Details of the Probe

General Information of Probe

Probe ID
LDPC0162
Probe Name
TH214
Synonyms
SCHEMBL22558799
Probe Type
ABPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 2 Molecular Weight (mw) 574.6
Lipid-water partition coefficient (xlogp) 5.7
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C31H28F2N4O3S
IUPAC Name
4-[bis(4-fluorophenyl)methylidene]-1-[2-[1-(4-prop-2-ynoxyphenyl)sulfonyltriazol-4-yl]ethyl]piperidine
Canonical SMILES
C#CCOC1=CC=C(C=C1)S(=O)(=O)N2C=C(N=N2)CCN3CCC(=C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)CC3
InChI
InChI=1S/C31H28F2N4O3S/c1-2-21-40-29-11-13-30(14-12-29)41(38,39)37-22-28(34-35-37)17-20-36-18-15-25(16-19-36)31(23-3-7-26(32)8-4-23)24-5-9-27(33)10-6-24/h1,3-14,22H,15-21H2
InChIKey
RXZYFLNIZRCITN-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

147 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
26S proteasome non-ATPase regulatory subunit 2 (PSMD2) LDTP05782 Y400(14.13)  LDD0258 
3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) LDTP03998 Y182(20.00)  LDD0258 
5'-nucleotidase domain-containing protein 1 (NT5DC1) LDTP17247 Y310(20.00)  LDD0258 
5'-nucleotidase domain-containing protein 2 (NT5DC2) LDTP18414 Y457(14.95)  LDD0258 
5-demethoxyubiquinone hydroxylase, mitochondrial (COQ7) LDTP10984 Y61(20.00)  LDD0258 
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 Y223(20.00); Y503(20.00); Y385(18.53); Y243(17.20)  LDD0258 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 Y237(12.50)  LDD0258 
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) LDTP03291 Y214(10.49)  LDD0258 
Actin, alpha cardiac muscle 1 (ACTC1) LDTP05069 Y93(13.85); Y71(11.61)  LDD0258 
Actin, cytoplasmic 1 (ACTB) LDTP04876 Y198(20.00); Y91(20.00); Y53(19.87); Y306(17.35)  LDD0258 
Adenosine 5'-monophosphoramidase HINT1 (HINT1) LDTP04306 Y94(16.22)  LDD0258 
Adenosylhomocysteinase (AHCY) LDTP03242 Y143(20.00); Y165(20.00); Y39(5.77)  LDD0258 
Adenylate kinase isoenzyme 1 (AK1) LDTP01788 Y164(10.70)  LDD0258 
Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) LDTP03560 Y442(20.00); Y373(15.21)  LDD0258 
Aldo-keto reductase family 1 member B1 (AKR1B1) LDTP02765 Y190(5.64)  LDD0258 
Alpha-enolase (ENO1) LDTP02159 Y270(20.00); Y407(20.00); Y44(20.00); Y57(20.00)  LDD0258 
Asparagine synthetase [glutamine-hydrolyzing] (ASNS) LDTP02264 Y536(14.31)  LDD0258 
Aspartate--tRNA ligase, mitochondrial (DARS2) LDTP07581 Y237(5.18)  LDD0258 
ATP synthase subunit beta, mitochondrial (ATP5F1B) LDTP02150 Y230(20.00); Y247(20.00)  LDD0258 
ATP-dependent 6-phosphofructokinase, liver type (PFKL) LDTP02925 Y674(20.00)  LDD0258 
ATP-dependent RNA helicase A (DHX9) LDTP05550 Y902(9.70)  LDD0258 
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1) LDTP00717 Y30(9.89)  LDD0258 
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) LDTP13781 Y156(20.00)  LDD0258 
C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) LDTP02580 Y852(13.32)  LDD0258 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 Y253(13.54)  LDD0258 
Calcyclin-binding protein (CACYBP) LDTP12163 Y181(20.00); Y199(10.66)  LDD0258 
Carbonic anhydrase 2 (CA2) LDTP01806 Y40(12.38); Y51(6.01)  LDD0258 
Citrate synthase, mitochondrial (CS) LDTP01205 Y381(20.00); Y345(6.10); Y185(6.01)  LDD0258 
Creatine kinase B-type (CKB) LDTP02616 Y39(20.00); Y100(9.99)  LDD0258 
CTP synthase 1 (CTPS1) LDTP02922 Y554(20.00)  LDD0258 
Cullin-associated NEDD8-dissociated protein 1 (CAND1) LDTP08296 Y372(16.80); Y398(5.31)  LDD0258 
Cyclin-dependent kinase 1 (CDK1) LDTP02149 Y270(8.31)  LDD0258 
dCTP pyrophosphatase 1 (DCTPP1) LDTP12013 Y102(17.90); Y129(7.22)  LDD0258 
Diacylglycerol kinase alpha (DGKA) LDTP03251 Y240(20.00); Y22(16.38); Y258(15.27); Y19(13.52)  LDD0258 
DNA replication licensing factor MCM4 (MCM4) LDTP03680 Y471(5.95)  LDD0258 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 Y111(13.22)  LDD0258 
DNA replication licensing factor MCM7 (MCM7) LDTP03682 Y345(20.00); Y539(20.00)  LDD0258 
Dolichyl-phosphate beta-glucosyltransferase (ALG5) LDTP14214 Y74(10.78)  LDD0258 
Dynamin-2 (DNM2) LDTP04374 Y265(6.42)  LDD0258 
Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA) LDTP02694 Y105(20.00); Y84(10.79); Y235(9.46)  LDD0258 
Elongation factor 1-alpha 2 (EEF1A2) LDTP05460 Y177(17.58)  LDD0258 
Elongation factor 2 (EEF2) LDTP02672 Y730(15.49); Y639(14.08); Y265(10.75); Y443(10.51)  LDD0258 
Elongation factor Tu, mitochondrial (TUFM) LDTP04251 Y122(20.00); Y133(13.69); Y246(8.74)  LDD0258 
Endoplasmic reticulum chaperone BiP (HSPA5) LDTP02534 Y65(19.18)  LDD0258 
Enoyl-CoA delta isomerase 2 (ECI2) LDTP01245 Y169(20.00)  LDD0258 
Eukaryotic initiation factor 4A-I (EIF4A1) LDTP04878 Y356(20.00); Y48(18.71); Y197(18.07); Y70(5.68)  LDD0258 
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) LDTP03915 Y330(7.87)  LDD0258 
FAST kinase domain-containing protein 4 (TBRG4) LDTP10049 Y281(20.00)  LDD0258 
Fatty acid synthase (FASN) LDTP04243 Y2034(20.00); Y289(20.00); Y2269(17.46); Y2439(14.48)  LDD0258 
Fructose-bisphosphate aldolase A (ALDOA) LDTP02008 Y328(12.72); Y302(11.12)  LDD0258 
Galactokinase (GALK1) LDTP04424 Y236(9.61)  LDD0258 
Gamma-enolase (ENO2) LDTP02328 Y25(12.53)  LDD0258 
Glucose-6-phosphate isomerase (GPI) LDTP02162 Y392(20.00); Y144(19.09); Y351(17.61)  LDD0258 
Glucosidase 2 subunit beta (PRKCSH) LDTP02718 Y465(20.00)  LDD0258 
Glutaminase kidney isoform, mitochondrial (GLS) LDTP01465 Y308(10.08)  LDD0258 
Glutathione S-transferase A4 (GSTA4) LDTP00575 Y9(20.00)  LDD0258 
Glutathione S-transferase P (GSTP1) LDTP02333 Y8(16.18); Y80(15.07); Y64(14.17); Y50(5.01)  LDD0258 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) LDTP02038 Y276(20.00); Y320(20.00); Y314(15.02); Y255(9.58)  LDD0258 
Glycogen phosphorylase, liver form (PYGL) LDTP02161 Y204(10.22)  LDD0258 
GTP-binding nuclear protein Ran (RAN) LDTP05007 Y147(9.06); Y39(6.04); Y155(5.15)  LDD0258 
Heat shock cognate 71 kDa protein (HSPA8) LDTP02541 Y107(20.00); Y149(20.00); Y183(16.41); Y41(14.59)  LDD0258 
Heat shock protein HSP 90-alpha (HSP90AA1) LDTP02225 Y480(20.00); Y61(20.00); Y604(15.94); Y434(15.92)  LDD0258 
Heme oxygenase 1 (HMOX1) LDTP02359 Y134(10.13)  LDD0258 
Heme oxygenase 2 (HMOX2) LDTP03540 Y154(5.19)  LDD0258 
Histone acetyltransferase type B catalytic subunit (HAT1) LDTP00479 Y14(7.08)  LDD0258 
Histone deacetylase 1 (HDAC1) LDTP05918 Y358(20.00); Y87(14.51); Y221(10.09); Y201(10.03)  LDD0258 
Hypoxanthine-guanine phosphoribosyltransferase (HPRT1) LDTP01782 Y105(20.00)  LDD0258 
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) LDTP02611 Y509(15.94); Y430(6.61)  LDD0258 
Insulin-degrading enzyme (IDE) LDTP02743 Y302(17.38)  LDD0258 
Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) LDTP04211 Y274(20.00)  LDD0258 
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (IDH3A) LDTP04345 Y137(13.96)  LDD0258 
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (IDH3B) LDTP00885 Y340(20.00)  LDD0258 
Isoleucine--tRNA ligase, cytoplasmic (IARS1) LDTP03947 Y608(15.52); Y94(7.83)  LDD0258 
Isoleucine--tRNA ligase, mitochondrial (IARS2) LDTP12588 Y465(10.80)  LDD0258 
L-lactate dehydrogenase A chain (LDHA) LDTP01766 Y127(20.00); Y239(19.61)  LDD0258 
L-lactate dehydrogenase B chain (LDHB) LDTP02179 Y173(20.00); Y84(20.00); Y240(8.30)  LDD0258 
L-xylulose reductase (DCXR) LDTP08082 Y149(18.15)  LDD0258 
Macrophage migration inhibitory factor (MIF) LDTP02713 Y76(20.00)  LDD0258 
Malate dehydrogenase, cytoplasmic (MDH1) LDTP03907 Y192(6.51)  LDD0258 
Malate dehydrogenase, mitochondrial (MDH2) LDTP03908 Y56(20.00); Y161(14.19); Y253(10.64); Y80(6.36)  LDD0258 
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) LDTP02565 Y73(14.24)  LDD0258 
Methionine--tRNA ligase, cytoplasmic (MARS1) LDTP04730 Y201(18.11)  LDD0258 
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) LDTP12227 Y413(11.33)  LDD0258 
Methylthioribose-1-phosphate isomerase (MRI1) LDTP11260 Y205(11.19)  LDD0258 
Mitochondrial genome maintenance exonuclease 1 (MGME1) LDTP11090 Y205(10.17)  LDD0258 
Mitogen-activated protein kinase 14 (MAPK14) LDTP06547 Y182(20.00)  LDD0258 
Multifunctional protein CAD (CAD) LDTP03401 Y1322(10.19)  LDD0258 
Myosin-9 (MYH9) LDTP03764 Y650(5.69)  LDD0258 
NEDD8-conjugating enzyme Ubc12 (UBE2M) LDTP04898 Y172(20.00); Y86(10.32)  LDD0258 
Neurolysin, mitochondrial (NLN) LDTP11494 Y245(7.10)  LDD0258 
Ornithine aminotransferase, mitochondrial (OAT) LDTP02021 Y69(15.80); Y85(13.67); Y50(12.13); Y55(10.82)  LDD0258 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 Y84(20.00); Y87(13.20)  LDD0258 
Parkinson disease protein 7 (PARK7) LDTP10878 Y139(20.00)  LDD0258 
Peptidyl-prolyl cis-trans isomerase A (PPIA) LDTP05028 Y79(14.60); Y48(14.43)  LDD0258 
Peptidyl-prolyl cis-trans isomerase B (PPIB) LDTP03216 Y133(20.00)  LDD0258 
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) LDTP05029 Y27(13.90)  LDD0258 
Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4) LDTP05372 Y111(20.00); Y225(20.00); Y113(10.93)  LDD0258 
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (PIN4) LDTP13793 Y71(20.00)  LDD0258 
Phenylalanine--tRNA ligase alpha subunit (FARSA) LDTP13831 Y305(11.27); Y310(10.01)  LDD0258 
Phosphoglycerate kinase 1 (PGK1) LDTP01787 Y196(20.00); Y161(16.49); Y324(12.71)  LDD0258 
Phosphoglycerate mutase 1 (PGAM1) LDTP02963 Y142(20.00); Y92(20.00); Y26(10.81)  LDD0258 
Presequence protease, mitochondrial (PITRM1) LDTP07003 Y383(20.00)  LDD0258 
Prostaglandin reductase 2 (PTGR2) LDTP08979 Y51(11.38); Y259(5.14)  LDD0258 
Proteasome subunit alpha type-2 (PSMA2) LDTP03331 Y167(20.00)  LDD0258 
Proteasome subunit alpha type-6 (PSMA6) LDTP04884 Y105(20.00); Y96(12.87); Y107(10.10); Y103(9.22)  LDD0258 
Proteasome subunit alpha type-7 (PSMA7) LDTP00449 Y153(10.65)  LDD0258 
Proteasome subunit beta type-6 (PSMB6) LDTP03418 Y95(8.58)  LDD0258 
Protein disulfide-isomerase (P4HB) LDTP02188 Y414(10.06); Y99(9.57); Y327(5.93)  LDD0258 
Protein disulfide-isomerase A3 (PDIA3) LDTP03521 Y356(20.00); Y222(14.32); Y95(5.76); Y67(5.48)  LDD0258 
Protein disulfide-isomerase A4 (PDIA4) LDTP02677 Y595(20.00); Y392(12.39)  LDD0258 
Protein O-GlcNAcase (OGA) LDTP00988 Y805(6.50)  LDD0258 
Protein phosphatase 1G (PPM1G) LDTP00616 Y364(20.00); Y74(19.99); Y405(14.68); Y160(11.73)  LDD0258 
Pseudouridylate synthase RPUSD2 (RPUSD2) LDTP15370 Y177(12.58)  LDD0258 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 Y164(20.00); Y908(20.00)  LDD0258 
Putative elongation factor 1-alpha-like 3 (EEF1A1P5) LDTP15029 Y167(20.00); Y29(20.00); Y418(20.00); Y177(16.84)  LDD0258 
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1) LDTP02279 Y243(7.62)  LDD0258 
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHB) LDTP02549 Y334(20.00)  LDD0258 
Pyruvate kinase PKM (PKM) LDTP02733 Y161(20.00); Y390(20.00); Y83(20.00); Y175(16.07)  LDD0258 
Ras GTPase-activating protein-binding protein 1 (G3BP1) LDTP05812 Y40(10.89)  LDD0258 
RNA-splicing ligase RtcB homolog (RTCB) LDTP13992 Y184(20.00)  LDD0258 
RuvB-like 1 (RUVBL1) LDTP13816 Y454(20.00)  LDD0258 
S-adenosylmethionine synthase isoform type-2 (MAT2A) LDTP03577 Y235(20.00); Y371(8.35)  LDD0258 
S-formylglutathione hydrolase (ESD) LDTP02521 Y67(12.71); Y202(11.65); Y191(5.02)  LDD0258 
Serine hydroxymethyltransferase, mitochondrial (SHMT2) LDTP03689 Y96(20.00); Y176(10.82); Y100(5.26)  LDD0258 
Serine/threonine-protein kinase VRK1 (VRK1) LDTP11030 Y204(9.78)  LDD0258 
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) LDTP03522 Y495(20.00)  LDD0258 
Sialic acid synthase (NANS) LDTP12473 Y71(18.77)  LDD0258 
Spermidine synthase (SRM) LDTP03008 Y278(18.20)  LDD0258 
Spliceosome RNA helicase DDX39B (DDX39B) LDTP05991 Y39(6.58); Y266(6.45)  LDD0258 
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) LDTP03139 Y128(12.82)  LDD0258 
SUMO-conjugating enzyme UBC9 (UBE2I) LDTP05062 Y68(6.92)  LDD0258 
Threonine--tRNA ligase 1, cytoplasmic (TARS1) LDTP03365 Y540(20.00)  LDD0258 
Transcription intermediary factor 1-beta (TRIM28) LDTP05808 Y208(14.58); Y242(12.09)  LDD0258 
Transitional endoplasmic reticulum ATPase (VCP) LDTP04665 Y495(18.64); Y755(10.67)  LDD0258 
Transketolase (TKT) LDTP03487 Y275(8.87)  LDD0258 
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) LDTP03912 Y271(20.00)  LDD0258 
Trifunctional purine biosynthetic protein adenosine-3 (GART) LDTP03156 Y662(9.78)  LDD0258 
Triosephosphate isomerase (TPI1) LDTP04851 Y202(19.77)  LDD0258 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 Y508(7.16)  LDD0258 
tRNA methyltransferase 10 homolog C (TRMT10C) LDTP07937 Y307(20.00)  LDD0258 
Tubulin alpha-1B chain (TUBA1B) LDTP05074 Y108(20.00); Y262(20.00); Y272(20.00); Y312(20.00)  LDD0258 
Tubulin alpha-1C chain (TUBA1C) LDTP11074 Y282(14.11)  LDD0258 
Ubiquitin-like modifier-activating enzyme 1 (UBA1) LDTP03166 Y873(20.00); Y471(9.71)  LDD0258 
Uridine-cytidine kinase 1 (UCK1) LDTP12116 Y205(20.00)  LDD0258 
V-type proton ATPase catalytic subunit A (ATP6V1A) LDTP03859 Y464(14.77)  LDD0258 
WD repeat-containing protein 82 (WDR82) LDTP07715 Y71(5.51)  LDD0258 
X-ray repair cross-complementing protein 5 (XRCC5) LDTP02642 Y316(20.00)  LDD0258 
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⏷ Show the Full List of 147 Enzyme
33 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
14-3-3 protein epsilon (YWHAE) LDTP04969 Y131(20.00); Y152(14.12); Y49(12.83); Y214(7.01)  LDD0258 
14-3-3 protein gamma (YWHAG) LDTP04953 Y123(20.00); Y154(20.00); Y49(13.97)  LDD0258 
14-3-3 protein theta (YWHAQ) LDTP03385 Y48(11.33); Y128(7.92)  LDD0258 
14-3-3 protein zeta/delta (YWHAZ) LDTP05043 Y48(13.97); Y118(13.77); Y128(5.43)  LDD0258 
Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) LDTP01601 Y322(18.63)  LDD0258 
ADP/ATP translocase 2 (SLC25A5) LDTP02087 Y81(13.85); Y95(5.69)  LDD0258 
Annexin A5 (ANXA5) LDTP02307 Y308(20.00); Y94(15.26)  LDD0258 
AP-1 complex subunit beta-1 (AP1B1) LDTP05625 Y121(17.16)  LDD0258 
AP-2 complex subunit beta (AP2B1) LDTP05038 Y121(17.16)  LDD0258 
ATP synthase subunit alpha, mitochondrial (ATP5F1A) LDTP03327 Y311(19.27); Y343(6.16)  LDD0258 
Autophagy-related protein 2 homolog B (ATG2B) LDTP10147 Y649(17.81)  LDD0258 
Calreticulin (CALR) LDTP03402 Y109(20.00); Y150(13.14); Y57(11.86)  LDD0258 
Chloride intracellular channel protein 1 (CLIC1) LDTP00244 Y209(15.85)  LDD0258 
Clathrin heavy chain 1 (CLTC) LDTP05252 Y1451(20.00); Y634(20.00)  LDD0258 
Cystatin-B (CSTB) LDTP02009 Y97(18.78)  LDD0258 
Exportin-2 (CSE1L) LDTP04662 Y278(20.00)  LDD0258 
Filamin-B (FLNB) LDTP01197 Y596(20.00)  LDD0258 
Heat shock protein HSP 90-beta (HSP90AB1) LDTP02262 Y192(20.00); Y211(20.00); Y457(20.00); Y472(20.00)  LDD0258 
Hsp90 co-chaperone Cdc37 (CDC37) LDTP06549 Y331(17.38)  LDD0258 
Hypoxia up-regulated protein 1 (HYOU1) LDTP14066 Y116(13.03)  LDD0258 
Importin subunit beta-1 (KPNB1) LDTP06242 Y529(20.00)  LDD0258 
Importin-5 (IPO5) LDTP00266 Y853(15.15)  LDD0258 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 Y95(20.00)  LDD0258 
Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) LDTP00821 Y265(20.00)  LDD0258 
Small ribosomal subunit protein RACK1 (RACK1) LDTP05057 Y140(20.00); Y194(12.86)  LDD0258 
Solute carrier family 25 member 3 (SLC25A3) LDTP05238 Y208(11.01)  LDD0258 
Surfeit locus protein 4 (SURF4) LDTP00592 Y24(9.93)  LDD0258 
T-complex protein 1 subunit delta (CCT4) LDTP04391 Y24(16.29); Y179(10.46)  LDD0258 
Thioredoxin domain-containing protein 17 (TXNDC17) LDTP11103 Y99(15.18)  LDD0258 
Ubiquilin-4 (UBQLN4) LDTP12533 Y279(11.72)  LDD0258 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 Y225(20.00)  LDD0258 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 Y236(5.08)  LDD0258 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 Y67(8.68)  LDD0258 
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⏷ Show the Full List of 33 Transporter and channel
3 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
High mobility group protein B1 (HMGB1) LDTP02343 Y16(20.00); Y109(16.46)  LDD0258 
Metastasis-associated protein MTA2 (MTA2) LDTP01414 Y437(14.14)  LDD0258 
Splicing factor, proline- and glutamine-rich (SFPQ) LDTP03212 Y527(20.00)  LDD0258 
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138 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
14-3-3 protein beta/alpha (YWHAB) LDTP03617 Y120(20.00); Y50(13.97)  LDD0258 
26S proteasome non-ATPase regulatory subunit 10 (PSMD10) LDTP01323 Y138(20.00)  LDD0258 
Actin-like protein 6A (ACTL6A) LDTP01756 Y186(20.00)  LDD0258 
Adenylyl cyclase-associated protein 1 (CAP1) LDTP05294 Y419(20.00)  LDD0258 
Coatomer subunit alpha (COPA) LDTP04571 Y249(20.00); Y628(19.92)  LDD0258 
Coatomer subunit gamma-1 (COPG1) LDTP14216 Y531(17.59)  LDD0258 
Cofilin-1 (CFL1) LDTP03244 Y117(20.00); Y82(20.00); Y140(15.20); Y85(14.77)  LDD0258 
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) LDTP06083 Y4252(20.00); Y2792(11.82); Y2892(5.23)  LDD0258 
Desmoglein-2 (DSG2) LDTP06042 Y476(14.89)  LDD0258 
DnaJ homolog subfamily A member 1 (DNAJA1) LDTP03606 Y381(20.00); Y376(16.50); Y33(7.45)  LDD0258 
Dynactin subunit 1 (DCTN1) LDTP06082 Y1149(5.05)  LDD0258 
Elongation factor 1-beta (EEF1B2) LDTP03283 Y62(11.10); Y126(11.05)  LDD0258 
Elongation factor 1-delta (EEF1D) LDTP03499 Y18(20.00); Y26(20.00)  LDD0258 
Elongation factor 1-gamma (EEF1G) LDTP03367 Y145(20.00); Y416(20.00); Y24(19.21)  LDD0258 
Elongator complex protein 1 (ELP1) LDTP01511 Y1182(15.43)  LDD0258 
Endoplasmin (HSP90B1) LDTP02734 Y355(20.00); Y429(18.08); Y727(5.56)  LDD0258 
Enhancer of mRNA-decapping protein 3 (EDC3) LDTP10299 Y475(7.95)  LDD0258 
Eukaryotic translation initiation factor 1A, X-chromosomal (EIF1AX) LDTP04129 Y106(5.49)  LDD0258 
Eukaryotic translation initiation factor 3 subunit D (EIF3D) LDTP00619 Y50(10.42)  LDD0258 
Far upstream element-binding protein 2 (KHSRP) LDTP09938 Y625(20.00); Y626(20.00); Y644(20.00)  LDD0258 
Heat shock 70 kDa protein 1A (HSPA1A) LDTP02434 Y115(20.00); Y545(18.14); Y183(15.60); Y525(11.45)  LDD0258 
Heat shock 70 kDa protein 4 (HSPA4) LDTP03695 Y435(7.78)  LDD0258 
Heat shock 70 kDa protein 4L (HSPA4L) LDTP14545 Y692(20.00)  LDD0258 
Heat shock protein 75 kDa, mitochondrial (TRAP1) LDTP05697 Y327(20.00); Y317(13.25)  LDD0258 
Heat shock protein beta-1 (HSPB1) LDTP02053 Y23(11.30)  LDD0258 
Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) LDTP10962 Y240(20.00)  LDD0258 
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) LDTP02364 Y357(20.00); Y366(20.00); Y167(15.84); Y341(9.59)  LDD0258 
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) LDTP00500 Y295(14.91); Y167(8.90)  LDD0258 
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) LDTP06032 Y116(11.89); Y244(11.49)  LDD0258 
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) LDTP04514 Y266(20.00); Y272(20.00); Y276(10.92); Y210(10.18)  LDD0258 
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) LDTP03615 Y266(20.00); Y276(20.00); Y82(20.00); Y180(11.54)  LDD0258 
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) LDTP04714 Y276(5.89)  LDD0258 
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) LDTP04952 Y72(20.00)  LDD0258 
Heterogeneous nuclear ribonucleoprotein M (HNRNPM) LDTP04500 Y681(11.70); Y64(8.76)  LDD0258 
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) LDTP05259 Y613(20.00); Y802(20.00); Y257(15.28); Y824(14.89)  LDD0258 
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) LDTP03182 Y174(20.00)  LDD0258 
Histone H2B type 1-D (H2BC5) LDTP04822 Y84(5.49)  LDD0258 
Histone H4 (H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16) LDTP05004 Y89(20.00); Y73(19.93)  LDD0258 
Histone-binding protein RBBP4 (RBBP4) LDTP05590 Y132(17.15); Y154(5.78)  LDD0258 
Histone-binding protein RBBP7 (RBBP7) LDTP06562 Y20(9.94); Y131(8.62); Y153(7.42)  LDD0258 
Hsc70-interacting protein (ST13) LDTP04367 Y213(20.00)  LDD0258 
Insulin receptor substrate 4 (IRS4) LDTP00398 Y743(20.00); Y808(20.00)  LDD0258 
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) LDTP05525 Y145(20.00); Y435(5.22)  LDD0258 
Large ribosomal subunit protein eL15 (RPL15) LDTP04919 Y81(5.42)  LDD0258 
Large ribosomal subunit protein eL21 (RPL21) LDTP04107 Y65(11.48)  LDD0258 
Large ribosomal subunit protein eL24 (RPL24) LDTP05186 Y55(20.00); Y11(8.42)  LDD0258 
Large ribosomal subunit protein eL27 (RPL27) LDTP04922 Y75(5.24)  LDD0258 
Large ribosomal subunit protein eL28 (RPL28) LDTP04108 Y40(9.44)  LDD0258 
Large ribosomal subunit protein eL31 (RPL31) LDTP05023 Y25(20.00)  LDD0258 
Large ribosomal subunit protein eL32 (RPL32) LDTP05025 Y60(11.34); Y95(8.74)  LDD0258 
Large ribosomal subunit protein eL38 (RPL38) LDTP05051 Y43(13.18); Y41(10.98)  LDD0258 
Large ribosomal subunit protein uL1 (RPL10A) LDTP05024 Y107(20.00)  LDD0258 
Large ribosomal subunit protein uL13 (RPL13A) LDTP03899 Y137(16.54); Y149(5.40)  LDD0258 
Large ribosomal subunit protein uL14 (RPL23) LDTP05008 Y38(9.18)  LDD0258 
Large ribosomal subunit protein uL29 (RPL35) LDTP03999 Y78(11.08)  LDD0258 
Large ribosomal subunit protein uL4 (RPL4) LDTP03815 Y161(20.00); Y277(7.34)  LDD0258 
Large ribosomal subunit protein uL5 (RPL11) LDTP05026 Y170(15.54)  LDD0258 
Methylosome protein WDR77 (WDR77) LDTP11066 Y122(20.00); Y36(11.22)  LDD0258 
Mitotic checkpoint protein BUB3 (BUB3) LDTP00838 Y53(20.00); Y65(16.20); Y42(15.23)  LDD0258 
Myotrophin (MTPN) LDTP04819 Y21(12.11)  LDD0258 
Neudesin (NENF) LDTP13630 Y137(20.00)  LDD0258 
Nuclear autoantigenic sperm protein (NASP) LDTP04241 Y540(17.73); Y635(13.66)  LDD0258 
Nucleobindin-2 (NUCB2) LDTP05160 Y169(6.11)  LDD0258 
Nucleolar protein 56 (NOP56) LDTP00313 Y152(12.59); Y284(10.67)  LDD0258 
Nucleolin (NCL) LDTP02990 Y351(13.31)  LDD0258 
Nucleophosmin (NPM1) LDTP02164 Y29(11.70)  LDD0258 
Nucleosome assembly protein 1-like 1 (NAP1L1) LDTP04684 Y96(14.78); Y106(10.94)  LDD0258 
Perilipin-3 (PLIN3) LDTP01021 Y251(10.59)  LDD0258 
PHD finger protein 6 (PHF6) LDTP08552 Y301(17.97)  LDD0258 
Phosphatidylethanolamine-binding protein 1 (PEBP1) LDTP03520 Y81(13.45); Y120(5.79)  LDD0258 
Plastin-3 (PLS3) LDTP02692 Y127(12.95); Y450(11.36); Y302(10.38); Y465(10.08)  LDD0258 
Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1) LDTP04015 Y102(11.19)  LDD0258 
Poly(rC)-binding protein 2 (PCBP2) LDTP06367 Y182(20.00)  LDD0258 
Polyadenylate-binding protein 1 (PABPC1) LDTP02595 Y364(19.01); Y291(5.92)  LDD0258 
Polypyrimidine tract-binding protein 1 (PTBP1) LDTP03364 Y430(6.46)  LDD0258 
Prefoldin subunit 5 (PFDN5) LDTP10873 Y43(20.00)  LDD0258 
Profilin-1 (PFN1) LDTP02218 Y129(17.15); Y60(6.16)  LDD0258 
Programmed cell death protein 5 (PDCD5) LDTP00417 Y80(10.23)  LDD0258 
Proliferating cell nuclear antigen (PCNA) LDTP02596 Y249(10.77)  LDD0258 
Protein canopy homolog 2 (CNPY2) LDTP13841 Y92(10.36)  LDD0258 
Protein NipSnap homolog 1 (NIPSNAP1) LDTP19912 Y72(18.33)  LDD0258 
Protein SGT1 homolog (SUGT1) LDTP13935 Y90(5.53)  LDD0258 
Protein transport protein Sec23B (SEC23B) LDTP06391 Y707(8.47)  LDD0258 
Putative protein FAM10A5 (ST13P5) LDTP17811 Y213(20.00)  LDD0258 
Ran-specific GTPase-activating protein (RANBP1) LDTP04049 Y103(20.00)  LDD0258 
Reticulon-3 (RTN3) LDTP01522 Y1004(20.00)  LDD0258 
Reticulon-4 (RTN4) LDTP12412 Y1091(20.00)  LDD0258 
Rho GDP-dissociation inhibitor 1 (ARHGDIA) LDTP04510 Y128(15.49); Y51(12.49)  LDD0258 
Serine-threonine kinase receptor-associated protein (STRAP) LDTP13991 Y114(10.03)  LDD0258 
Serpin H1 (SERPINH1) LDTP04363 Y135(10.30)  LDD0258 
Single-stranded DNA-binding protein, mitochondrial (SSBP1) LDTP05437 Y73(10.64)  LDD0258 
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) LDTP00862 Y182(18.93)  LDD0258 
Small ribosomal subunit protein eS1 (RPS3A) LDTP04913 Y155(11.41); Y205(9.10)  LDD0258 
Small ribosomal subunit protein eS12 (RPS12) LDTP03321 Y127(20.00)  LDD0258 
Small ribosomal subunit protein eS17 (RPS17) LDTP02302 Y53(20.00)  LDD0258 
Small ribosomal subunit protein eS19 (RPS19) LDTP03864 Y54(20.00)  LDD0258 
Small ribosomal subunit protein eS24 (RPS24) LDTP05012 Y81(20.00); Y76(12.38)  LDD0258 
Small ribosomal subunit protein eS26 (RPS26) LDTP05014 Y62(19.49); Y73(6.66)  LDD0258 
Small ribosomal subunit protein eS27 (RPS27) LDTP03987 Y31(13.92)  LDD0258 
Small ribosomal subunit protein eS4, X isoform (RPS4X) LDTP04997 Y149(12.34); Y54(8.16)  LDD0258 
Small ribosomal subunit protein eS7 (RPS7) LDTP04958 Y177(6.11)  LDD0258 
Small ribosomal subunit protein eS8 (RPS8) LDTP04964 Y113(16.22); Y83(10.82)  LDD0258 
Small ribosomal subunit protein uS11 (RPS14) LDTP04970 Y72(20.00)  LDD0258 
Small ribosomal subunit protein uS12 (RPS23) LDTP04971 Y134(20.00)  LDD0258 
Small ribosomal subunit protein uS13 (RPS18) LDTP04972 Y40(9.89); Y77(8.36)  LDD0258 
Small ribosomal subunit protein uS15 (RPS13) LDTP04974 Y89(6.30)  LDD0258 
Small ribosomal subunit protein uS17 (RPS11) LDTP04975 Y92(11.61)  LDD0258 
Small ribosomal subunit protein uS19 (RPS15) LDTP05011 Y123(20.00); Y115(10.58)  LDD0258 
Small ribosomal subunit protein uS4 (RPS9) LDTP04109 Y13(12.50)  LDD0258 
Small ribosomal subunit protein uS5 (RPS2) LDTP02809 Y133(20.00); Y248(20.00); Y250(20.00); Y266(10.35)  LDD0258 
Small ribosomal subunit protein uS7 (RPS5) LDTP04110 Y188(14.76); Y48(6.57); Y45(5.16)  LDD0258 
Small ribosomal subunit protein uS9 (RPS16) LDTP04966 Y115(19.45)  LDD0258 
Splicing factor 3B subunit 3 (SF3B3) LDTP06376 Y1166(18.21)  LDD0258 
Splicing factor U2AF 65 kDa subunit (U2AF2) LDTP03352 Y469(20.00)  LDD0258 
Stalled ribosome sensor GCN1 (GCN1) LDTP09821 Y252(20.00); Y2186(14.17)  LDD0258 
Stress-70 protein, mitochondrial (HSPA9) LDTP03860 Y652(20.00); Y161(14.83); Y128(11.63); Y181(9.63)  LDD0258 
Stress-induced-phosphoprotein 1 (STIP1) LDTP03619 Y354(8.95); Y451(5.01)  LDD0258 
Structural maintenance of chromosomes protein 4 (SMC4) LDTP12606 Y197(9.30)  LDD0258 
Synapse-associated protein 1 (SYAP1) LDTP10062 Y60(16.93)  LDD0258 
T-complex protein 1 subunit alpha (TCP1) LDTP02934 Y131(20.00); Y121(15.33)  LDD0258 
T-complex protein 1 subunit beta (CCT2) LDTP05113 Y439(10.84); Y408(8.15)  LDD0258 
T-complex protein 1 subunit epsilon (CCT5) LDTP04201 Y280(11.90); Y274(6.36)  LDD0258 
T-complex protein 1 subunit eta (CCT7) LDTP10990 Y111(20.00); Y358(20.00)  LDD0258 
T-complex protein 1 subunit gamma (CCT3) LDTP04249 Y303(11.78); Y247(9.83); Y232(7.36)  LDD0258 
T-complex protein 1 subunit theta (CCT8) LDTP04390 Y30(20.00); Y173(14.16); Y47(11.43); Y468(5.55)  LDD0258 
Transgelin-2 (TAGLN2) LDTP03846 Y192(20.00)  LDD0258 
Tubulin beta chain (TUBB) LDTP02205 Y310(20.00); Y36(20.00); Y50(20.00); Y51(20.00)  LDD0258 
Tubulin beta-2A chain (TUBB2A) LDTP05998 Y51(20.00)  LDD0258 
Tubulin beta-2B chain (TUBB2B) LDTP11277 Y51(9.48); Y36(9.08); Y310(8.46)  LDD0258 
Tubulin beta-3 chain (TUBB3) LDTP05904 Y310(20.00); Y106(15.12); Y51(10.13)  LDD0258 
Tubulin beta-4A chain (TUBB4A) LDTP02037 Y59(20.00); Y106(16.94)  LDD0258 
Tubulin beta-4B chain (TUBB4B) LDTP05076 Y51(20.00); Y59(20.00); Y36(6.09)  LDD0258 
Tubulin beta-6 chain (TUBB6) LDTP11233 Y50(19.90); Y51(16.14)  LDD0258 
Tubulin-specific chaperone A (TBCA) LDTP01184 Y94(11.22)  LDD0258 
Tumor protein D54 (TPD52L2) LDTP00759 Y106(20.00); Y126(11.46)  LDD0258 
Ubiquilin-1 (UBQLN1) LDTP13626 Y269(11.72)  LDD0258 
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) LDTP05033 Y105(20.00)  LDD0258 
Zinc finger protein 503 (ZNF503) LDTP10295 Y602(20.00)  LDD0258 
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Full Information of The Labelling Profiles of This Probe

Quantification: Probe vs DMSO
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
100 uM
Quantitative Method
SILAC
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK293T-DGKA)
Interaction Atlas ID
 LDD0258 
Download The Altas

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.