1867(0.83)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C582(0.93); C1867(0.71); C1585(0.95); C957(1.53)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1717(2.09); C957(1.64)  LDD1702  [4]
 LDCM0031  Epigallocatechin gallate HEK-293T 14.29  LDD0183  [5]
 LDCM0468  Fragment33 HCT 116 C770(1.24); C783(1.24); C1585(0.80); C1867(1.26)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C770(4.17); C783(4.17); C1585(2.58); C582(0.87)  LDD0744  [8]
 LDCM0117  HHS-0201 DM93 Y1176(0.94)  LDD0265  [7]
 LDCM0119  HHS-0401 DM93 Y1424(14.06)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y1176(1.82); Y1424(11.15)  LDD0268  [7]
 LDCM0022  KB02 HCT 116 C171(5.98); C770(9.32); C783(9.32); C1325(5.51)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C171(3.90); C770(11.50); C783(11.50); C1325(1.91)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C171(20.00); C770(13.61); C783(13.61); C1325(3.66)  LDD0082  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C957(0.43)  LDD2096  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C171(0.72)  LDD2099  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C171(0.53)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C171(0.73)  LDD2125  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C957(1.37)  LDD2128  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C171(1.01)  LDD2136  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C171(0.53)  LDD2140  [4]
 LDCM0029  Quercetin HEK-293T 4.23  LDD0181  [5]
 LDCM0021  THZ1 HCT 116 C1867(1.45); C1872(1.45); C770(1.13); C783(1.13)  LDD2173  [8]
 LDCM0111  W14 Hep-G2 C171(10.48)  LDD0238  [16]
 LDCM0112  W16 Hep-G2 C171(0.81)  LDD0239  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RalA-binding protein 1 (RALBP1) . Q15311
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein (GABARAP) ATG8 family O95166
Bardet-Biedl syndrome 4 protein (BBS4) BBS4 family Q96RK4
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
Bardet-Biedl syndrome 1 protein (BBS1) . Q8NFJ9
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Abl interactor 2 (ABI2) ABI family Q9NYB9
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Centrosomal protein of 131 kDa (CEP131) CEP131 family Q9UPN4
Centrosomal protein of 72 kDa (CEP72) CEP72 family Q9P209
Protein FAM81A (FAM81A) FAM81 family Q8TBF8
Centriole and centriolar satellite protein OFD1 (OFD1) OFD1 family O75665
Coiled-coil domain-containing protein 14 (CCDC14) . Q49A88
Cytohesin-4 (CYTH4) . Q9UIA0
Microspherule protein 1 (MCRS1) . Q96EZ8
Pericentrin (PCNT) . O95613
Progesterone-induced-blocking factor 1 (PIBF1) . Q8WXW3
Protein moonraker (KIAA0753) . Q2KHM9
Sperm-associated antigen 5 (SPAG5) . Q96R06

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402