Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name DA-P3  Probe Info 
Probe concentration 15 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name Dopamine  Competitor Info 
Competitor Concentration 450 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 60 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12218  Sentrin-specific protease 2 (SENP2) 26.1
 LDTP03679  Dual specificity protein kinase TTK (TTK) 21.0
 LDTP07266  ORC ubiquitin ligase 1 (OBI1) 20.7
 LDTP10930  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) 20.6
 LDTP06713  DNA excision repair protein ERCC-6-like (ERCC6L) 20.6
 LDTP01004  Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) 16.0
 LDTP09792  Inositol hexakisphosphate kinase 1 (IP6K1) 14.6
 LDTP00968  Acyl-CoA (8-3)-desaturase (FADS1) 14.2
 LDTP01164  Gamma-glutamylcyclotransferase (GGCT) 13.8
 LDTP05228  Calcium-transporting ATPase type 2C member 1 (ATP2C1) 13.4
 LDTP04435  Interleukin-1 receptor-associated kinase 1 (IRAK1) 12.7
 LDTP06104  Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) 11.9
 LDTP03481  DNA-3-methyladenine glycosylase (MPG) 11.2
 LDTP02000  3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) 10.6
 LDTP19838  Immunity-related GTPase family Q protein (IRGQ) 10.4
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) 10.0
 LDTP01126  NEDD4-binding protein 1 (N4BP1) 9.8
 LDTP04261  Choline-phosphate cytidylyltransferase A (PCYT1A) 9.5
 LDTP09517  Ubiquitin carboxyl-terminal hydrolase 33 (USP33) 9.5
 LDTP00697  Cytochrome b5 type B (CYB5B) 8.8
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 8.6
 LDTP01697  3'(2'),5'-bisphosphate nucleotidase 1 (BPNT1) 8.5
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 8.4
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) 8.3
 LDTP00384  Copper chaperone for superoxide dismutase (CCS) 7.6
 LDTP03540  Heme oxygenase 2 (HMOX2) 7.5
 LDTP00497  Cyclin-G-associated kinase (GAK) 7.5
 LDTP08906  Calcium/calmodulin-dependent protein kinase kinase 1 (CAMKK1) 7.3
 LDTP00694  E3 ubiquitin-protein ligase Praja-2 (PJA2) 7.2
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 6.9
 LDTP09044  ATPase family gene 2 protein homolog A (AFG2A) 6.5
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 6.5
 LDTP08378  Serine/threonine-protein kinase VRK2 (VRK2) 6.4
 LDTP10438  tRNA N(3)-methylcytidine methyltransferase METTL2A (METTL2A) 6.2
 LDTP00837  Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) 6.1
 LDTP11601  (E3-independent) E2 ubiquitin-conjugating enzyme (UBE2O) 5.9
 LDTP15939  PITH domain-containing protein 1 (PITHD1) 5.9
 LDTP03186  E3 ubiquitin-protein ligase CBL (CBL) 5.7
 LDTP04236  Ribose-5-phosphate isomerase (RPIA) 5.6
 LDTP12312  Ras-related protein Rab-18 (RAB18) 5.3
 LDTP02770  Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) 5.3
 LDTP10935  Kinesin-like protein KIF2C (KIF2C) 5.2
 LDTP14051  Ubiquitin carboxyl-terminal hydrolase 15 (USP15) 5.1
 LDTP14065  Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5) 4.7
 LDTP00999  GDP-mannose 4,6 dehydratase (GMDS) 4.7
 LDTP06535  Serine/threonine-protein kinase N1 (PKN1) 4.7
 LDTP09058  Formylglycine-generating enzyme (SUMF1) 4.7
 LDTP04185  Glutamate--cysteine ligase catalytic subunit (GCLC) 4.6
 LDTP12599  Ubiquitin-like-conjugating enzyme ATG3 (ATG3) 4.5
 LDTP08485  Serine/threonine-protein kinase VRK3 (VRK3) 4.4
 LDTP01028  Protein arginine N-methyltransferase 3 (PRMT3) 4.4
 LDTP04620  5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) 4.4
 LDTP06145  Protein disulfide-isomerase A5 (PDIA5) 4.3
 LDTP14027  5'-AMP-activated protein kinase subunit beta-1 (PRKAB1) 4.3
 LDTP10406  Selenocysteine lyase (SCLY) 4.1
 LDTP18130  Phosphotriesterase-related protein (PTER) 4.0
 LDTP06977  GPI ethanolamine phosphate transferase 2 (PIGG) 4.0
 LDTP08084  BRCA1-associated protein (BRAP) 4.0
 LDTP13868  Fibronectin type-III domain-containing protein 3A (FNDC3A) 4.0
 LDTP11996  3'-5' RNA helicase YTHDC2 (YTHDC2) 4.0
Transporter and channel
Click to Show/Hide to Show 32 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08040  Zinc finger FYVE domain-containing protein 16 (ZFYVE16) 56.6
 LDTP13953  Endophilin-B1 (SH3GLB1) 45.3
 LDTP12191  Vezatin (VEZT) 22.8
 LDTP07203  ER membrane protein complex subunit 10 (EMC10) 17.7
 LDTP04227  Guided entry of tail-anchored proteins factor CAMLG (CAMLG) 14.7
 LDTP11609  Endoplasmic reticulum junction formation protein lunapark (LNPK) 12.7
 LDTP07152  Acyl-CoA-binding domain-containing protein 5 (ACBD5) 11.9
 LDTP06902  mRNA export factor GLE1 (GLE1) 11.2
 LDTP14068  Cysteine protease ATG4B (ATG4B) 11.1
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 9.6
 LDTP00958  TBC1 domain family member 4 (TBC1D4) 8.7
 LDTP11877  Golgi resident protein GCP60 (ACBD3) 8.5
 LDTP08881  Transmembrane protein 199 (TMEM199) 8.0
 LDTP03839  Nuclear pore glycoprotein p62 (NUP62) 7.6
 LDTP00198  Synaptosomal-associated protein 23 (SNAP23) 7.4
 LDTP11161  Extended synaptotagmin-1 (ESYT1) 7.2
 LDTP09204  Nucleoporin NUP35 (NUP35) 7.1
 LDTP12281  Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC) 6.5
 LDTP10378  Nuclear envelope pore membrane protein POM 121 (POM121) 5.6
 LDTP07002  Transport and Golgi organization protein 1 homolog (MIA3) 5.5
 LDTP01380  Wolframin (WFS1) 5.4
 LDTP04866  Protein transport protein Sec61 subunit beta (SEC61B) 5.0
 LDTP04309  Nuclear pore complex protein Nup153 (NUP153) 4.9
 LDTP13498  Nuclear pore complex protein Nup50 (NUP50) 4.9
 LDTP01051  Target of Myb1 membrane trafficking protein (TOM1) 4.8
 LDTP12292  Junctophilin-1 (JPH1) 4.7
 LDTP01133  Copine-3 (CPNE3) 4.6
 LDTP02009  Cystatin-B (CSTB) 4.5
 LDTP11732  Magnesium transporter protein 1 (MAGT1) 4.4
 LDTP13018  Stromal interaction molecule 2 (STIM2) 4.4
 LDTP05780  Syntaxin-5 (STX5) 4.3
 LDTP03905  Peroxisomal biogenesis factor 19 (PEX19) 4.3
Transcription factor
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10039  Myocardin-related transcription factor A (MRTFA) 111.8
 LDTP06748  Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) 25.8
 LDTP03043  Transcription factor BTF3 (BTF3) 13.7
 LDTP03903  Signal transducer and activator of transcription 3 (STAT3) 5.0
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 4.9
 LDTP05439  Proto-oncogene c-Rel (REL) 4.3
 LDTP05710  Nuclear factor of activated T-cells, cytoplasmic 3 (NFATC3) 4.1
 LDTP09564  Zinc finger CCCH domain-containing protein 15 (ZC3H15) 4.0
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02040  HLA class I histocompatibility antigen, A alpha chain (HLA-A) 11.9
Other
Click to Show/Hide to Show 103 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01210  Transforming acidic coiled-coil-containing protein 1 (TACC1) 92.2
 LDTP07476  RAD50-interacting protein 1 (RINT1) 52.3
 LDTP10062  Synapse-associated protein 1 (SYAP1) 37.5
 LDTP12412  Reticulon-4 (RTN4) 36.6
 LDTP19787  RING finger protein 214 (RNF214) 32.5
 LDTP08795  GH3 domain-containing protein (GHDC) 31.5
 LDTP03079  Calpastatin (CAST) 31.0
 LDTP05655  A-kinase anchor protein 13 (AKAP13) 28.6
 LDTP08950  ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) 25.8
 LDTP13402  Dynactin subunit 4 (DCTN4) 22.5
 LDTP08588  Spindle and kinetochore-associated protein 3 (SKA3) 22.4
 LDTP01177  Hyaluronan mediated motility receptor (HMMR) 21.2
 LDTP01684  BAG family molecular chaperone regulator 3 (BAG3) 20.1
 LDTP16116  BSD domain-containing protein 1 (BSDC1) 19.6
 LDTP13241  LIM domain-containing protein 1 (LIMD1) 19.4
 LDTP12596  Protein diaphanous homolog 3 (DIAPH3) 17.9
 LDTP01522  Reticulon-3 (RTN3) 15.2
 LDTP13414  ADP-ribosylation factor-binding protein GGA2 (GGA2) 15.2
 LDTP07345  Cell division cycle-associated protein 2 (CDCA2) 15.0
 LDTP01637  Pericentrin (PCNT) 14.4
 LDTP04112  Microtubule-associated protein 1B (MAP1B) 14.4
 LDTP07864  Syntaxin-binding protein 4 (STXBP4) 14.3
 LDTP09242  Kinetochore scaffold 1 (KNL1) 14.2
 LDTP13922  Tudor and KH domain-containing protein (TDRKH) 14.0
 LDTP09820  La-related protein 4B (LARP4B) 13.4
 LDTP10753  Sperm-associated antigen 5 (SPAG5) 12.7
 LDTP09806  UBX domain-containing protein 4 (UBXN4) 12.5
 LDTP09215  Torsin-1A-interacting protein 2 (TOR1AIP2) 12.3
 LDTP07598  BRCA1-associated ATM activator 1 (BRAT1) 12.3
 LDTP03426  Protein ITPRID2 (ITPRID2) 12.2
 LDTP05557  Golgin subfamily A member 2 (GOLGA2) 11.8
 LDTP01683  BAG family molecular chaperone regulator 2 (BAG2) 11.2
 LDTP14228  Transforming acidic coiled-coil-containing protein 3 (TACC3) 11.1
 LDTP00493  Calmegin (CLGN) 10.7
 LDTP14910  MAP7 domain-containing protein 1 (MAP7D1) 10.3
 LDTP12948  Charged multivesicular body protein 5 (CHMP5) 10.2
 LDTP12306  ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3) 10.2
 LDTP01021  Perilipin-3 (PLIN3) 10.0
 LDTP11597  182 kDa tankyrase-1-binding protein (TNKS1BP1) 9.4
 LDTP14259  Testis-expressed protein 264 (TEX264) 9.2
 LDTP16285  Transducin beta-like protein 2 (TBL2) 8.7
 LDTP00229  Copper transport protein ATOX1 (ATOX1) 8.2
 LDTP07509  Protein FAM117B (FAM117B) 8.2
 LDTP01155  Ankyrin repeat domain-containing protein 17 (ANKRD17) 8.2
 LDTP07297  Microtubule-associated protein 1S (MAP1S) 8.2
 LDTP13439  A-kinase anchor protein 11 (AKAP11) 7.6
 LDTP00473  Protein lin-7 homolog A (LIN7A) 7.5
 LDTP08735  Spartin (SPART) 7.5
 LDTP07742  Rab11 family-interacting protein 1 (RAB11FIP1) 7.4
 LDTP19626  Glucocorticoid-induced transcript 1 protein (GLCCI1) 7.2
 LDTP08634  Cytoskeleton-associated protein 2-like (CKAP2L) 7.2
 LDTP15727  Protein LTV1 homolog (LTV1) 6.9
 LDTP02263  Signal recognition particle receptor subunit alpha (SRPRA) 6.6
 LDTP07124  Rho GTPase-activating protein 21 (ARHGAP21) 6.6
 LDTP07522  Centrosomal protein of 85 kDa (CEP85) 6.5
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) 6.4
 LDTP06515  Coiled-coil domain-containing protein 6 (CCDC6) 6.4
 LDTP07575  Protein aurora borealis (BORA) 6.3
 LDTP07061  Synaptosomal-associated protein 47 (SNAP47) 6.3
 LDTP00019  Shootin-1 (SHTN1) 6.2
 LDTP12443  Anillin (ANLN) 6.1
 LDTP15899  Kanadaptin (SLC4A1AP) 6.1
 LDTP00737  Centriolar coiled-coil protein of 110 kDa (CCP110) 6.1
 LDTP09837  A-kinase anchor protein 1, mitochondrial (AKAP1) 6.0
 LDTP01914  Putative HLA class I histocompatibility antigen, alpha chain H (HLA-H) 6.0
 LDTP14217  Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) 5.9
 LDTP10849  Regulator of microtubule dynamics protein 3 (RMDN3) 5.9
 LDTP07658  Spindle assembly abnormal protein 6 homolog (SASS6) 5.8
 LDTP12791  BTB/POZ domain-containing protein KCTD5 (KCTD5) 5.8
 LDTP15840  Tetratricopeptide repeat protein 1 (TTC1) 5.8
 LDTP03404  Microtubule-associated protein 4 (MAP4) 5.7
 LDTP02230  Laminin subunit beta-1 (LAMB1) 5.6
 LDTP12640  Gamma-taxilin (TXLNG) 5.6
 LDTP13913  Inner nuclear membrane protein Man1 (LEMD3) 5.4
 LDTP13323  Multifunctional methyltransferase subunit TRM112-like protein (TRMT112) 5.3
 LDTP08535  MAP7 domain-containing protein 3 (MAP7D3) 5.3
 LDTP16155  Opioid growth factor receptor (OGFR) 5.2
 LDTP02605  Collagen alpha-1(VI) chain (COL6A1) 5.2
 LDTP11019  Endophilin-A2 (SH3GL1) 5.2
 LDTP10834  RUN and FYVE domain-containing protein 1 (RUFY1) 5.0
 LDTP12025  UPF0488 protein C8orf33 (C8orf33) 5.0
 LDTP04092  Crk-like protein (CRKL) 4.9
 LDTP09128  EH domain-binding protein 1 (EHBP1) 4.8
 LDTP06254  Sarcolemmal membrane-associated protein (SLMAP) 4.7
 LDTP13269  Cysteine and histidine-rich domain-containing protein 1 (CHORDC1) 4.7
 LDTP16080  Protein FAM114A2 (FAM114A2) 4.6
 LDTP13978  Ubiquitin-fold modifier-conjugating enzyme 1 (UFC1) 4.6
 LDTP00916  Protein ZNRD2 (ZNRD2) 4.6
 LDTP09118  SLAIN motif-containing protein 1 (SLAIN1) 4.6
 LDTP14884  Protein Shroom1 (SHROOM1) 4.4
 LDTP06051  Kelch-like ECH-associated protein 1 (KEAP1) 4.3
 LDTP06378  Disks large-associated protein 5 (DLGAP5) 4.3
 LDTP09363  TBC1 domain family member 15 (TBC1D15) 4.3
 LDTP00512  Protein transport protein Sec16A (SEC16A) 4.2
 LDTP13519  Proteasome activator complex subunit 2 (PSME2) 4.2
 LDTP03151  Oxysterol-binding protein 1 (OSBP) 4.2
 LDTP11539  Regulator of nonsense transcripts 3B (UPF3B) 4.2
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) 4.2
 LDTP17648  UPF0688 protein C1orf174 (C1orf174) 4.1
 LDTP08069  HAUS augmin-like complex subunit 6 (HAUS6) 4.1
 LDTP06268  Condensin complex subunit 2 (NCAPH) 4.1
 LDTP10251  Protein Spindly (SPDL1) 4.1
 LDTP14104  NEDD8 ultimate buster 1 (NUB1) 4.1

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348