Details of the Target
General Information of Target
Target ID | LDTP00473 | |||||
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Target Name | Protein lin-7 homolog A (LIN7A) | |||||
Gene Name | LIN7A | |||||
Gene ID | 8825 | |||||
Synonyms |
MALS1; VELI1; Protein lin-7 homolog A; Lin-7A; hLin-7; Mammalian lin-seven protein 1; MALS-1; Tax interaction protein 33; TIP-33; Vertebrate lin-7 homolog 1; Veli-1 |
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3D Structure | ||||||
Sequence |
MLKPSVTSAPTADMATLTVVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSE
FCTAIREVYQYMHETITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGF NVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKD SVKLVVRYTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQQTQQNHMS |
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Target Bioclass |
Other
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Family |
Lin-7 family
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Subcellular location |
Cell membrane
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Function |
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
---|---|---|---|---|---|
Probe 1 Probe Info |
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Y133(6.75) | LDD3495 | [1] | |
DBIA Probe Info |
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C62(2.27) | LDD3456 | [2] | |
DA-P3 Probe Info |
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7.52 | LDD0179 | [3] | |
m-APA Probe Info |
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N.A. | LDD2231 | [4] | |
IA-alkyne Probe Info |
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C81(0.00); C62(0.00) | LDD0165 | [5] | |
NAIA_5 Probe Info |
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N.A. | LDD2224 | [6] | |
IPM Probe Info |
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C62(0.00); C81(0.00) | LDD2156 | [7] | |
Phosphinate-6 Probe Info |
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N.A. | LDD0018 | [8] | |
AOyne Probe Info |
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15.00 | LDD0443 | [9] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
---|---|---|---|---|---|
LDCM0214 | AC1 | HEK-293T | C81(0.94) | LDD1507 | [10] |
LDCM0215 | AC10 | HEK-293T | C81(1.07) | LDD1508 | [10] |
LDCM0226 | AC11 | HEK-293T | C81(1.14) | LDD1509 | [10] |
LDCM0237 | AC12 | HEK-293T | C81(1.08) | LDD1510 | [10] |
LDCM0259 | AC14 | HEK-293T | C62(0.95); C81(1.01) | LDD1512 | [10] |
LDCM0270 | AC15 | HEK-293T | C81(0.94) | LDD1513 | [10] |
LDCM0276 | AC17 | HEK-293T | C81(1.06) | LDD1515 | [10] |
LDCM0277 | AC18 | HEK-293T | C81(0.98) | LDD1516 | [10] |
LDCM0278 | AC19 | HEK-293T | C81(1.17) | LDD1517 | [10] |
LDCM0279 | AC2 | HEK-293T | C81(1.00) | LDD1518 | [10] |
LDCM0280 | AC20 | HEK-293T | C81(1.00) | LDD1519 | [10] |
LDCM0281 | AC21 | HEK-293T | C81(0.94) | LDD1520 | [10] |
LDCM0282 | AC22 | HEK-293T | C62(1.09); C81(1.05) | LDD1521 | [10] |
LDCM0283 | AC23 | HEK-293T | C81(0.91) | LDD1522 | [10] |
LDCM0284 | AC24 | HEK-293T | C81(0.98) | LDD1523 | [10] |
LDCM0285 | AC25 | HEK-293T | C81(1.12) | LDD1524 | [10] |
LDCM0286 | AC26 | HEK-293T | C81(1.05) | LDD1525 | [10] |
LDCM0287 | AC27 | HEK-293T | C81(1.12) | LDD1526 | [10] |
LDCM0288 | AC28 | HEK-293T | C81(1.01) | LDD1527 | [10] |
LDCM0289 | AC29 | HEK-293T | C81(1.03) | LDD1528 | [10] |
LDCM0290 | AC3 | HEK-293T | C81(1.02) | LDD1529 | [10] |
LDCM0291 | AC30 | HEK-293T | C62(1.14); C81(1.01) | LDD1530 | [10] |
LDCM0292 | AC31 | HEK-293T | C81(1.03) | LDD1531 | [10] |
LDCM0293 | AC32 | HEK-293T | C81(0.91) | LDD1532 | [10] |
LDCM0294 | AC33 | HEK-293T | C81(1.02) | LDD1533 | [10] |
LDCM0295 | AC34 | HEK-293T | C81(1.06) | LDD1534 | [10] |
LDCM0296 | AC35 | HEK-293T | C81(1.09) | LDD1535 | [10] |
LDCM0297 | AC36 | HEK-293T | C81(1.00) | LDD1536 | [10] |
LDCM0298 | AC37 | HEK-293T | C81(1.02) | LDD1537 | [10] |
LDCM0299 | AC38 | HEK-293T | C62(1.19); C81(0.99) | LDD1538 | [10] |
LDCM0300 | AC39 | HEK-293T | C81(1.01) | LDD1539 | [10] |
LDCM0301 | AC4 | HEK-293T | C81(1.00) | LDD1540 | [10] |
LDCM0302 | AC40 | HEK-293T | C81(1.02) | LDD1541 | [10] |
LDCM0303 | AC41 | HEK-293T | C81(1.15) | LDD1542 | [10] |
LDCM0304 | AC42 | HEK-293T | C81(1.10) | LDD1543 | [10] |
LDCM0305 | AC43 | HEK-293T | C81(1.11) | LDD1544 | [10] |
LDCM0306 | AC44 | HEK-293T | C81(1.09) | LDD1545 | [10] |
LDCM0307 | AC45 | HEK-293T | C81(1.16) | LDD1546 | [10] |
LDCM0308 | AC46 | HEK-293T | C62(1.00); C81(1.01) | LDD1547 | [10] |
LDCM0309 | AC47 | HEK-293T | C81(1.06) | LDD1548 | [10] |
LDCM0310 | AC48 | HEK-293T | C81(1.08) | LDD1549 | [10] |
LDCM0311 | AC49 | HEK-293T | C81(1.03) | LDD1550 | [10] |
LDCM0312 | AC5 | HEK-293T | C81(0.91) | LDD1551 | [10] |
LDCM0313 | AC50 | HEK-293T | C81(1.03) | LDD1552 | [10] |
LDCM0314 | AC51 | HEK-293T | C81(1.12) | LDD1553 | [10] |
LDCM0315 | AC52 | HEK-293T | C81(1.10) | LDD1554 | [10] |
LDCM0316 | AC53 | HEK-293T | C81(0.98) | LDD1555 | [10] |
LDCM0317 | AC54 | HEK-293T | C62(0.99); C81(1.03) | LDD1556 | [10] |
LDCM0318 | AC55 | HEK-293T | C81(0.92) | LDD1557 | [10] |
LDCM0319 | AC56 | HEK-293T | C81(1.03) | LDD1558 | [10] |
LDCM0320 | AC57 | HEK-293T | C81(1.10) | LDD1559 | [10] |
LDCM0321 | AC58 | HEK-293T | C81(1.01) | LDD1560 | [10] |
LDCM0322 | AC59 | HEK-293T | C81(1.15) | LDD1561 | [10] |
LDCM0323 | AC6 | HEK-293T | C62(1.00); C81(0.97) | LDD1562 | [10] |
LDCM0324 | AC60 | HEK-293T | C81(0.96) | LDD1563 | [10] |
LDCM0325 | AC61 | HEK-293T | C81(0.96) | LDD1564 | [10] |
LDCM0326 | AC62 | HEK-293T | C62(0.95); C81(1.03) | LDD1565 | [10] |
LDCM0327 | AC63 | HEK-293T | C81(0.92) | LDD1566 | [10] |
LDCM0328 | AC64 | HEK-293T | C81(0.93) | LDD1567 | [10] |
LDCM0334 | AC7 | HEK-293T | C81(0.96) | LDD1568 | [10] |
LDCM0345 | AC8 | HEK-293T | C81(0.92) | LDD1569 | [10] |
LDCM0248 | AKOS034007472 | HEK-293T | C81(0.91) | LDD1511 | [10] |
LDCM0356 | AKOS034007680 | HEK-293T | C81(0.98) | LDD1570 | [10] |
LDCM0275 | AKOS034007705 | HEK-293T | C81(0.97) | LDD1514 | [10] |
LDCM0367 | CL1 | HEK-293T | C62(0.84); C81(1.14) | LDD1571 | [10] |
LDCM0368 | CL10 | HEK-293T | C62(0.81); C81(1.89) | LDD1572 | [10] |
LDCM0369 | CL100 | HEK-293T | C81(1.04) | LDD1573 | [10] |
LDCM0370 | CL101 | HEK-293T | C62(1.12); C81(1.01) | LDD1574 | [10] |
LDCM0371 | CL102 | HEK-293T | C81(1.04) | LDD1575 | [10] |
LDCM0372 | CL103 | HEK-293T | C81(1.00) | LDD1576 | [10] |
LDCM0373 | CL104 | HEK-293T | C81(0.96) | LDD1577 | [10] |
LDCM0374 | CL105 | HEK-293T | C62(0.99); C81(1.12) | LDD1578 | [10] |
LDCM0375 | CL106 | HEK-293T | C81(0.99) | LDD1579 | [10] |
LDCM0376 | CL107 | HEK-293T | C81(0.98) | LDD1580 | [10] |
LDCM0377 | CL108 | HEK-293T | C81(1.01) | LDD1581 | [10] |
LDCM0378 | CL109 | HEK-293T | C62(0.99); C81(1.04) | LDD1582 | [10] |
LDCM0379 | CL11 | HEK-293T | C81(0.91) | LDD1583 | [10] |
LDCM0380 | CL110 | HEK-293T | C81(1.06) | LDD1584 | [10] |
LDCM0381 | CL111 | HEK-293T | C81(0.89) | LDD1585 | [10] |
LDCM0382 | CL112 | HEK-293T | C81(0.99) | LDD1586 | [10] |
LDCM0383 | CL113 | HEK-293T | C62(0.98); C81(1.02) | LDD1587 | [10] |
LDCM0384 | CL114 | HEK-293T | C81(1.12) | LDD1588 | [10] |
LDCM0385 | CL115 | HEK-293T | C81(1.16) | LDD1589 | [10] |
LDCM0386 | CL116 | HEK-293T | C81(1.10) | LDD1590 | [10] |
LDCM0387 | CL117 | HEK-293T | C62(1.01); C81(0.95) | LDD1591 | [10] |
LDCM0388 | CL118 | HEK-293T | C81(0.95) | LDD1592 | [10] |
LDCM0389 | CL119 | HEK-293T | C81(1.12) | LDD1593 | [10] |
LDCM0390 | CL12 | HEK-293T | C81(1.15) | LDD1594 | [10] |
LDCM0391 | CL120 | HEK-293T | C81(1.09) | LDD1595 | [10] |
LDCM0392 | CL121 | HEK-293T | C62(0.98); C81(0.98) | LDD1596 | [10] |
LDCM0393 | CL122 | HEK-293T | C81(0.90) | LDD1597 | [10] |
LDCM0394 | CL123 | HEK-293T | C81(1.25) | LDD1598 | [10] |
LDCM0395 | CL124 | HEK-293T | C81(1.05) | LDD1599 | [10] |
LDCM0396 | CL125 | HEK-293T | C62(1.02); C81(0.87) | LDD1600 | [10] |
LDCM0397 | CL126 | HEK-293T | C81(1.05) | LDD1601 | [10] |
LDCM0398 | CL127 | HEK-293T | C81(1.08) | LDD1602 | [10] |
LDCM0399 | CL128 | HEK-293T | C81(0.98) | LDD1603 | [10] |
LDCM0400 | CL13 | HEK-293T | C62(1.11); C81(1.55) | LDD1604 | [10] |
LDCM0401 | CL14 | HEK-293T | C81(0.99) | LDD1605 | [10] |
LDCM0402 | CL15 | HEK-293T | C81(1.14) | LDD1606 | [10] |
LDCM0403 | CL16 | HEK-293T | C81(1.02) | LDD1607 | [10] |
LDCM0404 | CL17 | HEK-293T | C81(0.98) | LDD1608 | [10] |
LDCM0405 | CL18 | HEK-293T | C81(0.96) | LDD1609 | [10] |
LDCM0406 | CL19 | HEK-293T | C81(1.01) | LDD1610 | [10] |
LDCM0407 | CL2 | HEK-293T | C81(0.99) | LDD1611 | [10] |
LDCM0408 | CL20 | HEK-293T | C81(0.97) | LDD1612 | [10] |
LDCM0409 | CL21 | HEK-293T | C81(1.26) | LDD1613 | [10] |
LDCM0410 | CL22 | HEK-293T | C62(1.02); C81(1.11) | LDD1614 | [10] |
LDCM0411 | CL23 | HEK-293T | C81(0.99) | LDD1615 | [10] |
LDCM0412 | CL24 | HEK-293T | C81(1.02) | LDD1616 | [10] |
LDCM0413 | CL25 | HEK-293T | C62(0.91); C81(1.00) | LDD1617 | [10] |
LDCM0414 | CL26 | HEK-293T | C81(0.95) | LDD1618 | [10] |
LDCM0415 | CL27 | HEK-293T | C81(0.98) | LDD1619 | [10] |
LDCM0416 | CL28 | HEK-293T | C81(1.02) | LDD1620 | [10] |
LDCM0417 | CL29 | HEK-293T | C81(1.00) | LDD1621 | [10] |
LDCM0418 | CL3 | HEK-293T | C81(1.08) | LDD1622 | [10] |
LDCM0419 | CL30 | HEK-293T | C81(0.95) | LDD1623 | [10] |
LDCM0420 | CL31 | HEK-293T | C81(1.09) | LDD1624 | [10] |
LDCM0421 | CL32 | HEK-293T | C81(0.93) | LDD1625 | [10] |
LDCM0422 | CL33 | HEK-293T | C81(1.53) | LDD1626 | [10] |
LDCM0423 | CL34 | HEK-293T | C62(0.93); C81(1.15) | LDD1627 | [10] |
LDCM0424 | CL35 | HEK-293T | C81(0.98) | LDD1628 | [10] |
LDCM0425 | CL36 | HEK-293T | C81(1.07) | LDD1629 | [10] |
LDCM0426 | CL37 | HEK-293T | C62(1.14); C81(0.92) | LDD1630 | [10] |
LDCM0428 | CL39 | HEK-293T | C81(1.52) | LDD1632 | [10] |
LDCM0429 | CL4 | HEK-293T | C81(1.02) | LDD1633 | [10] |
LDCM0430 | CL40 | HEK-293T | C81(1.05) | LDD1634 | [10] |
LDCM0431 | CL41 | HEK-293T | C81(0.95) | LDD1635 | [10] |
LDCM0432 | CL42 | HEK-293T | C81(0.96) | LDD1636 | [10] |
LDCM0433 | CL43 | HEK-293T | C81(1.19) | LDD1637 | [10] |
LDCM0434 | CL44 | HEK-293T | C81(0.92) | LDD1638 | [10] |
LDCM0435 | CL45 | HEK-293T | C81(1.83) | LDD1639 | [10] |
LDCM0436 | CL46 | HEK-293T | C62(1.01); C81(1.12) | LDD1640 | [10] |
LDCM0437 | CL47 | HEK-293T | C81(1.07) | LDD1641 | [10] |
LDCM0438 | CL48 | HEK-293T | C81(1.02) | LDD1642 | [10] |
LDCM0439 | CL49 | HEK-293T | C62(1.03); C81(0.78) | LDD1643 | [10] |
LDCM0440 | CL5 | HEK-293T | C81(0.98) | LDD1644 | [10] |
LDCM0441 | CL50 | HEK-293T | C81(0.94) | LDD1645 | [10] |
LDCM0443 | CL52 | HEK-293T | C81(1.03) | LDD1646 | [10] |
LDCM0444 | CL53 | HEK-293T | C81(1.05) | LDD1647 | [10] |
LDCM0445 | CL54 | HEK-293T | C81(1.04) | LDD1648 | [10] |
LDCM0446 | CL55 | HEK-293T | C81(1.01) | LDD1649 | [10] |
LDCM0447 | CL56 | HEK-293T | C81(1.07) | LDD1650 | [10] |
LDCM0448 | CL57 | HEK-293T | C81(1.58) | LDD1651 | [10] |
LDCM0449 | CL58 | HEK-293T | C62(1.15); C81(1.11) | LDD1652 | [10] |
LDCM0450 | CL59 | HEK-293T | C81(0.95) | LDD1653 | [10] |
LDCM0451 | CL6 | HEK-293T | C81(1.11) | LDD1654 | [10] |
LDCM0452 | CL60 | HEK-293T | C81(1.18) | LDD1655 | [10] |
LDCM0453 | CL61 | HEK-293T | C62(1.09); C81(0.96) | LDD1656 | [10] |
LDCM0454 | CL62 | HEK-293T | C81(1.05) | LDD1657 | [10] |
LDCM0455 | CL63 | HEK-293T | C81(1.00) | LDD1658 | [10] |
LDCM0456 | CL64 | HEK-293T | C81(1.08) | LDD1659 | [10] |
LDCM0457 | CL65 | HEK-293T | C81(1.03) | LDD1660 | [10] |
LDCM0458 | CL66 | HEK-293T | C81(1.06) | LDD1661 | [10] |
LDCM0459 | CL67 | HEK-293T | C81(1.07) | LDD1662 | [10] |
LDCM0460 | CL68 | HEK-293T | C81(0.91) | LDD1663 | [10] |
LDCM0461 | CL69 | HEK-293T | C81(1.09) | LDD1664 | [10] |
LDCM0462 | CL7 | HEK-293T | C81(1.09) | LDD1665 | [10] |
LDCM0463 | CL70 | HEK-293T | C62(1.12); C81(1.02) | LDD1666 | [10] |
LDCM0464 | CL71 | HEK-293T | C81(1.05) | LDD1667 | [10] |
LDCM0465 | CL72 | HEK-293T | C81(1.06) | LDD1668 | [10] |
LDCM0466 | CL73 | HEK-293T | C62(1.03); C81(1.05) | LDD1669 | [10] |
LDCM0467 | CL74 | HEK-293T | C81(0.92) | LDD1670 | [10] |
LDCM0469 | CL76 | HEK-293T | C81(0.93) | LDD1672 | [10] |
LDCM0470 | CL77 | HEK-293T | C81(1.18) | LDD1673 | [10] |
LDCM0471 | CL78 | HEK-293T | C81(0.96) | LDD1674 | [10] |
LDCM0472 | CL79 | HEK-293T | C81(1.01) | LDD1675 | [10] |
LDCM0473 | CL8 | HEK-293T | C81(1.02) | LDD1676 | [10] |
LDCM0474 | CL80 | HEK-293T | C81(0.99) | LDD1677 | [10] |
LDCM0475 | CL81 | HEK-293T | C81(0.92) | LDD1678 | [10] |
LDCM0476 | CL82 | HEK-293T | C62(1.14); C81(1.08) | LDD1679 | [10] |
LDCM0477 | CL83 | HEK-293T | C81(1.03) | LDD1680 | [10] |
LDCM0478 | CL84 | HEK-293T | C81(1.09) | LDD1681 | [10] |
LDCM0479 | CL85 | HEK-293T | C62(0.92); C81(0.91) | LDD1682 | [10] |
LDCM0480 | CL86 | HEK-293T | C81(0.98) | LDD1683 | [10] |
LDCM0481 | CL87 | HEK-293T | C81(0.91) | LDD1684 | [10] |
LDCM0482 | CL88 | HEK-293T | C81(1.01) | LDD1685 | [10] |
LDCM0483 | CL89 | HEK-293T | C81(0.94) | LDD1686 | [10] |
LDCM0484 | CL9 | HEK-293T | C81(1.14) | LDD1687 | [10] |
LDCM0485 | CL90 | HEK-293T | C81(1.63) | LDD1688 | [10] |
LDCM0486 | CL91 | HEK-293T | C81(0.97) | LDD1689 | [10] |
LDCM0487 | CL92 | HEK-293T | C81(1.13) | LDD1690 | [10] |
LDCM0488 | CL93 | HEK-293T | C81(1.01) | LDD1691 | [10] |
LDCM0489 | CL94 | HEK-293T | C62(0.98); C81(1.11) | LDD1692 | [10] |
LDCM0490 | CL95 | HEK-293T | C81(1.33) | LDD1693 | [10] |
LDCM0491 | CL96 | HEK-293T | C81(1.09) | LDD1694 | [10] |
LDCM0492 | CL97 | HEK-293T | C62(0.90); C81(1.10) | LDD1695 | [10] |
LDCM0493 | CL98 | HEK-293T | C81(1.04) | LDD1696 | [10] |
LDCM0494 | CL99 | HEK-293T | C81(1.38) | LDD1697 | [10] |
LDCM0027 | Dopamine | HEK-293T | 7.52 | LDD0179 | [3] |
LDCM0495 | E2913 | HEK-293T | C81(1.18) | LDD1698 | [10] |
LDCM0468 | Fragment33 | HEK-293T | C81(1.06) | LDD1671 | [10] |
LDCM0427 | Fragment51 | HEK-293T | C81(0.98) | LDD1631 | [10] |
LDCM0022 | KB02 | HEK-293T | C81(1.00) | LDD1492 | [10] |
LDCM0023 | KB03 | HEK-293T | C81(0.93) | LDD1497 | [10] |
LDCM0024 | KB05 | SW1990 | C62(2.27) | LDD3456 | [2] |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
Protein name | Family | Uniprot ID | |||
---|---|---|---|---|---|
Peripheral plasma membrane protein CASK (CASK) | CAMK Ser/Thr protein kinase family | O14936 |
Transporter and channel
Protein name | Family | Uniprot ID | |||
---|---|---|---|---|---|
MyoD family inhibitor (MDFI) | MDFI family | Q99750 |
Other
References