Details of the Competitor

General Information of Competitor

Competitor ID
LDCM0032
Competitor Name
Oleacein
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 320.3
Lipid-water partition coefficient (xlogp) 1.1
Rotatable Bond Count (rotbonds) 10
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C17H20O6
IUPAC Name
2-(3,4-dihydroxyphenyl)ethyl (Z,3S)-4-formyl-3-(2-oxoethyl)hex-4-enoate
Canonical SMILES
CC=C(C=O)C(CC=O)CC(=O)OCCC1=CC(=C(C=C1)O)O
InChI
InChI=1S/C17H20O6/c1-2-13(11-19)14(5-7-18)10-17(22)23-8-6-12-3-4-15(20)16(21)9-12/h2-4,7,9,11,14,20-21H,5-6,8,10H2,1H3/b13-2+/t14-/m0/s1
InChIKey
XLPXUPOZUYGVPD-AGIOQNCLSA-N

The Competitor Interaction Atlas

Probe(s) Related This Competitor

ABPP Probe
Click To Hide/Show 1 Probe Related to This Competitor
Probe Name Structure Concentration Cell-system Ref
DA-P3
 Probe Info  		15 uM Human normal cells (HEK-293T) [1]

Target(s) List of this Competitor

67 Enzyme Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
(E3-independent) E2 ubiquitin-conjugating enzyme (UBE2O) LDTP11601 5.97  LDD0184 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) LDTP02984 9.26  LDD0184 
26S proteasome non-ATPase regulatory subunit 9 (PSMD9) LDTP00225 4.18  LDD0184 
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) LDTP02000 6.02  LDD0184 
6-phosphogluconolactonase (PGLS) LDTP14535 6.77  LDD0184 
Asparagine synthetase [glutamine-hydrolyzing] (ASNS) LDTP02264 4.11  LDD0184 
CTP synthase 1 (CTPS1) LDTP02922 5.96  LDD0184 
Cyclin-G-associated kinase (GAK) LDTP00497 7.97  LDD0184 
E3 ubiquitin-protein ligase Praja-2 (PJA2) LDTP00694 4.05  LDD0184 
E3 ubiquitin-protein ligase UBR4 (UBR4) LDTP07118 5.15  LDD0184 
E3 ubiquitin-protein ligase ZNF598 (ZNF598) LDTP08231 7.45  LDD0184 
Elongation factor-like GTPase 1 (EFL1) LDTP08023 11.86  LDD0184 
Endoribonuclease Dicer (DICER1) LDTP13733 5.26  LDD0184 
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) LDTP02770 11.32  LDD0184 
Fructose-2,6-bisphosphatase TIGAR (TIGAR) LDTP12405 9.37  LDD0184 
GDP-mannose 4,6 dehydratase (GMDS) LDTP00999 11.40  LDD0184 
Glutamate--cysteine ligase catalytic subunit (GCLC) LDTP04185 7.30  LDD0184 
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (GFPT1) LDTP05481 4.55  LDD0184 
Glutathione S-transferase Mu 2 (GSTM2) LDTP03420 4.00  LDD0184 
Glycerol-3-phosphate phosphatase (PGP) LDTP00089 4.28  LDD0184 
Glycogen [starch] synthase, muscle (GYS1) LDTP02696 7.35  LDD0184 
GTP-binding protein 1 (GTPBP1) LDTP14415 6.78  LDD0184 
Heme oxygenase 2 (HMOX2) LDTP03540 15.05  LDD0184 
Histidine--tRNA ligase, cytoplasmic (HARS1) LDTP02602 5.38  LDD0184 
Immunity-related GTPase family Q protein (IRGQ) LDTP19838 6.70  LDD0184 
Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) LDTP03084 5.82  LDD0184 
Inositol hexakisphosphate kinase 1 (IP6K1) LDTP09792 5.82  LDD0184 
Inositol-3-phosphate synthase 1 (ISYNA1) LDTP12364 9.11  LDD0184 
Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2) LDTP03003 12.23  LDD0184 
Interleukin-1 receptor-associated kinase 1 (IRAK1) LDTP04435 10.39  LDD0184 
Kinesin-like protein KIF11 (KIF11) LDTP04519 5.43  LDD0184 
Lymphokine-activated killer T-cell-originated protein kinase (PBK) LDTP10500 10.26  LDD0184 
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) LDTP00747 6.26  LDD0184 
Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5) LDTP14065 4.18  LDD0184 
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) LDTP00837 7.02  LDD0184 
N-alpha-acetyltransferase 10 (NAA10) LDTP03938 4.34  LDD0184 
Phosphatidylinositol 4-kinase beta (PI4KB) LDTP13112 11.57  LDD0184 
Phospholipase DDHD2 (DDHD2) LDTP01435 10.82  LDD0184 
Protein NDRG3 (NDRG3) LDTP18530 4.46  LDD0184 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 4.01  LDD0184 
Putative ATP-dependent RNA helicase DHX57 (DHX57) LDTP07502 4.02  LDD0184 
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (RPAP2) LDTP08615 12.10  LDD0184 
Ras-related protein Rab-18 (RAB18) LDTP12312 5.30  LDD0184 
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) LDTP00751 14.82  LDD0184 
Ribonucleoside-diphosphate reductase large subunit (RRM1) LDTP03259 4.12  LDD0184 
Serine/threonine-protein kinase Nek9 (NEK9) LDTP09412 13.44  LDD0184 
Serine/threonine-protein kinase RIO2 (RIOK2) LDTP11299 4.86  LDD0184 
Serine/threonine-protein kinase WNK1 (WNK1) LDTP11909 5.17  LDD0184 
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) LDTP06199 4.24  LDD0184 
Signal peptidase complex subunit 2 (SPCS2) LDTP06270 4.80  LDD0184 
Sphingolipid delta(4)-desaturase DES1 (DEGS1) LDTP00544 9.88  LDD0184 
Squalene monooxygenase (SQLE) LDTP06142 4.14  LDD0184 
SRSF protein kinase 1 (SRPK1) LDTP10809 4.75  LDD0184 
STE20-like serine/threonine-protein kinase (SLK) LDTP11819 4.93  LDD0184 
Terminal uridylyltransferase 4 (TUT4) LDTP07171 5.55  LDD0184 
Thioredoxin-like protein 1 (TXNL1) LDTP00758 6.75  LDD0184 
TNF receptor-associated factor 6 (TRAF6) LDTP14064 10.70  LDD0184 
Transcription termination factor 2 (TTF2) LDTP13682 9.42  LDD0184 
tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 (NSUN6) LDTP09487 4.25  LDD0184 
tRNA (guanine(6)-N2)-methyltransferase THUMP3 (THUMPD3) LDTP11266 4.42  LDD0184 
tRNA N(3)-methylcytidine methyltransferase METTL2B (METTL2B) LDTP07515 9.34  LDD0184 
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) LDTP05475 5.02  LDD0184 
Ubiquitin carboxyl-terminal hydrolase 10 (USP10) LDTP06190 6.93  LDD0184 
Ubiquitin carboxyl-terminal hydrolase 16 (USP16) LDTP14159 9.10  LDD0184 
Ubiquitin-like modifier-activating enzyme 6 (UBA6) LDTP00013 4.91  LDD0184 
Ubiquitin-like-conjugating enzyme ATG3 (ATG3) LDTP12599 10.09  LDD0184 
Uridine-cytidine kinase 2 (UCK2) LDTP11571 10.34  LDD0184 
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⏷ Show the Full List of 67 Enzyme
15 Transporter and channel Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
ADP-ribosylation factor-binding protein GGA1 (GGA1) LDTP13415 4.53  LDD0184 
Cystatin-B (CSTB) LDTP02009 4.33  LDD0184 
DnaJ homolog subfamily B member 14 (DNAJB14) LDTP09352 10.07  LDD0184 
Extended synaptotagmin-1 (ESYT1) LDTP11161 5.27  LDD0184 
Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC) LDTP12281 8.70  LDD0184 
Junctophilin-1 (JPH1) LDTP12292 6.06  LDD0184 
Methylosome subunit pICln (CLNS1A) LDTP04597 4.69  LDD0184 
Reticulon-1 (RTN1) LDTP06633 4.67  LDD0184 
Signal recognition particle 19 kDa protein (SRP19) LDTP02330 11.61  LDD0184 
Sorting nexin-1 (SNX1) LDTP05938 6.17  LDD0184 
Syntaxin-17 (STX17) LDTP04770 13.66  LDD0184 
TBC1 domain family member 4 (TBC1D4) LDTP00958 18.51  LDD0184 
WD repeat-containing protein 47 (WDR47) LDTP01475 4.27  LDD0184 
Wolframin (WFS1) LDTP01380 4.31  LDD0184 
Zinc finger FYVE domain-containing protein 16 (ZFYVE16) LDTP08040 13.63  LDD0184 
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⏷ Show the Full List of 15 Transporter and channel
3 Transcription factor Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Myocardin-related transcription factor A (MRTFA) LDTP10039 8.45  LDD0184 
Nuclear factor NF-kappa-B p100 subunit (NFKB2) LDTP05254 19.65  LDD0184 
Signal transducer and activator of transcription 3 (STAT3) LDTP03903 12.46  LDD0184 
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1 Immunoglobulin Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Palladin (PALLD) LDTP09680 16.63  LDD0184 
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92 Other Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) LDTP08950 11.17  LDD0184 
Alpha-internexin (INA) LDTP06527 6.18  LDD0184 
Anillin (ANLN) LDTP12443 8.39  LDD0184 
Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A) LDTP09828 9.91  LDD0184 
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP3) LDTP10656 10.26  LDD0184 
Ataxin-2-like protein (ATXN2L) LDTP09655 4.25  LDD0184 
BAG family molecular chaperone regulator 3 (BAG3) LDTP01684 11.93  LDD0184 
BLOC-1-related complex subunit 6 (BORCS6) LDTP10361 4.01  LDD0184 
BolA-like protein 2 (BOLA2; BOLA2B) LDTP11870 6.09  LDD0184 
BRCA1-associated ATM activator 1 (BRAT1) LDTP07598 6.21  LDD0184 
BSD domain-containing protein 1 (BSDC1) LDTP16116 7.16  LDD0184 
BTB/POZ domain-containing protein KCTD12 (KCTD12) LDTP15705 6.98  LDD0184 
Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) LDTP13007 5.23  LDD0184 
Calcium-regulated heat-stable protein 1 (CARHSP1) LDTP13916 7.01  LDD0184 
Calponin-3 (CNN3) LDTP06383 6.05  LDD0184 
Centriolar coiled-coil protein of 110 kDa (CCP110) LDTP00737 8.53  LDD0184 
Centrosomal protein of 55 kDa (CEP55) LDTP06886 4.29  LDD0184 
Centrosomal protein of 97 kDa (CEP97) LDTP08523 4.13  LDD0184 
CLIP-associating protein 2 (CLASP2) LDTP01129 5.66  LDD0184 
Coiled-coil domain-containing protein 6 (CCDC6) LDTP06515 31.98  LDD0184 
Coiled-coil domain-containing protein R3HCC1L (R3HCC1L) LDTP08095 7.29  LDD0184 
Condensin complex subunit 2 (NCAPH) LDTP06268 8.09  LDD0184 
Cytosolic Fe-S cluster assembly factor NUBP1 (NUBP1) LDTP04560 6.33  LDD0184 
Cytospin-A (SPECC1L) LDTP07348 6.92  LDD0184 
DISP complex protein LRCH3 (LRCH3) LDTP10417 4.14  LDD0184 
Double-stranded RNA-binding protein Staufen homolog 1 (STAU1) LDTP01677 6.46  LDD0184 
Dynactin subunit 4 (DCTN4) LDTP13402 5.55  LDD0184 
Elongator complex protein 1 (ELP1) LDTP01511 5.02  LDD0184 
G2 and S phase-expressed protein 1 (GTSE1) LDTP12865 5.88  LDD0184 
Gamma-taxilin (TXLNG) LDTP12640 5.99  LDD0184 
Gem-associated protein 5 (GEMIN5) LDTP09504 4.56  LDD0184 
Gephyrin (GPHN) LDTP12448 6.42  LDD0184 
GH3 domain-containing protein (GHDC) LDTP08795 5.19  LDD0184 
Glucocorticoid-induced transcript 1 protein (GLCCI1) LDTP19626 5.94  LDD0184 
GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1) LDTP06255 5.43  LDD0184 
Guanine nucleotide-binding protein subunit beta-like protein 1 (GNB1L) LDTP18337 4.19  LDD0184 
HAUS augmin-like complex subunit 6 (HAUS6) LDTP08069 15.27  LDD0184 
Hyaluronan mediated motility receptor (HMMR) LDTP01177 39.61  LDD0184 
Inner nuclear membrane protein Man1 (LEMD3) LDTP13913 4.10  LDD0184 
Jupiter microtubule associated homolog 2 (JPT2) LDTP12077 10.28  LDD0184 
Kinesin light chain 2 (KLC2) LDTP11695 4.21  LDD0184 
Leucine-rich repeat-containing protein 40 (LRRC40) LDTP19976 4.52  LDD0184 
LIM domain-containing protein 1 (LIMD1) LDTP13241 5.76  LDD0184 
MAP7 domain-containing protein 3 (MAP7D3) LDTP08535 10.38  LDD0184 
Melanoma-associated antigen D2 (MAGED2) LDTP13657 5.57  LDD0184 
Microtubule-associated protein 1B (MAP1B) LDTP04112 29.94  LDD0184 
Microtubule-associated protein 1S (MAP1S) LDTP07297 10.55  LDD0184 
Microtubule-associated protein 4 (MAP4) LDTP03404 5.49  LDD0184 
Mini-chromosome maintenance complex-binding protein (MCMBP) LDTP11197 5.37  LDD0184 
Mitochondrial fission regulator 1-like (MTFR1L) LDTP15947 6.35  LDD0184 
Muskelin (MKLN1) LDTP13525 8.94  LDD0184 
NHL repeat-containing protein 2 (NHLRC2) LDTP09049 14.69  LDD0184 
Opioid growth factor receptor (OGFR) LDTP16155 11.30  LDD0184 
Oxidation resistance protein 1 (OXR1) LDTP08888 6.81  LDD0184 
Oxysterol-binding protein 1 (OSBP) LDTP03151 10.62  LDD0184 
Oxysterol-binding protein-related protein 11 (OSBPL11) LDTP11367 28.41  LDD0184 
Partitioning defective 3 homolog (PARD3) LDTP09512 5.05  LDD0184 
Prefoldin subunit 3 (VBP1) LDTP04935 5.02  LDD0184 
PRKC apoptosis WT1 regulator protein (PAWR) LDTP10435 4.88  LDD0184 
Probable RNA-binding protein EIF1AD (EIF1AD) LDTP09008 4.19  LDD0184 
Protein diaphanous homolog 1 (DIAPH1) LDTP01011 5.78  LDD0184 
Protein ITPRID2 (ITPRID2) LDTP03426 4.82  LDD0184 
Protein LTV1 homolog (LTV1) LDTP15727 11.14  LDD0184 
Protein odr-4 homolog (ODR4) LDTP17214 7.62  LDD0184 
Protein PRRC2A (PRRC2A) LDTP04199 4.14  LDD0184 
Protein PRRC2B (PRRC2B) LDTP14978 6.20  LDD0184 
RAD50-interacting protein 1 (RINT1) LDTP07476 28.59  LDD0184 
Rho GTPase-activating protein 21 (ARHGAP21) LDTP07124 8.34  LDD0184 
RING finger protein 214 (RNF214) LDTP19787 15.49  LDD0184 
RNA polymerase II-associated protein 1 (RPAP1) LDTP11327 5.69  LDD0184 
RNA polymerase II-associated protein 3 (RPAP3) LDTP12000 7.81  LDD0184 
Serine/threonine-protein phosphatase 6 regulatory subunit 2 (PPP6R2) LDTP01151 10.21  LDD0184 
Serine/threonine-protein phosphatase 6 regulatory subunit 3 (PPP6R3) LDTP06983 4.61  LDD0184 
Serpin B6 (SERPINB6) LDTP03719 15.65  LDD0184 
SH3 and PX domain-containing protein 2B (SH3PXD2B) LDTP00039 13.52  LDD0184 
Shootin-1 (SHTN1) LDTP00019 8.38  LDD0184 
SLAIN motif-containing protein 1 (SLAIN1) LDTP09118 5.93  LDD0184 
Sperm-associated antigen 5 (SPAG5) LDTP10753 6.63  LDD0184 
Src substrate cortactin (CTTN) LDTP06094 4.60  LDD0184 
Synaptosomal-associated protein 47 (SNAP47) LDTP07061 9.77  LDD0184 
TBC1 domain family member 15 (TBC1D15) LDTP09363 4.91  LDD0184 
TBC1 domain family member 9B (TBC1D9B) LDTP15057 14.77  LDD0184 
Tetratricopeptide repeat protein 4 (TTC4) LDTP01678 4.11  LDD0184 
Thyroid receptor-interacting protein 6 (TRIP6) LDTP06439 5.08  LDD0184 
TIP41-like protein (TIPRL) LDTP01285 5.10  LDD0184 
Transforming acidic coiled-coil-containing protein 1 (TACC1) LDTP01210 5.16  LDD0184 
Transmembrane protein 209 (TMEM209) LDTP18272 8.35  LDD0184 
Trinucleotide repeat-containing gene 6B protein (TNRC6B) LDTP13710 12.55  LDD0184 
Ubiquitin-associated protein 2 (UBAP2) LDTP07132 7.26  LDD0184 
UPF0488 protein C8orf33 (C8orf33) LDTP12025 5.30  LDD0184 
WD repeat-containing protein 62 (WDR62) LDTP00755 5.29  LDD0184 
Zinc finger C3HC-type protein 1 (ZC3HC1) LDTP08325 5.83  LDD0184 
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⏷ Show the Full List of 92 Other

Full Information of The Labelling Profiles of This Competitor

Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 15 uM
Quantitative Method LFQ
Competitor Name Oleacein
Competitor Concentration 150 uM
In Vitro Experiment Model Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Interaction Atlas ID  LDD0184  Download The Altas

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348