Details of the Target

General Information of Target

Target ID LDTP14214
Target Name Dolichyl-phosphate beta-glucosyltransferase (ALG5)
Gene Name ALG5
Gene ID 29880
Synonyms
Dolichyl-phosphate beta-glucosyltransferase; DolP-glucosyltransferase; EC 2.4.1.117; Asparagine-linked glycosylation protein 5 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKWYLMTVVVLIGLTVRWTVSLNSYSGAGKPPMFGDYEAQRHWQEITFNLPVKQWYFNS
SDNNLQYWGLDYPPLTAYHSLLCAYVAKFINPDWIALHTSRGYESQAHKLFMRTTVLIAD
LLIYIPAVVLYCCCLKEISTKKKIANALCILLYPGLILIDYGHFQYNSVSLGFALWGVLG
ISCDCDLLGSLAFCLAINYKQMELYHALPFFCFLLGKCFKKGLKGKGFVLLVKLACIVVA
SFVLCWLPFFTEREQTLQVLRRLFPVDRGLFEDKVANIWCSFNVFLKIKDILPRHIQLIM
SFCSTFLSLLPACIKLILQPSSKGFKFTLVSCALSFFLFSFQVHEKSILLVSLPVCLVLS
EIPFMSTWFLLVSTFSMLPLLLKDELLMPSVVTTMAFFIACVTSFSIFEKTSEEELQLKS
FSISVRKYLPCFTFLSRIIQYLFLISVITMVLLTLMTVTLDPPQKLPDLFSVLVCFVSCL
NFLFFLVYFNIIIMWDSKSGRNQKKIS
Target Bioclass
Enzyme
Family
Glycosyltransferase 2 family
Subcellular location
Endoplasmic reticulum membrane
Function Required for the assembly of lipid-linked oligosaccharides in kidney epithelial cells, and protein N-glycosylation. Required for polycystin-1 (PKD1) glycosylation and maturation.
Uniprot ID
Q9Y673
Ensemble ID
ENST00000239891.4
HGNC ID
HGNC:20266

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CFPAC1 SNV: p.T312S DBIA    Probe Info 
HT115 SNV: p.R309Ter DBIA    Probe Info 
MDAMB468 SNV: p.E42Q DBIA    Probe Info 
RKO SNV: p.R133C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.68  LDD0402  [1]
FBPP2
 Probe Info  		10.61  LDD0318  [2]
TH211
 Probe Info  		Y74(20.00); Y127(20.00)  LDD0260  [3]
TH214
 Probe Info  		Y74(10.78)  LDD0258  [3]
TH216
 Probe Info  		Y74(15.41)  LDD0259  [3]
STPyne
 Probe Info  		K122(1.25); K139(8.38); K202(7.43); K44(4.63)  LDD0277  [4]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [5]
BTD
 Probe Info  		C236(1.50)  LDD1700  [6]
EA-probe
 Probe Info  		N.A.  LDD0440  [7]
Acrolein
 Probe Info  		N.A.  LDD0222  [8]
DBIA
 Probe Info  		C194(0.93)  LDD0078  [9]
ATP probe
 Probe Info  		K44(0.00); K139(0.00); K202(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		C194(0.00); C236(0.00)  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		C236(0.00); C194(0.00)  LDD0037  [11]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
IPM
 Probe Info  		C236(0.00); C194(0.00)  LDD0005  [13]
NHS
 Probe Info  		N.A.  LDD0010  [13]
VSF
 Probe Info  		N.A.  LDD0007  [13]
W1
 Probe Info  		N.A.  LDD0236  [14]
AOyne
 Probe Info  		15.00  LDD0443  [15]
NAIA_5
 Probe Info  		C236(0.00); C194(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C112
 Probe Info  		17.03  LDD1799  [17]
C141
 Probe Info  		11.24  LDD1823  [17]
C187
 Probe Info  		21.86  LDD1865  [17]
C191
 Probe Info  		10.48  LDD1868  [17]
C388
 Probe Info  		53.08  LDD2047  [17]
FFF probe11
 Probe Info  		20.00  LDD0471  [18]
VE-P
 Probe Info  		N.A.  LDD0396  [19]
Alk-rapa
 Probe Info  		4.04  LDD0213  [20]
OEA-DA
 Probe Info  		5.65  LDD0046  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C236(1.03)  LDD2112  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C236(0.94)  LDD2103  [6]
 LDCM0214  AC1 HCT 116 C194(0.98)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C194(0.88); C236(0.91)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C194(0.58); C236(0.76)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C194(0.58); C236(0.75)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C194(0.59); C236(0.71)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C194(0.47); C236(0.65)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C194(0.52); C236(0.69)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C194(0.50); C236(0.73)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C194(0.49); C236(0.68)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C194(0.49); C236(0.66)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C194(0.76); C236(0.88)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C194(0.67); C236(0.84)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C194(0.82); C236(0.70)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C194(0.59); C236(0.74)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C194(0.59); C236(0.78)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C194(0.53); C236(0.66)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C194(0.99); C236(0.95)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C194(0.76); C236(1.01)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C194(0.76); C236(1.02)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C194(0.72); C236(1.11)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C194(0.79); C236(1.11)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C194(0.89); C236(1.07)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C194(0.85); C236(1.06)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C194(1.39); C236(1.02)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C194(0.83); C236(0.86)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C194(0.89); C236(1.06)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C194(0.86); C236(1.01)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C194(0.87); C236(1.00)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C194(0.87); C236(1.14)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C194(0.86); C236(1.02)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C194(0.75); C236(1.11)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C194(0.73); C236(1.11)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C194(0.99)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C194(1.05)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C194(1.10)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C194(0.99)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C194(0.97)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C194(1.09)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C194(1.08)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C194(0.91)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C194(0.95)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C194(0.87)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C194(0.97)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C194(0.95)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C194(0.84); C236(0.84)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C194(1.04)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C194(0.91)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C194(0.92)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C194(1.11)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C194(1.18)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C194(1.36)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C194(1.15)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C194(1.22)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C194(1.29)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C194(1.06)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C194(0.90); C236(0.92)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C194(1.09)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C194(1.09)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C194(1.27)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C194(1.57)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C194(1.17)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C194(1.28)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C194(1.05)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C194(1.32)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C194(0.94); C236(1.28)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C194(0.95); C236(0.95)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C194(1.00); C236(1.03)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C194(0.89)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C236(0.91); C194(1.02)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C194(0.93); C236(0.94)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C194(1.04); C236(1.17)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C194(1.10); C236(1.14)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C236(0.97); C194(1.08)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C194(0.81); C236(1.04)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C236(0.77); C194(0.81)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C236(0.79); C194(0.86)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C194(0.78); C236(0.87)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C236(0.61); C194(0.81)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C194(1.02)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C236(0.53); C194(0.91)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C236(0.68); C194(0.84)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C236(0.59); C194(0.82)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C236(0.66); C194(0.84)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C236(0.58); C194(0.89)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C194(0.89); C236(1.00)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C194(0.80); C236(0.86)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C194(1.01); C236(1.02)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C236(0.93); C194(0.95)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C236(0.92); C194(1.03)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C194(0.98)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C236(0.87); C194(1.03)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C236(0.83); C194(0.99)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C236(0.87); C194(0.95)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C236(0.92); C194(0.93)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C194(0.98); C236(1.03)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C236(1.05); C194(1.05)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C194(0.89); C236(1.26)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C194(0.83); C236(1.16)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C194(0.95); C236(1.46)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C194(0.78); C236(1.03)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C194(1.01)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C194(0.85); C236(0.93)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C194(0.98); C236(1.47)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C194(0.91); C236(0.98)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C194(0.81); C236(0.89)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C194(0.87); C236(0.90)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C194(0.93); C236(0.96)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C194(0.97); C236(1.17)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C194(0.84); C236(0.86)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C236(0.78); C194(0.79)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C236(0.73); C194(0.78)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C236(0.80); C194(0.91)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C194(0.75); C236(1.03)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C194(0.80); C236(1.38)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C194(0.78); C236(0.82)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C194(0.76); C236(0.88)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C194(0.77); C236(0.93)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C194(0.80); C236(1.14)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C194(0.86); C236(1.35)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C194(0.79); C236(1.07)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C194(0.89); C236(1.00)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C194(0.85); C236(0.96)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C236(0.90); C194(0.97)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C194(0.73); C236(1.15)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C194(1.01); C236(1.16)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C194(0.88); C236(1.09)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C194(0.92); C236(1.07)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C194(0.94); C236(1.22)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C194(0.86); C236(1.22)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C194(0.80); C236(1.10)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C194(0.75); C236(0.95)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C194(0.96); C236(1.24)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C194(0.95); C236(1.17)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C236(0.90); C194(0.98)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C194(0.83); C236(1.35)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C194(1.11); C236(1.49)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C194(0.95); C236(1.41)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C194(0.75); C236(0.80)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C236(0.64); C194(0.74)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C236(0.62); C194(0.78)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C236(0.73); C194(0.74)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C194(0.88); C236(1.05)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C236(0.75); C194(0.78)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C194(0.73); C236(0.77)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C194(0.93); C236(0.95)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C194(0.68); C236(0.70)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C194(0.71); C236(0.91)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C194(0.77); C236(0.80)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C194(0.81); C236(1.03)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C194(0.78); C236(1.03)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C194(0.75); C236(0.92)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C194(0.67); C236(0.80)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C194(0.47); C236(0.73)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C194(0.68); C236(0.81)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C194(0.99); C236(0.97)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C236(0.81); C194(1.01)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C194(0.79); C236(0.86)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.50  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C194(0.93)  LDD0078  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HCT 116 C236(0.99); C194(1.16)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C236(0.84); C194(0.86)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C194(0.96)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C236(0.72); C194(0.82)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C236(0.90); C194(1.02)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C236(0.89); C194(0.98)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C236(0.90); C194(0.98)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C194(1.07); C236(1.29)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C194(1.01); C236(1.25)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C236(1.10); C194(1.13)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C194(1.11); C236(1.38)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C194(0.99); C236(1.15)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C194(0.81); C236(0.83)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C194(1.00); C236(1.18)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C236(1.08); C194(1.08)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C236(0.86); C194(0.86)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C236(0.49); C194(0.87)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C236(0.50); C194(0.83)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C236(0.58); C194(0.89)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C236(0.57); C194(0.93)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C236(0.90); C194(0.92)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C194(0.90); C236(0.97)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C194(0.84); C236(0.88)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C236(0.82); C194(0.84)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C194(0.83); C236(0.86)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C194(0.95); C236(1.01)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C236(1.01); C194(1.03)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C236(0.89); C194(0.90)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C194(0.82); C236(0.97)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C194(0.89); C236(2.34)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C194(0.99); C236(1.62)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C194(0.92); C236(1.23)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C194(0.77); C236(0.84)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C236(0.73); C194(0.87)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C236(0.95); C194(0.96)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C194(0.81); C236(0.81)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C236(0.90); C194(0.99)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C236(0.81); C194(0.86)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C194(0.90); C236(1.06)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C236(0.72); C194(0.80)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C236(1.08); C194(1.11)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C236(0.68); C194(0.76)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C236(0.64); C194(0.69)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C236(0.80); C194(0.86)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C194(0.81); C236(0.90)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C236(0.74); C194(0.77)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C194(0.73); C236(0.77)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C194(0.82); C236(0.74)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C194(0.80); C236(0.83)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C194(0.73); C236(0.59)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C194(0.77); C236(0.72)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C194(0.94); C236(1.09)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C194(0.87); C236(0.82)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C194(0.78); C236(1.03)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C194(0.88); C236(1.07)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C194(0.83); C236(1.03)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C194(0.85); C236(1.10)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C194(0.79); C236(1.10)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C194(0.74); C236(0.96)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C194(0.80); C236(1.03)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C194(0.76); C236(1.05)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C194(0.93); C236(1.04)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C194(0.76); C236(0.95)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C194(0.83); C236(1.14)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C194(0.91); C236(1.15)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C194(0.81); C236(1.13)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C194(0.85); C236(1.33)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C194(0.86); C236(1.44)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C194(0.99); C236(1.21)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C194(1.15); C236(1.24)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C194(1.07); C236(1.33)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C194(0.93); C236(1.09)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C194(0.96); C236(1.08)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C194(0.97); C236(1.10)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C194(0.88); C236(1.32)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C194(0.85); C236(1.06)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C194(1.04); C236(1.03)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C194(1.08); C236(1.12)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C194(0.87); C236(1.16)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C194(0.86); C236(1.06)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C194(0.94); C236(1.13)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C194(0.93); C236(1.15)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C194(0.83); C236(1.04)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C194(0.89); C236(1.38)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C194(0.96); C236(1.15)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C194(0.89); C236(0.93)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C194(0.88); C236(1.09)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C194(0.82); C236(0.79)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C194(0.81); C236(0.92)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C194(0.91); C236(0.87)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C194(0.75); C236(0.81)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C194(0.78); C236(0.79)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C194(0.78); C236(0.93)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C194(0.96); C236(0.75)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C194(0.85); C236(1.29)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C194(0.84); C236(0.95)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C194(0.79); C236(0.90)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C194(0.94); C236(0.79)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C194(0.83); C236(0.91)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C194(0.77); C236(0.85)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C194(1.03); C236(0.86)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C194(0.82); C236(0.96)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C194(0.89); C236(0.77)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C194(0.88); C236(0.73)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C194(0.84); C236(1.00)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C194(0.81); C236(0.82)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C194(0.79); C236(0.95)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C194(0.87); C236(0.93)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C194(0.73); C236(0.78)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C194(0.78); C236(0.68)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C194(0.92); C236(0.79)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C194(0.77); C236(1.05)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C194(0.83); C236(0.95)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C194(0.72); C236(0.77)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C194(0.97); C236(0.92)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C194(0.99); C236(1.01)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C194(1.12); C236(0.90)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C194(1.01)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C194(0.93)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C194(0.91)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C194(0.90)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C194(0.91)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C194(0.96)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C194(0.92)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C194(0.96)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C194(0.94)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C236(0.87); C194(0.97)  LDD1698  [22]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [7]
 LDCM0625  F8 Ramos C236(1.39); C194(1.47)  LDD2187  [23]
 LDCM0573  Fragment11 Ramos C236(0.38); C194(0.83)  LDD2190  [23]
 LDCM0575  Fragment13 Ramos C236(1.25); C194(1.02)  LDD2192  [23]
 LDCM0580  Fragment21 Ramos C236(1.29); C194(0.99)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C236(0.70); C194(0.82)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C236(0.92); C194(0.70)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C236(0.89); C194(0.92)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C236(1.42); C194(1.24)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C236(0.92); C194(1.53)  LDD2200  [23]
 LDCM0468  Fragment33 HCT 116 C194(0.78); C236(0.98)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C236(1.98); C194(1.06)  LDD2203  [23]
 LDCM0427  Fragment51 HCT 116 C194(0.76); C236(1.07)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C194(1.27)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C236(0.97); C194(0.75)  LDD2205  [23]
 LDCM0015  HNE MDA-MB-231 C236(0.93)  LDD0346  [23]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [5]
 LDCM0022  KB02 HCT 116 C236(1.87)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C236(1.05)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C236(1.85)  LDD0082  [9]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C236(1.16)  LDD2102  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C236(1.08)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C236(1.01)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C236(0.77)  LDD2093  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C236(2.05)  LDD2100  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C236(1.00)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C236(1.36)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C236(1.03)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C236(0.91)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C236(0.96)  LDD2108  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C236(2.45)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C236(1.01)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C236(0.78)  LDD2114  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C236(1.97)  LDD2119  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C236(1.05)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C236(0.84)  LDD2136  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C236(1.50)  LDD1700  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C236(0.60)  LDD2141  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C194(1.03)  LDD2206  [24]
 LDCM0628  OTUB2-COV-1 HEK-293T C194(1.04); C236(0.70)  LDD2207  [24]
 LDCM0131  RA190 MM1.R C194(0.67)  LDD0304  [25]
 LDCM0090  Rapamycin JHH-7 4.04  LDD0213  [20]
 LDCM0021  THZ1 HCT 116 C236(1.22)  LDD2173  [9]

References

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Mass spectrometry data entry: PXD018580
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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Mass spectrometry data entry: PXD028853
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
20 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
21 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
25 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.