Details of the Target

General Information of Target

Target ID LDTP01806
Target Name Carbonic anhydrase 2 (CA2)
Gene Name CA2
Gene ID 760
Synonyms
Carbonic anhydrase 2; EC 4.2.1.1; Carbonate dehydratase II; Carbonic anhydrase C; CAC; Carbonic anhydrase II; CA-II; Cyanamide hydratase CA2; EC 4.2.1.69
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
Target Type
Successful
Target Bioclass
Enzyme
Family
Alpha-carbonic anhydrase family
Subcellular location
Cytoplasm
Function
Catalyzes the reversible hydration of carbon dioxide. Can also hydrate cyanamide to urea. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Essential for bone resorption and osteoclast differentiation. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption.
TTD ID
T20401
Uniprot ID
P00918
DrugMap ID
TTANPDJ
Ensemble ID
ENST00000285379.10
HGNC ID
HGNC:1373
ChEMBL ID
CHEMBL205

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		1.75  LDD0448  [1]
TH214
 Probe Info  		Y40(12.38); Y51(6.01)  LDD0258  [2]
ONAyne
 Probe Info  		N.A.  LDD0273  [3]
HHS-465
 Probe Info  		Y127(10.00); Y40(6.49); Y51(2.62)  LDD2237  [4]
ATP probe
 Probe Info  		K45(0.00); K18(0.00); K24(0.00); K167(0.00)  LDD0199  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
1d-yne
 Probe Info  		N.A.  LDD0356  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0149  [8]
NHS
 Probe Info  		K39(0.00); K224(0.00); K167(0.00); K45(0.00)  LDD0010  [9]
Ox-W18
 Probe Info  		W97(0.00); W244(0.00)  LDD2175  [10]
1c-yne
 Probe Info  		K76(0.00); K39(0.00); K227(0.00); K132(0.00)  LDD0228  [7]
AOyne
 Probe Info  		5.60  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IMP2070
 Probe Info  		1.91  LDD0280  [12]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 30 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acetazolamide Small molecular drug DB00819
Bendroflumethiazide Small molecular drug DB00436
Benzthiazide Small molecular drug D0L2MX
Brinzolamide Small molecular drug DB01194
Celecoxib Small molecular drug DB00482
Chlorothiazide Small molecular drug D0M9WM
Cyclothiazide Small molecular drug D03CNS
Diazoxide Small molecular drug DB01119
Dichlorphenamide Small molecular drug D0J4GO
Diclofenamide Small molecular drug DB01144
Dorzolamide Small molecular drug D05UYW
Ethinamate Small molecular drug D0CK3G
Ethoxzolamide Small molecular drug D07INV
Furosemide Small molecular drug DB00695
Hydroflumethiazide Small molecular drug DB00774
Methazolamide Small molecular drug DB00703
Quinethazone Small molecular drug DB01325
Salicyclic Acid Small molecular drug D07HBX
Sulfamylon Small molecular drug D0K1QD
Sulpiride Small molecular drug DB00391
Sulthiame Small molecular drug DB08329
Topiramate Small molecular drug DB00273
Trichlormethiazide Small molecular drug DB01021
Urea Small molecular drug DB03904
Valdecoxib Small molecular drug DB00580
Zonisamide Small molecular drug DB00909
Sodium Carbonate . DB09460
Sodium Sulfate . DB09472
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548
Phase 3
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cg-100649 Small molecular drug D0W2CX
Curcumin Small molecular drug D07SDQ
Guaiacol Small molecular drug D02JUW
Phenol Small molecular drug D0L6HN
Sulthiame Small molecular drug D06PII
Paraben . D0A8JP
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Coumate Small molecular drug D0Y6OA
Stx-140 Small molecular drug D07ZNI
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Butylatedhydroxytoluene Small molecular drug D0W1SL
Sulfamide Small molecular drug D0V0UK
Investigative
Click To Hide/Show 314 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(2,2-dimethyl-1,3-dioxolan-4-yl)Methyl Sulfamate Small molecular drug D01KOO
(2-bromophenyl)Difluoromethanesulfonamide Small molecular drug D04JIN
(4-bromophenyl)Difluoromethanesulfonamide Small molecular drug D0IU3X
(9beta13alpha14beta17alpha)-2-methoxyestra-135(10)-triene-317-diyl Disulfamate Small molecular drug DB08416
1,2,4-triazole Small molecular drug D0OT2H
1,4-dihydro-1-methyl-4-oxo-3-pyridinesulfonamide Small molecular drug D05RAB
1,4-phenylene Disulfamate Small molecular drug D0C6ED
1-(3,4-dichlorophenyl)-3-hydroxyurea Small molecular drug D09UQM
1-benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide Small molecular drug D04SNH
1-cyclohexylamido-5-sulfonamidoindane Small molecular drug D0G9NE
1-pentafluorophenylamido-5-sulfonamidoindane Small molecular drug D0O4KL
1-pentenyl-4-(Aminosulfonyl)Benzoate Small molecular drug D06OVA
1-valproylamido-5-sulfonamidoindane Small molecular drug D0KZ2D
124-triazole Small molecular drug DB03594
2,2,2-trifluoro-n-(4-sulfamoyl-phenyl)-acetamide Small molecular drug D0RK7J
2,2-dimethyl-n-(4-sulfamoyl-phenyl)-propionamide Small molecular drug D03DAM
2,3-dihydro-1h-indene-5-sulfonamide Small molecular drug D0LC0F
2,4-dichloro-5-sulfamoylbenzoic Acid Small molecular drug D0S6CO
2,4-disulfamyltrifluoromethylaniline Small molecular drug D0M3PO
2,6-di-t-butylphenol Small molecular drug D06MZK
2,6-di-tert-butyl-4-methoxyphenol Small molecular drug D09ZUN
2,6-difluorobenzenesulfonamide Small molecular drug D05DFJ
2-(4-chlorobenzyloxyamino)-n-hydroxyacetamide Small molecular drug D05BMD
2-(4-chlorobenzyloxyamino)-n-hydroxyhexanamide Small molecular drug D06NDR
2-(4-chlorobenzyloxyamino)-n-hydroxypropanamide Small molecular drug D0G0OP
2-(4-hydroxybenzylideneamino)Ethanesulfonamide Small molecular drug D09SFY
2-(4-tert-butylbenzylideneamino)Ethanesulfonamide Small molecular drug D08ORD
2-(Benzylideneamino)Ethanesulfonamide Small molecular drug D0U0QW
2-(Benzyloxyamino)-n-hydroxyhexanamide Small molecular drug D0Y1XM
2-(N''-acetyl-hydrazino)-benzenesulfonamide Small molecular drug D02KDH
2-acetamido-5-sulfonamidoindane Small molecular drug D00FGB
2-amino-benzenesulfonamide Small molecular drug D0OI1H
2-butylamido-5-sulfonamidoindane Small molecular drug D0SF3B
2-cyclohexylamido-5-sulfonamidoindane Small molecular drug D0HN0R
2-ethylamido-5-sulfonamidoindane Small molecular drug D08AOA
2-hydrazinocarbonyl-benzenesulfonamide Small molecular drug D06KTD
2-hydrazinylbenzenesulfonamide Small molecular drug D0G0FJ
2-hydroxycinnamic Acid Small molecular drug D05WQF
2-mercapto-n-(4-sulfamoyl-phenyl)-benzamide Small molecular drug D01EEM
2-methoxyestradiol-17-o-sulfamate Small molecular drug D04GDW
2-methoxyestrrone-3-o-sulfamate Small molecular drug D09PUF
2-morpholin-4-yl-n-(4-sulfamoyl-phenyl)-acetamide Small molecular drug D0D0BO
2-nonylamido-5-sulfonamidoindane Small molecular drug D07PNA
2-oxo-2h-thiochromene-3-carboxylic Acid Small molecular drug D0D6UR
2-pentafluorophenylamido-5-sulfonamidoindane Small molecular drug D0J3SP
2-propylamido-5-sulfonamidoindane Small molecular drug D0O8WV
2-sulfamoyl-benzoic Acid Methyl Ester Small molecular drug D07CQI
2-sulfhydryl-ethanol Small molecular drug D0Q5FV
2-valproylamido-5-sulfonamidoindane Small molecular drug D07LYW
26-difluorobenzenesulfonamide Small molecular drug DB03270
3,5-difluorobenzenesulfonamide Small molecular drug D0S6GK
3-((4-aminophenyl)Diazenyl)Benzenesulfonamide Small molecular drug D0H4CF
3-((4-hydroxyphenyl)Diazenyl)Benzenesulfonamide Small molecular drug D0C7WG
3-(3-phenyl-ureido)-benzenesulfonamide Small molecular drug D06ZMH
3-(4'-hydroxyphenyl)Diazenylbenzenesulfonamide Small molecular drug D0BD0K
3-(4-sulfamoylphenyl)Propanoic Acid Small molecular drug D09CSP
3-amino-benzenesulfonamide Small molecular drug D0J2AE
3-bromophenyl-difluoromethanesulfonamide Small molecular drug D01JTI
3-chloro-4-hydrazino-benzenesulfonamide Small molecular drug D01UDU
3-fluoro-4-hydrazino-benzenesulfonamide Small molecular drug D01YHK
3-hydroxy-2-methoxybenzaldehyde Small molecular drug D0C9ZY
3-mercapto-n-(4-sulfamoyl-phenyl)-propionamide Small molecular drug D0DY9U
3-mercuri-4-aminobenzenesulfonamide Small molecular drug D0A2PD
3-nitro-benzenesulfonamide Small molecular drug D07ZHE
3-phenyl-5-sulfamoyl-1h-indole-2-carboxamide Small molecular drug D07OMY
3-phenylprop-1-enylboronic Acid Small molecular drug D04RCR
3-[4-(Aminosulfonyl)Phenyl]Propanoic Acid Small molecular drug DB08156
35-difluorobenzenesulfonamide Small molecular drug DB02087
4,4'-thiodipyridine-3-sulfonamide Small molecular drug D03KRB
4,6-dinitro Salicylic Acid Small molecular drug D0BR1D
4-((4-hydroxyphenyl)Diazenyl)Benzenesulfonamide Small molecular drug D04HRS
4-((Benzylideneamino)Methyl)Benzenesulfonamide Small molecular drug D0I1XT
4-(2-aminoethyl)Benzenesulfonamide Small molecular drug D04NSN
4-(2-aminopyrimidin-4-ylamino)Benzenesulfonamide Small molecular drug D0TY8X
4-(2-methyl-8-quinolinoxy)-3-pyridinesulfonamide Small molecular drug D05ETN
4-(2-phenylacetamido)-3-bromobenzenesulfonamide Small molecular drug D0Z5GE
4-(2-phenylacetamido)-3-chlorobenzenesulfonamide Small molecular drug D0A3JR
4-(2-phenylacetamido)-3-fluorobenzenesulfonamide Small molecular drug D0O9VU
4-(2-phenylacetamido)Benzenesulfonamide Small molecular drug D0O0UE
4-(2-phenylacetamidoethyl)Benzenesulfonamide Small molecular drug D09LWR
4-(2-phenylacetamidomethyl)Benzenesulfonamide Small molecular drug D06XNT
4-(2-propynylthio)Pyridine-3-sulfonamide Small molecular drug D02BMV
4-(2-pyridin-2-ylacetamido)Benzenesulfonamide Small molecular drug D0N7WP
4-(2-pyridin-4-ylacetamido)Benzenesulfonamide Small molecular drug D00GVA
4-(4-cyanophenoxy)-3-pyridinesulfonamide Small molecular drug D05EBZ
4-(4-fluorophenoxy)-3-pyridinesulfonamide Small molecular drug D08JCC
4-(4-hydroxybenzylideneamino)Benzoic Acid Small molecular drug D0R6JK
4-(4-tert-butylbenzylideneamino)Benzoic Acid Small molecular drug D02DCD
4-(5-methyl-2-pirazolino)-3-pyridinesulfonamide Small molecular drug D0R4KQ
4-(Allylamino)-3-pyridinesulfonamide Small molecular drug D09TKG
4-(Benzylideneamino)Benzenesulfonamide Small molecular drug D0S2II
4-(Benzylideneamino)Benzoic Acid Small molecular drug D0K4IH
4-(Carbamolymethylthio)Pyridine-3-sulfonamide Small molecular drug D0V5OW
4-(Cyanomethylthio)Pyridine-3-sulfonamide Small molecular drug D01OTW
4-(Hydroxymercury)Benzoic Acid Small molecular drug D07QHM
4-(Hydroxymethyl)Benzenesulfonamide Small molecular drug D05XZM
4-(Methylhydrazino)-3-pyridinesulfonamide Small molecular drug D0Q5VB
4-(N-methyl-hydrazino)-benzenesulfonamide Small molecular drug D0M7VN
4-(N-oxide-2-pyridylthio)Pyridine-3-sulfonamide Small molecular drug D02NQK
4-(Quinolinoxy)-3-pyridinesulfonamide Small molecular drug D05JAJ
4-amino-3-chloro-benzenesulfonamide Small molecular drug D0YU8J
4-amino-6-chlorobenzene-1,3-disulfonamide Small molecular drug D0Z1HY
4-amino-n-(4-sulfamoylbenzyl)Benzenesulfonamide Small molecular drug D0X6IE
4-azidobenzenesulfonamide Small molecular drug D0Z6TM
4-benzenesulfonylamino-benzenesulfonamide Small molecular drug D0YD9F
4-benzythiopyridine-3-sulfonamide Small molecular drug D06IOI
4-bromophenylboronic Acid Small molecular drug D0Z1CL
4-butylphenylboronic Acid Small molecular drug D05NFU
4-chloro-n-(5-sulfamoyl-indan-2-yl)-benzamide Small molecular drug D0A8HW
4-cyanophenol Small molecular drug D00IUB
4-ethoxy-3-pyridinesulfonamide Small molecular drug D04VSP
4-ethynyl Benzene Sulfonamide Small molecular drug D0LJ5P
4-flourobenzenesulfonamide Small molecular drug D00SJT
4-fluoro-n-(4-sulfamoylbenzyl)Benzenesulfonamide Small molecular drug D0X9LJ
4-hydrazino-3-pyridinesulfonamide Small molecular drug D0UM1I
4-hydrazino-benzenesulfonamide Small molecular drug D0NN3Q
4-hydrazinocarbonyl-benzenesulfonamide Small molecular drug D0Q0EK
4-isothiocyanatobenzenesulfonamide Small molecular drug D0U1AN
4-methanesulfonylamino-benzenesulfonamide Small molecular drug D00NUK
4-methoxy-3-pyridinesulfonamide Small molecular drug D00IKQ
4-methoxyphenylboronic Acid Small molecular drug D0A4HS
4-methoxyphenylsulfamide Small molecular drug D0T8SN
4-methylamino-benzenesulfonamide Small molecular drug D07AGM
4-methylimidazole Small molecular drug D0KK4F
4-methylphenyl-difluoromethanesulfonamide Small molecular drug D06GPL
4-methylthiopyridine-3-sulfonamide Small molecular drug D0J7GU
4-nitro-benzenesulfonamide Small molecular drug D06LVE
4-nitrophenyl Phosphate Small molecular drug D0T0YI
4-nitrophenyl-difluoromethanesulfonamide Small molecular drug D0I5YQ
4-nitrophenylsulfamide Small molecular drug D0I8DW
4-phenoxyphenylboronic Acid Small molecular drug D0D2JA
4-sulfonamide-[1-(4-aminobutane)]Benzamide Small molecular drug D0O0HT
4-thiocyanato-benzenesulfonamide Small molecular drug D05PRS
4-[2-(2-thienyl)Acetamidoethyl]Benzenesulfonamide Small molecular drug D01ISX
4-[2-(2-thienyl)Acetamido]Benzenesulfonamide Small molecular drug D0W9VC
4-[2-(3-phenyl-ureido)-ethyl]-benzenesulfonamide Small molecular drug D09LUD
5-amino-[1,3,4]Thiadiazole-2-thiol Small molecular drug D0X1MY
5-chlorosalicylic Acid Small molecular drug D05FMD
5-hydroxy-1-tosyl-1h-pyrrol-2(5h)-one Small molecular drug D06SME
5-[(Phenylsulfonyl)Amino]-134-thiadiazole-2-sulfonamide Small molecular drug DB07050
6-(Aminomethyl)-2h-chromen-2-one Small molecular drug D0N1AW
6-(Hydroxymethyl)-2h-chromen-2-one Small molecular drug D0L5TZ
6-amino-benzothiazole-2-sulfonic Acid Amide Small molecular drug D0O1QT
6-hydroxy-1,3-benzothiazole-2-sulfonamide Small molecular drug D0A6HS
6-hydroxy-13-benzothiazole-2-sulfonamide Small molecular drug DB08765
6-hydroxybenzo[D][1,3]Oxathiol-2-one Small molecular drug D0M8UY
6-methoxy-2-oxo-2h-chromene-3-carboxylic Acid Small molecular drug D00XJA
6-methyl-2-oxo-2h-chromene-3-carboxylic Acid Small molecular drug D0G3BI
6-nitro-benzothiazole-2-sulfonic Acid Amide Small molecular drug D07JYF
Acetate Ion Small molecular drug D0F2ME
Acetylsulfanilamide Small molecular drug D04POB
Al-4623 Small molecular drug DB03877
Al4623 Small molecular drug D09HNP
Al5300 Small molecular drug D08CNG
Al5424 Small molecular drug D0D6UL
Al5927 Small molecular drug D0M8HC
Al6528 Small molecular drug D09LMH
Al7089a Small molecular drug D04XMZ
Al7089a Small molecular drug DB02220
Al7099a Small molecular drug D0XX9C
Al7182 Small molecular drug D0B8CU
Allyl 4-(Aminosulfonyl)Benzoate Small molecular drug D05NAR
Aminobenzolamide Derivative Small molecular drug D05QEK
Azide Small molecular drug D09JHA
Benzolamide Small molecular drug D0E8CC
Benzothiazole-2-sulfonic Acid Amide Small molecular drug D0XL5K
Beta-naphthylboronic Acid Small molecular drug D0C8ZY
Biphenyl-4-ylboronic Acid Small molecular drug D09OSN
Carzenide Small molecular drug D09PWX
Catechin Small molecular drug D0V7AA
Catechol Small molecular drug D07QJJ
Cl-5343 Small molecular drug D0VD7H
Coumarin Small molecular drug D03ZMQ
Dansylamide Small molecular drug D0S7NH
Decane-1,10-diyl Disulfamate Small molecular drug D00YEF
Decyl Sulfamate Small molecular drug D09WSJ
Di(2,6-di-t-butylphenol) Small molecular drug D0C3SL
Di(2,6-diisopropylphenol) Small molecular drug D0A0RT
Di(2,6-dimethylphenol) Small molecular drug D04LNI
Ellagic Acid Small molecular drug D0A1CM
Ellagic Acid Small molecular drug DB08846
Emate Small molecular drug D0R7QY
Ethyl 3-[4-(Aminosulfonyl)Phenyl]Propanoate Small molecular drug D00ZUQ
Formic Acid Small molecular drug D06EWG
Formic Acid Small molecular drug DB01942
Gallicacid Small molecular drug D0Y3TZ
Hydrosulfide Small molecular drug D0T6ZX
Indane-5-sulfonamide Small molecular drug DB08165
Iodide Small molecular drug D08RKK
Irosustat Small molecular drug DB02292
Mercuribenzoic Acid Small molecular drug D06CGS
Methyl 4-(4-hydroxybenzylideneamino)Benzoate Small molecular drug D07AUN
Methyl 4-(4-tert-butylbenzylideneamino)Benzoate Small molecular drug D05DIH
Methyl Mercury Ion Small molecular drug D09CZV
Mmi270 Small molecular drug D0A4TC
N-(1-benzofuran-3-ylmethyl)Sulfamide Small molecular drug D0M7DE
N-(2,3-difluoro-benzyl)-4-sulfamoyl-benzamide Small molecular drug D0A7ZH
N-(2,6-diflouro-benzyl)-4-sulfamoyl-benzamide Small molecular drug D0S5LS
N-(2-flouro-benzyl)-4-sulfamoyl-benzamide Small molecular drug D0U7GL
N-(2-thienylmethyl)-2,5-thiophenedisulfonamide Small molecular drug D0L4KE
N-(2-thienylmethyl)-25-thiophenedisulfonamide Small molecular drug DB02986
N-(23-difluoro-benzyl)-4-sulfamoyl-benzamide Small molecular drug DB07742
N-(26-diflouro-benzyl)-4-sulfamoyl-benzamide Small molecular drug DB03844
N-(4-cyanophenyl)Sulfamide Small molecular drug D0M4EV
N-(4-sulfamoyl-phenyl)-benzamide Small molecular drug D0KB6T
N-(4-sulfamoyl-phenyl)-butyramide Small molecular drug D0K3LN
N-(4-sulfamoyl-phenyl)-isobutyramide Small molecular drug D0T2YZ
N-(4-sulfamoyl-phenyl)-propionamide Small molecular drug D0N8LR
N-(4-sulfamoylphenylethyl)-4-sulfamoylbenzamide Small molecular drug D07YSQ
N-(5-ethyl-1,3,4-thiadiazol-2-yl)Sulfamide Small molecular drug D0S4NO
N-(5-mercapto-[1,3,4]Thiadiazol-2-yl)-acetamide Small molecular drug D0J1PZ
N-(5-phenyl-1,3,4-thiadiazol-2-yl)Sulfamide Small molecular drug D06JVR
N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)Sulfamide Small molecular drug D0T2VH
N-(Pentafluorophenyl)Sulfamide Small molecular drug D0PA5L
N-(Phosphonacetyl)-l-aspartate Small molecular drug D0L6CN
N-1,3,4-thiadiazol-2-ylsulfamide Small molecular drug D00BMI
N-benzyl-4-sulfamoyl-benzamide Small molecular drug D07RZN
N-hydroxysulfamide Small molecular drug D09CXX
N-propynyl Amidebenzenesulphonide Small molecular drug D01XFH
N-[(4-bromo-1-benzothien-3-yl)Methyl]Sulfamide Small molecular drug D0LM8L
N-[(5-chloro-1-benzothien-3-yl)Methyl]Sulfamide Small molecular drug D0GI2R
N-[2-(1h-indol-5-yl)-butyl]-4-sulfamoyl-benzamide Small molecular drug D0N8RD
N-[4-(Aminosulfonyl)Phenyl]-2-mercaptobenzamide Small molecular drug DB07476
N-[4-(Trifluoromethyl)Phenyl]Sulfamide"] Small molecular drug D0K5NQ
N-[5-(Ethylthio)-1,3,4-thiadiazol-2-yl]Sulfamide Small molecular drug D0E3VJ
N-[5-(Methylthio)-1,3,4-thiadiazol-2-yl]Sulfamide Small molecular drug D04PSK
N-{2-[4-(Aminosulfonyl)Phenyl]Ethyl}Acetamide Small molecular drug D0M7QA
Nitrate Small molecular drug D00RJT
Nsc-654077 Small molecular drug D0B4IN
Octane-1,8-diyl Disulfamate Small molecular drug D0D4OV
Octyl Sulfamate Small molecular drug D05TLB
P-coumaric Acid Small molecular drug D0AU0M
P-hydroxymercuribenzoic Acid Small molecular drug DB01671
P-toluenesulfonamide Small molecular drug D0ZC3W
P-tolylboronic Acid Small molecular drug D0L8ZG
Paraoxon Small molecular drug D08XQI
Pentane-1,5-diamine Small molecular drug D02QGI
Pentanoic Acid (4-sulfamoyl-phenyl)-amide Small molecular drug D0Q0XO
Phenethylboronic Acid Small molecular drug D06ORV
Phenoxyarsonous Acid Small molecular drug D01GNQ
Phenyl Boronic Acid Small molecular drug D0EJ9B
Phenyl-phosphonic Acid Small molecular drug D00CIW
Phenyldifluoromethanesulfonamide Small molecular drug D0UN0E
Phenylmethanesulfonamide Small molecular drug D07SIA
Phenylsulfamate Small molecular drug D0L4FM
Phenylsulfamide Small molecular drug D06IYU
Prontocil Small molecular drug D0SV6C
Prop-2-ynyl 4-sulfamoylbenzoate Small molecular drug D00IAE
Quinoline-8-sulfonamide Small molecular drug D0F7SO
Resorcinol Small molecular drug D02DBP
Saccharin Small molecular drug D0A0YX
Sodium 2,3,5,6-tetrafluorobenzoate Small molecular drug D0G6OW
Sodium Perfluorohexanesulfonamide Small molecular drug D0F4ZW
Sodium Trithiocarbonate Small molecular drug D0D5XC
Sulfamic Acid 12-sulfamoyloxy-dodecyl Ester Small molecular drug D07ZXR
Sulfamic Acid 16-sulfamoyloxy-hexadecyl Ester Small molecular drug D07CBA
Sulfamic Acid 3-sulfamoyloxy-phenyl Ester Small molecular drug D07IHP
Sulfamic Acid 4-sulfamoyloxy-butyl Ester Small molecular drug D04BKU
Sulfamic Acid 4-sulfamoyloxymethyl-benzyl Ester Small molecular drug D0N5KX
Sulfamic Acid 6-sulfamoyloxy-hexyl Ester Small molecular drug D0X0PO
Sulfamic Acid 7-sulfamoyloxy-heptyl Ester Small molecular drug D05FNN
Sulfamic Acid Benzo[1,3]Dioxol-2-ylmethyl Ester Small molecular drug D0A5XB
Sulfamic Acid Chroman-2-ylmethyl Ester Small molecular drug D04MAM
Syringic Acid Small molecular drug D0Q7DJ
Trecadrine Small molecular drug D0S8RD
(17beta)-17-(Cyanomethyl)-2-methoxyestra-1(10)24-trien-3-yl Sulfamate . DB07596
(4-sulfamoyl-phenyl)-thiocarbamic Acid O-(2-thiophen-3-yl-ethyl) Ester . DB03333
(4as4br10bs12as)-12a-methyl-13-dioxo-2-(Pyridin-3-ylmethyl)-12344a4b5610b111212a-dodecahydronaphtho[21-f]Isoquinolin-8-yl Sulfamate . DB08418
(4s-trans)-4-(Methylamino)-56-dihydro-6-methyl-4h-thieno(23-b)Thiopyran-2-sulfonamide-77-dioxide . DB04081
(R)-n-(3-indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide . DB02479
(S)-indapamide . DB07467
(S)-n-(3-indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide . DB03950
1-acetamido-5-sulfonamidoindane . D00XIB
1-methyl-3-oxo-13-dihydro-benzo[C]Isothiazole-5-sulfonic Acid Amide . DB03294
1-n-(4-sulfamoylphenyl-ethyl)-246-trimethylpyridinium . DB04763
2-(13-thiazol-4-yl)-1h-benzimidazole-5-sulfonamide . DB08083
2-(Cycloheptylmethyl)-11-dioxido-1-benzothiophen-6-yl Sulfamate . DB06954
2-(Hydrazinocarbonyl)-3-phenyl-1h-indole-5-sulfonamide . DB08659
2-acetylamino-indan-5-sulfonic Acid Hydrate . D08TBP
2-amino-indan-5-sulfonic Acid . D0C4QB
2-chloro-5-[(1s)-1-hydroxy-3-oxo-2h-isoindol-1-yl]Benzenesulfonamide . DB08046
3-nitro-4-(2-oxo-pyrrolidin-1-yl)-benzenesulfonamide . DB04394
4-(2-hydroxy-ethyl)-benzenesulfonamide . D04VLI
4-(4-hydroxy-benzylideneamino)-benzenesulfonamide . D03VUQ
4-(Aminosulfonyl)-n-[(234-trifluorophenyl)Methyl]-benzamide . DB04549
4-(Aminosulfonyl)-n-[(24-difluorophenyl)Methyl]-benzamide . DB04180
4-(Aminosulfonyl)-n-[(246-trifluorophenyl)Methyl]-benzamide . DB02221
4-(Aminosulfonyl)-n-[(25-difluorophenyl)Methyl]-benzamide . DB03039
4-(Aminosulfonyl)-n-[(345-trifluorophenyl)Methyl]-benzamide . DB02861
4-(Aminosulfonyl)-n-[(4-fluorophenyl)Methyl]-benzamide . DB02429
4-({[(4-methylpiperazin-1-yl)Amino]Carbonothioyl}Amino)Benzenesulfonamide . DB08202
4-amino-3-bromo-benzenesulfonamide . D0P6AM
4-amino-3-fluoro-benzenesulfonamide . D04CVC
4-amino-3-iodo-benzenesulfonamide . D01STY
4-sulfonamide-[4-(Thiomethylaminobutane)]Benzamide . DB04002
4-[(3-bromo-4-o-sulfamoylbenzyl)(4-cyanophenyl)Amino]-4h-[124]-triazole . DB04600
4-[(4-o-sulfamoylbenzyl)(4-cyanophenyl)Amino]-4h-[124]-triazole . DB04601
5-(2-chlorophenyl)-134-thiadiazole-2-sulfonamide . DB07632
5-{[(4-amino-3-chloro-5-fluorophenyl)Sulfonyl]Amino}-134-thiadiazole-2-sulfonamide . DB06891
6-chloro-3-(Dichloromethyl)-34-dihydro-2h-124-benzothiadiazine-7-sulfonamide 11-dioxide . DB08645
6-hydroxy-benzothiazole-2-sulfonic Acid Amide . D0Q2LL
Al-6619 [2h-thieno[32-e]-12-thiazine-6-sulfonamide2-(3-hydroxyphenyl)-3-(4-morpholinyl)- 11-dioxide] . DB03262
Al-6629 [2h-thieno[32-e]-12-thiazine-6-sulfonamide2-(3-methoxyphenyl)-3-(4-morpholinyl)- 11-dioxide] . DB03598
Aminodi(Ethyloxy)Ethylaminocarbonylbenzenesulfonamide . DB02535
Cyanamide . DB02679
N-(23456-pentaflouro-benzyl)-4-sulfamoyl-benzamide . DB02610
N-({[4-(Aminosulfonyl)Phenyl]Amino}Carbonyl)-4-methylbenzenesulfonamide . DB08301
N-hydroxysulfonamides . D03EAQ
N-[(2r)-5-(Aminosulfonyl)-23-dihydro-1h-inden-2-yl]-2-propylpentanamide . DB07048
Phenylalanylaminodi(Ethyloxy)Ethyl Benzenesulfonamideaminocarbonylbenzenesulfonamide . DB07710
Sulfamate . D03VDJ
Sulfamic Acid 23-o-(1-methylethylidene)-45-o-sulfonyl-beta-fructopyranose Ester . DB02894
Thiophene-25-disulfonic Acid 2-amide-5-(4-methyl-benzylamide) . DB07363
Thioureido Sulfonamide . D0I0RT
Patented
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ferulic Acid Small molecular drug D03SLR
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Methyclothiazide Small molecular drug DB00232

References

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2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target. ACS Chem Biol. 2021 Jun 18;16(6):982-990. doi: 10.1021/acschembio.1c00218. Epub 2021 May 18.
Mass spectrometry data entry: PXD024915 , PXD024913