General Information of Experiment

Probe Name DA-2  Probe Info 
Probe concentration 10 uM
Criteria Other data
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Chronic myeloid leukemia [ICD-11:2A20]
Model Name Human chronic myeloid leukemia cells (K562)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 121 Protein Related to This Bioclass
Target ID Target Name
 LDTP10404  2-oxoadipate dehydrogenase complex component E1 (DHTKD1)
 LDTP10869  26S proteasome non-ATPase regulatory subunit 1 (PSMD1)
 LDTP05782  26S proteasome non-ATPase regulatory subunit 2 (PSMD2)
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1)
 LDTP05069  Actin, alpha cardiac muscle 1 (ACTC1)
 LDTP05073  Actin, alpha skeletal muscle (ACTA1)
 LDTP04689  Adenosine kinase (ADK)
 LDTP04262  Alanine--tRNA ligase, cytoplasmic (AARS1)
 LDTP15371  Aldehyde dehydrogenase family 16 member A1 (ALDH16A1)
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1)
 LDTP05436  Aldo-keto reductase family 1 member C1 (AKR1C1)
 LDTP02100  Alkaline phosphatase, placental type (ALPP)
 LDTP15993  Aminopeptidase B (RNPEP)
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1)
 LDTP00866  Asparagine--tRNA ligase, cytoplasmic (NARS1)
 LDTP01783  Aspartate aminotransferase, mitochondrial (GOT2)
 LDTP04561  ATP-citrate synthase (ACLY)
 LDTP02925  ATP-dependent 6-phosphofructokinase, liver type (PFKL)
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP)
 LDTP05550  ATP-dependent RNA helicase A (DHX9)
 LDTP09766  ATP-dependent RNA helicase DDX1 (DDX1)
 LDTP00314  ATP-dependent RNA helicase DDX3X (DDX3X)
 LDTP00664  ATP-dependent RNA helicase DDX3Y (DDX3Y)
 LDTP00684  ATP-dependent RNA helicase DHX15 (DHX15)
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A)
 LDTP01564  Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2)
 LDTP02222  Bifunctional glutamate/proline--tRNA ligase (EPRS1)
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)
 LDTP02911  Calpain-2 catalytic subunit (CAPN2)
 LDTP02909  cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
 LDTP02831  Carbonyl reductase [NADPH] 1 (CBR1)
 LDTP12048  Complex I assembly factor ACAD9, mitochondrial (ACAD9)
 LDTP02616  Creatine kinase B-type (CKB)
 LDTP02922  CTP synthase 1 (CTPS1)
 LDTP05949  Cullin-4A (CUL4A)
 LDTP05950  Cullin-4B (CUL4B)
 LDTP08296  Cullin-associated NEDD8-dissociated protein 1 (CAND1)
 LDTP04124  Cytosolic phospholipase A2 (PLA2G4A)
 LDTP04646  Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1)
 LDTP02497  Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT)
 LDTP03316  DNA replication licensing factor MCM3 (MCM3)
 LDTP03680  DNA replication licensing factor MCM4 (MCM4)
 LDTP03681  DNA replication licensing factor MCM5 (MCM5)
 LDTP06150  DNA replication licensing factor MCM6 (MCM6)
 LDTP03682  DNA replication licensing factor MCM7 (MCM7)
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC)
 LDTP03564  DNA-directed RNA polymerase II subunit RPB2 (POLR2B)
 LDTP06098  E3 ubiquitin/ISG15 ligase TRIM25 (TRIM25)
 LDTP02694  Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA)
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM)
 LDTP03518  Enoyl-CoA hydratase, mitochondrial (ECHS1)
 LDTP04243  Fatty acid synthase (FASN)
 LDTP02386  Fructose-bisphosphate aldolase C (ALDOC)
 LDTP03103  Glutathione S-transferase Mu 3 (GSTM3)
 LDTP02161  Glycogen phosphorylase, liver form (PYGL)
 LDTP01782  Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)
 LDTP03003  Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)
 LDTP03947  Isoleucine--tRNA ligase, cytoplasmic (IARS1)
 LDTP12588  Isoleucine--tRNA ligase, mitochondrial (IARS2)
 LDTP13056  Leucine--tRNA ligase, cytoplasmic (LARS1)
 LDTP03817  Lon protease homolog, mitochondrial (LONP1)
 LDTP06294  Lysine--tRNA ligase (KARS1)
 LDTP03907  Malate dehydrogenase, cytoplasmic (MDH1)
 LDTP05971  Mannosyl-oligosaccharide glucosidase (MOGS)
 LDTP02565  Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM)
 LDTP12915  Methionine adenosyltransferase 2 subunit beta (MAT2B)
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA)
 LDTP06631  NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial (NDUFA9)
 LDTP06192  Neutral alpha-glucosidase AB (GANAB)
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT)
 LDTP02796  Nucleoside diphosphate kinase A (NME1)
 LDTP12610  Obg-like ATPase 1 (OLA1)
 LDTP10878  Parkinson disease protein 7 (PARK7)
 LDTP03216  Peptidyl-prolyl cis-trans isomerase B (PPIB)
 LDTP04440  Peroxisomal multifunctional enzyme type 2 (HSD17B4)
 LDTP03818  Phosphoglucomutase-1 (PGM1)
 LDTP01787  Phosphoglycerate kinase 1 (PGK1)
 LDTP02186  Phosphoglycerate kinase 2 (PGK2)
 LDTP02375  Poly [ADP-ribose] polymerase 1 (PARP1)
 LDTP09899  Probable ATP-dependent RNA helicase DDX17 (DDX17)
 LDTP02924  Probable ATP-dependent RNA helicase DDX5 (DDX5)
 LDTP16026  Probable cysteine--tRNA ligase, mitochondrial (CARS2)
 LDTP13750  Proliferation-associated protein 2G4 (PA2G4)
 LDTP03331  Proteasome subunit alpha type-2 (PSMA2)
 LDTP03413  Proteasome subunit alpha type-5 (PSMA5)
 LDTP00449  Proteasome subunit alpha type-7 (PSMA7)
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3)
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6)
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS)
 LDTP00343  Pyridoxal kinase (PDXK)
 LDTP03644  Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1)
 LDTP02733  Pyruvate kinase PKM (PKM)
 LDTP04895  Ras-related protein Rab-10 (RAB10)
 LDTP04399  Ras-related protein Rab-7a (RAB7A)
 LDTP04910  Ras-related protein Rap-1b (RAP1B)
 LDTP04882  Ribose-phosphate pyrophosphokinase 1 (PRPS1)
 LDTP02592  Ribose-phosphate pyrophosphokinase 2 (PRPS2)
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2)
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2)
 LDTP00299  Serine/threonine-protein kinase 25 (STK25)
 LDTP03819  Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PPP1CC)
 LDTP07929  Staphylococcal nuclease domain-containing protein 1 (SND1)
 LDTP03572  Succinate dehydrogenase flavoprotein subunit, mitochondrial (SDHA)
 LDTP06658  Thioredoxin reductase 1, cytoplasmic (TXNRD1)
 LDTP03365  Threonine--tRNA ligase 1, cytoplasmic (TARS1)
 LDTP02055  Thymidylate synthase (TYMS)
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA)
 LDTP03156  Trifunctional purine biosynthetic protein adenosine-3 (GART)
 LDTP04851  Triosephosphate isomerase (TPI1)
 LDTP07907  Tubulin alpha-1A chain (TUBA1A)
 LDTP06639  Tyrosine-protein phosphatase non-receptor type 21 (PTPN21)
 LDTP01283  U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200)
 LDTP13927  Ubiquitin-conjugating enzyme E2 D4 (UBE2D4)
 LDTP12851  UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1)
 LDTP03366  Valine--tRNA ligase (VARS1)
 LDTP04289  Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL)
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR)
 LDTP04096  Vesicle-fusing ATPase (NSF)
 LDTP02642  X-ray repair cross-complementing protein 5 (XRCC5)
Transporter and channel
Click to Show/Hide to Show 32 Protein Related to This Bioclass
Target ID Target Name
 LDTP04969  14-3-3 protein epsilon (YWHAE)
 LDTP04953  14-3-3 protein gamma (YWHAG)
 LDTP02609  ADP/ATP translocase 3 (SLC25A6)
 LDTP02247  Annexin A6 (ANXA6)
 LDTP05625  AP-1 complex subunit beta-1 (AP1B1)
 LDTP05038  AP-2 complex subunit beta (AP2B1)
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A)
 LDTP03405  Calnexin (CANX)
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1)
 LDTP04578  Clathrin heavy chain 2 (CLTCL1)
 LDTP02057  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1)
 LDTP01301  Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (SLC25A12)
 LDTP00501  Exportin-1 (XPO1)
 LDTP04662  Exportin-2 (CSE1L)
 LDTP01197  Filamin-B (FLNB)
 LDTP05017  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1)
 LDTP06242  Importin subunit beta-1 (KPNB1)
 LDTP00266  Importin-5 (IPO5)
 LDTP10663  Importin-9 (IPO9)
 LDTP12916  Myoferlin (MYOF)
 LDTP01295  Nuclear pore complex protein Nup155 (NUP155)
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93)
 LDTP03717  Prohibitin 1 (PHB1)
 LDTP04707  Protein SEC13 homolog (SEC13)
 LDTP03837  Signal recognition particle 14 kDa protein (SRP14)
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1)
 LDTP14636  Solute carrier family 25 member 16 (SLC25A16)
 LDTP05273  Spectrin beta chain, non-erythrocytic 1 (SPTBN1)
 LDTP01969  Transferrin receptor protein 1 (TFRC)
 LDTP00196  Unconventional myosin-Ic (MYO1C)
 LDTP10741  Vacuolar protein sorting-associated protein 35 (VPS35)
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2)
Transcription factor
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name
 LDTP12964  Forkhead box protein J2 (FOXJ2)
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO)
 LDTP03903  Signal transducer and activator of transcription 3 (STAT3)
 LDTP03212  Splicing factor, proline- and glutamine-rich (SFPQ)
Other
Click to Show/Hide to Show 95 Protein Related to This Bioclass
Target ID Target Name
 LDTP03617  14-3-3 protein beta/alpha (YWHAB)
 LDTP04902  Actin-related protein 3 (ACTR3)
 LDTP16166  Actin-related protein 3B (ACTR3B)
 LDTP02631  Alpha-actinin-1 (ACTN1)
 LDTP05542  Alpha-actinin-3 (ACTN3)
 LDTP02620  Annexin A3 (ANXA3)
 LDTP02354  Annexin A4 (ANXA4)
 LDTP05719  Cleavage stimulation factor subunit 3 (CSTF3)
 LDTP04571  Coatomer subunit alpha (COPA)
 LDTP04570  Coatomer subunit beta (COPB1)
 LDTP06543  DNA damage-binding protein 1 (DDB1)
 LDTP04028  DNA mismatch repair protein Msh2 (MSH2)
 LDTP04518  DNA mismatch repair protein Msh6 (MSH6)
 LDTP06450  ELAV-like protein 1 (ELAVL1)
 LDTP03283  Elongation factor 1-beta (EEF1B2)
 LDTP03499  Elongation factor 1-delta (EEF1D)
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2)
 LDTP13813  Eukaryotic translation initiation factor 3 subunit L (EIF3L)
 LDTP04743  Eukaryotic translation initiation factor 6 (EIF6)
 LDTP02779  Ezrin (EZR)
 LDTP04544  F-actin-capping protein subunit alpha-1 (CAPZA1)
 LDTP10078  Far upstream element-binding protein 1 (FUBP1)
 LDTP09938  Far upstream element-binding protein 2 (KHSRP)
 LDTP06598  Fascin (FSCN1)
 LDTP10015  GPI transamidase component PIG-T (PIGT)
 LDTP03694  Heat shock 70 kDa protein 1-like (HSPA1L)
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF)
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1)
 LDTP02750  Heterogeneous nuclear ribonucleoprotein L (HNRNPL)
 LDTP04500  Heterogeneous nuclear ribonucleoprotein M (HNRNPM)
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR)
 LDTP17065  Heterogeneous nuclear ribonucleoprotein U-like protein 2 (HNRNPUL2)
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)
 LDTP02060  Histone H2A type 1-B/E (H2AC4; H2AC8)
 LDTP06628  Histone H2B type 2-E (H2BC21)
 LDTP00272  Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
 LDTP05688  Interleukin enhancer-binding factor 2 (ILF2)
 LDTP05689  Interleukin enhancer-binding factor 3 (ILF3)
 LDTP06681  Inverted formin-2 (INF2)
 LDTP02756  Junction plakoglobin (JUP)
 LDTP02305  Keratin, type II cytoskeletal 7 (KRT7)
 LDTP03265  Laminin subunit alpha-2 (LAMA2)
 LDTP04094  Large proline-rich protein BAG6 (BAG6)
 LDTP04389  Large ribosomal subunit protein eL14 (RPL14)
 LDTP05196  Large ribosomal subunit protein eL19 (RPL19)
 LDTP05360  Large ribosomal subunit protein eL20 (RPL18A)
 LDTP04107  Large ribosomal subunit protein eL21 (RPL21)
 LDTP05378  Large ribosomal subunit protein eL6 (RPL6)
 LDTP02109  Large ribosomal subunit protein uL10 (RPLP0)
 LDTP03517  Large ribosomal subunit protein uL11 (RPL12)
 LDTP04106  Large ribosomal subunit protein uL18 (RPL5)
 LDTP05027  Large ribosomal subunit protein uL2 (RPL8)
 LDTP04027  Matrin-3 (MATR3)
 LDTP02164  Nucleophosmin (NPM1)
 LDTP03520  Phosphatidylethanolamine-binding protein 1 (PEBP1)
 LDTP06330  Plectin (PLEC)
 LDTP02595  Polyadenylate-binding protein 1 (PABPC1)
 LDTP03364  Polypyrimidine tract-binding protein 1 (PTBP1)
 LDTP01932  Prelamin-A/C (LMNA)
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP)
 LDTP02596  Proliferating cell nuclear antigen (PCNA)
 LDTP14956  Putative heat shock protein HSP 90-beta 2 (HSP90AB2P)
 LDTP13956  Putative RNA-binding protein Luc7-like 2 (LUC7L2)
 LDTP04355  Rab GDP dissociation inhibitor beta (GDI2)
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1)
 LDTP03775  RNA-binding protein FUS (FUS)
 LDTP04395  RNA-binding protein FXR1 (FXR1)
 LDTP13991  Serine-threonine kinase receptor-associated protein (STRAP)
 LDTP06583  Serine/arginine-rich splicing factor 7 (SRSF7)
 LDTP03479  SHC-transforming protein 1 (SHC1)
 LDTP04913  Small ribosomal subunit protein eS1 (RPS3A)
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X)
 LDTP05002  Small ribosomal subunit protein eS6 (RPS6)
 LDTP04964  Small ribosomal subunit protein eS8 (RPS8)
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11)
 LDTP02809  Small ribosomal subunit protein uS5 (RPS2)
 LDTP05985  Spectrin alpha chain, non-erythrocytic 1 (SPTAN1)
 LDTP01251  Splicing factor 3B subunit 1 (SF3B1)
 LDTP06376  Splicing factor 3B subunit 3 (SF3B3)
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1)
 LDTP03619  Stress-induced-phosphoprotein 1 (STIP1)
 LDTP11643  Superkiller complex protein 8 (SKIC8)
 LDTP02934  T-complex protein 1 subunit alpha (TCP1)
 LDTP05113  T-complex protein 1 subunit beta (CCT2)
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5)
 LDTP03888  T-complex protein 1 subunit zeta (CCT6A)
 LDTP11277  Tubulin beta-2B chain (TUBB2B)
 LDTP02037  Tubulin beta-4A chain (TUBB4A)
 LDTP11233  Tubulin beta-6 chain (TUBB6)
 LDTP05650  Twinfilin-1 (TWF1)
 LDTP05033  Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A)
 LDTP01206  Vesicle-trafficking protein SEC22b (SEC22B)
 LDTP02297  Vimentin (VIM)
 LDTP05641  WASH complex subunit 5 (WASHC5)

References

1 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.