Details of the Target

General Information of Target

Target ID LDTP10404
Target Name 2-oxoadipate dehydrogenase complex component E1 (DHTKD1)
Gene Name DHTKD1
Gene ID 55526
Synonyms
KIAA1630; 2-oxoadipate dehydrogenase complex component E1; E1a; OADC-E1; OADH-E1; EC 1.2.4.-; 2-oxoadipate dehydrogenase, mitochondrial; Alpha-ketoadipate dehydrogenase; Alpha-KADH-E1; Dehydrogenase E1 and transketolase domain-containing protein 1; Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVAPVWYLVAAALLVGFILFLTRSRGRAASAGQEPLHNEELAGAGRVAQPGPLEPEEPRA
GGRPRRRRDLGSRLQAQRRAQRVAWAEADENEEEAVILAQEEEGVEKPAETHLSGKIGAK
KLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKEEERLRLEEEQKEEEERKAREE
QAQREHEEYLKLKEAFVVEEEGVGETMTEEQSQSFLTEFINYIKQSKVVLLEDLASQVGL
RTQDTINRIQDLLAEGTITGVIDDRGKFIYITPEELAAVANFIRQRGRVSIAELAQASNS
LIAWGRESPAQAPA
Target Bioclass
Enzyme
Family
Alpha-ketoglutarate dehydrogenase family
Subcellular location
Mitochondrion
Function
2-oxoadipate dehydrogenase (E1a) component of the 2-oxoadipate dehydrogenase complex (OADHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC. Catalyzes the irreversible decarboxylation of 2-oxoadipate via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) (Probable). Can catalyze the decarboxylation of 2-oxoglutarate in vitro, but at a much lower rate than 2-oxoadipate. Responsible for the last step of L-lysine, L-hydroxylysine and L-tryptophan catabolism with the common product being 2-oxoadipate (Probable).
Uniprot ID
Q96HY7
Ensemble ID
ENST00000263035.9
HGNC ID
HGNC:23537

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K188(4.00); K827(10.00)  LDD0277  [1]
Probe 1
 Probe Info  		Y33(45.45); Y313(55.93); Y382(51.08); Y485(45.37)  LDD3495  [2]
BTD
 Probe Info  		C808(0.55)  LDD2109  [3]
AHL-Pu-1
 Probe Info  		C720(6.49)  LDD0170  [4]
DBIA
 Probe Info  		C383(0.89)  LDD0078  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C429(0.00); C64(0.00); C383(0.00); C808(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C429(0.00); C383(0.00); C808(0.00); C839(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C429(0.00); C64(0.00); C383(0.00); C839(0.00)  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD2156  [8]
TFBX
 Probe Info  		C383(0.00); C839(0.00); C64(0.00)  LDD0148  [9]
Acrolein
 Probe Info  		C64(0.00); C839(0.00); C383(0.00)  LDD0217  [10]
NAIA_5
 Probe Info  		C429(0.00); C885(0.00); C392(0.00); C64(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0071  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C808(1.41)  LDD2117  [3]
 LDCM0025  4SU-RNA DM93 C720(6.49)  LDD0170  [4]
 LDCM0214  AC1 HEK-293T C429(1.03)  LDD0812  [5]
 LDCM0215  AC10 HEK-293T C429(0.91)  LDD0813  [5]
 LDCM0216  AC100 HEK-293T C429(0.75)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C429(0.83)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C429(0.74)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C429(0.70)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C429(0.72)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C429(0.71)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C429(0.80)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C429(0.99)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C429(0.78)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C429(0.74)  LDD0823  [5]
 LDCM0226  AC11 HEK-293T C429(0.95)  LDD0824  [5]
 LDCM0227  AC110 HEK-293T C429(0.89)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C429(1.06)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C429(0.83)  LDD0827  [5]
 LDCM0230  AC113 HEK-293T C429(0.67)  LDD0828  [5]
 LDCM0231  AC114 HEK-293T C429(0.56)  LDD0829  [5]
 LDCM0232  AC115 HEK-293T C429(0.68)  LDD0830  [5]
 LDCM0233  AC116 HEK-293T C429(0.55)  LDD0831  [5]
 LDCM0234  AC117 HEK-293T C429(0.59)  LDD0832  [5]
 LDCM0235  AC118 HEK-293T C429(0.67)  LDD0833  [5]
 LDCM0236  AC119 HEK-293T C429(0.53)  LDD0834  [5]
 LDCM0237  AC12 HEK-293T C429(1.57)  LDD0835  [5]
 LDCM0238  AC120 HEK-293T C429(0.88)  LDD0836  [5]
 LDCM0239  AC121 HEK-293T C429(0.51)  LDD0837  [5]
 LDCM0240  AC122 HEK-293T C429(0.63)  LDD0838  [5]
 LDCM0241  AC123 HEK-293T C429(0.51)  LDD0839  [5]
 LDCM0242  AC124 HEK-293T C429(0.59)  LDD0840  [5]
 LDCM0243  AC125 HEK-293T C429(0.65)  LDD0841  [5]
 LDCM0244  AC126 HEK-293T C429(0.71)  LDD0842  [5]
 LDCM0245  AC127 HEK-293T C429(0.92)  LDD0843  [5]
 LDCM0246  AC128 HEK-293T C429(0.93)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C429(0.76)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C429(0.79)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C429(0.94)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C429(0.97)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C429(0.83)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C429(0.85)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C429(1.03)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C429(0.84)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C429(0.88)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C429(0.95)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C429(0.80)  LDD0856  [5]
 LDCM0259  AC14 HEK-293T C429(1.61)  LDD0857  [5]
 LDCM0260  AC140 HEK-293T C429(0.90)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C429(0.85)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C429(0.80)  LDD0860  [5]
 LDCM0263  AC143 HEK-293T C429(0.76)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C429(0.85)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C429(1.08)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C429(0.88)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C429(1.09)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C429(0.95)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C429(1.04)  LDD0867  [5]
 LDCM0270  AC15 HEK-293T C429(1.28)  LDD0868  [5]
 LDCM0271  AC150 HEK-293T C429(0.89)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C429(0.80)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C429(0.96)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C429(0.86)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C429(1.02)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C429(0.92)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C429(1.01)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C429(1.13)  LDD2165  [5]
 LDCM0276  AC17 HEK-293T C429(0.83)  LDD0874  [5]
 LDCM0277  AC18 HEK-293T C429(0.90)  LDD0875  [5]
 LDCM0278  AC19 HEK-293T C429(1.14)  LDD0876  [5]
 LDCM0279  AC2 HEK-293T C429(0.86)  LDD0877  [5]
 LDCM0280  AC20 HEK-293T C429(0.76)  LDD0878  [5]
 LDCM0281  AC21 HEK-293T C429(1.23)  LDD0879  [5]
 LDCM0282  AC22 HEK-293T C429(0.88)  LDD0880  [5]
 LDCM0283  AC23 HEK-293T C429(0.80)  LDD0881  [5]
 LDCM0284  AC24 HEK-293T C429(0.88)  LDD0882  [5]
 LDCM0285  AC25 PaTu 8988t C429(0.98); C383(1.60)  LDD1164  [5]
 LDCM0286  AC26 PaTu 8988t C429(1.08); C383(1.39)  LDD1165  [5]
 LDCM0287  AC27 PaTu 8988t C429(1.08); C383(1.74)  LDD1166  [5]
 LDCM0288  AC28 PaTu 8988t C429(0.74); C383(1.87)  LDD1167  [5]
 LDCM0289  AC29 PaTu 8988t C429(0.94); C383(2.16)  LDD1168  [5]
 LDCM0290  AC3 HEK-293T C429(0.96)  LDD0888  [5]
 LDCM0291  AC30 PaTu 8988t C429(0.82); C383(1.25)  LDD1170  [5]
 LDCM0292  AC31 PaTu 8988t C429(0.92); C383(1.33)  LDD1171  [5]
 LDCM0293  AC32 PaTu 8988t C429(0.94); C383(2.25)  LDD1172  [5]
 LDCM0294  AC33 PaTu 8988t C429(1.08); C383(0.95)  LDD1173  [5]
 LDCM0295  AC34 PaTu 8988t C429(0.24); C383(1.50)  LDD1174  [5]
 LDCM0296  AC35 HEK-293T C429(1.23)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C429(1.25)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C429(1.34)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C429(1.04)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C429(1.05)  LDD0898  [5]
 LDCM0301  AC4 HEK-293T C429(0.98)  LDD0899  [5]
 LDCM0302  AC40 HEK-293T C429(1.07)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C429(1.10)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C429(1.15)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C429(0.78)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C429(0.98)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C429(1.32)  LDD0905  [5]
 LDCM0308  AC46 HEK-293T C429(0.87)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C429(1.02)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C429(0.84)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C429(1.01)  LDD0909  [5]
 LDCM0312  AC5 HEK-293T C429(0.97)  LDD0910  [5]
 LDCM0313  AC50 HEK-293T C429(1.07)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C429(1.05)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C429(0.84)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C429(1.24)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C429(1.01)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C429(0.82)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C429(0.77)  LDD0917  [5]
 LDCM0320  AC57 HEK-293T C429(1.36)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C429(1.20)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C429(1.25)  LDD0920  [5]
 LDCM0323  AC6 HEK-293T C429(0.83)  LDD0921  [5]
 LDCM0324  AC60 HEK-293T C429(1.39)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C429(0.98)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C429(1.24)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C429(1.19)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C429(1.49)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C429(1.41)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C429(1.26)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C429(1.17)  LDD0929  [5]
 LDCM0334  AC7 HEK-293T C429(1.14)  LDD0932  [5]
 LDCM0345  AC8 HEK-293T C429(1.27)  LDD0943  [5]
 LDCM0365  AC98 HEK-293T C429(1.06)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C429(0.79)  LDD0964  [5]
 LDCM0248  AKOS034007472 HEK-293T C429(1.42)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C429(1.60)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C429(0.95)  LDD0873  [5]
 LDCM0020  ARS-1620 HCC44 C383(0.89)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C429(20.00); C383(20.00); C839(3.42); C64(0.51)  LDD2227  [11]
 LDCM0367  CL1 HCT 116 C429(0.87)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C429(0.33)  LDD0685  [5]
 LDCM0369  CL100 HEK-293T C429(0.82)  LDD0967  [5]
 LDCM0370  CL101 HEK-293T C429(1.02)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C429(1.92)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C429(1.01)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C429(1.10)  LDD0971  [5]
 LDCM0374  CL105 HEK-293T C429(0.98)  LDD0972  [5]
 LDCM0375  CL106 HEK-293T C429(1.08)  LDD0973  [5]
 LDCM0376  CL107 HEK-293T C429(1.08)  LDD0974  [5]
 LDCM0377  CL108 HEK-293T C429(1.13)  LDD0975  [5]
 LDCM0378  CL109 HEK-293T C429(1.86)  LDD0976  [5]
 LDCM0379  CL11 HCT 116 C429(0.26)  LDD0696  [5]
 LDCM0380  CL110 HEK-293T C429(1.04)  LDD0978  [5]
 LDCM0381  CL111 HEK-293T C429(0.94)  LDD0979  [5]
 LDCM0382  CL112 PaTu 8988t C429(0.89); C383(2.16)  LDD1261  [5]
 LDCM0383  CL113 PaTu 8988t C429(1.30); C383(1.51)  LDD1262  [5]
 LDCM0384  CL114 PaTu 8988t C429(0.96); C383(1.31)  LDD1263  [5]
 LDCM0385  CL115 PaTu 8988t C429(0.88); C383(1.19)  LDD1264  [5]
 LDCM0386  CL116 PaTu 8988t C429(1.71); C383(1.67)  LDD1265  [5]
 LDCM0387  CL117 HEK-293T C429(1.08)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C429(1.42)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C429(0.97)  LDD0987  [5]
 LDCM0390  CL12 HCT 116 C429(0.27)  LDD0707  [5]
 LDCM0391  CL120 HEK-293T C429(0.91)  LDD0989  [5]
 LDCM0392  CL121 HEK-293T C429(0.95)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C429(0.88)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C429(1.76)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C429(0.78)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C429(1.04)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C429(1.23)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C429(1.41)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C429(0.99)  LDD0997  [5]
 LDCM0400  CL13 HCT 116 C429(0.74)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C429(0.98)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C429(0.94)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C429(0.95)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C429(0.85)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C429(0.87)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C429(1.17)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C429(0.95)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C429(0.48)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C429(0.38)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C429(0.22)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C429(0.79)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C429(0.26)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C429(0.36)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C429(0.87)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C429(1.06)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C429(0.58)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C429(0.63)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C429(0.87)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C429(0.90)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C429(0.90)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C429(0.91)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C429(0.94)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C429(0.22)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C429(0.37)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C429(0.43)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C429(0.31)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C429(0.28)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C429(0.66)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C429(0.54)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C429(0.47)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C429(0.28)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C429(0.28)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C429(0.56)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C429(0.38)  LDD0752  [5]
 LDCM0436  CL46 HEK-293T C429(0.77)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C429(0.91)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C429(0.76)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C429(0.76)  LDD1037  [5]
 LDCM0440  CL5 HCT 116 C429(1.08)  LDD0757  [5]
 LDCM0441  CL50 HEK-293T C429(0.78)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C429(0.96)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C429(0.83)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C429(0.79)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C429(0.81)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C429(0.69)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C429(0.89)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C429(0.94)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C429(0.81)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C429(0.60)  LDD1048  [5]
 LDCM0451  CL6 HCT 116 C429(0.96)  LDD0768  [5]
 LDCM0452  CL60 HEK-293T C429(0.50)  LDD1050  [5]
 LDCM0453  CL61 PaTu 8988t C429(1.03); C383(1.68)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C429(1.02); C383(1.74)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C429(1.06); C383(2.69)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C429(0.87); C383(2.03)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C429(0.91); C383(1.16)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C429(0.76); C383(1.40)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C429(0.45); C383(0.67)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C429(0.35); C383(0.56)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C429(0.18); C383(0.60)  LDD1340  [5]
 LDCM0462  CL7 HCT 116 C429(0.50)  LDD0779  [5]
 LDCM0463  CL70 PaTu 8988t C429(0.54); C383(0.72)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C429(1.26); C383(1.61)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C429(1.52); C383(2.18)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C429(0.54); C383(0.70)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C429(1.10); C383(2.15)  LDD1346  [5]
 LDCM0469  CL76 HCT 116 C429(1.13)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C429(1.06)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C429(1.05)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C429(0.43)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C429(0.28)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C429(1.29)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C429(0.58)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C429(0.23)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C429(0.24)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C429(0.24)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C429(1.01)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C429(1.80)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C429(0.93)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C429(0.34)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C429(0.27)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C429(0.29)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C429(1.12)  LDD0802  [5]
 LDCM0486  CL91 HEK-293T C429(0.79)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C429(1.16)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C429(0.93)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C429(1.00)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C429(1.06)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C429(0.94)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C429(0.95)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C429(0.99)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C429(0.84)  LDD1092  [5]
 LDCM0495  E2913 HEK-293T C64(1.12); C383(0.86); C808(1.02); C839(1.21)  LDD1698  [13]
 LDCM0625  F8 Ramos C839(0.62)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C839(0.81)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C64(0.80); C839(4.12)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C839(0.78)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C839(0.55)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C839(0.92)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C839(0.48)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C839(0.83)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C839(0.91)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C839(1.26)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C839(1.04)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C839(1.23)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C839(0.57)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C839(0.56)  LDD2201  [14]
 LDCM0468  Fragment33 PaTu 8988t C429(0.32); C383(0.65)  LDD1347  [5]
 LDCM0596  Fragment38 Ramos C839(0.87)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C64(0.48); C839(0.81)  LDD2184  [14]
 LDCM0427  Fragment51 HCT 116 C429(0.22)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C839(1.12)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C839(0.51)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C64(0.73); C839(0.21)  LDD2186  [14]
 LDCM0571  Fragment9 Ramos C839(0.90)  LDD2188  [14]
 LDCM0022  KB02 HEK-293T C64(1.06); C383(0.95); C808(0.97); C392(1.03)  LDD1492  [13]
 LDCM0023  KB03 Jurkat C383(4.41)  LDD0315  [15]
 LDCM0024  KB05 G361 C64(0.93)  LDD3311  [16]
 LDCM0109  NEM HeLa N.A.  LDD0227  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C808(0.55)  LDD2109  [3]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840