Details of the Target

General Information of Target

Target ID LDTP09655
Target Name Ataxin-2-like protein (ATXN2L)
Gene Name ATXN2L
Gene ID 11273
Synonyms
A2D; A2LG; A2LP; A2RP; Ataxin-2-like protein; Ataxin-2 domain protein; Ataxin-2-related protein
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MLKPQPLQQPSQPQQPPPTQQAVARRPPGGTSPPNGGLPGPLATSAAPPGPPAAASPCLG
PVAAAGSGLRRGAEGILAPQPPPPQQHQERPGAAAIGSARGQSTGKGPPQSPVFEGVYNN
SRMLHFLTAVVGSTCDVKVKNGTTYEGIFKTLSSKFELAVDAVHRKASEPAGGPRREDIV
DTMVFKPSDVMLVHFRNVDFNYATKDKFTDSAIAMNSKVNGEHKEKVLQRWEGGDSNSDD
YDLESDMSNGWDPNEMFKFNEENYGVKTTYDSSLSSYTVPLEKDNSEEFRQRELRAAQLA
REIESSPQYRLRIAMENDDGRTEEEKHSAVQRQGSGRESPSLASREGKYIPLPQRVREGP
RGGVRCSSSRGGRPGLSSLPPRGPHHLDNSSPGPGSEARGINGGPSRMSPKAQRPLRGAK
TLSSPSNRPSGETSVPPPPAVGRMYPPRSPKSAAPAPISASCPEPPIGSAVPTSSASIPV
TSSVSDPGVGSISPASPKISLAPTDVKELSTKEPGRTLEPQELARIAGKVPGLQNEQKRF
QLEELRKFGAQFKLQPSSSPENSLDPFPPRILKEEPKGKEKEVDGLLTSEPMGSPVSSKT
ESVSDKEDKPPLAPSGGTEGPEQPPPPCPSQTGSPPVGLIKGEDKDEGPVAEQVKKSTLN
PNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQYISYIPQIHMG
PAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVA
ATPYSSYIPYNPQQFPGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSSTP
QYPSAEQPTPQALYATVHQSYPHHATQLHAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQ
APHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYAIHHQQLPHGFTNM
AHVTQAHVQTGITAAPPPHPGAPHPPQVMLLHPPQSHGGPPQGAVPQSGVPALSASTPSP
YPYIGHPQGEQPGQAPGFPGGADDRIREFSLAGGIWHGRAEGLQVGQDARVLGGE
Target Bioclass
Other
Family
Ataxin-2 family
Subcellular location
Membrane
Function Involved in the regulation of stress granule and P-body formation.
Uniprot ID
Q8WWM7
Ensemble ID
ENST00000325215.10
HGNC ID
HGNC:31326

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.Q841R .
CCK81 SNV: p.V857I DBIA    Probe Info 
CHL1 SNV: p.G142D DBIA    Probe Info 
EFO27 Deletion: p.Q1002KfsTer50 .
G361 SNV: p.S678F .
HCC15 SNV: p.V180E DBIA    Probe Info 
HCT116 Deletion: p.Q1002KfsTer50 .
HCT15 SNV: p.R310C; p.A932T .
HT115 SNV: p.D1044Y .
HUH1 SNV: p.A453T .
ICC4 SNV: p.Q1067K DBIA    Probe Info 
ICC8 SNV: p.S510C DBIA    Probe Info 
JM1 SNV: p.D318G .
JURKAT Deletion: p.Q1002KfsTer50 .
MCC26 SNV: p.P627S .
MEWO Substitution: p.S860F .
MOLM13 SNV: p.P1018A .
MOLT4 Deletion: p.P636RfsTer19 .
MONOMAC6 SNV: p.P41S .
NB1 SNV: p.S937N .
NCIH23 SNV: p.S426I .
PF382 SNV: p.P909T .
RL952 Deletion: p.Q1002KfsTer50
SNV: p.A454V		 .
SBC5 SNV: p.P625L DBIA    Probe Info 
SNU1 Deletion: p.G234VfsTer33; p.Q1002KfsTer50 .
SW1116 SNV: p.Q900K .
TOV21G Deletion: p.Q941SfsTer48 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.42  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
TH211
 Probe Info  		Y349(5.65)  LDD0260  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
STPyne
 Probe Info  		K155(8.13); K166(8.68); K326(9.92); K348(10.00)  LDD0277  [6]
Probe 1
 Probe Info  		Y118(11.71); Y145(13.73); Y202(10.42); Y270(7.16)  LDD3495  [7]
DBIA
 Probe Info  		C135(3.21)  LDD3312  [8]
P12
 Probe Info  		11.64  LDD0202  [9]
DA-P3
 Probe Info  		4.32  LDD0181  [10]
AHL-Pu-1
 Probe Info  		C628(6.55)  LDD0168  [11]
HHS-475
 Probe Info  		Y270(0.24); Y349(0.26); Y309(0.77)  LDD0264  [12]
HHS-465
 Probe Info  		Y349(4.78)  LDD2237  [13]
5E-2FA
 Probe Info  		H87(0.00); H385(0.00); H386(0.00); H194(0.00)  LDD2235  [14]
ATP probe
 Probe Info  		K507(0.00); K656(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [16]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [16]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [16]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
IPM
 Probe Info  		N.A.  LDD0005  [18]
NHS
 Probe Info  		K205(0.00); K529(0.00)  LDD0010  [18]
SF
 Probe Info  		Y349(0.00); Y309(0.00); Y264(0.00)  LDD0028  [19]
VSF
 Probe Info  		N.A.  LDD0007  [18]
1c-yne
 Probe Info  		N.A.  LDD0228  [20]
1d-yne
 Probe Info  		N.A.  LDD0357  [20]
Acrolein
 Probe Info  		H386(0.00); H385(0.00); H164(0.00); H125(0.00)  LDD0217  [21]
NAIA_5
 Probe Info  		C366(0.00); C135(0.00)  LDD2223  [22]
HHS-482
 Probe Info  		Y349(1.41)  LDD2239  [13]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C191
 Probe Info  		13.09  LDD1868  [23]
C193
 Probe Info  		5.50  LDD1869  [23]
FFF probe11
 Probe Info  		10.32  LDD0471  [24]
FFF probe13
 Probe Info  		19.76  LDD0475  [24]
FFF probe14
 Probe Info  		20.00  LDD0477  [24]
FFF probe2
 Probe Info  		17.27  LDD0463  [24]
FFF probe3
 Probe Info  		16.55  LDD0464  [24]
JN0003
 Probe Info  		20.00  LDD0469  [24]
VE-P
 Probe Info  		N.A.  LDD0396  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C628(6.55)  LDD0168  [11]
 LDCM0026  4SU-RNA+native RNA HEK-293T C462(20.00); C628(3.53)  LDD0169  [11]
 LDCM0214  AC1 HEK-293T C628(1.07); C58(1.07); C135(1.08)  LDD1507  [26]
 LDCM0215  AC10 HEK-293T C628(0.96); C58(1.15); C462(0.84); C135(0.96)  LDD1508  [26]
 LDCM0226  AC11 HEK-293T C628(0.89); C58(1.12); C462(1.09); C135(1.04)  LDD1509  [26]
 LDCM0237  AC12 HEK-293T C628(0.93); C58(0.97); C135(0.98)  LDD1510  [26]
 LDCM0259  AC14 HEK-293T C628(0.95); C58(0.93); C462(1.00); C135(0.99)  LDD1512  [26]
 LDCM0270  AC15 HEK-293T C628(1.03); C58(1.00); C462(1.08); C135(0.99)  LDD1513  [26]
 LDCM0276  AC17 HEK-293T C628(1.01); C58(0.84); C135(0.98)  LDD1515  [26]
 LDCM0277  AC18 HEK-293T C628(1.06); C58(1.05); C462(1.03); C135(0.95)  LDD1516  [26]
 LDCM0278  AC19 HEK-293T C628(0.76); C58(0.99); C462(1.53); C135(0.90)  LDD1517  [26]
 LDCM0279  AC2 HEK-293T C628(0.97); C58(1.07); C462(1.12); C135(0.99)  LDD1518  [26]
 LDCM0280  AC20 HEK-293T C628(1.07); C58(1.18); C135(0.94)  LDD1519  [26]
 LDCM0281  AC21 HEK-293T C628(0.95); C58(0.80); C462(0.84); C135(1.05)  LDD1520  [26]
 LDCM0282  AC22 HEK-293T C628(1.00); C58(1.01); C462(1.04); C135(1.07)  LDD1521  [26]
 LDCM0283  AC23 HEK-293T C628(1.00); C58(0.93); C462(1.96); C135(0.96)  LDD1522  [26]
 LDCM0284  AC24 HEK-293T C628(0.99); C58(0.98); C135(1.00)  LDD1523  [26]
 LDCM0285  AC25 HEK-293T C628(0.90); C58(0.90); C135(0.97)  LDD1524  [26]
 LDCM0286  AC26 HEK-293T C628(0.93); C58(1.01); C462(1.00); C135(0.90)  LDD1525  [26]
 LDCM0287  AC27 HEK-293T C628(0.79); C58(0.87); C462(1.21); C135(0.92)  LDD1526  [26]
 LDCM0288  AC28 HEK-293T C628(0.95); C58(1.06); C135(0.89)  LDD1527  [26]
 LDCM0289  AC29 HEK-293T C628(0.98); C58(1.04); C462(1.09); C135(0.99)  LDD1528  [26]
 LDCM0290  AC3 HEK-293T C628(0.90); C58(1.02); C462(1.16); C135(1.09)  LDD1529  [26]
 LDCM0291  AC30 HEK-293T C628(0.95); C58(0.99); C462(1.24); C135(0.98)  LDD1530  [26]
 LDCM0292  AC31 HEK-293T C628(1.09); C58(0.99); C462(1.45); C135(0.95)  LDD1531  [26]
 LDCM0293  AC32 HEK-293T C628(1.02); C58(0.95); C135(0.99)  LDD1532  [26]
 LDCM0294  AC33 HEK-293T C628(1.09); C58(0.91); C135(0.98)  LDD1533  [26]
 LDCM0295  AC34 HEK-293T C628(1.00); C58(1.14); C462(1.21); C135(0.97)  LDD1534  [26]
 LDCM0296  AC35 HEK-293T C628(1.01); C58(1.05); C462(1.20); C135(1.04)  LDD1535  [26]
 LDCM0297  AC36 HEK-293T C628(0.99); C58(1.23); C135(0.98)  LDD1536  [26]
 LDCM0298  AC37 HEK-293T C628(1.07); C58(0.83); C462(1.21); C135(1.04)  LDD1537  [26]
 LDCM0299  AC38 HEK-293T C628(0.98); C58(1.23); C462(0.74); C135(1.02)  LDD1538  [26]
 LDCM0300  AC39 HEK-293T C628(1.27); C58(0.82); C462(1.18); C135(1.05)  LDD1539  [26]
 LDCM0301  AC4 HEK-293T C628(0.92); C58(1.02); C135(0.92)  LDD1540  [26]
 LDCM0302  AC40 HEK-293T C628(1.08); C58(0.92); C135(0.99)  LDD1541  [26]
 LDCM0303  AC41 HEK-293T C628(1.07); C58(1.08); C135(0.80)  LDD1542  [26]
 LDCM0304  AC42 HEK-293T C628(0.93); C58(1.10); C462(1.26); C135(1.00)  LDD1543  [26]
 LDCM0305  AC43 HEK-293T C628(0.85); C58(1.12); C462(1.11); C135(1.02)  LDD1544  [26]
 LDCM0306  AC44 HEK-293T C628(1.07); C58(0.97); C135(0.95)  LDD1545  [26]
 LDCM0307  AC45 HEK-293T C628(1.12); C58(0.96); C462(1.13); C135(1.05)  LDD1546  [26]
 LDCM0308  AC46 HEK-293T C628(0.97); C58(1.15); C462(0.78); C135(0.99)  LDD1547  [26]
 LDCM0309  AC47 HEK-293T C628(1.17); C58(1.05); C462(1.00); C135(1.02)  LDD1548  [26]
 LDCM0310  AC48 HEK-293T C628(1.18); C58(0.95); C135(1.00)  LDD1549  [26]
 LDCM0311  AC49 HEK-293T C628(1.05); C58(1.04); C135(0.94)  LDD1550  [26]
 LDCM0312  AC5 HEK-293T C628(1.03); C58(0.92); C462(1.01); C135(1.08)  LDD1551  [26]
 LDCM0313  AC50 HEK-293T C628(0.89); C58(1.09); C462(0.91); C135(1.04)  LDD1552  [26]
 LDCM0314  AC51 HEK-293T C628(0.83); C58(0.95); C462(1.25); C135(1.05)  LDD1553  [26]
 LDCM0315  AC52 HEK-293T C628(0.96); C58(1.09); C135(0.98)  LDD1554  [26]
 LDCM0316  AC53 HEK-293T C628(1.09); C58(0.88); C462(1.14); C135(1.05)  LDD1555  [26]
 LDCM0317  AC54 HEK-293T C628(1.01); C58(1.14); C462(0.90); C135(1.01)  LDD1556  [26]
 LDCM0318  AC55 HEK-293T C628(1.16); C58(1.04); C462(0.93); C135(1.01)  LDD1557  [26]
 LDCM0319  AC56 HEK-293T C628(1.02); C58(1.00); C135(1.00)  LDD1558  [26]
 LDCM0320  AC57 HEK-293T C628(1.06); C58(1.22); C135(0.92)  LDD1559  [26]
 LDCM0321  AC58 HEK-293T C628(1.10); C58(1.15); C462(1.03); C135(0.96)  LDD1560  [26]
 LDCM0322  AC59 HEK-293T C628(1.02); C58(1.06); C462(1.21); C135(1.02)  LDD1561  [26]
 LDCM0323  AC6 HEK-293T C628(1.05); C58(1.10); C462(1.24); C135(1.02)  LDD1562  [26]
 LDCM0324  AC60 HEK-293T C628(1.01); C58(1.18); C135(0.96)  LDD1563  [26]
 LDCM0325  AC61 HEK-293T C628(1.17); C58(0.89); C462(0.89); C135(1.01)  LDD1564  [26]
 LDCM0326  AC62 HEK-293T C628(0.97); C58(0.99); C462(1.21); C135(1.07)  LDD1565  [26]
 LDCM0327  AC63 HEK-293T C628(1.17); C58(1.00); C462(1.11); C135(0.96)  LDD1566  [26]
 LDCM0328  AC64 HEK-293T C628(0.93); C58(1.08); C135(1.00)  LDD1567  [26]
 LDCM0334  AC7 HEK-293T C628(0.96); C58(1.03); C462(0.82); C135(0.96)  LDD1568  [26]
 LDCM0345  AC8 HEK-293T C628(1.14); C58(0.98); C135(1.01)  LDD1569  [26]
 LDCM0248  AKOS034007472 HEK-293T C628(1.09); C58(0.82); C462(0.91); C135(1.01)  LDD1511  [26]
 LDCM0356  AKOS034007680 HEK-293T C628(1.08); C58(0.91); C135(0.97)  LDD1570  [26]
 LDCM0275  AKOS034007705 HEK-293T C628(1.04); C58(1.04); C135(1.01)  LDD1514  [26]
 LDCM0156  Aniline NCI-H1299 12.70  LDD0403  [1]
 LDCM0088  C45 HEK-293T 11.64  LDD0202  [9]
 LDCM0087  Capsaicin HEK-293T 5.15  LDD0185  [10]
 LDCM0108  Chloroacetamide HeLa C135(0.00); H386(0.00); H385(0.00); H164(0.00)  LDD0222  [21]
 LDCM0367  CL1 HEK-293T C628(1.00); C58(0.82); C462(0.71); C135(1.09)  LDD1571  [26]
 LDCM0368  CL10 HEK-293T C628(0.98); C58(1.14); C462(0.81); C135(1.16)  LDD1572  [26]
 LDCM0369  CL100 HEK-293T C628(0.88); C58(1.01); C462(0.93); C135(0.96)  LDD1573  [26]
 LDCM0370  CL101 HEK-293T C628(0.96); C58(0.84); C462(0.80); C135(1.00)  LDD1574  [26]
 LDCM0371  CL102 HEK-293T C628(0.88); C58(0.96); C462(0.92); C135(1.00)  LDD1575  [26]
 LDCM0372  CL103 HEK-293T C628(0.97); C58(1.04); C462(0.96); C135(0.97)  LDD1576  [26]
 LDCM0373  CL104 HEK-293T C628(0.92); C58(0.84); C462(0.88); C135(0.98)  LDD1577  [26]
 LDCM0374  CL105 HEK-293T C628(0.94); C58(0.83); C462(0.77); C135(1.03)  LDD1578  [26]
 LDCM0375  CL106 HEK-293T C628(1.06); C58(1.07); C462(0.78); C135(1.08)  LDD1579  [26]
 LDCM0376  CL107 HEK-293T C628(0.97); C58(1.19); C462(0.88); C135(0.99)  LDD1580  [26]
 LDCM0377  CL108 HEK-293T C628(1.04); C58(1.22); C462(0.97); C135(0.99)  LDD1581  [26]
 LDCM0378  CL109 HEK-293T C628(0.96); C58(0.59); C462(0.86); C135(0.92)  LDD1582  [26]
 LDCM0379  CL11 HEK-293T C628(1.26); C58(1.02); C462(1.06); C135(1.10)  LDD1583  [26]
 LDCM0380  CL110 HEK-293T C628(0.93); C58(0.92); C462(0.79); C135(1.09)  LDD1584  [26]
 LDCM0381  CL111 HEK-293T C628(0.97); C58(0.95); C462(0.74); C135(0.89)  LDD1585  [26]
 LDCM0382  CL112 HEK-293T C628(0.87); C58(1.16); C462(0.80); C135(0.90)  LDD1586  [26]
 LDCM0383  CL113 HEK-293T C628(1.08); C58(0.95); C462(1.02); C135(0.99)  LDD1587  [26]
 LDCM0384  CL114 HEK-293T C628(0.90); C58(1.05); C462(0.84); C135(0.99)  LDD1588  [26]
 LDCM0385  CL115 HEK-293T C628(0.94); C58(0.95); C462(0.94); C135(1.02)  LDD1589  [26]
 LDCM0386  CL116 HEK-293T C628(0.94); C58(1.14); C462(0.81); C135(1.02)  LDD1590  [26]
 LDCM0387  CL117 HEK-293T C628(1.26); C58(0.96); C462(0.97); C135(1.04)  LDD1591  [26]
 LDCM0388  CL118 HEK-293T C628(1.04); C58(0.94); C462(0.98); C135(1.01)  LDD1592  [26]
 LDCM0389  CL119 HEK-293T C628(1.00); C58(1.11); C462(0.97); C135(1.00)  LDD1593  [26]
 LDCM0390  CL12 HEK-293T C628(1.13); C58(0.96); C135(1.05)  LDD1594  [26]
 LDCM0391  CL120 HEK-293T C628(0.90); C58(1.09); C462(0.78); C135(0.96)  LDD1595  [26]
 LDCM0392  CL121 HEK-293T C628(1.24); C58(0.77); C462(0.76); C135(1.05)  LDD1596  [26]
 LDCM0393  CL122 HEK-293T C628(1.00); C58(0.97); C462(0.72); C135(1.00)  LDD1597  [26]
 LDCM0394  CL123 HEK-293T C628(0.80); C58(1.03); C462(0.92); C135(1.01)  LDD1598  [26]
 LDCM0395  CL124 HEK-293T C628(1.00); C58(1.19); C462(0.73); C135(0.97)  LDD1599  [26]
 LDCM0396  CL125 HEK-293T C628(1.05); C58(1.13); C462(0.90); C135(1.12)  LDD1600  [26]
 LDCM0397  CL126 HEK-293T C628(1.01); C58(0.95); C462(0.88); C135(1.02)  LDD1601  [26]
 LDCM0398  CL127 HEK-293T C628(0.94); C58(1.06); C462(1.03); C135(1.06)  LDD1602  [26]
 LDCM0399  CL128 HEK-293T C628(0.92); C58(1.19); C462(1.08); C135(0.97)  LDD1603  [26]
 LDCM0400  CL13 HEK-293T C628(1.17); C58(0.95); C462(1.11); C135(1.09)  LDD1604  [26]
 LDCM0401  CL14 HEK-293T C628(1.09); C58(0.99); C462(1.00); C135(0.94)  LDD1605  [26]
 LDCM0402  CL15 HEK-293T C628(0.85); C58(0.90); C462(0.98); C135(1.04)  LDD1606  [26]
 LDCM0403  CL16 HEK-293T C628(0.90); C58(0.95); C462(0.78); C135(0.96)  LDD1607  [26]
 LDCM0404  CL17 HEK-293T C628(0.96); C58(0.92); C135(0.97)  LDD1608  [26]
 LDCM0405  CL18 HEK-293T C628(1.00); C58(1.19); C462(0.94); C135(0.97)  LDD1609  [26]
 LDCM0406  CL19 HEK-293T C628(0.95); C58(1.13); C462(1.03); C135(1.11)  LDD1610  [26]
 LDCM0407  CL2 HEK-293T C628(1.02); C58(0.99); C462(1.01); C135(0.97)  LDD1611  [26]
 LDCM0408  CL20 HEK-293T C628(1.09); C58(1.10); C135(0.97)  LDD1612  [26]
 LDCM0409  CL21 HEK-293T C628(1.16); C58(0.77); C462(1.22); C135(1.09)  LDD1613  [26]
 LDCM0410  CL22 HEK-293T C628(1.20); C58(0.99); C462(1.01); C135(1.05)  LDD1614  [26]
 LDCM0411  CL23 HEK-293T C628(1.16); C58(1.04); C462(1.20); C135(1.06)  LDD1615  [26]
 LDCM0412  CL24 HEK-293T C628(1.12); C58(0.87); C135(1.03)  LDD1616  [26]
 LDCM0413  CL25 HEK-293T C628(0.94); C58(0.89); C462(0.93); C135(1.11)  LDD1617  [26]
 LDCM0414  CL26 HEK-293T C628(1.06); C58(0.94); C462(0.88); C135(0.93)  LDD1618  [26]
 LDCM0415  CL27 HEK-293T C628(0.99); C58(0.92); C462(0.83); C135(1.09)  LDD1619  [26]
 LDCM0416  CL28 HEK-293T C628(0.92); C58(1.08); C462(0.76); C135(1.01)  LDD1620  [26]
 LDCM0417  CL29 HEK-293T C628(1.01); C58(0.87); C135(1.05)  LDD1621  [26]
 LDCM0418  CL3 HEK-293T C628(0.95); C58(1.16); C462(0.84); C135(1.14)  LDD1622  [26]
 LDCM0419  CL30 HEK-293T C628(1.11); C58(1.09); C462(0.73); C135(1.01)  LDD1623  [26]
 LDCM0420  CL31 HEK-293T C628(1.11); C58(1.02); C462(1.24); C135(1.05)  LDD1624  [26]
 LDCM0421  CL32 HEK-293T C628(1.18); C58(0.91); C135(0.99)  LDD1625  [26]
 LDCM0422  CL33 HEK-293T C628(1.17); C58(0.75); C462(0.95); C135(1.10)  LDD1626  [26]
 LDCM0423  CL34 HEK-293T C628(1.15); C58(1.02); C462(0.89); C135(1.11)  LDD1627  [26]
 LDCM0424  CL35 HEK-293T C628(1.30); C58(1.04); C462(1.07); C135(1.07)  LDD1628  [26]
 LDCM0425  CL36 HEK-293T C628(1.18); C58(0.84); C135(1.08)  LDD1629  [26]
 LDCM0426  CL37 HEK-293T C628(0.99); C58(0.74); C462(0.83); C135(0.98)  LDD1630  [26]
 LDCM0428  CL39 HEK-293T C628(1.07); C58(0.97); C462(0.88); C135(1.01)  LDD1632  [26]
 LDCM0429  CL4 HEK-293T C628(0.85); C58(0.92); C462(0.80); C135(0.98)  LDD1633  [26]
 LDCM0430  CL40 HEK-293T C628(1.17); C58(1.11); C462(0.75); C135(1.03)  LDD1634  [26]
 LDCM0431  CL41 HEK-293T C628(1.02); C58(0.89); C135(0.97)  LDD1635  [26]
 LDCM0432  CL42 HEK-293T C628(1.10); C58(1.05); C462(1.04); C135(0.98)  LDD1636  [26]
 LDCM0433  CL43 HEK-293T C628(0.84); C58(1.08); C462(1.14); C135(1.08)  LDD1637  [26]
 LDCM0434  CL44 HEK-293T C628(0.98); C58(1.11); C135(0.98)  LDD1638  [26]
 LDCM0435  CL45 HEK-293T C628(1.24); C58(0.70); C462(0.87); C135(1.06)  LDD1639  [26]
 LDCM0436  CL46 HEK-293T C628(1.36); C58(0.93); C462(0.89); C135(1.08)  LDD1640  [26]
 LDCM0437  CL47 HEK-293T C628(1.53); C58(0.96); C462(1.23); C135(1.06)  LDD1641  [26]
 LDCM0438  CL48 HEK-293T C628(1.17); C58(0.72); C135(1.05)  LDD1642  [26]
 LDCM0439  CL49 HEK-293T C628(0.97); C58(0.90); C462(0.81); C135(1.07)  LDD1643  [26]
 LDCM0440  CL5 HEK-293T C628(1.13); C58(1.10); C135(0.95)  LDD1644  [26]
 LDCM0441  CL50 HEK-293T C628(1.07); C58(0.91); C462(1.03); C135(0.91)  LDD1645  [26]
 LDCM0443  CL52 HEK-293T C628(0.92); C58(1.09); C462(0.66); C135(0.92)  LDD1646  [26]
 LDCM0444  CL53 HEK-293T C628(1.06); C58(0.99); C135(1.00)  LDD1647  [26]
 LDCM0445  CL54 HEK-293T C628(0.91); C58(1.15); C462(0.99); C135(1.01)  LDD1648  [26]
 LDCM0446  CL55 HEK-293T C628(1.02); C58(0.86); C462(1.11); C135(1.08)  LDD1649  [26]
 LDCM0447  CL56 HEK-293T C628(1.07); C58(1.11); C135(1.01)  LDD1650  [26]
 LDCM0448  CL57 HEK-293T C628(1.38); C58(0.72); C462(1.12); C135(1.10)  LDD1651  [26]
 LDCM0449  CL58 HEK-293T C628(1.17); C58(0.98); C462(1.11); C135(1.14)  LDD1652  [26]
 LDCM0450  CL59 HEK-293T C628(1.40); C58(0.90); C462(1.09); C135(1.03)  LDD1653  [26]
 LDCM0451  CL6 HEK-293T C628(0.95); C58(1.23); C462(0.95); C135(0.99)  LDD1654  [26]
 LDCM0452  CL60 HEK-293T C628(1.15); C58(0.80); C135(1.13)  LDD1655  [26]
 LDCM0453  CL61 HEK-293T C628(0.95); C58(0.89); C462(0.91); C135(1.08)  LDD1656  [26]
 LDCM0454  CL62 HEK-293T C628(1.12); C58(0.96); C462(0.74); C135(0.93)  LDD1657  [26]
 LDCM0455  CL63 HEK-293T C628(0.94); C58(1.06); C462(1.01); C135(0.99)  LDD1658  [26]
 LDCM0456  CL64 HEK-293T C628(0.92); C58(1.14); C462(0.92); C135(0.99)  LDD1659  [26]
 LDCM0457  CL65 HEK-293T C628(1.05); C58(1.00); C135(1.02)  LDD1660  [26]
 LDCM0458  CL66 HEK-293T C628(1.28); C58(1.03); C462(0.96); C135(0.97)  LDD1661  [26]
 LDCM0459  CL67 HEK-293T C628(0.90); C58(0.96); C462(1.02); C135(1.00)  LDD1662  [26]
 LDCM0460  CL68 HEK-293T C628(1.01); C58(0.89); C135(1.01)  LDD1663  [26]
 LDCM0461  CL69 HEK-293T C628(1.20); C58(1.02); C462(0.97); C135(1.09)  LDD1664  [26]
 LDCM0462  CL7 HEK-293T C628(1.34); C58(0.96); C462(1.02); C135(1.04)  LDD1665  [26]
 LDCM0463  CL70 HEK-293T C628(1.24); C58(1.00); C462(0.99); C135(1.07)  LDD1666  [26]
 LDCM0464  CL71 HEK-293T C628(1.21); C58(0.82); C462(0.92); C135(1.00)  LDD1667  [26]
 LDCM0465  CL72 HEK-293T C628(1.17); C58(0.89); C135(1.03)  LDD1668  [26]
 LDCM0466  CL73 HEK-293T C628(0.99); C58(0.79); C462(0.77); C135(1.01)  LDD1669  [26]
 LDCM0467  CL74 HEK-293T C628(0.99); C58(1.05); C462(0.80); C135(1.07)  LDD1670  [26]
 LDCM0469  CL76 HEK-293T C628(0.83); C58(1.00); C462(0.72); C135(0.99)  LDD1672  [26]
 LDCM0470  CL77 HEK-293T C628(0.99); C58(0.82); C135(0.93)  LDD1673  [26]
 LDCM0471  CL78 HEK-293T C628(0.96); C58(1.06); C462(1.06); C135(1.03)  LDD1674  [26]
 LDCM0472  CL79 HEK-293T C628(0.82); C58(0.86); C462(0.95); C135(1.03)  LDD1675  [26]
 LDCM0473  CL8 HEK-293T C628(0.82); C58(0.82); C135(0.93)  LDD1676  [26]
 LDCM0474  CL80 HEK-293T C628(1.06); C58(0.90); C135(0.88)  LDD1677  [26]
 LDCM0475  CL81 HEK-293T C628(1.24); C58(0.94); C462(0.84); C135(1.13)  LDD1678  [26]
 LDCM0476  CL82 HEK-293T C628(1.06); C58(0.93); C462(0.81); C135(1.03)  LDD1679  [26]
 LDCM0477  CL83 HEK-293T C628(1.18); C58(0.90); C462(0.80); C135(1.04)  LDD1680  [26]
 LDCM0478  CL84 HEK-293T C628(0.96); C58(0.90); C135(1.11)  LDD1681  [26]
 LDCM0479  CL85 HEK-293T C628(0.94); C58(0.98); C462(0.90); C135(1.09)  LDD1682  [26]
 LDCM0480  CL86 HEK-293T C628(1.00); C58(1.00); C462(1.12); C135(1.15)  LDD1683  [26]
 LDCM0481  CL87 HEK-293T C628(0.81); C58(1.01); C462(0.92); C135(1.11)  LDD1684  [26]
 LDCM0482  CL88 HEK-293T C628(0.98); C58(0.85); C462(1.01); C135(0.99)  LDD1685  [26]
 LDCM0483  CL89 HEK-293T C628(1.05); C58(1.22); C135(0.96)  LDD1686  [26]
 LDCM0484  CL9 HEK-293T C628(1.14); C58(0.79); C462(1.32); C135(1.12)  LDD1687  [26]
 LDCM0485  CL90 HEK-293T C628(0.91); C58(1.03); C462(1.04); C135(1.06)  LDD1688  [26]
 LDCM0486  CL91 HEK-293T C628(1.03); C58(1.17); C462(0.96); C135(1.03)  LDD1689  [26]
 LDCM0487  CL92 HEK-293T C628(1.02); C58(0.92); C135(0.89)  LDD1690  [26]
 LDCM0488  CL93 HEK-293T C628(1.24); C58(0.82); C462(1.00); C135(1.05)  LDD1691  [26]
 LDCM0489  CL94 HEK-293T C628(1.16); C58(1.14); C462(0.96); C135(1.04)  LDD1692  [26]
 LDCM0490  CL95 HEK-293T C628(1.33); C58(0.78); C462(1.18); C135(1.02)  LDD1693  [26]
 LDCM0491  CL96 HEK-293T C628(1.04); C58(1.01); C135(1.13)  LDD1694  [26]
 LDCM0492  CL97 HEK-293T C628(0.99); C58(0.84); C462(1.04); C135(0.93)  LDD1695  [26]
 LDCM0493  CL98 HEK-293T C628(0.98); C58(0.92); C462(0.80); C135(1.04)  LDD1696  [26]
 LDCM0494  CL99 HEK-293T C628(0.97); C58(1.05); C462(1.14); C135(0.98)  LDD1697  [26]
 LDCM0495  E2913 HEK-293T C628(1.07); C58(1.28); C462(0.92); C135(1.00)  LDD1698  [26]
 LDCM0031  Epigallocatechin gallate HEK-293T 8.70  LDD0183  [10]
 LDCM0625  F8 Ramos C58(1.27); C135(0.56)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C58(1.35)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C58(4.42); C135(20.00)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C58(0.80)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C58(0.85)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C58(0.83); C135(1.59)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C58(0.63)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C58(0.89)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C58(1.42)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C58(1.48)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C58(1.06)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C58(1.11)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C58(0.93)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C58(1.43)  LDD2201  [27]
 LDCM0468  Fragment33 HEK-293T C628(0.92); C58(1.09); C462(0.87); C135(1.06)  LDD1671  [26]
 LDCM0596  Fragment38 Ramos C58(0.86)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C58(0.98)  LDD2184  [27]
 LDCM0427  Fragment51 HEK-293T C628(0.97); C58(0.96); C462(0.73); C135(0.96)  LDD1631  [26]
 LDCM0610  Fragment52 Ramos C58(1.46)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C58(1.06)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C58(1.02); C135(0.33)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C58(0.73)  LDD2188  [27]
 LDCM0116  HHS-0101 DM93 Y270(0.24); Y349(0.26); Y309(0.77)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y349(0.17); Y309(0.58); Y270(0.65)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y349(0.20); Y270(0.36); Y309(0.53)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y349(0.26); Y270(0.46); Y309(0.57)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y349(0.16); Y270(0.50); Y309(0.67)  LDD0268  [12]
 LDCM0107  IAA HeLa H385(0.00); H125(0.00); H386(0.00)  LDD0221  [21]
 LDCM0022  KB02 HEK-293T C628(0.94); C58(0.74); C135(0.98)  LDD1492  [26]
 LDCM0023  KB03 HEK-293T C628(1.08); C58(1.07); C135(1.04)  LDD1497  [26]
 LDCM0024  KB05 HMCB C135(3.21)  LDD3312  [8]
 LDCM0030  Luteolin HEK-293T 6.69  LDD0182  [10]
 LDCM0109  NEM HeLa H386(0.00); H164(0.00); H385(0.00)  LDD0223  [21]
 LDCM0032  Oleacein HEK-293T 4.25  LDD0184  [10]
 LDCM0029  Quercetin HEK-293T 4.32  LDD0181  [10]
 LDCM0131  RA190 MM1.R C462(1.93)  LDD0304  [28]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras GTPase-activating protein-binding protein 1 (G3BP1) . Q13283
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Erythropoietin receptor (EPOR) Type I cytokine receptor family P19235
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 12-4 (KRTAP12-4) KRTAP type 12 family P60329

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
10 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.