Details of the Target

General Information of Target

Target ID LDTP06583
Target Name Serine/arginine-rich splicing factor 7 (SRSF7)
Gene Name SRSF7
Gene ID 6432
Synonyms
SFRS7; Serine/arginine-rich splicing factor 7; Splicing factor 9G8; Splicing factor, arginine/serine-rich 7
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSRYGRYGGETKVYVGNLGTGAGKGELERAFSYYGPLRTVWIARNPPGFAFVEFEDPRDA
EDAVRGLDGKVICGSRVRVELSTGMPRRSRFDRPPARRPFDPNDRCYECGEKGHYAYDCH
RYSRRRRSRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRRSRSASLRRSR
SGSIKGSRYFQSPSRSRSRSRSISRPRSSRSKSRSPSPKRSRSPSGSPRRSASPERMD
Target Bioclass
Other
Family
Splicing factor SR family
Subcellular location
Nucleus
Function
Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.
Uniprot ID
Q16629
Ensemble ID
ENST00000313117.11
HGNC ID
HGNC:10789

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.R87G DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.S123G DBIA    Probe Info 
J82 SNV: p.R169S .
KASUMI2 SNV: p.R131Q DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		10.00  LDD0393  [1]
TH211
 Probe Info  		Y115(20.00); Y33(18.77); Y7(17.42); Y14(12.04)  LDD0260  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K12(2.53); K185(6.67); K24(10.00); K70(1.65)  LDD0277  [4]
BTD
 Probe Info  		C73(10.87)  LDD1699  [5]
ONAyne
 Probe Info  		K185(0.00); K70(0.00)  LDD0273  [4]
OPA-S-S-alkyne
 Probe Info  		K70(1.67); K24(3.00)  LDD3494  [6]
Probe 1
 Probe Info  		Y14(15.35); Y33(23.87)  LDD3495  [7]
AHL-Pu-1
 Probe Info  		C106(3.32)  LDD0169  [8]
HHS-475
 Probe Info  		Y117(1.57)  LDD0264  [9]
HHS-465
 Probe Info  		Y117(5.68); Y33(2.03)  LDD2237  [10]
DBIA
 Probe Info  		C109(1.13); C106(1.00); C119(0.94)  LDD0078  [11]
5E-2FA
 Probe Info  		N.A.  LDD2235  [12]
ATP probe
 Probe Info  		N.A.  LDD0199  [13]
m-APA
 Probe Info  		N.A.  LDD2231  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C119(0.00); C106(0.00); C109(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [15]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C106(0.00); C109(0.00); C119(0.00)  LDD0037  [14]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
TFBX
 Probe Info  		N.A.  LDD0027  [17]
1d-yne
 Probe Info  		N.A.  LDD0356  [18]
Compound 10
 Probe Info  		N.A.  LDD2216  [19]
IPM
 Probe Info  		C73(0.00); C119(0.00)  LDD0005  [20]
NHS
 Probe Info  		N.A.  LDD0010  [20]
SF
 Probe Info  		Y189(0.00); Y7(0.00); Y33(0.00); Y14(0.00)  LDD0028  [21]
Phosphinate-6
 Probe Info  		C73(0.00); C106(0.00); C109(0.00); C119(0.00)  LDD0018  [22]
1c-yne
 Probe Info  		N.A.  LDD0228  [18]
Acrolein
 Probe Info  		C119(0.00); C73(0.00); H120(0.00)  LDD0217  [23]
Crotonaldehyde
 Probe Info  		C73(0.00); H120(0.00); C119(0.00)  LDD0219  [23]
Methacrolein
 Probe Info  		C119(0.00); C73(0.00)  LDD0218  [23]
W1
 Probe Info  		C119(0.00); C109(0.00)  LDD0236  [24]
HHS-482
 Probe Info  		Y117(0.92); Y7(1.04)  LDD2239  [10]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		15.45  LDD1865  [25]
C191
 Probe Info  		9.71  LDD1868  [25]
FFF probe12
 Probe Info  		6.25  LDD0473  [26]
FFF probe13
 Probe Info  		8.28  LDD0475  [26]
FFF probe2
 Probe Info  		5.10  LDD0463  [26]
STS-1
 Probe Info  		N.A.  LDD0136  [27]
STS-2
 Probe Info  		N.A.  LDD0138  [27]
DA-2
 Probe Info  		N.A.  LDD0071  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C73(0.82)  LDD2112  [5]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C119(0.79)  LDD2095  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C119(1.30); C73(0.53)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C119(1.69); C73(1.17)  LDD2152  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C119(0.86)  LDD2132  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C106(3.32)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C109(1.18); C106(0.97); C119(0.97)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C109(0.97); C106(0.87); C119(0.68)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C109(0.86); C106(0.82); C119(0.88)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C109(0.91); C106(0.84); C119(0.87)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C109(0.82); C106(0.82); C119(0.95)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C109(0.94); C106(1.01); C119(1.07)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C109(0.84); C106(0.85); C119(1.16)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C109(1.11); C106(1.06); C119(1.04)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C109(1.38); C106(1.21); C119(0.99)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C109(1.15); C106(1.10); C119(0.90)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C109(1.34); C106(0.97); C119(0.78)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C109(0.89); C106(0.78); C119(0.78)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C109(1.07); C106(1.04); C119(0.67)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C109(1.40); C106(0.97); C119(0.79)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C109(1.40); C106(1.00); C119(0.78)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C109(1.34); C106(1.07); C119(0.93)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C109(0.76); C106(0.95); C119(1.10)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C106(1.03); C119(1.41)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C106(1.09); C119(1.64)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C106(1.03); C119(1.66)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C106(1.01); C119(1.33)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C106(0.97); C119(1.24)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C106(1.14); C119(1.25)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C109(0.85); C106(0.84); C119(0.64)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C106(1.20); C119(1.54)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C106(0.99); C119(1.13)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C106(1.09); C119(1.26)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C106(0.99); C119(1.08)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C106(1.02); C119(1.35)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C106(1.03); C119(1.16)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C106(1.06); C119(1.74)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C106(1.10); C119(1.52)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C109(0.98); C106(0.59); C119(1.04)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C109(0.67); C106(0.46); C119(0.63)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C109(0.80); C106(0.57); C119(0.65)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C109(0.69); C106(0.47); C119(0.76)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C109(0.55); C106(0.49); C119(0.63)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C109(0.70); C106(0.51); C119(0.74)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C109(0.71); C106(0.55); C119(0.62)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C109(0.88); C106(0.61); C119(0.65)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C109(0.81); C106(0.98); C119(0.79)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C109(0.66); C106(0.70); C119(0.70)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C109(0.76); C106(0.44); C119(0.67)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C109(0.61); C106(0.67); C119(0.65)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C109(1.24); C106(1.10); C119(0.70)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C109(0.79); C106(0.45); C119(0.59)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C109(0.71); C106(0.56); C119(0.70)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C109(0.58); C106(0.43); C119(0.59)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C109(0.74); C119(0.93); C106(0.98)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C109(0.89); C106(1.32); C119(1.37)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C109(0.71); C119(0.97); C106(0.99)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C109(0.80); C106(1.18); C119(1.18)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C109(0.71); C106(1.16); C119(1.27)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C109(0.83); C106(1.54); C119(1.76)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C109(0.77); C106(1.26); C119(1.29)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C109(0.72); C119(0.73); C106(0.75)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C109(0.69); C106(0.99); C119(1.09)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C109(0.88); C106(1.11); C119(1.16)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C109(0.72); C106(1.23); C119(1.42)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C109(1.02); C106(2.06); C119(2.35)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C109(0.79); C106(1.20); C119(1.35)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C109(0.78); C106(1.15); C119(1.30)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C109(0.70); C106(1.00); C119(1.16)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C109(0.73); C106(1.06); C119(1.28)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C106(0.67); C109(0.69)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C106(0.70); C109(0.78)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C109(0.70); C106(0.80)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C119(1.04); C109(1.15); C106(1.17)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C109(0.64); C106(0.83)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C109(0.64); C106(0.73)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C109(0.75); C106(0.82)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C109(0.59); C106(0.67)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C109(0.65); C106(0.79)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C109(2.64); C106(2.68)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C109(2.49); C106(2.54)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C109(2.62); C106(2.75)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C109(2.47); C106(2.58)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C106(2.97); C109(2.98)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C119(0.81); C106(0.95); C109(1.07)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C106(2.21); C109(2.21)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C109(1.94); C106(2.04)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C106(2.09); C109(2.10)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C109(3.00); C106(3.02)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C109(2.35); C106(2.45)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C109(1.04); C106(1.06)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C106(1.20); C109(1.21)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C109(1.17); C106(1.21)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C109(1.19); C106(1.21)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C109(1.14); C106(1.17)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C119(0.64); C106(0.79); C109(1.01)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C109(1.39); C106(1.41)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C109(1.21); C106(1.27)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C109(1.07); C106(1.10)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C109(1.21); C106(1.26)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C109(1.13); C106(1.16)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C109(1.29); C106(1.32)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C119(0.86); C109(1.08); C106(1.08)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C119(0.96); C106(1.04); C109(1.07)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C119(0.70); C106(0.89); C109(0.94)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C106(1.32); C109(1.35); C119(1.79)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C119(0.72); C106(0.86); C109(1.13)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C106(1.41); C109(1.42); C119(1.78)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C119(0.68); C109(1.13); C106(1.14)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C119(0.93); C106(1.23); C109(1.25)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C106(1.22); C109(1.27); C119(1.27)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C109(1.18); C106(1.21); C119(1.29)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C106(1.43); C109(1.47); C119(1.66)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C106(1.53); C109(1.58); C119(2.73)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C109(0.91); C106(1.08)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C109(0.74); C106(0.98)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C109(0.75); C106(1.06)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C119(0.68); C106(0.95); C109(0.98)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C109(0.93); C106(1.53)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C109(1.06); C106(1.20)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C106(0.93); C109(0.94)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C109(0.80); C106(1.19)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C109(1.08); C106(1.33)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C109(1.02); C106(1.28)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C109(0.95); C106(1.17)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C109(1.11); C106(1.43)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C109(1.44); C106(1.72)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C109(1.66); C106(1.83)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C119(0.60); C106(0.99); C109(1.06)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C109(1.35); C106(1.59)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C109(1.06); C106(1.25)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C109(1.43); C106(1.62)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C109(1.56); C106(1.71)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C109(1.24); C106(1.51)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C109(1.90); C106(2.33)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C109(1.32); C106(1.67)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C109(1.71); C106(2.10)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C109(1.25); C106(1.59)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C109(1.27); C106(1.73)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C119(0.55); C109(0.86); C106(0.92)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C109(1.28); C106(1.66)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C109(1.17); C106(1.56)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C109(1.35); C106(1.66)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C109(1.25); C106(1.39); C119(1.60)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C109(0.74); C106(1.03); C119(1.54)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C109(0.58); C106(0.73); C119(1.16)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C109(0.71); C106(0.78); C119(1.12)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C109(0.81); C106(0.86); C119(1.15)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C109(0.64); C106(0.73); C119(1.33)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C109(0.80); C106(0.90); C119(1.49)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C119(0.86); C109(1.53); C106(1.54)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C109(1.10); C106(1.10); C119(1.82)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C109(0.82); C106(0.86); C119(1.76)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C109(0.77); C106(0.84); C119(1.40)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C109(0.26); C106(0.35); C119(1.28)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C109(0.75); C106(0.89); C119(1.09)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C109(0.33); C106(0.39); C119(1.35)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C109(1.02); C106(1.06); C119(1.55)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C109(1.24); C106(1.70); C119(2.14)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C106(0.77); C119(0.81); C109(0.86)  LDD0683  [11]
 LDCM0545  Acetamide MDA-MB-231 C73(0.44)  LDD2138  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C73(0.83)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C109(0.83); C106(0.81); C119(0.71)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C119(0.90); C106(1.30); C109(1.50)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C109(0.82); C106(0.85); C119(1.16)  LDD0592  [11]
 LDCM0020  ARS-1620 HCC44 C109(1.13); C106(1.00); C119(0.94)  LDD0078  [11]
 LDCM0498  BS-3668 MDA-MB-231 C119(1.50); C73(0.55)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa C119(0.00); C73(0.00); H120(0.00)  LDD0222  [23]
 LDCM0367  CL1 HCT 116 C109(0.94); C119(1.02); C106(1.21)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C119(1.25); C106(1.32); C109(1.58)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C119(0.93); C106(1.09); C109(1.29)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C119(0.63); C106(1.03); C109(1.10)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C119(0.70); C106(0.99); C109(1.05)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C119(0.66); C106(1.11); C109(1.12)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C119(0.68); C106(1.14); C109(1.21)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C106(0.49); C109(0.55)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C106(0.49); C109(0.51)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C106(0.59); C109(0.66)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C106(0.54); C109(0.58)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C109(0.70); C106(0.71)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C109(0.80); C106(0.96); C119(0.99)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C109(0.51); C106(0.53)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C106(0.51); C109(0.55)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C109(1.43); C106(1.47)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C109(1.99); C106(2.05)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C109(2.18); C106(2.20)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C109(2.39); C106(2.52)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C109(2.59); C106(2.63)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C109(1.34); C106(1.35)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C109(1.06); C106(1.10)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C109(1.31); C106(1.36)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C119(1.20); C106(1.50); C109(1.57)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C106(1.12); C109(1.14)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C119(1.40); C106(2.26); C109(2.28)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C119(0.69); C109(0.90); C106(0.94)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C106(0.97); C109(0.99); C119(1.27)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C106(1.18); C109(1.21); C119(1.39)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C109(0.80); C106(0.92)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C106(0.79); C109(0.84)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C109(0.84); C106(1.04)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C109(0.84); C106(0.91)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C109(0.80); C119(1.02); C106(1.14)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C109(1.04); C119(1.17); C106(1.23)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C119(0.94); C109(1.03); C106(1.07)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C106(1.41); C109(1.51)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C106(1.06); C109(1.24)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C106(1.88); C109(2.73)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C106(1.40); C109(1.99)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C119(1.02); C109(1.33); C106(1.34)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C106(2.09); C109(2.88)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C106(1.78); C109(2.73)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C106(3.10); C109(4.63)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C106(1.91); C109(2.60)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C109(2.84); C106(1.86)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C109(2.89); C106(1.95)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C109(2.01); C106(1.71)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C109(2.53); C106(1.84)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C109(2.70); C106(2.11)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C109(2.81); C106(2.06)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C109(1.60); C106(1.28); C119(1.21)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C109(1.89); C106(1.65)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C106(0.91)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C109(1.18); C106(0.99)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C109(0.85); C106(0.79)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C109(0.86); C106(0.80)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C109(1.12); C106(1.11)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C109(0.66); C106(0.76)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C109(0.72); C106(0.75)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C109(1.69); C106(0.98)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C109(1.27); C106(1.20); C119(0.98)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C109(0.93); C106(0.66)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C109(1.14); C106(0.83)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C109(0.57); C106(0.56)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C109(1.43); C106(1.06)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C109(0.82); C106(0.69)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C109(1.11); C106(0.69)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C109(1.10); C106(0.69)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C109(1.01); C106(0.84)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C109(1.07); C106(0.92)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C109(1.16); C106(0.79)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C109(1.64); C106(1.45); C119(1.02)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C109(1.01); C106(0.90)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C109(1.14); C106(0.95)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C109(1.17); C106(1.10)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C109(1.12); C106(0.95)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C109(1.03); C106(0.86)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C109(1.26); C106(1.03)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C109(1.24); C106(0.89)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C109(1.32); C106(0.76)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C109(1.17); C106(1.07)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C109(1.09); C106(1.16)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C109(1.80); C106(1.54); C119(1.26)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C109(1.20); C106(1.27)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C109(1.75); C106(1.35)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C109(1.55); C106(1.39)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C109(0.97); C106(1.29)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C109(0.59); C106(1.26)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C109(0.80); C106(1.12)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C109(1.28); C106(1.38)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C109(1.07); C106(1.39)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C109(0.86); C106(1.28)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C109(1.26); C106(1.17)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C109(0.96); C106(1.24); C119(1.25)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C109(1.01); C106(1.30)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C109(0.98); C106(1.27)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C109(0.99); C106(1.36)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C109(1.06); C106(1.46)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C109(1.15); C106(1.45)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C109(0.88); C106(0.69); C119(0.97)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C109(0.55); C106(0.51); C119(0.77)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C109(0.71); C106(0.64); C119(1.12)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C109(1.22); C106(0.76); C119(1.47)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C109(0.70); C106(0.97); C119(0.72)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C109(1.30); C106(0.82); C119(0.84)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C109(1.05); C106(0.63); C119(1.10)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C109(0.69); C106(0.66); C119(1.88)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C109(1.04); C106(0.75); C119(1.29)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C109(0.80); C106(0.73); C119(1.38)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C109(0.81); C106(0.77); C119(0.92)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C109(0.83); C106(0.69); C119(0.74)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C109(1.14); C106(0.69); C119(0.90)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C109(0.77); C106(0.75); C119(1.07)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C109(0.80); C106(0.79); C119(1.73)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C109(1.13); C106(1.12); C119(1.09)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C109(0.67); C106(0.48); C119(0.64)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C109(1.39); C106(1.10); C119(0.69)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C109(1.11); C106(0.99); C119(0.77)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C109(1.01); C106(1.03); C119(0.76)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C109(1.17); C106(1.18); C119(1.03)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C109(0.90); C106(0.84); C119(0.73)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C109(1.48); C106(1.03); C119(0.84)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C109(1.33); C106(1.02); C119(0.81)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C109(0.93); C106(0.99); C119(0.88)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C109(1.23); C106(1.18); C119(0.92)  LDD0811  [11]
 LDCM0495  E2913 HEK-293T C119(1.01); C106(0.88); C109(0.92)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C119(1.01)  LDD1702  [5]
 LDCM0573  Fragment11 Ramos C119(20.00)  LDD2190  [30]
 LDCM0576  Fragment14 Ramos C119(0.72)  LDD2193  [30]
 LDCM0586  Fragment28 Ramos C119(1.02)  LDD2198  [30]
 LDCM0468  Fragment33 HCT 116 C109(1.12); C106(1.31)  LDD0785  [11]
 LDCM0566  Fragment4 Ramos C119(0.86)  LDD2184  [30]
 LDCM0427  Fragment51 HCT 116 C109(0.55); C106(0.51)  LDD0744  [11]
 LDCM0569  Fragment7 Ramos C119(0.80)  LDD2186  [30]
 LDCM0116  HHS-0101 DM93 Y117(1.57)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y117(1.11)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y117(1.09)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y117(1.11)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y117(0.36)  LDD0268  [9]
 LDCM0107  IAA HeLa H114(0.00); C119(0.00); C73(0.00); H120(0.00)  LDD0221  [23]
 LDCM0022  KB02 HCT 116 C119(1.41); C106(1.33); C109(1.13)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C119(3.97); C106(1.30); C109(1.31)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C119(1.95); C106(1.31); C109(1.23)  LDD0082  [11]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C119(2.17)  LDD2121  [5]
 LDCM0109  NEM HeLa H114(0.00); H120(0.00)  LDD0223  [23]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C73(0.58)  LDD2089  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C119(0.91)  LDD2093  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C73(0.70)  LDD2097  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C119(1.54); C73(0.77)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C73(0.45)  LDD2100  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C73(0.41)  LDD2104  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C73(0.40)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C119(1.71); C73(0.93)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C73(1.02)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C119(0.93); C73(0.39)  LDD2109  [5]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C73(0.77)  LDD2110  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C119(1.06); C73(0.63)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C73(0.65)  LDD2114  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C73(0.46)  LDD2115  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C119(0.72); C73(1.79)  LDD2119  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C73(0.65)  LDD2120  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C73(1.05)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C119(1.11); C73(0.76)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C119(1.14); C73(0.45)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C119(1.28); C73(0.47)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C73(0.72)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C119(1.02); C73(1.23)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C73(0.62)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C73(0.81)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C119(1.13); C73(1.59)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C119(1.24); C73(0.64)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C119(1.06); C73(0.72)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C119(1.95); C73(1.31)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C119(1.01); C73(0.37)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C73(0.52)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C73(0.69)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C119(1.00)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C119(0.79); C73(0.65)  LDD2146  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C119(0.65); C73(0.48)  LDD2148  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C119(1.76)  LDD2150  [5]
 LDCM0021  THZ1 HCT 116 C119(1.27); C109(1.36)  LDD2173  [11]
 LDCM0110  W12 Hep-G2 C119(5.20)  LDD0237  [24]
 LDCM0111  W14 Hep-G2 C119(1.36)  LDD0238  [24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SRSF protein kinase 1 (SRPK1) CMGC Ser/Thr protein kinase family Q96SB4
SRSF protein kinase 2 (SRPK2) CMGC Ser/Thr protein kinase family P78362
E3 ubiquitin-protein ligase RBBP6 (RBBP6) . Q7Z6E9
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear RNA export factor 1 (NXF1) NXF family Q9UBU9
RNA-binding protein with serine-rich domain 1 (RNPS1) Splicing factor SR family Q15287
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Putative RNA-binding protein Luc7-like 2 (LUC7L2) Luc7 family Q9Y383
Pre-mRNA-splicing factor 38A (PRPF38A) PRP38 family Q8NAV1

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD042888
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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD029500 , PXD031647
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD033004
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578