Details of the Target

General Information of Target

Target ID LDTP07124
Target Name Rho GTPase-activating protein 21 (ARHGAP21)
Gene Name ARHGAP21
Gene ID 57584
Synonyms
ARHGAP10; KIAA1424; Rho GTPase-activating protein 21; Rho GTPase-activating protein 10; Rho-type GTPase-activating protein 21
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMATRRTGLSEGDGDKLKACEVSKNKDGKEQSETVSLSEDETFSWPGPKTVTLKRTSQGF
GFTLRHFIVYPPESAIQFSYKDEENGNRGGKQRNRLEPMDTIFVKQVKEGGPAFEAGLCT
GDRIIKVNGESVIGKTYSQVIALIQNSDTTLELSVMPKDEDILQVLQFTKDVTALAYSQD
AYLKGNEAYSGNARNIPEPPPICYPWLPSAPSAMAQPVEISPPDSSLSKQQTSTPVLTQP
GRAYRMEIQVPPSPTDVAKSNTAVCVCNESVRTVIVPSEKVVDLLSNRNNHTGPSHRTEE
VRYGVSEQTSLKTVSRTTSPPLSIPTTHLIHQPAGSRSLEPSGILLKSGNYSGHSDGISS
SRSQAVEAPSVSVNHYSPNSHQHIDWKNYKTYKEYIDNRRLHIGCRTIQERLDSLRAASQ
STTDYNQVVPNRTTLQGRRRSTSHDRVPQSVQIRQRSVSQERLEDSVLMKYCPRSASQGA
LTSPSVSFSNHRTRSWDYIEGQDETLENVNSGTPIPDSNGEKKQTYKWSGFTEQDDRRGI
CERPRQQEIHKSFRGSNFTVAPSVVNSDNRRMSGRGVGSVSQFKKIPPDLKTLQSNRNFQ
TTCGMSLPRGISQDRSPLVKVRSNSLKAPSTHVTKPSFSQKSFVSIKDQRPVNHLHQNSL
LNQQTWVRTDSAPDQQVETGKSPSLSGASAKPAPQSSENAGTSDLELPVSQRNQDLSLQE
AETEQSDTLDNKEAVILREKPPSGRQTPQPLRHQSYILAVNDQETGSDTTCWLPNDARRE
VHIKRMEERKASSTSPPGDSLASIPFIDEPTSPSIDHDIAHIPASAVISASTSQVPSIAT
VPPCLTTSAPLIRRQLSHDHESVGPPSLDAQPNSKTERSKSYDEGLDDYREDAKLSFKHV
SSLKGIKIADSQKSSEDSGSRKDSSSEVFSDAAKEGWLHFRPLVTDKGKRVGGSIRPWKQ
MYVVLRGHSLYLYKDKREQTTPSEEEQPISVNACLIDISYSETKRKNVFRLTTSDCECLF
QAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPRQSLS
IRQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTSPPKDKGTWRKGIPSIMRKTFEKKPT
ATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELN
KGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLK
RLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTH
MPDQYKIVETLIQHHDWFFTEEGAEEPLTTVQEESTVDSQPVPNIDHLLTNIGRTGVSPG
DVSDSATSDSTKSKGSWGSGKDQYSRELLVSSIFAAASRKRKKPKEKAQPSSSEDELDNV
FFKKENVEQCHNDTKEESKKESETLGRKQKIIIAKENSTRKDPSTTKDEKISLGKESTPS
EEPSPPHNSKHNKSPTLSCRFAILKESPRSLLAQKSSHLEETGSDSGTLLSTSSQASLAR
FSMKKSTSPETKHSEFLANVSTITSDYSTTSSATYLTSLDSSRLSPEVQSVAESKGDEAD
DERSELISEGRPVETDSESEFPVFPTALTSERLFRGKLQEVTKSSRRNSEGSELSCTEGS
LTSSLDSRRQLFSSHKLIECDTLSRKKSARFKSDSGSLGDAKNEKEAPSLTKVFDVMKKG
KSTGSLLTPTRGESEKQEPTWKTKIADRLKLRPRAPADDMFGVGNHKVNAETAKRKSIRR
RHTLGGHRDATEISVLNFWKVHEQSGERESELSAVNRLKPKCSAQDLSISDWLARERLRT
STSDLSRGEIGDPQTENPSTREIATTDTPLSLHCNTGSSSSTLASTNRPLLSIPPQSPDQ
INGESFQNVSKNASSAANAQPHKLSETPGSKAEFHPCL
Target Bioclass
Other
Subcellular location
Golgi apparatus membrane
Function
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.
Uniprot ID
Q5T5U3
Ensemble ID
ENST00000396432.7
HGNC ID
HGNC:23725

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.P843H .
BICR22 SNV: p.T846K .
DU145 SNV: p.R1076H .
ICC4 SNV: p.R1296G .
KU1919 SNV: p.D910N .
MEWO Substitution: p.P865F .
SUPT1 Deletion: p.N25IfsTer29 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DA-P3
 Probe Info  		6.61  LDD0179  [2]
AHL-Pu-1
 Probe Info  		C540(3.19); C1449(2.28)  LDD0169  [3]
DBIA
 Probe Info  		C264(0.95); C266(0.95)  LDD0078  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
NAIA_4
 Probe Info  		C203(0.00); C1842(0.00)  LDD2226  [6]
TFBX
 Probe Info  		C265(0.00); C267(0.00)  LDD0027  [5]
IPM
 Probe Info  		C1676(0.00); C20(0.00); C603(0.00); C405(0.00)  LDD0147  [5]
Phosphinate-6
 Probe Info  		C1700(0.00); C267(0.00); C1957(0.00); C1842(0.00)  LDD0018  [7]
AOyne
 Probe Info  		12.00  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C540(3.19); C1449(2.28)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C541(1.09); C1450(1.04); C1700(1.01); C603(1.05)  LDD1507  [10]
 LDCM0215  AC10 PaTu 8988t C264(1.84); C266(1.84)  LDD1094  [4]
 LDCM0216  AC100 PaTu 8988t C264(1.28); C266(1.28)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C264(1.02); C266(1.02)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C264(1.14); C266(1.14)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C264(1.04); C266(1.04)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C264(1.15); C266(1.15)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C264(1.35); C266(1.35)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C264(1.24); C266(1.24)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C264(1.01); C266(1.01)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C264(1.51); C266(1.51)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C264(1.78); C266(1.78)  LDD1104  [4]
 LDCM0226  AC11 PaTu 8988t C264(1.77); C266(1.77)  LDD1105  [4]
 LDCM0227  AC110 PaTu 8988t C264(1.71); C266(1.71)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C264(1.98); C266(1.98)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C264(1.49); C266(1.49)  LDD1108  [4]
 LDCM0230  AC113 HCT 116 C264(1.02); C266(1.02)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C264(1.38); C266(1.38)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C264(1.50); C266(1.50)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C264(1.76); C266(1.76)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C264(1.17); C266(1.17)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C264(1.03); C266(1.03)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C264(1.66); C266(1.66)  LDD0553  [4]
 LDCM0237  AC12 PaTu 8988t C264(1.70); C266(1.70)  LDD1116  [4]
 LDCM0238  AC120 HCT 116 C264(1.41); C266(1.41)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C264(1.05); C266(1.05)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C264(1.38); C266(1.38)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C264(1.37); C266(1.37)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C264(1.37); C266(1.37)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C264(1.40); C266(1.40)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C264(1.92); C266(1.92)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C264(1.81); C266(1.81)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C264(1.53); C266(1.53)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C264(0.72); C266(0.72)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C264(0.98); C266(0.98)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C264(0.96); C266(0.96)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C264(0.62); C266(0.62)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C264(0.80); C266(0.80)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C264(1.03); C266(1.03)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C264(0.79); C266(0.79)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C264(0.76); C266(0.76)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C264(0.72); C266(0.72)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C264(0.87); C266(0.87)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C264(0.73); C266(0.73)  LDD0575  [4]
 LDCM0259  AC14 PaTu 8988t C264(1.39); C266(1.39)  LDD1138  [4]
 LDCM0260  AC140 HCT 116 C264(0.71); C266(0.71)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C264(0.82); C266(0.82)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C264(0.72); C266(0.72)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C264(1.21); C266(1.21)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C264(1.67); C266(1.94)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C264(1.33); C266(1.49)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C266(1.20); C264(1.26)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C264(1.49); C266(1.86)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C264(1.75); C266(2.10)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C264(1.58); C266(1.88)  LDD0586  [4]
 LDCM0270  AC15 PaTu 8988t C264(1.10); C266(1.10)  LDD1149  [4]
 LDCM0271  AC150 HCT 116 C264(1.14); C266(1.32)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C266(1.20); C264(1.24)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C266(1.44); C264(1.45)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C264(2.02); C266(2.04)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C264(1.32); C266(1.38)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C264(1.45); C266(1.71)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C264(1.34); C266(1.13)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C264(1.20); C266(1.18)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C264(0.52); C266(0.52)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C264(0.73); C266(0.73)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C264(0.63); C266(0.63)  LDD0595  [4]
 LDCM0279  AC2 HEK-293T C541(0.97); C1450(1.01); C1152(0.91); C119(0.84)  LDD1518  [10]
 LDCM0280  AC20 HCT 116 C264(0.72); C266(0.72)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C264(0.58); C266(0.58)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C264(0.62); C266(0.62)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C264(0.64); C266(0.64)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C264(0.49); C266(0.49)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C541(1.14); C1450(0.94); C1700(1.00); C603(1.07)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C541(0.97); C1450(1.00); C1152(1.11); C119(0.79)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C541(1.00); C1450(1.03); C1152(0.77); C1700(0.99)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C541(1.01); C1450(0.93); C1152(0.88); C1700(1.03)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C541(1.00); C1450(1.01); C1700(0.98); C603(0.97)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C541(1.01); C1450(1.02); C1152(0.84); C1700(0.97)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C541(0.99); C1450(0.97); C1152(0.97); C1700(0.91)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C541(0.94); C1450(1.00); C1152(0.94); C1700(1.00)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C541(0.94); C1450(0.99); C1152(1.03); C1700(0.96)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C541(1.10); C1450(1.04); C1700(1.08); C603(1.05)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C541(1.02); C1450(1.01); C1152(1.07); C119(0.83)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C541(1.03); C1450(1.05); C1152(1.12); C1700(0.97)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C541(1.02); C1450(0.93); C1152(0.79); C1700(1.01)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C541(0.99); C1450(1.00); C1700(1.00); C603(0.96)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C541(1.00); C1450(0.92); C1152(1.25); C1700(0.92)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C541(0.88); C1450(0.98); C1152(1.11); C1700(0.92)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C541(1.12); C1450(0.94); C1152(0.91); C1700(1.09)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C541(0.92); C1450(1.08); C1152(1.05); C1700(1.01)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C541(1.06); C1450(1.04); C1700(1.00); C603(1.04)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C541(1.08); C1450(1.02); C1152(1.00); C119(0.94)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C541(1.06); C1450(0.95); C1152(0.92); C1700(0.94)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C541(0.99); C1450(0.92); C1152(0.78); C1700(1.05)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C541(1.01); C1450(1.01); C1700(1.10); C603(1.27)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C541(0.99); C1450(1.02); C1152(1.06); C1700(0.94)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C541(0.89); C1450(1.02); C1152(0.97); C1700(0.97)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C541(0.93); C1450(0.97); C1152(1.14); C1700(1.03)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C541(1.08); C1450(0.94); C1700(1.03); C603(1.15)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C541(1.05); C1450(0.97); C1700(0.99); C603(0.97)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C541(1.03); C1450(1.01); C1152(1.01); C119(1.03)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C541(1.01); C1450(0.97); C1152(0.98); C1700(0.95)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C541(0.99); C1450(0.90); C1152(0.82); C1700(1.04)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C541(1.00); C1450(0.97); C1700(1.00); C603(1.06)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C541(0.99); C1450(1.01); C1152(0.70); C1700(0.90)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C541(0.88); C1450(0.95); C1152(1.09); C1700(0.96)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C541(1.02); C1450(1.04); C1152(1.11); C1700(1.04)  LDD1558  [10]
 LDCM0320  AC57 PaTu 8988t C264(1.18); C266(1.18)  LDD1199  [4]
 LDCM0321  AC58 PaTu 8988t C264(0.85); C266(0.85)  LDD1200  [4]
 LDCM0322  AC59 PaTu 8988t C264(0.98); C266(0.98)  LDD1201  [4]
 LDCM0323  AC6 PaTu 8988t C264(1.33); C266(1.33)  LDD1202  [4]
 LDCM0324  AC60 PaTu 8988t C264(0.99); C266(0.99)  LDD1203  [4]
 LDCM0325  AC61 PaTu 8988t C264(0.98); C266(0.98)  LDD1204  [4]
 LDCM0326  AC62 PaTu 8988t C264(0.96); C266(0.96)  LDD1205  [4]
 LDCM0327  AC63 PaTu 8988t C264(1.02); C266(1.02)  LDD1206  [4]
 LDCM0328  AC64 PaTu 8988t C264(1.17); C266(1.17)  LDD1207  [4]
 LDCM0329  AC65 PaTu 8988t C264(0.95); C266(0.95)  LDD1208  [4]
 LDCM0330  AC66 PaTu 8988t C264(0.96); C266(0.96)  LDD1209  [4]
 LDCM0331  AC67 PaTu 8988t C264(1.04); C266(1.04)  LDD1210  [4]
 LDCM0332  AC68 HCT 116 C264(0.96); C266(0.96)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C264(1.07); C266(1.07)  LDD0650  [4]
 LDCM0334  AC7 PaTu 8988t C264(1.42); C266(1.42)  LDD1213  [4]
 LDCM0335  AC70 HCT 116 C264(1.22); C266(1.22)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C264(0.82); C266(0.82)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C264(1.15); C266(1.15)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C264(1.62); C266(1.62)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C264(1.33); C266(1.33)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C264(1.89); C266(1.89)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C264(1.26); C266(1.26)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C264(1.23); C266(1.23)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C264(1.07); C266(1.07)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C264(0.93); C266(0.93)  LDD0661  [4]
 LDCM0345  AC8 PaTu 8988t C264(1.23); C266(1.23)  LDD1224  [4]
 LDCM0346  AC80 HCT 116 C264(1.25); C266(1.25)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C264(0.88); C266(0.88)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C264(1.87); C266(1.87)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C264(1.69); C266(1.69)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C264(1.43); C266(1.43)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C264(1.09); C266(1.09)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C264(1.28); C266(1.28)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C264(1.15); C266(1.15)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C264(1.37); C266(1.37)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C264(1.63); C266(1.63)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C264(1.24); C266(1.24)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C264(1.90); C266(1.90)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C264(1.74); C266(1.74)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C264(1.35); C266(1.35)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C264(1.06); C266(1.06)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C264(1.50); C266(1.50)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C264(1.58); C266(1.58)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C264(1.86); C266(1.86)  LDD0681  [4]
 LDCM0365  AC98 PaTu 8988t C264(1.29); C266(1.29)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C264(1.10); C266(1.10)  LDD1245  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C264(2.06); C266(2.06)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C264(1.78); C266(1.78)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C264(1.77); C266(1.77)  LDD1154  [4]
 LDCM0020  ARS-1620 HCC44 C264(0.95); C266(0.95)  LDD0078  [4]
 LDCM0367  CL1 HEK-293T C541(0.86); C1450(0.88); C1152(0.94); C1700(0.95)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C541(0.84); C1450(0.94); C1152(1.00); C1700(1.04)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C541(1.08); C1450(0.92); C1152(0.90); C1700(0.93)  LDD1573  [10]
 LDCM0370  CL101 PaTu 8988t C264(1.40); C266(1.40)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C264(1.66); C266(1.66)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C264(1.54); C266(1.54)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C264(1.32); C266(1.32)  LDD1252  [4]
 LDCM0374  CL105 HCT 116 C264(0.61); C266(0.61)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C264(0.56); C266(0.56)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C264(0.61); C266(0.61)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C264(0.58); C266(0.58)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C264(0.62); C266(0.62)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C541(0.75); C1450(1.02); C1152(0.96); C1700(0.98)  LDD1583  [10]
 LDCM0380  CL110 HCT 116 C264(0.49); C266(0.49)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C264(0.58); C266(0.58)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C541(0.99); C1450(1.02); C1152(0.92); C1700(0.96)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C541(0.96); C1450(1.00); C1152(1.01); C1700(0.99)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C541(1.11); C1450(0.84); C1152(0.87); C1700(1.08)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C541(1.05); C1450(0.95); C1152(0.98); C1700(1.00)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C541(1.03); C1450(1.03); C1152(1.00); C1700(1.09)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C541(1.03); C1450(0.94); C1152(0.97); C1700(0.99)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C541(1.11); C1450(0.91); C1152(1.05); C1700(1.17)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C541(0.93); C1450(0.98); C1152(0.90); C1700(0.99)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C541(0.74); C1450(1.07); C1152(1.07); C1700(0.99)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C541(1.00); C1450(1.02); C1152(0.89); C1700(0.97)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C541(1.01); C1450(0.86); C1152(1.05); C1700(1.05)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C541(1.12); C1450(0.85); C1152(1.03); C1700(1.08)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C541(0.94); C1450(0.84); C1152(0.93); C1700(0.90)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C541(0.99); C1450(1.00); C1152(0.91); C1700(0.15)  LDD1599  [10]
 LDCM0396  CL125 PaTu 8988t C264(0.90); C266(0.90)  LDD1275  [4]
 LDCM0397  CL126 PaTu 8988t C264(0.87); C266(0.87)  LDD1276  [4]
 LDCM0398  CL127 PaTu 8988t C264(0.93); C266(0.93)  LDD1277  [4]
 LDCM0399  CL128 PaTu 8988t C264(1.04); C266(1.04)  LDD1278  [4]
 LDCM0400  CL13 HEK-293T C541(1.02); C1450(0.96); C1152(0.84); C1700(1.25)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C541(0.96); C1450(0.84); C1152(1.01); C1700(1.00)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C541(0.94); C1450(0.89); C1152(0.95); C1700(1.02)  LDD1606  [10]
 LDCM0403  CL16 HCT 116 C264(1.05); C266(1.05)  LDD0720  [4]
 LDCM0404  CL17 HEK-293T C541(0.96); C1450(0.95); C1700(1.00); C603(1.08)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C541(0.90); C1450(1.05); C1152(0.97); C119(1.07)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C541(0.85); C1450(1.02); C1152(0.96); C1700(0.93)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C541(0.95); C1450(0.88); C1152(0.94); C1700(1.09)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C541(0.90); C1450(0.93); C1152(0.90); C1700(1.13)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C541(0.91); C1450(0.91); C1700(1.08); C603(1.04)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C541(0.83); C1450(1.11); C1152(1.24); C1700(0.94)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C541(0.83); C1450(1.07); C1152(1.00); C1700(0.95)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C541(0.79); C1450(1.06); C1152(1.11); C1700(0.96)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C541(0.95); C1450(0.86); C1152(0.99); C1700(0.95)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C541(0.99); C1450(0.99); C1152(1.01); C1700(1.06)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C541(0.95); C1450(0.97); C1152(0.90); C1700(0.99)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C541(0.88); C1450(0.92); C1152(0.87); C1700(0.90)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C541(0.97); C1450(0.97); C1700(0.98); C603(0.96)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C541(0.87); C1450(0.92); C1152(0.91); C1700(1.05)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C541(0.94); C1450(1.02); C1152(1.08); C119(0.93)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C541(0.89); C1450(0.96); C1152(1.10); C1700(0.91)  LDD1624  [10]
 LDCM0421  CL32 HCT 116 C264(1.19); C266(1.19)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C264(1.29); C266(1.29)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C264(0.98); C266(0.98)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C264(1.02); C266(1.02)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C264(0.75); C266(0.75)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C264(0.89); C266(0.89)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C264(1.08); C266(1.08)  LDD0745  [4]
 LDCM0429  CL4 HEK-293T C541(0.93); C1450(1.10); C1152(0.91); C1700(0.95)  LDD1633  [10]
 LDCM0430  CL40 HCT 116 C264(1.09); C266(1.09)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C264(1.03); C266(1.03)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C264(0.78); C266(0.78)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C264(0.97); C266(0.97)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C264(0.86); C266(0.86)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C264(0.87); C266(0.87)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C541(0.84); C1450(1.08); C1152(1.54); C1700(0.95)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C541(0.79); C1450(1.10); C1152(0.99); C1700(0.96)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C541(0.77); C1450(1.14); C1152(1.05); C1700(1.04)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C541(0.97); C1450(0.92); C1152(0.92); C1700(0.97)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C541(1.00); C1450(1.06); C1700(1.02); C603(1.08)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C541(0.99); C1450(0.85); C1152(1.02); C1700(1.00)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C541(0.95); C1450(1.00); C1152(0.87); C1700(1.00)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C541(1.00); C1450(0.90); C1700(1.15); C603(1.12)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C541(0.84); C1450(0.93); C1152(0.96); C119(0.82)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C541(0.92); C1450(1.02); C1152(0.93); C1700(1.00)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C541(1.03); C1450(0.90); C1152(0.79); C1700(1.08)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C541(1.03); C1450(0.95); C1700(1.21); C603(1.21)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C541(0.90); C1450(1.06); C1152(0.79); C1700(0.99)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C541(0.83); C1450(1.07); C1152(1.00); C1700(1.01)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C541(0.90); C1450(1.01); C1152(0.83); C119(1.08)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C541(0.87); C1450(1.09); C1152(1.11); C1700(0.93)  LDD1655  [10]
 LDCM0453  CL61 HCT 116 C264(1.23); C266(1.23)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C264(1.44); C266(1.44)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C264(1.12); C266(1.12)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C264(0.94); C266(0.94)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C264(1.03); C266(1.03)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C264(1.20); C266(1.20)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C264(1.19); C266(1.19)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C264(0.93); C266(0.93)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C264(1.33); C266(1.33)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C541(0.97); C1450(1.02); C1152(0.94); C1700(0.97)  LDD1665  [10]
 LDCM0463  CL70 HCT 116 C264(1.21); C266(1.21)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C264(1.18); C266(1.18)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C264(1.20); C266(1.20)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C264(0.98); C266(0.98)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C264(1.55); C266(1.55)  LDD0784  [4]
 LDCM0469  CL76 HEK-293T C541(0.96); C1450(0.97); C1152(0.95); C1700(0.98)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C541(0.95); C1450(0.91); C1700(1.03); C603(1.18)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C541(0.90); C1450(1.07); C1152(1.01); C119(0.92)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C541(0.97); C1450(0.95); C1152(0.92); C1700(0.92)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C541(0.88); C1450(0.66); C1152(0.84); C1700(1.04)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C541(0.96); C1450(0.88); C1152(0.85); C1700(0.97)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C541(0.91); C1450(0.99); C1700(1.01); C603(1.09)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C541(0.84); C1450(1.03); C1152(0.88); C1700(0.95)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C541(0.81); C1450(1.05); C1152(0.97); C1700(1.06)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C541(0.90); C1450(1.05); C1152(1.04); C1700(0.95)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C541(1.03); C1450(0.88); C1152(0.97); C1700(0.93)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C541(1.03); C1450(0.89); C1152(0.99); C1700(1.05)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C541(1.02); C1450(0.96); C1152(0.90); C1700(0.95)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C541(1.03); C1450(0.94); C1152(0.96); C1700(0.94)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C541(1.06); C1450(1.04); C1700(1.05); C603(1.05)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C541(0.93); C1450(1.02); C1700(0.96); C603(1.08)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C541(0.97); C1450(0.85); C1152(0.79); C119(0.74)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C541(0.88); C1450(0.93); C1152(0.89); C1700(0.95)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C541(0.97); C1450(0.84); C1152(0.77); C1700(1.03)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C541(0.94); C1450(1.00); C1700(1.04); C603(0.93)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C541(0.94); C1450(1.05); C1152(1.01); C1700(0.99)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C541(0.85); C1450(0.96); C1152(0.97); C1700(1.02)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C541(0.85); C1450(1.01); C1152(1.06); C1700(0.98)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C541(1.03); C1450(0.90); C1152(0.92); C1700(1.02)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C541(1.01); C1450(0.83); C1152(0.98); C1700(1.04)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C541(1.07); C1450(0.95); C1152(0.89); C1700(0.93)  LDD1697  [10]
 LDCM0028  Dobutamine HEK-293T 4.97  LDD0180  [2]
 LDCM0027  Dopamine HEK-293T 6.61  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C541(1.07); C1450(0.96); C1152(0.96); C1700(1.03)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C603(1.90)  LDD1702  [11]
 LDCM0031  Epigallocatechin gallate HEK-293T 10.56  LDD0183  [2]
 LDCM0468  Fragment33 HCT 116 C264(0.95); C266(0.95)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C264(0.96); C266(0.96)  LDD0744  [4]
 LDCM0022  KB02 HCT 116 C264(3.53); C266(3.53)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C264(1.43); C266(1.43)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C264(2.71); C266(2.71)  LDD0082  [4]
 LDCM0032  Oleacein HEK-293T 8.34  LDD0184  [2]
 LDCM0029  Quercetin HEK-293T 8.58  LDD0181  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Elongation factor 1-delta (EEF1D) EF-1-beta/EF-1-delta family P29692

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761