Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C141  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 104 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 86.8
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 48.5
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 48.5
 LDTP01983  NADH-ubiquinone oxidoreductase chain 2 (MT-ND2) 45.3
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 38.1
 LDTP12020  Histone-lysine N-methyltransferase SMYD3 (SMYD3) 32.0
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 30.9
 LDTP00697  Cytochrome b5 type B (CYB5B) 30.5
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 29.0
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 28.8
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 27.5
 LDTP05905  Acid ceramidase (ASAH1) 25.5
 LDTP02505  Lysosomal protective protein (CTSA) 25.5
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 25.3
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 25.1
 LDTP04542  Thimet oligopeptidase (THOP1) 24.4
 LDTP00975  Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (MAN1A2) 24.3
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 23.8
 LDTP01769  Dihydrofolate reductase (DHFR) 22.5
 LDTP02359  Heme oxygenase 1 (HMOX1) 22.2
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 21.9
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 21.0
 LDTP02837  Beta-galactosidase (GLB1) 20.3
 LDTP11700  Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP) 19.0
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 18.9
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 18.5
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 18.4
 LDTP10329  Ceramide synthase 2 (CERS2) 18.1
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 17.9
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 17.5
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 17.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 16.9
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 16.8
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 16.6
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 15.8
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 15.7
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 15.6
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 15.6
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 15.6
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 15.5
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 15.3
 LDTP03540  Heme oxygenase 2 (HMOX2) 15.0
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 14.9
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 14.3
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 13.5
 LDTP11127  ADP-dependent glucokinase (ADPGK) 13.4
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 13.2
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 13.1
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 13.0
 LDTP06617  Ceramide glucosyltransferase (UGCG) 12.8
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 12.8
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 12.4
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 12.4
 LDTP06283  Exosome complex component RRP42 (EXOSC7) 12.3
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 12.1
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 12.1
 LDTP01141  E3 ubiquitin-protein ligase BRE1B (RNF40) 12.1
 LDTP07620  Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (PAOX) 12.1
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 11.9
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 11.9
 LDTP01562  Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) 11.7
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 11.6
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 11.6
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 11.6
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 11.6
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 11.4
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 11.3
 LDTP00717  Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1) 11.2
 LDTP14214  Dolichyl-phosphate beta-glucosyltransferase (ALG5) 11.2
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 11.2
 LDTP00988  Protein O-GlcNAcase (OGA) 11.2
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 10.9
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 10.8
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 10.7
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 10.6
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 10.5
 LDTP12163  Calcyclin-binding protein (CACYBP) 10.3
 LDTP07504  Lysophospholipid acyltransferase 5 (LPCAT3) 10.3
 LDTP02000  3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) 10.1
 LDTP00338  Lysosomal alpha-mannosidase (MAN2B1) 10.1
 LDTP03249  Plasma membrane calcium-transporting ATPase 4 (ATP2B4) 10.1
 LDTP02141  Alpha-galactosidase A (GLA) 9.9
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 9.9
 LDTP13131  7-dehydrocholesterol reductase (DHCR7) 9.8
 LDTP05408  Antigen peptide transporter 1 (TAP1) 9.8
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 9.8
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 9.8
 LDTP09251  Atlastin-2 (ATL2) 9.6
 LDTP00950  Dynamin-like 120 kDa protein, mitochondrial (OPA1) 9.4
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 9.4
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 9.3
 LDTP07218  E3 ubiquitin-protein ligase BRE1A (RNF20) 9.3
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 9.2
 LDTP12509  N-lysine methyltransferase SMYD2 (SMYD2) 9.2
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 9.2
 LDTP03145  Catechol O-methyltransferase (COMT) 9.1
 LDTP10981  Mitochondrial intermediate peptidase (MIPEP) 9.1
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 9.1
 LDTP00597  Serine palmitoyltransferase 1 (SPTLC1) 9.1
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 9.1
 LDTP04203  Phosphatidylserine synthase 1 (PTDSS1) 9.1
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 9.1
 LDTP01389  Delta(14)-sterol reductase TM7SF2 (TM7SF2) 8.9
 LDTP07367  Nucleoredoxin (NXN) 8.9
Transporter and channel
Click to Show/Hide to Show 68 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 99.7
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 65.3
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 50.9
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 42.8
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 40.5
 LDTP08881  Transmembrane protein 199 (TMEM199) 40.2
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 39.4
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 35.3
 LDTP07531  Sideroflexin-4 (SFXN4) 32.7
 LDTP16813  Tetraspanin-3 (TSPAN3) 31.8
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 31.6
 LDTP15481  Transmembrane protein 87A (TMEM87A) 31.1
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 30.5
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 30.3
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 29.9
 LDTP11615  Protein tweety homolog 3 (TTYH3) 29.2
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 28.8
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 27.9
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 26.4
 LDTP02215  Prosaposin (PSAP) 26.0
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 25.6
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 23.8
 LDTP12636  Lysosomal cobalamin transport escort protein LMBD1 (LMBRD1) 22.3
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 21.0
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 20.1
 LDTP11812  Protein ARV1 (ARV1) 19.7
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 19.6
 LDTP15948  Transmembrane protein 126A (TMEM126A) 19.4
 LDTP07236  Protein GPR107 (GPR107) 18.1
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 17.5
 LDTP00970  Gasdermin-E (GSDME) 16.2
 LDTP03380  Stomatin (STOM) 16.2
 LDTP15648  BRI3-binding protein (BRI3BP) 15.9
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 15.6
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 15.1
 LDTP11213  Nucleoporin NDC1 (NDC1) 15.0
 LDTP20002  Transmembrane protein 160 (TMEM160) 14.9
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 14.2
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 14.2
 LDTP00592  Surfeit locus protein 4 (SURF4) 13.7
 LDTP05900  Metaxin-1 (MTX1) 13.4
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 12.8
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 12.6
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 12.6
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 12.5
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 12.4
 LDTP07156  Protein wntless homolog (WLS) 12.3
 LDTP12451  Integral membrane protein 2C (ITM2C) 12.2
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 12.1
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 11.8
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 11.7
 LDTP09515  Importin-4 (IPO4) 11.6
 LDTP06549  Hsp90 co-chaperone Cdc37 (CDC37) 11.6
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 11.4
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 10.8
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 10.7
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 10.7
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 10.7
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 10.6
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 10.6
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 10.4
 LDTP10065  Transmembrane protein 230 (TMEM230) 10.1
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 9.8
 LDTP11041  Calcium uptake protein 1, mitochondrial (MICU1) 9.5
 LDTP13833  Integral membrane protein 2B (ITM2B) 9.4
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 9.4
 LDTP12383  Protein GPR108 (GPR108) 9.4
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 8.9
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 14.9
Other
Click to Show/Hide to Show 64 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05160  Nucleobindin-2 (NUCB2) 99.0
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 95.7
 LDTP11076  Apolipoprotein L2 (APOL2) 64.9
 LDTP18145  Small integral membrane protein 19 (SMIM19) 50.6
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 47.2
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 45.6
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 43.1
 LDTP00105  Protein unc-119 homolog B (UNC119B) 41.1
 LDTP01522  Reticulon-3 (RTN3) 38.6
 LDTP15634  Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) 37.3
 LDTP14458  Tetraspanin-6 (TSPAN6) 34.1
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 29.7
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 26.9
 LDTP13797  HIG1 domain family member 1A, mitochondrial (HIGD1A) 22.5
 LDTP18883  Protein CEBPZOS (CEBPZOS) 22.0
 LDTP16080  Protein FAM114A2 (FAM114A2) 21.9
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 21.1
 LDTP05375  Nucleobindin-1 (NUCB1) 21.1
 LDTP01075  Protein CutA (CUTA) 21.1
 LDTP13630  Neudesin (NENF) 20.3
 LDTP12412  Reticulon-4 (RTN4) 19.6
 LDTP14939  Membralin (TMEM259) 19.4
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 19.2
 LDTP10056  Protein FAM162A (FAM162A) 19.2
 LDTP07476  RAD50-interacting protein 1 (RINT1) 18.9
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 18.3
 LDTP16006  Optic atrophy 3 protein (OPA3) 18.0
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 17.4
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 17.4
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 17.3
 LDTP13086  Syntaxin-18 (STX18) 17.0
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 16.7
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 15.6
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) 14.9
 LDTP00859  Synaptogyrin-2 (SYNGR2) 14.9
 LDTP19963  TraB domain-containing protein (TRABD) 14.6
 LDTP08224  Protein LYRIC (MTDH) 13.9
 LDTP12377  Mediator of RNA polymerase II transcription subunit 4 (MED4) 13.5
 LDTP15283  Nucleolar protein 9 (NOP9) 13.5
 LDTP07916  Protein MTSS 2 (MTSS2) 13.5
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 13.1
 LDTP19785  Transmembrane protein 35B (TMEM35B) 13.0
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 12.2
 LDTP00779  Trans-Golgi network integral membrane protein 2 (TGOLN2) 12.0
 LDTP18272  Transmembrane protein 209 (TMEM209) 12.0
 LDTP03175  Galanin peptides (GAL) 11.6
 LDTP00986  Syntaxin-10 (STX10) 11.6
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 11.4
 LDTP05960  Trophoblast glycoprotein (TPBG) 11.3
 LDTP11143  Centromere protein K (CENPK) 11.1
 LDTP09920  Golgi apparatus protein 1 (GLG1) 11.1
 LDTP01652  Centrosomal protein 43 (CEP43) 10.9
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 10.2
 LDTP11911  Golgi phosphoprotein 3 (GOLPH3) 10.1
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 9.7
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 9.6
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 9.6
 LDTP15095  Receptor expression-enhancing protein 3 (REEP3) 9.6
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 9.5
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 9.4
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 9.4
 LDTP10046  Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ERGIC1) 9.1
 LDTP16285  Transducin beta-like protein 2 (TBL2) 9.1
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 9.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587