Details of the Target

General Information of Target

Target ID	LDTP10501
Target Name	DnaJ homolog subfamily C member 1 (DNAJC1)
Gene Name	DNAJC1
Gene ID	64215
Synonyms	HTJ1; DnaJ homolog subfamily C member 1; DnaJ protein homolog MTJ1
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MEGISNFKTPSKLSEKKKSVLCSTPTINIPASPFMQKLGFGTGVNVYLMKRSPRGLSHSP WAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGE KSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFE TIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEM MTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVC TNEDPKDRPSAAHIVEALETDV
Target Bioclass	Transcription factor
Subcellular location	Endoplasmic reticulum membrane
Function	May modulate protein synthesis.
Uniprot ID	Q96KC8
Ensemble ID	ENST00000376980.8
HGNC ID	HGNC:20090

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 22 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
m-APA Probe Info	10.91	LDD0402	[1]
FBPP2 Probe Info	2.02	LDD0324	[2]
CHEMBL5175495 Probe Info	10.09	LDD0196	[3]
STPyne Probe Info	K209(1.14); K260(10.00); K540(0.85)	LDD0277	[4]
BTD Probe Info	C535(0.95)	LDD2099	[5]
AHL-Pu-1 Probe Info	C380(3.08)	LDD0169	[6]
HPAP Probe Info	3.20	LDD0062	[7]
Acrolein Probe Info	N.A.	LDD0222	[8]
DBIA Probe Info	C380(1.03)	LDD0078	[9]
IA-alkyne Probe Info	N.A.	LDD0162	[10]
NAIA_5 Probe Info	N.A.	LDD2224	[11]
WYneN Probe Info	N.A.	LDD0021	[12]
WYneO Probe Info	N.A.	LDD0022	[12]
DA-P3 Probe Info	N.A.	LDD0178	[13]
IPM Probe Info	N.A.	LDD0147	[14]
TFBX Probe Info	N.A.	LDD0148	[14]
YN-1 Probe Info	N.A.	LDD0446	[15]
Phosphinate-6 Probe Info	N.A.	LDD0018	[16]
Crotonaldehyde Probe Info	N.A.	LDD0219	[8]
Methacrolein Probe Info	N.A.	LDD0218	[8]
W1 Probe Info	N.A.	LDD0236	[17]
AOyne Probe Info	13.70	LDD0443	[18]

PAL-AfBPP Probe

Click To Hide/Show 81 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
C022 Probe Info	14.42	LDD1728	[19]
C040 Probe Info	19.03	LDD1740	[19]
C041 Probe Info	7.21	LDD1741	[19]
C053 Probe Info	5.06	LDD1751	[19]
C055 Probe Info	19.97	LDD1752	[19]
C056 Probe Info	41.07	LDD1753	[19]
C063 Probe Info	10.56	LDD1760	[19]
C070 Probe Info	16.00	LDD1766	[19]
C072 Probe Info	7.78	LDD1768	[19]
C082 Probe Info	6.54	LDD1774	[19]
C087 Probe Info	9.19	LDD1779	[19]
C091 Probe Info	23.26	LDD1782	[19]
C092 Probe Info	25.63	LDD1783	[19]
C094 Probe Info	31.12	LDD1785	[19]
C095 Probe Info	5.06	LDD1786	[19]
C100 Probe Info	5.31	LDD1789	[19]
C106 Probe Info	23.43	LDD1793	[19]
C107 Probe Info	7.52	LDD1794	[19]
C112 Probe Info	38.05	LDD1799	[19]
C130 Probe Info	6.77	LDD1812	[19]
C134 Probe Info	42.22	LDD1816	[19]
C135 Probe Info	17.27	LDD1817	[19]
C141 Probe Info	14.93	LDD1823	[19]
C143 Probe Info	21.26	LDD1825	[19]
C153 Probe Info	21.41	LDD1834	[19]
C159 Probe Info	10.70	LDD1839	[19]
C160 Probe Info	8.17	LDD1840	[19]
C161 Probe Info	14.42	LDD1841	[19]
C169 Probe Info	46.21	LDD1849	[19]
C187 Probe Info	15.24	LDD1865	[19]
C210 Probe Info	39.40	LDD1884	[19]
C218 Probe Info	13.18	LDD1892	[19]
C220 Probe Info	12.30	LDD1894	[19]
C225 Probe Info	5.78	LDD1898	[19]
C228 Probe Info	25.11	LDD1901	[19]
C231 Probe Info	12.64	LDD1904	[19]
C235 Probe Info	19.56	LDD1908	[19]
C238 Probe Info	14.22	LDD1911	[19]
C243 Probe Info	11.16	LDD1916	[19]
C246 Probe Info	16.00	LDD1919	[19]
C252 Probe Info	9.06	LDD1925	[19]
C264 Probe Info	24.76	LDD1935	[19]
C278 Probe Info	48.50	LDD1948	[19]
C282 Probe Info	17.51	LDD1952	[19]
C284 Probe Info	21.56	LDD1954	[19]
C285 Probe Info	20.11	LDD1955	[19]
C287 Probe Info	14.93	LDD1957	[19]
C289 Probe Info	39.40	LDD1959	[19]
C293 Probe Info	16.91	LDD1963	[19]
C296 Probe Info	19.70	LDD1966	[19]
C299 Probe Info	12.21	LDD1968	[19]
C305 Probe Info	15.14	LDD1974	[19]
C310 Probe Info	8.57	LDD1977	[19]
C314 Probe Info	15.56	LDD1981	[19]
C326 Probe Info	6.87	LDD1990	[19]
C338 Probe Info	12.13	LDD2001	[19]
C339 Probe Info	12.55	LDD2002	[19]
C343 Probe Info	22.78	LDD2005	[19]
C348 Probe Info	15.03	LDD2009	[19]
C349 Probe Info	20.11	LDD2010	[19]
C350 Probe Info	47.18	LDD2011	[19]
C355 Probe Info	29.04	LDD2016	[19]
C356 Probe Info	9.25	LDD2017	[19]
C362 Probe Info	59.71	LDD2023	[19]
C363 Probe Info	20.11	LDD2024	[19]
C364 Probe Info	18.13	LDD2025	[19]
C366 Probe Info	7.73	LDD2027	[19]
C373 Probe Info	6.23	LDD2033	[19]
C376 Probe Info	6.63	LDD2036	[19]
C388 Probe Info	36.50	LDD2047	[19]
C390 Probe Info	47.18	LDD2049	[19]
C399 Probe Info	7.84	LDD2058	[19]
C403 Probe Info	19.03	LDD2061	[19]
C407 Probe Info	20.68	LDD2064	[19]
C431 Probe Info	14.62	LDD2086	[19]
FFF probe11 Probe Info	20.00	LDD0471	[20]
FFF probe13 Probe Info	20.00	LDD0475	[20]
FFF probe14 Probe Info	20.00	LDD0477	[20]
FFF probe3 Probe Info	20.00	LDD0465	[20]
A-DA Probe Info	3.86	LDD0145	[21]
OEA-DA Probe Info	20.00	LDD0046	[22]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0026	4SU-RNA+native RNA	HEK-293T	C380(3.08)	LDD0169	[6]
LDCM0214	AC1	HCT 116	C225(1.10); C380(1.20)	LDD0531	[9]
LDCM0215	AC10	HCT 116	C225(0.79); C380(1.09)	LDD0532	[9]
LDCM0216	AC100	HEK-293T	C225(0.92); C380(0.72)	LDD0814	[9]
LDCM0217	AC101	HEK-293T	C225(0.95); C380(0.78)	LDD0815	[9]
LDCM0218	AC102	HEK-293T	C225(1.01); C380(0.80)	LDD0816	[9]
LDCM0219	AC103	HEK-293T	C225(0.89); C380(0.74)	LDD0817	[9]
LDCM0220	AC104	HEK-293T	C225(0.97); C380(0.93)	LDD0818	[9]
LDCM0221	AC105	HEK-293T	C225(0.92); C380(0.69)	LDD0819	[9]
LDCM0222	AC106	HEK-293T	C225(0.98); C380(0.95)	LDD0820	[9]
LDCM0223	AC107	HEK-293T	C225(1.07); C380(0.88)	LDD0821	[9]
LDCM0224	AC108	HEK-293T	C225(1.10); C380(0.87)	LDD0822	[9]
LDCM0225	AC109	HEK-293T	C225(0.96); C380(0.85)	LDD0823	[9]
LDCM0226	AC11	HCT 116	C225(0.90); C380(1.02)	LDD0543	[9]
LDCM0227	AC110	HEK-293T	C225(1.04); C380(0.57)	LDD0825	[9]
LDCM0228	AC111	HEK-293T	C225(1.07); C380(0.65)	LDD0826	[9]
LDCM0229	AC112	HEK-293T	C225(0.90); C380(0.57)	LDD0827	[9]
LDCM0230	AC113	HCT 116	C225(1.09)	LDD0547	[9]
LDCM0231	AC114	HCT 116	C225(0.93)	LDD0548	[9]
LDCM0232	AC115	HCT 116	C225(1.01)	LDD0549	[9]
LDCM0233	AC116	HCT 116	C225(1.08)	LDD0550	[9]
LDCM0234	AC117	HCT 116	C225(1.26)	LDD0551	[9]
LDCM0235	AC118	HCT 116	C225(1.02)	LDD0552	[9]
LDCM0236	AC119	HCT 116	C225(1.11)	LDD0553	[9]
LDCM0237	AC12	HCT 116	C225(0.84); C380(1.01)	LDD0554	[9]
LDCM0238	AC120	HCT 116	C225(0.89)	LDD0555	[9]
LDCM0239	AC121	HCT 116	C225(1.35)	LDD0556	[9]
LDCM0240	AC122	HCT 116	C225(0.99)	LDD0557	[9]
LDCM0241	AC123	HCT 116	C225(1.58)	LDD0558	[9]
LDCM0242	AC124	HCT 116	C225(1.07)	LDD0559	[9]
LDCM0243	AC125	HCT 116	C225(0.89)	LDD0560	[9]
LDCM0244	AC126	HCT 116	C225(1.04)	LDD0561	[9]
LDCM0245	AC127	HCT 116	C225(1.06)	LDD0562	[9]
LDCM0246	AC128	HCT 116	C225(1.34); C380(1.09)	LDD0563	[9]
LDCM0247	AC129	HCT 116	C225(1.02); C380(1.20)	LDD0564	[9]
LDCM0249	AC130	HCT 116	C225(1.16); C380(1.03)	LDD0566	[9]
LDCM0250	AC131	HCT 116	C225(1.12); C380(1.18)	LDD0567	[9]
LDCM0251	AC132	HCT 116	C225(1.11); C380(1.41)	LDD0568	[9]
LDCM0252	AC133	HCT 116	C225(1.16); C380(1.25)	LDD0569	[9]
LDCM0253	AC134	HCT 116	C225(1.27); C380(1.43)	LDD0570	[9]
LDCM0254	AC135	HCT 116	C225(1.22); C380(1.14)	LDD0571	[9]
LDCM0255	AC136	HCT 116	C225(1.12); C380(1.31)	LDD0572	[9]
LDCM0256	AC137	HCT 116	C225(1.14); C380(1.29)	LDD0573	[9]
LDCM0257	AC138	HCT 116	C225(1.31); C380(0.95)	LDD0574	[9]
LDCM0258	AC139	HCT 116	C225(1.35); C380(1.37)	LDD0575	[9]
LDCM0259	AC14	HCT 116	C225(0.77); C380(0.96)	LDD0576	[9]
LDCM0260	AC140	HCT 116	C225(1.47); C380(1.45)	LDD0577	[9]
LDCM0261	AC141	HCT 116	C225(1.47); C380(1.21)	LDD0578	[9]
LDCM0262	AC142	HCT 116	C225(1.12); C380(1.01)	LDD0579	[9]
LDCM0263	AC143	HCT 116	C225(0.96); C380(0.81)	LDD0580	[9]
LDCM0264	AC144	HCT 116	C225(0.94); C380(1.35)	LDD0581	[9]
LDCM0265	AC145	HCT 116	C225(0.85); C380(0.90)	LDD0582	[9]
LDCM0266	AC146	HCT 116	C225(0.75); C380(1.16)	LDD0583	[9]
LDCM0267	AC147	HCT 116	C225(1.05); C380(1.28)	LDD0584	[9]
LDCM0268	AC148	HCT 116	C225(0.73); C380(1.17)	LDD0585	[9]
LDCM0269	AC149	HCT 116	C225(0.73); C380(1.64)	LDD0586	[9]
LDCM0270	AC15	HCT 116	C225(0.87); C380(1.10)	LDD0587	[9]
LDCM0271	AC150	HCT 116	C380(0.91); C225(0.93)	LDD0588	[9]
LDCM0272	AC151	HCT 116	C225(0.85); C380(0.94)	LDD0589	[9]
LDCM0273	AC152	HCT 116	C225(0.85); C380(1.03)	LDD0590	[9]
LDCM0274	AC153	HCT 116	C225(0.67); C380(1.70)	LDD0591	[9]
LDCM0621	AC154	HCT 116	C225(0.84); C380(1.50)	LDD2158	[9]
LDCM0622	AC155	HCT 116	C225(0.76); C380(1.06)	LDD2159	[9]
LDCM0623	AC156	HCT 116	C225(0.84); C380(1.00)	LDD2160	[9]
LDCM0624	AC157	HCT 116	C225(0.77); C380(0.94)	LDD2161	[9]
LDCM0276	AC17	HCT 116	C380(1.10)	LDD0593	[9]
LDCM0277	AC18	HCT 116	C380(1.54)	LDD0594	[9]
LDCM0278	AC19	HCT 116	C380(1.16)	LDD0595	[9]
LDCM0279	AC2	HCT 116	C225(1.19); C380(1.35)	LDD0596	[9]
LDCM0280	AC20	HCT 116	C380(1.23)	LDD0597	[9]
LDCM0281	AC21	HCT 116	C380(1.09)	LDD0598	[9]
LDCM0282	AC22	HCT 116	C380(0.98)	LDD0599	[9]
LDCM0283	AC23	HCT 116	C380(1.08)	LDD0600	[9]
LDCM0284	AC24	HCT 116	C380(1.11)	LDD0601	[9]
LDCM0285	AC25	HCT 116	C225(1.11); C380(1.17)	LDD0602	[9]
LDCM0286	AC26	HCT 116	C225(0.93); C380(1.19)	LDD0603	[9]
LDCM0287	AC27	HCT 116	C380(1.05); C225(1.13)	LDD0604	[9]
LDCM0288	AC28	HCT 116	C380(1.06); C225(1.48)	LDD0605	[9]
LDCM0289	AC29	HCT 116	C380(1.04); C225(1.13)	LDD0606	[9]
LDCM0290	AC3	HCT 116	C225(1.07); C380(1.58)	LDD0607	[9]
LDCM0291	AC30	HCT 116	C380(1.05); C225(1.16)	LDD0608	[9]
LDCM0292	AC31	HCT 116	C380(0.98); C225(1.09)	LDD0609	[9]
LDCM0293	AC32	HCT 116	C380(0.97); C225(1.17)	LDD0610	[9]
LDCM0294	AC33	HCT 116	C380(1.06); C225(1.08)	LDD0611	[9]
LDCM0295	AC34	HCT 116	C225(1.00); C380(1.24)	LDD0612	[9]
LDCM0296	AC35	HCT 116	C380(0.73)	LDD0613	[9]
LDCM0297	AC36	HCT 116	C380(0.83)	LDD0614	[9]
LDCM0298	AC37	HCT 116	C380(0.97)	LDD0615	[9]
LDCM0299	AC38	HCT 116	C380(0.96)	LDD0616	[9]
LDCM0300	AC39	HCT 116	C380(1.11)	LDD0617	[9]
LDCM0301	AC4	HCT 116	C225(1.29); C380(1.55)	LDD0618	[9]
LDCM0302	AC40	HCT 116	C380(0.93)	LDD0619	[9]
LDCM0303	AC41	HCT 116	C380(0.93)	LDD0620	[9]
LDCM0304	AC42	HCT 116	C380(1.07)	LDD0621	[9]
LDCM0305	AC43	HCT 116	C380(1.04)	LDD0622	[9]
LDCM0306	AC44	HCT 116	C380(1.06)	LDD0623	[9]
LDCM0307	AC45	HCT 116	C380(1.23)	LDD0624	[9]
LDCM0308	AC46	HCT 116	C225(1.05); C380(1.25)	LDD0625	[9]
LDCM0309	AC47	HCT 116	C225(1.04); C380(1.28)	LDD0626	[9]
LDCM0310	AC48	HCT 116	C225(0.94); C380(1.19)	LDD0627	[9]
LDCM0311	AC49	HCT 116	C225(1.11); C380(1.33)	LDD0628	[9]
LDCM0312	AC5	HCT 116	C225(1.27); C380(1.55)	LDD0629	[9]
LDCM0313	AC50	HCT 116	C225(1.04); C380(1.37)	LDD0630	[9]
LDCM0314	AC51	HCT 116	C225(0.94); C380(1.35)	LDD0631	[9]
LDCM0315	AC52	HCT 116	C225(0.90); C380(1.32)	LDD0632	[9]
LDCM0316	AC53	HCT 116	C225(1.01); C380(1.03)	LDD0633	[9]
LDCM0317	AC54	HCT 116	C225(0.94); C380(1.08)	LDD0634	[9]
LDCM0318	AC55	HCT 116	C225(1.15); C380(1.18)	LDD0635	[9]
LDCM0319	AC56	HCT 116	C225(1.12); C380(1.28)	LDD0636	[9]
LDCM0320	AC57	HCT 116	C225(1.09); C380(1.47)	LDD0637	[9]
LDCM0321	AC58	HCT 116	C225(1.03); C380(1.57)	LDD0638	[9]
LDCM0322	AC59	HCT 116	C225(1.11); C380(1.65)	LDD0639	[9]
LDCM0323	AC6	HCT 116	C225(0.86); C380(1.03)	LDD0640	[9]
LDCM0324	AC60	HCT 116	C225(1.10); C380(1.54)	LDD0641	[9]
LDCM0325	AC61	HCT 116	C225(1.01); C380(1.32)	LDD0642	[9]
LDCM0326	AC62	HCT 116	C225(1.39); C380(1.75)	LDD0643	[9]
LDCM0327	AC63	HCT 116	C225(1.07); C380(1.43)	LDD0644	[9]
LDCM0328	AC64	HCT 116	C225(1.29); C380(1.94)	LDD0645	[9]
LDCM0329	AC65	HCT 116	C225(1.53); C380(2.08)	LDD0646	[9]
LDCM0330	AC66	HCT 116	C225(1.37); C380(1.91)	LDD0647	[9]
LDCM0331	AC67	HCT 116	C225(1.34); C380(2.20)	LDD0648	[9]
LDCM0332	AC68	HCT 116	C380(1.03)	LDD0649	[9]
LDCM0333	AC69	HCT 116	C380(0.62)	LDD0650	[9]
LDCM0334	AC7	HCT 116	C225(0.87); C380(0.97)	LDD0651	[9]
LDCM0335	AC70	HCT 116	C380(0.66)	LDD0652	[9]
LDCM0336	AC71	HCT 116	C380(0.59)	LDD0653	[9]
LDCM0337	AC72	HCT 116	C380(0.74)	LDD0654	[9]
LDCM0338	AC73	HCT 116	C380(0.75)	LDD0655	[9]
LDCM0339	AC74	HCT 116	C380(0.58)	LDD0656	[9]
LDCM0340	AC75	HCT 116	C380(0.80)	LDD0657	[9]
LDCM0341	AC76	HCT 116	C380(0.67)	LDD0658	[9]
LDCM0342	AC77	HCT 116	C380(0.86)	LDD0659	[9]
LDCM0343	AC78	HCT 116	C380(0.80)	LDD0660	[9]
LDCM0344	AC79	HCT 116	C380(0.71)	LDD0661	[9]
LDCM0345	AC8	HCT 116	C225(0.94); C380(1.04)	LDD0662	[9]
LDCM0346	AC80	HCT 116	C380(0.71)	LDD0663	[9]
LDCM0347	AC81	HCT 116	C380(0.62)	LDD0664	[9]
LDCM0348	AC82	HCT 116	C380(0.75)	LDD0665	[9]
LDCM0349	AC83	HEK-293T	C380(0.72)	LDD0947	[9]
LDCM0350	AC84	HEK-293T	C380(0.87)	LDD0948	[9]
LDCM0351	AC85	HEK-293T	C380(1.26)	LDD0949	[9]
LDCM0352	AC86	HEK-293T	C380(0.69)	LDD0950	[9]
LDCM0353	AC87	HEK-293T	C380(0.89)	LDD0951	[9]
LDCM0354	AC88	HEK-293T	C380(0.91)	LDD0952	[9]
LDCM0355	AC89	HEK-293T	C380(1.10)	LDD0953	[9]
LDCM0357	AC90	HEK-293T	C380(0.94)	LDD0955	[9]
LDCM0358	AC91	HEK-293T	C380(0.70)	LDD0956	[9]
LDCM0359	AC92	HEK-293T	C380(0.58)	LDD0957	[9]
LDCM0360	AC93	HEK-293T	C380(2.32)	LDD0958	[9]
LDCM0361	AC94	HEK-293T	C380(0.60)	LDD0959	[9]
LDCM0362	AC95	HEK-293T	C380(0.68)	LDD0960	[9]
LDCM0363	AC96	HEK-293T	C380(1.22)	LDD0961	[9]
LDCM0364	AC97	HEK-293T	C380(0.62)	LDD0962	[9]
LDCM0365	AC98	HEK-293T	C225(0.92); C380(1.05)	LDD0963	[9]
LDCM0366	AC99	HEK-293T	C225(0.93); C380(0.95)	LDD0964	[9]
LDCM0248	AKOS034007472	HCT 116	C225(0.76); C380(0.94)	LDD0565	[9]
LDCM0356	AKOS034007680	HCT 116	C225(0.78); C380(1.04)	LDD0673	[9]
LDCM0275	AKOS034007705	HCT 116	C225(0.98); C380(1.51)	LDD0592	[9]
LDCM0156	Aniline	NCI-H1299	11.61	LDD0403	[1]
LDCM0020	ARS-1620	HCC44	C380(1.03)	LDD0078	[9]
LDCM0087	Capsaicin	HEK-293T	36.13	LDD0185	[13]
LDCM0108	Chloroacetamide	HeLa	N.A.	LDD0222	[8]
LDCM0632	CL-Sc	Hep-G2	C225(20.00)	LDD2227	[11]
LDCM0367	CL1	HCT 116	C225(0.98); C380(0.99)	LDD0684	[9]
LDCM0368	CL10	HCT 116	C225(1.10); C380(1.17)	LDD0685	[9]
LDCM0369	CL100	HCT 116	C225(1.24); C380(1.54)	LDD0686	[9]
LDCM0370	CL101	HCT 116	C225(0.94); C380(1.07)	LDD0687	[9]
LDCM0371	CL102	HCT 116	C225(0.72); C380(1.04)	LDD0688	[9]
LDCM0372	CL103	HCT 116	C225(0.75); C380(1.00)	LDD0689	[9]
LDCM0373	CL104	HCT 116	C225(0.81); C380(1.04)	LDD0690	[9]
LDCM0374	CL105	HCT 116	C380(1.06)	LDD0691	[9]
LDCM0375	CL106	HCT 116	C380(1.38)	LDD0692	[9]
LDCM0376	CL107	HCT 116	C380(1.27)	LDD0693	[9]
LDCM0377	CL108	HCT 116	C380(1.26)	LDD0694	[9]
LDCM0378	CL109	HCT 116	C380(1.28)	LDD0695	[9]
LDCM0379	CL11	HCT 116	C380(0.87); C225(1.04)	LDD0696	[9]
LDCM0380	CL110	HCT 116	C380(1.78)	LDD0697	[9]
LDCM0381	CL111	HCT 116	C380(1.05)	LDD0698	[9]
LDCM0382	CL112	HCT 116	C380(0.92); C225(1.24)	LDD0699	[9]
LDCM0383	CL113	HCT 116	C380(1.02); C225(1.33)	LDD0700	[9]
LDCM0384	CL114	HCT 116	C380(1.14); C225(1.29)	LDD0701	[9]
LDCM0385	CL115	HCT 116	C380(1.11); C225(1.28)	LDD0702	[9]
LDCM0386	CL116	HCT 116	C225(1.07); C380(1.08)	LDD0703	[9]
LDCM0387	CL117	HCT 116	C380(1.71)	LDD0704	[9]
LDCM0388	CL118	HCT 116	C380(0.97)	LDD0705	[9]
LDCM0389	CL119	HCT 116	C380(0.92)	LDD0706	[9]
LDCM0390	CL12	HCT 116	C225(1.06); C380(1.10)	LDD0707	[9]
LDCM0391	CL120	HCT 116	C380(0.95)	LDD0708	[9]
LDCM0392	CL121	HCT 116	C225(0.94); C380(1.08)	LDD0709	[9]
LDCM0393	CL122	HCT 116	C225(0.93); C380(1.15)	LDD0710	[9]
LDCM0394	CL123	HCT 116	C225(1.01); C380(1.26)	LDD0711	[9]
LDCM0395	CL124	HCT 116	C225(1.09); C380(1.42)	LDD0712	[9]
LDCM0396	CL125	HCT 116	C380(0.92); C225(1.01)	LDD0713	[9]
LDCM0397	CL126	HCT 116	C225(0.98); C380(1.11)	LDD0714	[9]
LDCM0398	CL127	HCT 116	C225(0.97); C380(1.25)	LDD0715	[9]
LDCM0399	CL128	HCT 116	C225(1.25); C380(1.83)	LDD0716	[9]
LDCM0400	CL13	HCT 116	C225(0.98); C380(0.98)	LDD0717	[9]
LDCM0401	CL14	HCT 116	C225(0.98); C380(1.10)	LDD0718	[9]
LDCM0402	CL15	HCT 116	C380(0.85); C225(1.17)	LDD0719	[9]
LDCM0403	CL16	HCT 116	C380(0.77); C225(1.03)	LDD0720	[9]
LDCM0404	CL17	HCT 116	C380(0.70); C225(1.25)	LDD0721	[9]
LDCM0405	CL18	HCT 116	C380(0.98); C225(1.01)	LDD0722	[9]
LDCM0406	CL19	HCT 116	C380(0.90); C225(1.06)	LDD0723	[9]
LDCM0407	CL2	HCT 116	C380(0.92); C225(1.03)	LDD0724	[9]
LDCM0408	CL20	HCT 116	C380(1.13); C225(1.26)	LDD0725	[9]
LDCM0409	CL21	HCT 116	C380(1.16); C225(1.49)	LDD0726	[9]
LDCM0410	CL22	HCT 116	C380(1.19); C225(2.05)	LDD0727	[9]
LDCM0411	CL23	HCT 116	C380(0.75); C225(1.10)	LDD0728	[9]
LDCM0412	CL24	HCT 116	C380(0.94); C225(1.28)	LDD0729	[9]
LDCM0413	CL25	HCT 116	C225(1.48); C380(0.81)	LDD0730	[9]
LDCM0414	CL26	HCT 116	C225(0.97); C380(0.68)	LDD0731	[9]
LDCM0415	CL27	HCT 116	C225(1.13); C380(1.24)	LDD0732	[9]
LDCM0416	CL28	HCT 116	C225(1.18); C380(1.03)	LDD0733	[9]
LDCM0417	CL29	HCT 116	C225(1.59); C380(0.83)	LDD0734	[9]
LDCM0418	CL3	HCT 116	C225(0.90); C380(0.95)	LDD0735	[9]
LDCM0419	CL30	HCT 116	C225(1.11); C380(0.63)	LDD0736	[9]
LDCM0420	CL31	HCT 116	C225(1.14); C380(0.77)	LDD0737	[9]
LDCM0421	CL32	HCT 116	C225(1.38)	LDD0738	[9]
LDCM0422	CL33	HCT 116	C225(1.24)	LDD0739	[9]
LDCM0423	CL34	HCT 116	C225(1.06)	LDD0740	[9]
LDCM0424	CL35	HCT 116	C225(1.01)	LDD0741	[9]
LDCM0425	CL36	HCT 116	C225(1.17)	LDD0742	[9]
LDCM0426	CL37	HCT 116	C225(1.05)	LDD0743	[9]
LDCM0428	CL39	HCT 116	C225(1.03)	LDD0745	[9]
LDCM0429	CL4	HCT 116	C225(0.99); C380(0.93)	LDD0746	[9]
LDCM0430	CL40	HCT 116	C225(1.12)	LDD0747	[9]
LDCM0431	CL41	HCT 116	C225(0.92)	LDD0748	[9]
LDCM0432	CL42	HCT 116	C225(1.00)	LDD0749	[9]
LDCM0433	CL43	HCT 116	C225(1.43)	LDD0750	[9]
LDCM0434	CL44	HCT 116	C225(0.93)	LDD0751	[9]
LDCM0435	CL45	HCT 116	C225(1.26)	LDD0752	[9]
LDCM0436	CL46	HCT 116	C225(1.00)	LDD0753	[9]
LDCM0437	CL47	HCT 116	C225(1.25)	LDD0754	[9]
LDCM0438	CL48	HCT 116	C225(1.00)	LDD0755	[9]
LDCM0439	CL49	HCT 116	C225(0.96)	LDD0756	[9]
LDCM0440	CL5	HCT 116	C225(0.88); C380(0.91)	LDD0757	[9]
LDCM0441	CL50	HCT 116	C225(0.94)	LDD0758	[9]
LDCM0442	CL51	HCT 116	C225(1.08)	LDD0759	[9]
LDCM0443	CL52	HCT 116	C225(1.35)	LDD0760	[9]
LDCM0444	CL53	HCT 116	C225(0.89)	LDD0761	[9]
LDCM0445	CL54	HCT 116	C225(1.05)	LDD0762	[9]
LDCM0446	CL55	HCT 116	C225(0.91)	LDD0763	[9]
LDCM0447	CL56	HCT 116	C225(1.01)	LDD0764	[9]
LDCM0448	CL57	HCT 116	C225(0.83)	LDD0765	[9]
LDCM0449	CL58	HCT 116	C225(1.02)	LDD0766	[9]
LDCM0450	CL59	HCT 116	C225(0.85)	LDD0767	[9]
LDCM0451	CL6	HCT 116	C225(0.98); C380(1.06)	LDD0768	[9]
LDCM0452	CL60	HCT 116	C225(1.18)	LDD0769	[9]
LDCM0453	CL61	HCT 116	C225(0.97)	LDD0770	[9]
LDCM0454	CL62	HCT 116	C225(1.16)	LDD0771	[9]
LDCM0455	CL63	HCT 116	C225(0.93)	LDD0772	[9]
LDCM0456	CL64	HCT 116	C225(0.88)	LDD0773	[9]
LDCM0457	CL65	HCT 116	C225(0.97)	LDD0774	[9]
LDCM0458	CL66	HCT 116	C225(0.87)	LDD0775	[9]
LDCM0459	CL67	HCT 116	C225(0.82)	LDD0776	[9]
LDCM0460	CL68	HCT 116	C225(0.84)	LDD0777	[9]
LDCM0461	CL69	HCT 116	C225(0.90)	LDD0778	[9]
LDCM0462	CL7	HCT 116	C225(0.97); C380(1.12)	LDD0779	[9]
LDCM0463	CL70	HCT 116	C225(0.86)	LDD0780	[9]
LDCM0464	CL71	HCT 116	C225(0.97)	LDD0781	[9]
LDCM0465	CL72	HCT 116	C225(0.91)	LDD0782	[9]
LDCM0466	CL73	HCT 116	C225(0.90)	LDD0783	[9]
LDCM0467	CL74	HCT 116	C225(0.90)	LDD0784	[9]
LDCM0469	CL76	HCT 116	C225(1.12)	LDD0786	[9]
LDCM0470	CL77	HCT 116	C225(1.05)	LDD0787	[9]
LDCM0471	CL78	HCT 116	C225(1.04)	LDD0788	[9]
LDCM0472	CL79	HCT 116	C225(1.04)	LDD0789	[9]
LDCM0473	CL8	HCT 116	C225(1.63); C380(0.79)	LDD0790	[9]
LDCM0474	CL80	HCT 116	C225(0.99)	LDD0791	[9]
LDCM0475	CL81	HCT 116	C225(1.17)	LDD0792	[9]
LDCM0476	CL82	HCT 116	C225(1.36)	LDD0793	[9]
LDCM0477	CL83	HCT 116	C225(1.23)	LDD0794	[9]
LDCM0478	CL84	HCT 116	C225(1.25)	LDD0795	[9]
LDCM0479	CL85	HCT 116	C225(1.13)	LDD0796	[9]
LDCM0480	CL86	HCT 116	C225(0.96)	LDD0797	[9]
LDCM0481	CL87	HCT 116	C225(1.01)	LDD0798	[9]
LDCM0482	CL88	HCT 116	C225(1.17)	LDD0799	[9]
LDCM0483	CL89	HCT 116	C225(1.48)	LDD0800	[9]
LDCM0484	CL9	HCT 116	C225(0.90); C380(0.98)	LDD0801	[9]
LDCM0485	CL90	HCT 116	C225(1.23)	LDD0802	[9]
LDCM0486	CL91	HCT 116	C225(1.21); C380(1.12)	LDD0803	[9]
LDCM0487	CL92	HCT 116	C225(1.13); C380(1.02)	LDD0804	[9]
LDCM0488	CL93	HCT 116	C225(1.11); C380(1.20)	LDD0805	[9]
LDCM0489	CL94	HCT 116	C225(1.11); C380(1.56)	LDD0806	[9]
LDCM0490	CL95	HCT 116	C225(1.06); C380(1.18)	LDD0807	[9]
LDCM0491	CL96	HCT 116	C225(1.11); C380(1.40)	LDD0808	[9]
LDCM0492	CL97	HCT 116	C225(1.10); C380(1.31)	LDD0809	[9]
LDCM0493	CL98	HCT 116	C225(1.14); C380(1.21)	LDD0810	[9]
LDCM0494	CL99	HCT 116	C225(1.08); C380(1.24)	LDD0811	[9]
LDCM0634	CY-0357	Hep-G2	C380(50.00)	LDD2228	[11]
LDCM0028	Dobutamine	HEK-293T	24.48	LDD0180	[13]
LDCM0027	Dopamine	HEK-293T	4.86	LDD0179	[13]
LDCM0495	E2913	HEK-293T	C380(0.95); C225(0.97); C232(1.04)	LDD1698	[23]
LDCM0031	Epigallocatechin gallate	HEK-293T	4.24	LDD0183	[13]
LDCM0576	Fragment14	Ramos	C380(1.40)	LDD2193	[24]
LDCM0468	Fragment33	HCT 116	C225(1.07)	LDD0785	[9]
LDCM0566	Fragment4	Ramos	C380(1.54)	LDD2184	[24]
LDCM0427	Fragment51	HCT 116	C225(5.05)	LDD0744	[9]
LDCM0022	KB02	HCT 116	C380(2.48)	LDD0080	[9]
LDCM0023	KB03	HCT 116	C380(1.18)	LDD0081	[9]
LDCM0024	KB05	HCT 116	C380(1.89)	LDD0082	[9]
LDCM0506	Nucleophilic fragment 16a	MDA-MB-231	C535(0.95)	LDD2099	[5]
LDCM0516	Nucleophilic fragment 21a	MDA-MB-231	C535(0.90)	LDD2109	[5]
LDCM0534	Nucleophilic fragment 30a	MDA-MB-231	C535(1.03)	LDD2127	[5]
LDCM0544	Nucleophilic fragment 39	MDA-MB-231	C380(1.22)	LDD2137	[5]
LDCM0546	Nucleophilic fragment 40	MDA-MB-231	C535(0.70)	LDD2140	[5]
LDCM0550	Nucleophilic fragment 5a	MDA-MB-231	C535(1.55)	LDD2144	[5]
LDCM0554	Nucleophilic fragment 7a	MDA-MB-231	C535(0.62)	LDD2148	[5]
LDCM0014	Panhematin	HEK-293T	3.20	LDD0062	[7]
LDCM0029	Quercetin	HEK-293T	23.84	LDD0181	[13]
LDCM0131	RA190	MM1.R	C380(1.34)	LDD0304	[25]
LDCM0084	Ro 48-8071	A-549	3.86	LDD0145	[21]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme

Click To Hide/Show 2 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Cytochrome P450 4F2 (CYP4F2)				Cytochrome P450 family	P78329
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C)				V-ATPase proteolipid subunit family	P27449

Transporter and channel

Click To Hide/Show 2 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Endophilin-B1 (SH3GLB1)				Endophilin family	Q9Y371
Proteolipid protein 2 (PLP2)				.	Q04941

Cytokine and receptor

Click To Hide/Show 2 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7)				Chemokine-like factor family	Q96FZ5
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C)				.	O14798

Other

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Alpha-1-antichymotrypsin (SERPINA3)				Serpin family	P01011

References

1	Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2	Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1. Mass spectrometry data entry: PXD018580
3	Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4	A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10. Mass spectrometry data entry: PXD028270
5	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
6	Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z. Mass spectrometry data entry: PXD044625
7	A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12. Mass spectrometry data entry: PXD034651
8	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
12	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13	A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16. Mass spectrometry data entry: PXD043348
14	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
15	Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
16	DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22. Mass spectrometry data entry: PXD033004
17	Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18	Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
20	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21	A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
22	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
23	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
24	Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7. Mass spectrometry data entry: PXD027578
25	Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.

Details of the Target

Citation

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Correspondence

Prof. Feng Zhu

Prof. Feng Ni