Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name DA-P3  Probe Info 
Probe concentration 15 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name Luteolin  Competitor Info 
Competitor Concentration 150 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 72 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08799  Lysophosphatidylserine lipase ABHD12 (ABHD12) 153.0
 LDTP01004  Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) 58.8
 LDTP00598  Serine palmitoyltransferase 2 (SPTLC2) 56.6
 LDTP06713  DNA excision repair protein ERCC-6-like (ERCC6L) 36.3
 LDTP00497  Cyclin-G-associated kinase (GAK) 31.3
 LDTP00366  Dihydropyrimidinase-related protein 4 (DPYSL4) 29.7
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) 29.2
 LDTP02000  3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) 26.6
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 26.1
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) 24.5
 LDTP10935  Kinesin-like protein KIF2C (KIF2C) 24.0
 LDTP14159  Ubiquitin carboxyl-terminal hydrolase 16 (USP16) 20.5
 LDTP03003  Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2) 19.8
 LDTP12599  Ubiquitin-like-conjugating enzyme ATG3 (ATG3) 17.2
 LDTP08684  Phosphatase and actin regulator 4 (PHACTR4) 14.6
 LDTP05046  Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A) 14.5
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) 14.3
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 14.2
 LDTP08023  Elongation factor-like GTPase 1 (EFL1) 14.1
 LDTP19838  Immunity-related GTPase family Q protein (IRGQ) 13.6
 LDTP11819  STE20-like serine/threonine-protein kinase (SLK) 12.8
 LDTP11571  Uridine-cytidine kinase 2 (UCK2) 12.7
 LDTP02984  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) 12.4
 LDTP14051  Ubiquitin carboxyl-terminal hydrolase 15 (USP15) 12.3
 LDTP03481  DNA-3-methyladenine glycosylase (MPG) 11.5
 LDTP05228  Calcium-transporting ATPase type 2C member 1 (ATP2C1) 11.3
 LDTP10500  Lymphokine-activated killer T-cell-originated protein kinase (PBK) 11.0
 LDTP18530  Protein NDRG3 (NDRG3) 10.7
 LDTP06104  Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) 10.5
 LDTP04542  Thimet oligopeptidase (THOP1) 10.3
 LDTP04435  Interleukin-1 receptor-associated kinase 1 (IRAK1) 10.2
 LDTP12983  Sentrin-specific protease 1 (SENP1) 9.8
 LDTP02602  Histidine--tRNA ligase, cytoplasmic (HARS1) 9.7
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) 9.7
 LDTP00491  Aurora kinase A (AURKA) 9.4
 LDTP14535  6-phosphogluconolactonase (PGLS) 9.3
 LDTP06190  Ubiquitin carboxyl-terminal hydrolase 10 (USP10) 9.1
 LDTP00013  Ubiquitin-like modifier-activating enzyme 6 (UBA6) 8.9
 LDTP08617  Patatin-like phospholipase domain-containing protein 6 (PNPLA6) 8.9
 LDTP06536  Serine/threonine-protein kinase N2 (PKN2) 8.8
 LDTP02587  Alcohol dehydrogenase class-3 (ADH5) 8.7
 LDTP11601  (E3-independent) E2 ubiquitin-conjugating enzyme (UBE2O) 8.5
 LDTP04186  Glutamate--cysteine ligase regulatory subunit (GCLM) 8.5
 LDTP05475  Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) 8.2
 LDTP04620  5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) 8.1
 LDTP05639  Kinesin-like protein KIF1A (KIF1A) 8.1
 LDTP01474  Ubiquitin carboxyl-terminal hydrolase 19 (USP19) 7.2
 LDTP00616  Protein phosphatase 1G (PPM1G) 6.8
 LDTP13574  E3 ubiquitin-protein ligase HECTD1 (HECTD1) 6.6
 LDTP12364  Inositol-3-phosphate synthase 1 (ISYNA1) 6.6
 LDTP13137  Spastin (SPAST) 6.5
 LDTP03259  Ribonucleoside-diphosphate reductase large subunit (RRM1) 6.4
 LDTP06214  Kinesin-like protein KIF22 (KIF22) 6.4
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) 5.8
 LDTP13272  Septin-9 (SEPTIN9) 5.7
 LDTP03938  N-alpha-acetyltransferase 10 (NAA10) 5.7
 LDTP03577  S-adenosylmethionine synthase isoform type-2 (MAT2A) 5.5
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) 5.3
 LDTP01771  Glutathione reductase, mitochondrial (GSR) 5.2
 LDTP00225  26S proteasome non-ATPase regulatory subunit 9 (PSMD9) 5.2
 LDTP11996  3'-5' RNA helicase YTHDC2 (YTHDC2) 5.1
 LDTP10809  SRSF protein kinase 1 (SRPK1) 5.1
 LDTP12586  Phenylalanine--tRNA ligase beta subunit (FARSB) 4.8
 LDTP05289  AMP deaminase 2 (AMPD2) 4.7
 LDTP04333  GMP synthase [glutamine-hydrolyzing] (GMPS) 4.6
 LDTP08485  Serine/threonine-protein kinase VRK3 (VRK3) 4.6
 LDTP05481  Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (GFPT1) 4.6
 LDTP03156  Trifunctional purine biosynthetic protein adenosine-3 (GART) 4.5
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) 4.3
 LDTP00758  Thioredoxin-like protein 1 (TXNL1) 4.3
 LDTP02696  Glycogen [starch] synthase, muscle (GYS1) 4.2
 LDTP10709  Pseudouridylate synthase 7 homolog (PUS7) 4.2
Transporter and channel
Click to Show/Hide to Show 25 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04770  Syntaxin-17 (STX17) 41.1
 LDTP00958  TBC1 domain family member 4 (TBC1D4) 15.8
 LDTP12281  Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC) 14.6
 LDTP11161  Extended synaptotagmin-1 (ESYT1) 14.4
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 14.1
 LDTP09204  Nucleoporin NUP35 (NUP35) 12.0
 LDTP05938  Sorting nexin-1 (SNX1) 10.9
 LDTP02009  Cystatin-B (CSTB) 9.7
 LDTP07002  Transport and Golgi organization protein 1 homolog (MIA3) 8.9
 LDTP13415  ADP-ribosylation factor-binding protein GGA1 (GGA1) 8.1
 LDTP08897  Macoilin (MACO1) 7.9
 LDTP07152  Acyl-CoA-binding domain-containing protein 5 (ACBD5) 7.8
 LDTP10897  Nuclear pore complex protein Nup88 (NUP88) 7.4
 LDTP03839  Nuclear pore glycoprotein p62 (NUP62) 7.1
 LDTP00198  Synaptosomal-associated protein 23 (SNAP23) 6.5
 LDTP04597  Methylosome subunit pICln (CLNS1A) 6.2
 LDTP13498  Nuclear pore complex protein Nup50 (NUP50) 5.8
 LDTP09165  PDZ domain-containing protein 8 (PDZD8) 5.6
 LDTP02735  G2/mitotic-specific cyclin-B1 (CCNB1) 5.3
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) 5.2
 LDTP04866  Protein transport protein Sec61 subunit beta (SEC61B) 4.9
 LDTP16190  Protein FAM8A1 (FAM8A1) 4.7
 LDTP06902  mRNA export factor GLE1 (GLE1) 4.6
 LDTP00014  Extended synaptotagmin-2 (ESYT2) 4.6
 LDTP01380  Wolframin (WFS1) 4.2
Transcription factor
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06748  Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) 118.4
 LDTP03903  Signal transducer and activator of transcription 3 (STAT3) 50.4
 LDTP05248  Transcriptional activator protein Pur-alpha (PURA) 23.8
 LDTP11060  Ribosome quality control complex subunit TCF25 (TCF25) 9.2
 LDTP09564  Zinc finger CCCH domain-containing protein 15 (ZC3H15) 8.0
 LDTP10891  DnaJ homolog subfamily C member 2 (DNAJC2) 4.2
Other
Click to Show/Hide to Show 115 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14228  Transforming acidic coiled-coil-containing protein 3 (TACC3) 95.7
 LDTP07522  Centrosomal protein of 85 kDa (CEP85) 79.9
 LDTP08573  Ankyrin repeat and KH domain-containing protein 1 (ANKHD1) 75.6
 LDTP08535  MAP7 domain-containing protein 3 (MAP7D3) 71.5
 LDTP04112  Microtubule-associated protein 1B (MAP1B) 68.6
 LDTP01684  BAG family molecular chaperone regulator 3 (BAG3) 67.9
 LDTP07476  RAD50-interacting protein 1 (RINT1) 61.6
 LDTP06515  Coiled-coil domain-containing protein 6 (CCDC6) 41.2
 LDTP07061  Synaptosomal-associated protein 47 (SNAP47) 40.8
 LDTP19787  RING finger protein 214 (RNF214) 39.2
 LDTP01210  Transforming acidic coiled-coil-containing protein 1 (TACC1) 37.2
 LDTP15727  Protein LTV1 homolog (LTV1) 36.4
 LDTP10656  Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP3) 32.8
 LDTP05172  TATA element modulatory factor (TMF1) 31.0
 LDTP06268  Condensin complex subunit 2 (NCAPH) 30.8
 LDTP07297  Microtubule-associated protein 1S (MAP1S) 30.5
 LDTP03404  Microtubule-associated protein 4 (MAP4) 29.6
 LDTP01522  Reticulon-3 (RTN3) 28.6
 LDTP13383  Protein Hook homolog 1 (HOOK1) 24.1
 LDTP14978  Protein PRRC2B (PRRC2B) 23.8
 LDTP11530  Tether containing UBX domain for GLUT4 (ASPSCR1) 23.0
 LDTP10802  Ran-binding protein 9 (RANBP9) 22.4
 LDTP13304  Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1) 22.3
 LDTP04092  Crk-like protein (CRKL) 21.8
 LDTP14104  NEDD8 ultimate buster 1 (NUB1) 21.6
 LDTP11367  Oxysterol-binding protein-related protein 11 (OSBPL11) 20.8
 LDTP03151  Oxysterol-binding protein 1 (OSBP) 19.1
 LDTP00737  Centriolar coiled-coil protein of 110 kDa (CCP110) 18.7
 LDTP12640  Gamma-taxilin (TXLNG) 18.5
 LDTP04396  RNA-binding protein FXR2 (FXR2) 16.1
 LDTP13402  Dynactin subunit 4 (DCTN4) 16.0
 LDTP19976  Leucine-rich repeat-containing protein 40 (LRRC40) 15.2
 LDTP12865  G2 and S phase-expressed protein 1 (GTSE1) 15.0
 LDTP08735  Spartin (SPART) 13.3
 LDTP09049  NHL repeat-containing protein 2 (NHLRC2) 13.1
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) 12.4
 LDTP11019  Endophilin-A2 (SH3GL1) 12.3
 LDTP00019  Shootin-1 (SHTN1) 12.1
 LDTP05556  Golgin subfamily A member 3 (GOLGA3) 12.0
 LDTP09820  La-related protein 4B (LARP4B) 11.7
 LDTP05418  UBX domain-containing protein 1 (UBXN1) 11.4
 LDTP11066  Methylosome protein WDR77 (WDR77) 11.3
 LDTP01677  Double-stranded RNA-binding protein Staufen homolog 1 (STAU1) 11.1
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 11.0
 LDTP06439  Thyroid receptor-interacting protein 6 (TRIP6) 10.8
 LDTP02263  Signal recognition particle receptor subunit alpha (SRPRA) 10.8
 LDTP06383  Calponin-3 (CNN3) 10.7
 LDTP14217  Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) 10.6
 LDTP00512  Protein transport protein Sec16A (SEC16A) 10.6
 LDTP12000  RNA polymerase II-associated protein 3 (RPAP3) 10.3
 LDTP12448  Gephyrin (GPHN) 10.1
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) 10.1
 LDTP19626  Glucocorticoid-induced transcript 1 protein (GLCCI1) 10.0
 LDTP03426  Protein ITPRID2 (ITPRID2) 9.7
 LDTP18272  Transmembrane protein 209 (TMEM209) 9.5
 LDTP13657  Melanoma-associated antigen D2 (MAGED2) 8.8
 LDTP13323  Multifunctional methyltransferase subunit TRM112-like protein (TRMT112) 8.7
 LDTP13318  Translation initiation factor eIF2B subunit delta (EIF2B4) 8.7
 LDTP08523  Centrosomal protein of 97 kDa (CEP97) 8.4
 LDTP07345  Cell division cycle-associated protein 2 (CDCA2) 8.3
 LDTP13519  Proteasome activator complex subunit 2 (PSME2) 8.2
 LDTP04560  Cytosolic Fe-S cluster assembly factor NUBP1 (NUBP1) 7.9
 LDTP12948  Charged multivesicular body protein 5 (CHMP5) 7.7
 LDTP12596  Protein diaphanous homolog 3 (DIAPH3) 7.7
 LDTP12631  Double-stranded RNA-binding protein Staufen homolog 2 (STAU2) 7.6
 LDTP06094  Src substrate cortactin (CTTN) 7.3
 LDTP00755  WD repeat-containing protein 62 (WDR62) 7.0
 LDTP04722  BH3-interacting domain death agonist (BID) 6.9
 LDTP03706  Profilin-2 (PFN2) 6.8
 LDTP09655  Ataxin-2-like protein (ATXN2L) 6.7
 LDTP08273  Leucine zipper protein 1 (LUZP1) 6.6
 LDTP15840  Tetratricopeptide repeat protein 1 (TTC1) 6.5
 LDTP12914  Hsp70-binding protein 1 (HSPBP1) 6.5
 LDTP01678  Tetratricopeptide repeat protein 4 (TTC4) 6.4
 LDTP13978  Ubiquitin-fold modifier-conjugating enzyme 1 (UFC1) 6.2
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) 6.0
 LDTP10062  Synapse-associated protein 1 (SYAP1) 6.0
 LDTP09383  Protein CIP2A (CIP2A) 5.9
 LDTP07071  Centrosomal protein of 170 kDa (CEP170) 5.9
 LDTP06285  Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ACAP1) 5.9
 LDTP07605  La-related protein 1 (LARP1) 5.7
 LDTP06255  GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1) 5.6
 LDTP10431  Vesicle-trafficking protein SEC22a (SEC22A) 5.5
 LDTP08095  Coiled-coil domain-containing protein R3HCC1L (R3HCC1L) 5.5
 LDTP07903  La-related protein 4 (LARP4) 5.5
 LDTP10825  Oxysterol-binding protein-related protein 9 (OSBPL9) 5.4
 LDTP01567  Structural maintenance of chromosomes protein 2 (SMC2) 5.3
 LDTP14085  Protein PRRC2C (PRRC2C) 5.3
 LDTP01711  Protein ecdysoneless homolog (ECD) 5.3
 LDTP01285  TIP41-like protein (TIPRL) 5.2
 LDTP06361  Lethal(2) giant larvae protein homolog 1 (LLGL1) 5.1
 LDTP00808  Density-regulated protein (DENR) 5.0
 LDTP01129  CLIP-associating protein 2 (CLASP2) 5.0
 LDTP01914  Putative HLA class I histocompatibility antigen, alpha chain H (HLA-H) 4.9
 LDTP06281  Condensin complex subunit 1 (NCAPD2) 4.9
 LDTP14105  YTH domain-containing family protein 2 (YTHDF2) 4.8
 LDTP04199  Protein PRRC2A (PRRC2A) 4.8
 LDTP04385  Lipopolysaccharide-responsive and beige-like anchor protein (LRBA) 4.6
 LDTP11870  BolA-like protein 2 (BOLA2; BOLA2B) 4.6
 LDTP13044  Ribosome-binding protein 1 (RRBP1) 4.6
 LDTP05734  Protein flightless-1 homolog (FLII) 4.6
 LDTP18166  Zinc finger CCCH-type antiviral protein 1-like (ZC3HAV1L) 4.6
 LDTP08325  Zinc finger C3HC-type protein 1 (ZC3HC1) 4.5
 LDTP01511  Elongator complex protein 1 (ELP1) 4.5
 LDTP14426  TRAF-type zinc finger domain-containing protein 1 (TRAFD1) 4.5
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) 4.4
 LDTP05462  Caldesmon (CALD1) 4.3
 LDTP07400  Elongator complex protein 2 (ELP2) 4.3
 LDTP11930  Oxysterol-binding protein-related protein 3 (OSBPL3) 4.3
 LDTP05239  Vigilin (HDLBP) 4.3
 LDTP00202  AH receptor-interacting protein (AIP) 4.2
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) 4.2
 LDTP14192  MORF4 family-associated protein 1 (MRFAP1) 4.1
 LDTP04875  Myosin light polypeptide 6 (MYL6) 4.1
 LDTP01319  Eukaryotic translation initiation factor 3 subunit G (EIF3G) 4.0

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348