Details of the Target

General Information of Target

Target ID LDTP02595
Target Name Polyadenylate-binding protein 1 (PABPC1)
Gene Name PABPC1
Gene ID 26986
Synonyms
PAB1; PABP; PABP1; PABPC2; Polyadenylate-binding protein 1; PABP-1; Poly(A)-binding protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQ
QPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFS
AFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKERE
AELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFER
HEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKN
LDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVAT
KPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRA
AYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQ
RVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQ
GQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESP
ESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
Target Type
Clinical trial
Target Bioclass
Other
Family
Polyadenylate-binding protein type-1 family
Subcellular location
Cytoplasm
Function
Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability.; (Microbial infection) Positively regulates the replication of dengue virus (DENV).
TTD ID
T58679
Uniprot ID
P11940
DrugMap ID
TTHC8EF
Ensemble ID
ENST00000318607.10
HGNC ID
HGNC:8554
ChEMBL ID
CHEMBL1293286

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.D45N .
CORL88 SNV: p.Q417P .
HCT15 SNV: p.R278H; p.K324N .
MCC26 SNV: p.A247V .
MOLT4 SNV: p.R83H .
OCUM1 Substitution: p.I47P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 46 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		10.00  LDD0452  [1]
P2
 Probe Info  		10.00  LDD0449  [1]
P3
 Probe Info  		10.00  LDD0450  [1]
P8
 Probe Info  		3.64  LDD0451  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y364(17.49); Y297(11.61); Y291(9.30); Y382(6.91)  LDD0257  [3]
TH214
 Probe Info  		Y364(19.01); Y291(5.92)  LDD0258  [3]
TH216
 Probe Info  		Y364(20.00); Y140(13.17); Y382(9.17)  LDD0259  [3]
AZ-9
 Probe Info  		E66(0.94); E239(10.00); D165(10.00); Q61(0.94)  LDD2208  [4]
ONAyne
 Probe Info  		K512(0.00); K620(0.00); K312(0.00); K606(0.00)  LDD0273  [5]
OPA-S-S-alkyne
 Probe Info  		K157(1.38); K231(1.77); K512(3.06)  LDD3494  [6]
Probe 1
 Probe Info  		Y56(6.46); Y140(9.07); Y194(12.40); Y291(42.43)  LDD3495  [7]
THZ1-DTB
 Probe Info  		C128(1.08)  LDD0460  [8]
BTD
 Probe Info  		C132(1.88)  LDD1700  [9]
AHL-Pu-1
 Probe Info  		C339(2.44)  LDD0169  [10]
HHS-482
 Probe Info  		Y291(0.89); Y297(0.94); Y364(0.93); Y382(0.88)  LDD0285  [11]
HHS-475
 Probe Info  		Y297(0.70); Y291(0.78); Y140(0.81); Y511(0.84)  LDD0264  [12]
HHS-465
 Probe Info  		Y140(6.93); Y291(8.36); Y297(8.02); Y382(7.90)  LDD2237  [13]
DBIA
 Probe Info  		C132(0.83)  LDD1507  [14]
5E-2FA
 Probe Info  		H241(0.00); H595(0.00); H574(0.00); H377(0.00)  LDD2235  [15]
ATP probe
 Probe Info  		K188(0.00); K259(0.00); K138(0.00); K108(0.00)  LDD0199  [16]
m-APA
 Probe Info  		H595(0.00); H574(0.00); H377(0.00); H617(0.00)  LDD2231  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C128(0.00); C339(0.00); C132(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		C132(0.00); C128(0.00); C339(0.00)  LDD0032  [18]
IPIAA_H
 Probe Info  		C339(0.00); C132(0.00)  LDD0030  [19]
IPIAA_L
 Probe Info  		C132(0.00); C339(0.00)  LDD0031  [19]
Lodoacetamide azide
 Probe Info  		C128(0.00); C339(0.00); C132(0.00)  LDD0037  [17]
ATP probe
 Probe Info  		K324(0.00); K606(0.00); K246(0.00); K312(0.00)  LDD0035  [20]
IPM
 Probe Info  		C339(0.00); C132(0.00)  LDD0025  [21]
TFBX
 Probe Info  		N.A.  LDD0027  [21]
WYneO
 Probe Info  		N.A.  LDD0022  [22]
Compound 10
 Probe Info  		C132(0.00); C339(0.00)  LDD2216  [23]
Compound 11
 Probe Info  		N.A.  LDD2213  [23]
ENE
 Probe Info  		N.A.  LDD0006  [22]
NHS
 Probe Info  		K284(0.00); K512(0.00); K188(0.00); K259(0.00)  LDD0010  [22]
PF-06672131
 Probe Info  		N.A.  LDD0152  [24]
SF
 Probe Info  		K104(0.00); K312(0.00); K196(0.00); Y56(0.00)  LDD0028  [25]
STPyne
 Probe Info  		K620(0.00); K512(0.00)  LDD0009  [22]
VSF
 Probe Info  		N.A.  LDD0007  [22]
1c-yne
 Probe Info  		K620(0.00); K312(0.00); K606(0.00); K361(0.00)  LDD0228  [26]
Acrolein
 Probe Info  		C128(0.00); H144(0.00)  LDD0217  [27]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [27]
W1
 Probe Info  		C132(0.00); C339(0.00)  LDD0236  [28]
NAIA_5
 Probe Info  		C128(0.00); C339(0.00); C43(0.00); C132(0.00)  LDD2223  [29]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		7.19  LDD0471  [30]
FFF probe13
 Probe Info  		11.31  LDD0475  [30]
FFF probe14
 Probe Info  		9.00  LDD0477  [30]
FFF probe2
 Probe Info  		6.54  LDD0463  [30]
FFF probe3
 Probe Info  		6.17  LDD0464  [30]
JN0003
 Probe Info  		7.10  LDD0469  [30]
STS-2
 Probe Info  		N.A.  LDD0138  [31]
VE-P
 Probe Info  		N.A.  LDD0396  [32]
DA-2
 Probe Info  		N.A.  LDD0070  [33]
OEA-DA
 Probe Info  		4.29  LDD0046  [34]
STS-1
 Probe Info  		N.A.  LDD0068  [35]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C132(0.73); C339(0.35)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C132(0.96); C339(0.34)  LDD2112  [9]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C132(0.85)  LDD2095  [9]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C132(0.75)  LDD2130  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C132(1.04)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C132(1.70)  LDD2152  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C132(0.63)  LDD2131  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C339(2.44)  LDD0169  [10]
 LDCM0562  Abegg_cp(-)-11 HeLa C128(2.01)  LDD0313  [21]
 LDCM0214  AC1 HEK-293T C132(0.83)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C132(0.84)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C132(0.84)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C132(0.99)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C132(0.89)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C132(0.89)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C132(0.92)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C132(0.93)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C132(0.78)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C132(0.87)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C132(0.97)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C132(0.97)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C132(0.96)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C132(0.98)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C132(0.93)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C132(0.94)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C132(0.95)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C132(0.90)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C132(0.95)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C132(0.97)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C132(0.83)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C132(0.96)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C132(0.98)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C132(0.93)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C132(0.81)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C132(0.82)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C132(0.80)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C132(0.94)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C132(0.93)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C132(0.86)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C132(0.85)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C132(0.96)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C132(0.77)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C132(0.83)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C132(0.82)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C132(0.79)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C132(0.98)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C132(0.92)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C132(0.86)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C132(0.88)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C132(0.79)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C132(0.84)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C132(0.95)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C132(0.87)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C132(0.90)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C132(0.97)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C132(0.97)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C132(0.90)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C132(0.85)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C132(0.84)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C132(0.86)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C132(0.88)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C132(0.89)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C132(0.87)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C132(0.96)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C132(0.95)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C132(0.93)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C132(0.90)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C132(0.84)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C132(0.92)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C132(0.80)  LDD1569  [14]
 LDCM0545  Acetamide MDA-MB-231 C132(0.87)  LDD2138  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C132(0.63)  LDD2113  [9]
 LDCM0248  AKOS034007472 HEK-293T C132(0.92)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C132(0.86)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C132(0.79)  LDD1514  [14]
 LDCM0498  BS-3668 MDA-MB-231 C132(1.01)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [27]
 LDCM0632  CL-Sc Hep-G2 C339(3.54); C132(1.53); C132(1.30); C339(0.85)  LDD2227  [29]
 LDCM0367  CL1 HEK-293T C132(0.79)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C132(0.67)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C132(0.79)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C132(0.89)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C132(0.80)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C132(0.88)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C132(0.80)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C132(0.97)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C132(0.87)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C132(0.95)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C132(0.88)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C132(0.92)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C132(0.81)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C132(0.88)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C132(0.93)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C132(1.29)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C132(0.88)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C132(0.80)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C132(0.87)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C132(0.75)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C132(0.89)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C132(0.80)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C132(0.90)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C132(0.71)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C132(0.77)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C132(0.88)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C132(0.83)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C132(0.76)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C132(0.72)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C132(0.98)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C132(0.85)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C132(0.93)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C132(0.82)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C132(0.77)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C132(0.75)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C132(0.67)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C132(0.67)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C132(0.66)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C132(0.78)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C132(0.81)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C132(0.77)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C132(0.92)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C132(0.77)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C132(0.82)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C132(0.82)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C132(0.76)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C132(0.83)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C132(0.84)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C132(0.89)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C132(0.75)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C132(0.84)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C132(0.79)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C132(0.87)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C132(0.84)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C132(0.92)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C132(0.73)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C132(0.85)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C132(0.93)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C132(0.82)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C132(0.94)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C132(0.83)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C132(0.63)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C132(0.81)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C132(0.81)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C132(0.86)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C132(0.80)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C132(0.95)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C132(0.86)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C132(0.93)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C132(0.87)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C132(0.83)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C132(0.83)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C132(0.77)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C132(0.71)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C132(0.63)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C132(0.66)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C132(0.64)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C132(0.73)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C132(0.90)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C132(0.75)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C132(0.76)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C132(0.80)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C132(0.73)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C132(0.73)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C132(0.92)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C132(0.80)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C132(0.82)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C132(0.59)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C132(0.77)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C132(0.80)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C132(0.78)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C132(0.91)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C132(0.84)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C132(0.84)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C132(0.82)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C132(0.86)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C132(0.75)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C132(0.85)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C132(0.80)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C132(0.71)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C132(0.72)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C132(0.83)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C132(0.81)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C132(0.63)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C132(0.97)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C132(0.92)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C132(0.84)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C132(0.84)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C132(0.76)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C132(0.89)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C132(0.81)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C132(0.91)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C132(0.68)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C132(0.80)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C132(0.89)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C132(0.58)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C132(0.76)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C132(0.90)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C132(0.84)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C132(0.83)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C132(0.84)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C132(0.74)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C132(0.85)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C132(0.82)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C132(0.89)  LDD1697  [14]
 LDCM0634  CY-0357 Hep-G2 C132(3.35); C339(0.92)  LDD2228  [29]
 LDCM0495  E2913 HEK-293T C132(0.76)  LDD1698  [14]
 LDCM0625  F8 Ramos C339(0.63); C132(1.73); C128(0.39)  LDD2187  [36]
 LDCM0572  Fragment10 Ramos C339(0.85); C132(1.07); C128(0.72)  LDD2189  [36]
 LDCM0573  Fragment11 Ramos C339(0.06); C128(0.63)  LDD2190  [36]
 LDCM0574  Fragment12 Ramos C339(0.87); C132(0.76); C128(4.03)  LDD2191  [36]
 LDCM0575  Fragment13 Ramos C339(0.93); C132(1.27); C128(1.80)  LDD2192  [36]
 LDCM0576  Fragment14 Ramos C339(0.66); C132(0.87)  LDD2193  [36]
 LDCM0579  Fragment20 Ramos C339(0.93); C132(0.91); C128(0.93)  LDD2194  [36]
 LDCM0580  Fragment21 Ramos C339(1.25); C132(1.17); C128(7.84)  LDD2195  [36]
 LDCM0582  Fragment23 Ramos C339(1.36); C132(1.12); C128(4.76)  LDD2196  [36]
 LDCM0578  Fragment27 Ramos C339(1.21); C132(1.25)  LDD2197  [36]
 LDCM0586  Fragment28 Ramos C339(1.07); C132(0.64)  LDD2198  [36]
 LDCM0588  Fragment30 Ramos C339(0.92); C132(1.24); C128(4.60)  LDD2199  [36]
 LDCM0589  Fragment31 Ramos C339(1.35); C132(1.04); C128(2.87)  LDD2200  [36]
 LDCM0590  Fragment32 Ramos C339(0.65); C132(0.85); C128(2.61)  LDD2201  [36]
 LDCM0468  Fragment33 HEK-293T C132(0.82)  LDD1671  [14]
 LDCM0596  Fragment38 Ramos C339(1.45); C132(0.83); C128(14.13)  LDD2203  [36]
 LDCM0566  Fragment4 Ramos C339(0.75); C132(0.86); C128(0.65)  LDD2184  [36]
 LDCM0427  Fragment51 HEK-293T C132(0.88)  LDD1631  [14]
 LDCM0610  Fragment52 Ramos C339(1.15); C132(1.45); C128(2.85)  LDD2204  [36]
 LDCM0614  Fragment56 Ramos C339(0.91); C132(1.68); C128(2.71)  LDD2205  [36]
 LDCM0569  Fragment7 Ramos C339(0.67); C132(0.77); C128(0.51)  LDD2186  [36]
 LDCM0571  Fragment9 Ramos C339(0.69); C132(0.95); C128(0.91)  LDD2188  [36]
 LDCM0116  HHS-0101 DM93 Y297(0.70); Y291(0.78); Y140(0.81); Y511(0.84)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y297(0.62); Y291(0.67); Y140(0.75); Y56(0.78)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y291(0.73); Y194(0.76); Y513(0.76); Y297(0.80)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y297(0.72); Y291(0.77); Y364(0.86); Y382(0.87)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y364(0.75); Y291(0.81); Y140(0.82); Y382(0.84)  LDD0268  [12]
 LDCM0107  IAA HeLa N.A.  LDD0221  [27]
 LDCM0123  JWB131 DM93 Y291(0.89); Y297(0.94); Y364(0.93); Y382(0.88)  LDD0285  [11]
 LDCM0124  JWB142 DM93 Y140(0.88); Y291(0.65); Y297(0.68); Y364(0.69)  LDD0286  [11]
 LDCM0125  JWB146 DM93 Y140(1.56); Y291(1.09); Y297(0.95); Y364(1.06)  LDD0287  [11]
 LDCM0126  JWB150 DM93 Y140(3.52); Y291(2.17); Y297(3.02); Y364(2.66)  LDD0288  [11]
 LDCM0127  JWB152 DM93 Y140(3.55); Y291(1.62); Y297(1.86); Y364(1.77)  LDD0289  [11]
 LDCM0128  JWB198 DM93 Y291(0.98); Y297(1.13); Y364(1.10); Y382(0.94)  LDD0290  [11]
 LDCM0129  JWB202 DM93 Y140(1.06); Y291(0.40); Y297(0.63); Y364(0.44)  LDD0291  [11]
 LDCM0130  JWB211 DM93 Y140(1.34); Y291(0.88); Y297(0.88); Y364(0.98)  LDD0292  [11]
 LDCM0022  KB02 Ramos C339(0.48); C132(0.92); C128(0.43)  LDD2182  [36]
 LDCM0023  KB03 Ramos C339(0.70); C132(0.76); C128(0.96)  LDD2183  [36]
 LDCM0024  KB05 Ramos C339(0.51); C132(0.76); C128(0.73)  LDD2185  [36]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C132(0.94)  LDD2102  [9]
 LDCM0109  NEM HeLa H144(0.00); H377(0.00); C128(0.00)  LDD0223  [27]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C132(0.64)  LDD2089  [9]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C132(1.16)  LDD2090  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C132(0.77)  LDD2092  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C132(1.32)  LDD2094  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C132(0.66)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C132(0.68)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C132(1.32)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C132(0.72)  LDD2100  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C132(0.63)  LDD2101  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C132(0.93)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C132(1.01)  LDD2105  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C339(0.36)  LDD2106  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C132(0.88); C339(0.50)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C132(0.84)  LDD2109  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C132(1.63)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C132(0.71)  LDD2114  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C132(0.36)  LDD2115  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C132(0.46)  LDD2116  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C132(2.03)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C132(1.15)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C132(0.37)  LDD2122  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C132(0.25)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C132(0.99)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C132(0.18)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C132(1.00)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C132(0.97)  LDD2128  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C132(0.27)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C132(0.30)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C132(0.80)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C132(1.29)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C132(1.10)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C132(1.88)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C132(0.96)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C132(0.80)  LDD2141  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C132(1.03)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C132(3.31)  LDD2144  [9]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C132(7.04); C339(0.35)  LDD2145  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C132(1.07)  LDD2146  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C132(0.65)  LDD2148  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C132(1.38)  LDD2153  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C339(1.04); C132(0.92)  LDD2206  [37]
 LDCM0628  OTUB2-COV-1 HEK-293T C132(0.71); C339(0.63)  LDD2207  [37]
 LDCM0021  THZ1 HeLa S3 C128(1.08)  LDD0460  [8]
 LDCM0113  W17 Hep-G2 C132(11.84)  LDD0240  [28]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-dependent RNA helicase DDX3X (DDX3X) DEAD box helicase family O00571
Serine/threonine-protein kinase SMG1 (SMG1) PI3/PI4-kinase family Q96Q15
PAN2-PAN3 deadenylation complex subunit PAN3 (PAN3) PAN3 family Q58A45
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (GSPT2) Classic translation factor GTPase family Q8IYD1
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Nuclear cap-binding protein subunit 1 (NCBP1) NCBP1 family Q09161
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-2 (ATXN2) Ataxin-2 family Q99700
Protein Tob1 (TOB1) BTG family P50616
Protein Tob2 (TOB2) BTG family Q14106
Eukaryotic translation initiation factor 4E (EIF4E) Eukaryotic initiation factor 4E family P06730
Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) Eukaryotic initiation factor 4G family Q04637
Trinucleotide repeat-containing gene 6A protein (TNRC6A) GW182 family Q8NDV7
Trinucleotide repeat-containing gene 6B protein (TNRC6B) GW182 family Q9UPQ9
Trinucleotide repeat-containing gene 6C protein (TNRC6C) GW182 family Q9HCJ0
Polyadenylate-binding protein-interacting protein 2 (PAIP2) PAIP2 family Q9BPZ3
Insulin receptor substrate 1 (IRS1) . P35568
Polyadenylate-binding protein 2 (PABPN1) . Q86U42
Polyadenylate-binding protein-interacting protein 1 (PAIP1) . Q9H074

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Atrc-101 Antibody DO20LT

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
20 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
23 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
24 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
25 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
26 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
27 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
28 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
29 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
30 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
31 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
32 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
33 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
34 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
35 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
36 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
37 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.