Details of the Probe

General Information of Probe

Probe ID
LDPC0247
Probe Name
P1
Probe Type
ABPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 228.295
Lipid-water partition coefficient (xlogp) 1.7463
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 2
Chemical Identifiers
Formula
C14H16N2O
Canonical SMILES
C#CCN(C)CC=CC(=O)Nc1ccccc1
InChI
InChI=1S/C14H16N2O/c1-3-11-16(2)12-7-10-14(17)15-13-8-5-4-6-9-13/h1,4-10H,11-12H2,2H3,(H,15,17)/b10-7+
InChIKey
JBZKDRUSCSSBIW-JXMROGBWSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

46 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1) LDTP12397 1.76  LDD0448 
5'-3' exoribonuclease 2 (XRN2) LDTP11701 10.00  LDD0448 
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 7.70  LDD0452 
Actin, cytoplasmic 1 (ACTB) LDTP04876 10.00  LDD0452 
Actin, cytoplasmic 2 (ACTG1) LDTP05059 2.16  LDD0452 
Adenosylhomocysteinase (AHCY) LDTP03242 4.01  LDD0452 
Aldo-keto reductase family 1 member C3 (AKR1C3) LDTP03976 2.95  LDD0452 
Argininosuccinate synthase (ASS1) LDTP01807 1.70  LDD0452 
ATP-dependent RNA helicase A (DHX9) LDTP05550 2.83  LDD0452 
ATP-dependent RNA helicase DDX3X (DDX3X) LDTP00314 10.00  LDD0452 
Carbonic anhydrase 2 (CA2) LDTP01806 1.75  LDD0448 
Carboxylesterase 5A (CES5A) LDTP15093 1.94  LDD0448 
Cardiomyopathy-associated protein 5 (CMYA5) LDTP08837 10.00  LDD0448 
Cell division control protein 42 homolog (CDC42) LDTP04886 10.00  LDD0452 
Creatine kinase B-type (CKB) LDTP02616 5.75  LDD0452 
Dermcidin (DCD) LDTP05171 1.87  LDD0448 
DNA-dependent protein kinase catalytic subunit (PRKDC) LDTP05136 10.00  LDD0448 
E3 ubiquitin-protein ligase RNF180 (RNF180) LDTP08190 5.26  LDD0452 
Elongation factor 1-alpha 2 (EEF1A2) LDTP05460 10.00  LDD0452 
Elongation factor 2 (EEF2) LDTP02672 1.56  LDD0452 
Elongation factor Tu, mitochondrial (TUFM) LDTP04251 10.00  LDD0452 
Epidermal growth factor receptor (EGFR) LDTP01785 2.59  LDD0448 
Epoxide hydrolase 1 (EPHX1) LDTP02175 10.00  LDD0452 
Eukaryotic initiation factor 4A-I (EIF4A1) LDTP04878 2.59  LDD0452 
FACT complex subunit SPT16 (SUPT16H) LDTP14109 10.00  LDD0448 
Fructose-bisphosphate aldolase A (ALDOA) LDTP02008 3.09  LDD0452 
Glutathione S-transferase P (GSTP1) LDTP02333 10.00  LDD0452 
Heat shock cognate 71 kDa protein (HSPA8) LDTP02541 2.15  LDD0452 
Histone acetyltransferase KAT2A (KAT2A) LDTP09890 3.49  LDD0448 
L-lactate dehydrogenase A chain (LDHA) LDTP01766 2.12  LDD0452 
Malate dehydrogenase, mitochondrial (MDH2) LDTP03908 3.97  LDD0452 
Myosin-9 (MYH9) LDTP03764 10.00  LDD0452 
NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial (NDUFB11) LDTP12752 1.79  LDD0448 
Neutral alpha-glucosidase AB (GANAB) LDTP06192 3.06  LDD0452 
Probable ATP-dependent RNA helicase DDX46 (DDX46) LDTP07932 1.59  LDD0448 
Probable ATP-dependent RNA helicase DDX5 (DDX5) LDTP02924 10.00  LDD0452 
Probable phospholipid-transporting ATPase IIA (ATP9A) LDTP01124 2.10  LDD0452 
Pyruvate kinase PKM (PKM) LDTP02733 2.88  LDD0452 
Rho-associated protein kinase 2 (ROCK2) LDTP01127 3.66  LDD0448 
Serine/threonine-protein kinase PRP4 homolog (PRPF4B) LDTP05911 2.51  LDD0452 
Transitional endoplasmic reticulum ATPase (VCP) LDTP04665 10.00  LDD0448 
Transketolase (TKT) LDTP03487 2.00  LDD0452 
Triosephosphate isomerase (TPI1) LDTP04851 1.64  LDD0452 
Ubiquitin-like modifier-activating enzyme 1 (UBA1) LDTP03166 3.62  LDD0452 
UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1) LDTP12851 10.00  LDD0448 
Xaa-Pro aminopeptidase 1 (XPNPEP1) LDTP12444 10.00  LDD0452 
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⏷ Show the Full List of 46 Enzyme
18 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
14-3-3 protein epsilon (YWHAE) LDTP04969 1.67  LDD0452 
14-3-3 protein theta (YWHAQ) LDTP03385 1.93  LDD0452 
ADP/ATP translocase 2 (SLC25A5) LDTP02087 1.63  LDD0452 
Amino acid transporter heavy chain SLC3A2 (SLC3A2) LDTP02256 1.53  LDD0452 
Annexin A2 (ANXA2) LDTP02199 1.53  LDD0452 
Annexin A5 (ANXA5) LDTP02307 7.03  LDD0452 
Astrotactin-1 (ASTN1) LDTP00362 10.00  LDD0452 
Chloride intracellular channel protein 1 (CLIC1) LDTP00244 6.00  LDD0452 
Clathrin heavy chain 1 (CLTC) LDTP05252 10.00  LDD0452 
Desmoplakin (DSP) LDTP02815 7.69  LDD0452 
Fatty acid-binding protein 5 (FABP5) LDTP05292 10.00  LDD0448 
Filamin-A (FLNA) LDTP03107 10.00  LDD0452 
RNA-binding protein with serine-rich domain 1 (RNPS1) LDTP06350 2.74  LDD0448 
Serine/arginine repetitive matrix protein 1 (SRRM1) LDTP08637 3.28  LDD0448 
Signal recognition particle 14 kDa protein (SRP14) LDTP03837 10.00  LDD0452 
T-complex protein 1 subunit delta (CCT4) LDTP04391 10.00  LDD0452 
Urea transporter 1 (SLC14A1) LDTP05832 10.00  LDD0452 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 1.96  LDD0452 
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⏷ Show the Full List of 18 Transporter and channel
2 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Signal transducer and activator of transcription 1-alpha/beta (STAT1) LDTP03969 2.07  LDD0448 
Splicing factor, proline- and glutamine-rich (SFPQ) LDTP03212 10.00  LDD0452 
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2 GPCR Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Adhesion G protein-coupled receptor E2 (ADGRE2) LDTP13312 10.00  LDD0448 
Olfactory receptor 8H2 (OR8H2) LDTP17677 2.47  LDD0452 
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1 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Immunoglobulin superfamily member 22 (IGSF22) LDTP19752 2.04  LDD0448 
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83 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
14-3-3 protein beta/alpha (YWHAB) LDTP03617 1.82  LDD0448 
14-3-3 protein sigma (SFN) LDTP03618 4.62  LDD0448 
Alpha-actinin-4 (ACTN4) LDTP00843 3.53  LDD0452 
Ankyrin repeat and SAM domain-containing protein 3 (ANKS3) LDTP07862 1.64  LDD0448 
Aryl-hydrocarbon-interacting protein-like 1 (AIPL1) LDTP12926 1.74  LDD0448 
Bcl-2-associated transcription factor 1 (BCLAF1) LDTP12826 2.69  LDD0448 
Cilia- and flagella- associated protein 210 (CFAP210) LDTP19229 1.86  LDD0452 
Coiled-coil domain-containing protein 18 (CCDC18) LDTP17238 2.42  LDD0448 
Coiled-coil domain-containing protein 38 (CCDC38) LDTP19314 10.00  LDD0448 
Coiled-coil domain-containing protein 81 (CCDC81) LDTP17467 10.00  LDD0448 
Connector enhancer of kinase suppressor of ras 2 (CNKSR2) LDTP09705 3.32  LDD0448 
Disheveled-associated activator of morphogenesis 1 (DAAM1) LDTP14045 3.89  LDD0452 
DnaJ homolog subfamily A member 1 (DNAJA1) LDTP03606 10.00  LDD0448 
Elongation factor 1-beta (EEF1B2) LDTP03283 10.00  LDD0452 
Elongation factor 1-gamma (EEF1G) LDTP03367 1.86  LDD0452 
Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) LDTP05421 10.00  LDD0452 
Eukaryotic translation initiation factor 6 (EIF6) LDTP04743 10.00  LDD0448 
Fascin (FSCN1) LDTP06598 7.03  LDD0452 
Heat shock 70 kDa protein 1B (HSPA1B) LDTP02435 7.09  LDD0448 
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) LDTP02364 2.22  LDD0448 
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) LDTP03615 10.00  LDD0448 
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) LDTP04952 8.65  LDD0452 
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) LDTP00991 10.00  LDD0448 
Heterogeneous nuclear ribonucleoprotein R (HNRNPR) LDTP00756 10.00  LDD0452 
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) LDTP05259 10.00  LDD0452 
Histone H1.2 (H1-2) LDTP02845 2.62  LDD0448 
Histone H2A type 1-J (H2AC14) LDTP10999 2.89  LDD0448 
Histone H3-7 (H3-7) LDTP15019 3.53  LDD0448 
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) LDTP05004 1.70  LDD0452 
Hornerin (HRNR) LDTP08425 10.00  LDD0448 
Huntingtin-interacting protein 1-related protein (HIP1R) LDTP01139 2.13  LDD0448 
Keratin, type II cytoskeletal 8 (KRT8) LDTP02125 10.00  LDD0452 
Large ribosomal subunit protein eL14 (RPL14) LDTP04389 1.72  LDD0448 
Large ribosomal subunit protein eL15 (RPL15) LDTP04919 1.82  LDD0448 
Large ribosomal subunit protein eL18 (RPL18) LDTP05509 1.81  LDD0448 
Large ribosomal subunit protein eL24 (RPL24) LDTP05186 10.00  LDD0448 
Large ribosomal subunit protein eL31 (RPL31) LDTP05023 2.48  LDD0452 
Large ribosomal subunit protein eL42 (RPL36A) LDTP05188 1.51  LDD0448 
Large ribosomal subunit protein uL10 (RPLP0) LDTP02109 10.00  LDD0448 
Large ribosomal subunit protein uL16 (RPL10) LDTP03395 10.00  LDD0452 
Large ribosomal subunit protein uL18 (RPL5) LDTP04106 1.87  LDD0452 
Large ribosomal subunit protein uL23 (RPL23A) LDTP05001 4.16  LDD0448 
Large ribosomal subunit protein uL29 (RPL35) LDTP03999 1.54  LDD0452 
Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) LDTP03658 10.00  LDD0452 
Luc7-like protein 3 (LUC7L3) LDTP01534 1.68  LDD0448 
Matrix-remodeling-associated protein 7 (MXRA7) LDTP17003 10.00  LDD0448 
Moesin (MSN) LDTP03346 10.00  LDD0452 
Muellerian-inhibiting factor (AMH) LDTP01993 10.00  LDD0452 
Multiple myeloma tumor-associated protein 2 (MMTAG2) LDTP11223 10.00  LDD0448 
Nucleophosmin (NPM1) LDTP02164 1.50  LDD0452 
PDZ and LIM domain protein 1 (PDLIM1) LDTP00193 10.00  LDD0448 
Plasminogen activator inhibitor 2 (SERPINB2) LDTP02084 1.73  LDD0448 
Poly(rC)-binding protein 1 (PCBP1) LDTP06366 10.00  LDD0448 
Polyadenylate-binding protein 1 (PABPC1) LDTP02595 10.00  LDD0452 
Polypyrimidine tract-binding protein 1 (PTBP1) LDTP03364 10.00  LDD0452 
Pre-mRNA-splicing factor 38B (PRPF38B) LDTP17266 10.00  LDD0452 
Prelamin-A/C (LMNA) LDTP01932 10.00  LDD0452 
Putative ribosomal protein eL39-like 5 (RPL39P5) LDTP19326 1.77  LDD0448 
Putative RNA-binding protein Luc7-like 1 (LUC7L) LDTP12388 1.92  LDD0452 
Rab GDP dissociation inhibitor beta (GDI2) LDTP04355 10.00  LDD0452 
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) LDTP04117 10.00  LDD0452 
RNA-binding protein 39 (RBM39) LDTP06128 1.54  LDD0448 
Ryanodine receptor 3 (RYR3) LDTP06381 10.00  LDD0452 
Serine/arginine repetitive matrix protein 2 (SRRM2) LDTP13746 1.72  LDD0448 
Serine/arginine-rich splicing factor 6 (SRSF6) LDTP05802 1.70  LDD0448 
Serpin B11 (SERPINB11) LDTP10650 10.00  LDD0452 
SERPINE1 mRNA-binding protein 1 (SERBP1) LDTP09081 10.00  LDD0448 
SH3 domain-binding glutamic acid-rich-like protein 3 (SH3BGRL3) LDTP11804 10.00  LDD0448 
Small ribosomal subunit protein eS26 (RPS26) LDTP05014 4.23  LDD0452 
Small ribosomal subunit protein eS27 (RPS27) LDTP03987 1.81  LDD0448 
Small ribosomal subunit protein eS8 (RPS8) LDTP04964 3.22  LDD0448 
Small ribosomal subunit protein uS11 (RPS14) LDTP04970 10.00  LDD0448 
Small ribosomal subunit protein uS9 (RPS16) LDTP04966 2.58  LDD0452 
Splicing factor U2AF 26 kDa subunit (U2AF1L4) LDTP09562 2.79  LDD0452 
T-complex protein 1 subunit alpha (TCP1) LDTP02934 10.00  LDD0452 
T-complex protein 1 subunit epsilon (CCT5) LDTP04201 10.00  LDD0452 
T-complex protein 1 subunit gamma (CCT3) LDTP04249 10.00  LDD0452 
Testis-expressed protein 9 (TEX9) LDTP17734 5.16  LDD0452 
TOG array regulator of axonemal microtubules protein 2 (TOGARAM2) LDTP15199 1.60  LDD0448 
Tubulin beta chain (TUBB) LDTP02205 1.62  LDD0452 
Tubulin beta-4B chain (TUBB4B) LDTP05076 10.00  LDD0452 
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) LDTP05033 2.98  LDD0448 
Vimentin (VIM) LDTP02297 3.12  LDD0452 
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⏷ Show the Full List of 83 Other

Full Information of The Labelling Profiles of This Probe

Quantification: Probe vs DMSO
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
1 uM
Quantitative Method
LFQ
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Skin
Disease Model
Skin squamous cell carcinoma [ICD-11:2C31]
Model Name
Human skin squamous cell carcinoma cells (A431)
Interaction Atlas ID
 LDD0448 
Download The Altas
  
Experiment 2 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
1 uM
Quantitative Method
LFQ
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Cervix uteri
Disease Model
Endocervical adenocarcinoma [ICD-11:2C77]
Model Name
Human endocervical adenocarcinoma cells (HeLa)
Interaction Atlas ID
 LDD0452 
Download The Altas

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.