Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IMP2070  Probe Info 
Probe concentration 5 uM
Criteria Quantification: Probe vs DMSO
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Acute monocytic leukemia [ICD-11:2A60]
Model Name Human acute monocytic leukemia cells (THP-1)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01806  Carbonic anhydrase 2 (CA2) 1.9
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 1.6
Transporter and channel
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04426  B-cell receptor-associated protein 31 (BCAP31) 3.0
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02688  HLA class I histocompatibility antigen, alpha chain E (HLA-E) 7.3
Other
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05160  Nucleobindin-2 (NUCB2) 1.8

References

1 A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target. ACS Chem Biol. 2021 Jun 18;16(6):982-990. doi: 10.1021/acschembio.1c00218. Epub 2021 May 18.
Mass spectrometry data entry: PXD024915 , PXD024913