Details of the Target

General Information of Target

Target ID LDTP13044
Target Name Ribosome-binding protein 1 (RRBP1)
Gene Name RRBP1
Gene ID 6238
Synonyms
KIAA1398; Ribosome-binding protein 1; 180 kDa ribosome receptor homolog; RRp; ES/130-related protein; Ribosome receptor protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLMPLCGLLWWWWCCCSGWYCYGLCAPAPQMLRHQGLLKCRCRMLFNDLKVFLLRRPPQA
PLPMHGDPQPPGLAANNTLPALGAGGWAGWRGPREVVGREPPPVPPPPPLPPSSVEDDWG
GPATEPPASLLSSASSDDFCKEKTEDRYSLGSSLDSGMRTPLCRICFQGPEQGELLSPCR
CDGSVKCTHQPCLIKWISERGCWSCELCYYKYHVIAISTKNPLQWQAISLTVIEKVQVAA
AILGSLFLIASISWLIWSTFSPSARWQRQDLLFQICYGMYGFMDVVCIGLIIHEGPSVYR
IFKRWQAVNQQWKVLNYDKTKDLEDQKAGGRTNPRTSSSTQANIPSSEEETAGTPAPEQG
PAQAAGHPSGPLSHHHCAYTILHILSHLRPHEQRSPPGSSRELVMRVTTV
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum membrane
Function Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.
Uniprot ID
Q9P2E9
Ensemble ID
ENST00000246043.8
HGNC ID
HGNC:10448

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.K201RfsTer72 DBIA    Probe Info 
AN3CA Deletion: p.K231RfsTer42 DBIA    Probe Info 
CAL27 SNV: p.Q518K DBIA    Probe Info 
DU145 SNV: p.Q556H DBIA    Probe Info 
HT SNV: p.G967S .
HT115 SNV: p.F17C; p.S1052L DBIA    Probe Info 
HUH7 SNV: p.I755V .
JHH7 SNV: p.T954I; p.Q1307E .
L428 SNV: p.I160T .
LS180 Deletion: p.K746SfsTer25 DBIA    Probe Info 
MEWO SNV: p.Q1234Ter DBIA    Probe Info 
MFE319 Deletion: p.A495LfsTer66
Insertion: p.A530GfsTer26
SNV: p.L674M		 DBIA    Probe Info 
OVK18 SNV: p.Q408L DBIA    Probe Info 
SCC25 Substitution: p.Q426P .
SNU1 Deletion: p.K231RfsTer42
SNV: p.S924P		 DBIA    Probe Info 
TE11 SNV: p.Q408L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 38 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.41  LDD0402  [1]
A-EBA
 Probe Info  		3.10  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
W1
 Probe Info  		14.77  LDD0235  [4]
ONAyne
 Probe Info  		K1159(1.12); K1331(10.00); K300(1.33); K779(5.56)  LDD0274  [5]
Probe 1
 Probe Info  		Y1131(8.13)  LDD3495  [6]
P13
 Probe Info  		10.50  LDD0203  [7]
BTD
 Probe Info  		C1323(1.09); C933(1.03)  LDD1700  [8]
DA-P3
 Probe Info  		5.30  LDD0181  [9]
AHL-Pu-1
 Probe Info  		C892(2.33)  LDD0168  [10]
HHS-475
 Probe Info  		Y647(1.57)  LDD0264  [11]
DBIA
 Probe Info  		C933(1.04); C1216(0.99); C1038(0.95); C1128(0.85)  LDD0078  [12]
5E-2FA
 Probe Info  		H919(0.00); H940(0.00); H1099(0.00); H893(0.00)  LDD2235  [13]
ATP probe
 Probe Info  		K261(0.00); K1039(0.00); K1041(0.00); K301(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1038(0.00); C933(0.00); C892(0.00); C1216(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [16]
Lodoacetamide azide
 Probe Info  		C1038(0.00); C933(0.00); C1128(0.00); C1323(0.00)  LDD0037  [15]
NAIA_4
 Probe Info  		C892(0.00); C933(0.00); C1038(0.00); C1057(0.00)  LDD2226  [17]
TFBX
 Probe Info  		C1323(0.00); C1038(0.00); C1216(0.00); C933(0.00)  LDD0027  [18]
WYneN
 Probe Info  		C1323(0.00); C933(0.00); C892(0.00); C1038(0.00)  LDD0021  [19]
WYneO
 Probe Info  		C933(0.00); C1038(0.00)  LDD0022  [19]
Compound 10
 Probe Info  		N.A.  LDD2216  [20]
Compound 11
 Probe Info  		N.A.  LDD2213  [20]
IPM
 Probe Info  		C933(0.00); C892(0.00)  LDD0005  [19]
NHS
 Probe Info  		K691(0.00); K779(0.00); K430, K270, K340, K380, K410, K360, K470, K320, K450, K490(0.00); K420, K370, K350, K340, K490, K410, K360, K380, K460, K390, K430, K500, K270, K440, K450, K470, K320(0.00)  LDD0010  [19]
SF
 Probe Info  		K471, K391, K301(0.00); K441, K351, K311, K411, K261, K451, K341, K371, K461, K431, K401, K481, K421, K361, K381, K491, K331(0.00)  LDD0028  [21]
STPyne
 Probe Info  		K340, K430, K360, K320, K410, K270, K450, K380, K490, K470(0.00); K250, K230(0.00); K691(0.00)  LDD0009  [19]
VSF
 Probe Info  		C933(0.00); C1038(0.00)  LDD0007  [19]
Phosphinate-6
 Probe Info  		C1216(0.00); C933(0.00); C892(0.00)  LDD0018  [22]
1c-yne
 Probe Info  		K932(0.00); K1375(0.00); K231(0.00)  LDD0228  [23]
1d-yne
 Probe Info  		N.A.  LDD0357  [23]
Acrolein
 Probe Info  		C933(0.00); C1216(0.00); C1038(0.00); H1176(0.00)  LDD0217  [24]
Crotonaldehyde
 Probe Info  		C1128(0.00); C1323(0.00); C892(0.00); C1216(0.00)  LDD0219  [24]
Methacrolein
 Probe Info  		C933(0.00); C1128(0.00); C892(0.00); C1216(0.00)  LDD0218  [24]
AOyne
 Probe Info  		8.80  LDD0443  [25]
NAIA_5
 Probe Info  		C1038(0.00); C933(0.00); C1057(0.00); C892(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe15
 Probe Info  		12.28  LDD0478  [26]
FFF probe2
 Probe Info  		7.94  LDD0463  [26]
FFF probe3
 Probe Info  		20.00  LDD0464  [26]
DA-2
 Probe Info  		N.A.  LDD0072  [27]
OEA-DA
 Probe Info  		17.18  LDD0046  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C1323(0.80); C933(0.73); C1128(0.59)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1323(0.98); C933(0.88); C892(0.90); C1216(0.53)  LDD2112  [8]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C1323(0.84)  LDD2095  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C933(1.42)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1323(1.12); C1038(1.40); C933(1.21); C892(0.99)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1323(1.26); C933(1.84); C892(1.37)  LDD2152  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1323(0.99); C933(0.70); C892(1.23)  LDD2103  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1323(0.56); C892(0.55)  LDD2132  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C933(0.61); C892(1.08)  LDD2131  [8]
 LDCM0025  4SU-RNA HEK-293T C892(2.33)  LDD0168  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C892(2.32)  LDD0169  [10]
 LDCM0214  AC1 HCT 116 C1323(1.06); C1038(0.93); C1128(1.46); C1216(1.32)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C1323(1.25); C1128(1.18); C1216(1.23)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C1323(1.05); C1038(1.23); C1128(0.86); C1216(0.99)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C1323(1.10); C1038(1.09); C1128(0.95); C1216(0.96)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C1323(1.19); C1038(1.07); C1128(0.93); C1216(1.03)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C1323(1.45); C1038(1.22); C1128(0.98); C1216(1.09)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C1323(1.11); C1038(1.23); C1128(1.00); C1216(1.15)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C1323(1.25); C1038(1.13); C1128(0.97); C1216(1.08)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C1323(1.47); C1038(1.35); C1128(0.95); C1216(1.12)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C1323(1.31); C1038(1.08); C1128(1.06); C1216(1.14)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C1323(1.09); C1038(1.28); C1128(0.85); C1216(0.99)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C1323(0.97); C1038(1.02); C1128(0.79); C1216(0.93)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C1323(1.46); C1128(1.13); C1216(1.26)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C1323(1.16); C1038(1.27); C1128(0.90); C1216(0.97)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C1323(1.10); C1038(1.39); C1128(0.85); C1216(0.98)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C1323(1.24); C1038(1.27); C1128(0.97); C1216(1.02)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C1323(1.03); C1038(1.05); C1128(1.14); C1216(1.03)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C1323(1.25); C1038(1.06); C1128(1.18); C1216(1.23)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C1323(1.59); C1038(1.25); C1128(1.11); C1216(1.32)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C1323(1.37); C1038(1.21); C1128(1.29); C1216(1.19)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C1323(1.21); C1038(1.08); C1128(1.16); C1216(1.16)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C1323(1.13); C1038(1.25); C1128(1.33); C1216(1.07)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C1323(1.47); C1038(1.12); C1128(1.42); C1216(1.13)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C1323(1.16); C1128(1.07); C1216(1.23)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C1323(1.19); C1038(1.20); C1128(1.09); C1216(1.34)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C1323(0.94); C1038(1.08); C1128(1.00); C1216(1.04)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C1323(1.09); C1038(1.07); C1128(1.10); C1216(1.17)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C1323(0.89); C1038(0.95); C1128(1.29); C1216(1.16)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C1323(1.04); C1038(0.99); C1128(1.11); C1216(1.05)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C1323(1.22); C1038(1.08); C1128(1.04); C1216(1.09)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C1323(1.53); C1038(1.21); C1128(1.12); C1216(1.28)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C1323(1.48); C1038(1.13); C1128(1.36); C1216(1.21)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C1323(1.10); C1128(1.40); C1216(1.12); C933(0.63)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C1323(0.75); C1128(1.06); C1216(0.83); C933(0.75)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C1323(1.20); C1128(1.16); C1216(1.05); C933(0.76)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C1323(1.03); C1128(1.03); C1216(0.85); C933(0.81)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C1323(0.92); C1128(1.21); C1216(0.84); C933(0.89)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C1323(0.96); C1128(1.44); C1216(0.98); C933(0.91)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C1323(0.95); C1128(1.15); C1216(1.02); C933(0.78)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C1323(0.99); C1128(1.57); C1216(1.05); C933(0.77)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C1323(1.17); C1128(1.21); C1216(1.03); C933(1.02)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C1323(1.10); C1128(1.20); C1216(1.02); C933(0.89)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C1323(1.11); C1128(1.34); C1216(1.16); C933(1.29)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C1323(0.99); C1128(1.39); C1216(1.05); C933(1.23)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C1323(1.07); C1128(1.29); C1216(1.23)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C1323(1.05); C1128(1.38); C1216(1.09); C933(1.17)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C1323(1.21); C1128(1.26); C1216(1.04); C933(1.21)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C1323(0.86); C1128(1.24); C1216(0.93); C933(1.06)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C1323(1.19); C1216(1.09); C1128(1.10); C1038(1.11)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C1216(1.23); C1038(1.38); C1323(1.44); C1128(1.51)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C1216(1.07); C933(1.17); C1038(1.28); C1323(1.28)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C1038(1.25); C1216(1.25); C1323(1.29); C933(1.37)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C1216(1.28); C1128(1.30); C1038(1.46); C933(1.62)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C1216(1.65); C1128(1.78); C1323(1.90); C1038(1.93)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C1216(1.36); C1038(1.42); C1128(1.57); C1323(1.59)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C1128(1.12); C1323(1.22); C1216(1.26)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C1128(1.07); C1216(1.12); C933(1.31); C1038(1.34)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C1216(1.03); C933(1.14); C1038(1.15); C1128(1.25)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C1038(1.18); C1216(1.30); C933(1.36); C1128(1.38)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C1128(1.87); C1216(1.87); C1038(1.89); C1323(2.45)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C1323(1.48); C1038(1.38); C1128(1.53); C1216(1.18)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C1323(2.15); C1038(1.40); C1128(1.24); C1216(1.25)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C1323(1.37); C1038(0.98); C1128(1.23); C1216(1.00)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C1323(1.28); C1038(1.05); C1128(1.01); C1216(0.91)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C1323(0.95); C1128(1.00); C1216(1.02); C1038(1.07)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C1128(0.92); C1323(0.93); C1216(1.28); C1038(1.39)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C1128(0.98); C1323(1.00); C1216(1.06); C1038(1.18)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C1323(1.08); C1038(1.09); C1216(1.23); C933(1.24)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C1128(0.83); C1323(0.97); C1216(1.03); C1038(1.09)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C1323(1.00); C1128(1.02); C1038(1.08); C1216(1.13)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C1323(0.95); C1038(0.96); C1128(0.96); C1216(1.01)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C1128(0.95); C1323(1.03); C1216(1.05); C1038(1.07)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C1128(0.90); C1216(0.98); C1038(0.99); C1323(0.99)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C933(0.89); C1128(0.95); C1038(1.00); C1216(1.02)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C1128(0.98); C933(1.06); C1216(1.18); C1038(1.27)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C1128(1.01); C1216(1.13); C1038(1.22); C933(1.27)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C1128(0.96); C1216(1.15); C1038(1.24); C933(1.30)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C1128(0.74); C1216(1.06); C1038(1.12); C1323(1.51)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C1038(1.11); C1323(1.15); C1216(1.17); C1128(1.47)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C1128(0.99); C1216(1.18); C1038(1.27); C933(1.43)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C1128(0.95); C1216(1.12); C1038(1.28); C933(1.36)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C1128(0.97); C1216(1.34); C1038(1.64); C933(1.76)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C1128(0.94); C1216(1.23); C1038(1.40); C933(1.43)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C1128(1.03); C1216(1.46); C933(1.54); C1038(1.57)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C933(0.77); C1323(0.79); C1216(0.92); C1038(0.93)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C1323(0.78); C933(0.88); C1216(0.90); C1038(0.93)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C933(0.77); C1323(0.79); C1216(0.86); C1038(0.91)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C933(0.92); C1216(0.92); C1323(0.93); C1038(1.00)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C933(0.91); C1216(1.05); C1323(1.10); C1038(1.10)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C1038(1.03); C1323(1.27); C1216(1.34); C933(1.46)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C933(0.92); C1038(1.01); C1216(1.03); C1323(1.04)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C933(0.74); C1038(0.94); C1216(0.96); C1323(0.98)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C933(0.96); C1216(1.03); C1038(1.04); C1128(1.12)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C1216(1.01); C933(1.07); C1038(1.10); C1323(1.10)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C933(0.66); C1038(0.99); C1323(1.00); C1216(1.02)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C933(0.60); C1038(1.04); C1216(1.17); C1323(1.28)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C1323(0.87); C1128(0.99); C1216(1.01); C1038(1.01)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C1216(1.00); C1128(1.04); C1038(1.05); C1323(1.09)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C1323(0.93); C1216(0.97); C1038(1.05); C1128(1.15)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C1128(1.09); C1038(1.40); C1216(1.53); C1323(1.57)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C1038(0.92); C1323(1.13); C1216(1.33); C933(1.49)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C1128(0.96); C1216(1.25); C1038(1.32); C1323(1.84)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C1216(0.83); C1128(0.87); C1038(0.89); C1323(0.92)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C1128(0.91); C1216(0.98); C1323(1.02); C1038(1.10)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C1128(0.95); C1216(1.03); C1038(1.21); C1323(1.46)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C1128(1.14); C1216(1.23); C1038(1.31); C933(1.64)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C1128(1.09); C1216(1.31); C1038(1.31); C933(1.62)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C1128(1.08); C1038(1.53); C933(1.56); C1216(1.69)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C1038(1.03); C1323(1.07); C1216(1.27); C1128(1.33)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C1128(1.08); C1216(1.21); C1038(1.22); C1323(1.23)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C1128(1.25); C1038(1.36); C1216(1.40); C1323(1.65)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C1128(0.96); C1216(1.21); C1323(1.28)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C1038(1.02); C1128(1.22); C1216(1.22); C1323(1.32)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C1323(1.02); C1216(1.25); C1038(1.28); C1128(1.37)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C1128(1.34); C1216(1.34); C1038(1.38); C1323(1.57)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C1216(1.19); C1038(1.31); C1128(1.36); C1323(1.41)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C1216(1.29); C1128(1.43); C1323(1.49); C1038(1.49)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C1323(1.06); C1216(1.28); C1038(1.45); C1128(1.46)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C1323(1.14); C1216(1.22); C1128(1.34); C1038(1.52)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C1128(1.37); C1216(1.40); C1038(1.58); C1323(1.64)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C933(0.91); C1128(1.03); C1216(1.09); C1323(1.09)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C933(0.96); C1216(1.12); C1128(1.17); C1038(1.26)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C1323(1.06); C1128(1.07); C1216(1.11)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C933(0.99); C1128(1.01); C1216(1.03); C1038(1.20)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C933(1.01); C1323(1.06); C1216(1.09); C1128(1.09)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C1128(1.05); C1216(1.12); C1038(1.14); C1323(1.42)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C1128(1.13); C933(1.28); C1038(1.34); C1216(1.48)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C933(0.99); C1128(1.26); C1216(1.47); C1323(1.58)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C1128(1.22); C933(1.30); C1038(1.50); C1216(1.64)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C1128(1.07); C1216(1.14); C933(1.18); C1323(1.23)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C1128(1.01); C1216(1.14); C933(1.24); C1038(1.28)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C1216(0.97); C933(0.98); C1128(1.03); C1038(1.19)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C933(0.92); C1128(1.00); C1216(1.05); C1038(1.18)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C1128(1.06); C1323(1.23); C1216(1.40)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C933(0.93); C1216(1.17); C1038(1.18); C1128(1.20)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C1038(0.94); C1216(1.07); C1128(1.08); C1323(1.18)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C933(0.98); C1128(1.30); C1038(1.64); C1216(1.76)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C933(0.90); C1128(0.99); C1038(1.22); C1216(1.50)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C933(0.86); C1128(1.01); C1038(1.21); C1216(1.49)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C933(0.84); C1128(0.88); C1038(1.12); C1216(1.26)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C1128(0.96); C933(0.98); C1038(1.07); C1216(1.12)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C1128(0.91); C933(0.96); C1323(0.99); C1216(1.04)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C1128(0.84); C1216(1.10); C933(1.12); C1038(1.18)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C933(0.91); C1128(0.96); C1038(1.09); C1216(1.25)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C1128(0.83); C1323(0.95); C1216(0.95); C933(0.96)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C933(0.95); C1128(1.07); C1038(1.34); C1216(1.47)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C933(0.85); C1128(0.95); C1038(1.19); C1216(1.32)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C933(0.83); C1128(0.89); C1038(1.11); C1216(1.21)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C933(0.73); C1128(0.99); C1038(1.08); C1216(1.20)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C1128(0.96); C933(0.98); C1216(1.05); C1038(1.18)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C933(0.65); C1128(1.10); C1038(1.12); C1216(1.18)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C1128(0.92); C933(1.03); C1038(1.08); C1216(1.36)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C1128(1.13); C1038(1.22); C933(1.50); C1216(1.55)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C1128(0.91); C1216(0.98); C933(1.06); C1038(1.17)  LDD0683  [12]
 LDCM0545  Acetamide MDA-MB-231 C892(0.36); C1216(0.57)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C1038(0.82); C933(0.67); C892(0.75); C1216(0.72)  LDD2113  [8]
 LDCM0248  AKOS034007472 HCT 116 C1323(1.10); C1128(1.04); C1216(1.08)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C1128(1.07); C1323(1.15); C1216(1.17)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C1128(1.29); C1323(1.84); C1216(1.87)  LDD0592  [12]
 LDCM0020  ARS-1620 HCC44 C933(1.04); C1216(0.99); C1038(0.95); C1128(0.85)  LDD0078  [12]
 LDCM0498  BS-3668 MDA-MB-231 C1323(0.77); C933(0.47); C892(0.34); C1216(0.49)  LDD2091  [8]
 LDCM0088  C45 HEK-293T 10.50  LDD0203  [7]
 LDCM0108  Chloroacetamide HeLa C1323(0.00); C1216(0.00); C892(0.00); C933(0.00)  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C933(1.03); C1216(0.98); C1038(0.86); C1323(0.84)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C1128(0.94); C1323(0.95); C1216(0.97); C1038(1.03)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C1038(1.13); C1128(1.27); C1216(1.39); C1323(1.44)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C1038(1.01); C1323(1.16); C1216(1.30); C1128(1.37)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C1323(1.14); C1128(1.17); C1216(1.25)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C1323(1.03); C1216(1.09); C1128(1.29)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C1216(0.96); C1323(1.03); C1128(1.07)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C1216(1.09); C1323(1.11); C1128(1.20)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C1323(1.13); C1128(1.20); C1216(1.24); C1038(1.46)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C1323(1.35); C1128(1.36); C1216(1.52); C1038(1.59)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C1323(1.33); C1216(1.43); C1128(1.47); C1038(1.50)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C1323(1.19); C1128(1.40); C1216(1.51); C1038(1.79)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C1323(1.11); C1128(1.14); C1216(1.17); C1038(1.33)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C1038(1.22); C1216(1.34); C1128(1.44); C1323(1.55)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C1323(1.13); C1128(1.26); C1216(1.33); C1038(1.49)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C1323(0.98); C1038(1.18); C1128(1.21); C1216(1.28)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C1128(0.89); C933(0.94); C1216(1.04); C1323(1.17)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C1128(0.80); C1216(1.34); C1038(1.42); C933(1.54)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C1128(0.95); C1216(1.12); C1038(1.15); C933(1.50)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C1128(0.93); C1216(1.18); C1038(1.20); C933(1.42)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C1128(0.93); C1216(1.17); C933(1.23); C1038(1.28)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C933(0.99); C1038(1.31); C1128(1.42); C1216(1.49)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C1323(0.88); C933(0.94); C1216(1.00); C1038(1.06)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C933(0.89); C1323(1.01); C1216(1.09); C1038(1.10)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C1038(1.12); C1128(1.28); C1216(1.32); C1323(1.81)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C933(0.88); C1216(0.96); C1038(1.04); C1323(1.08)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C1216(1.01); C933(1.20); C1128(1.21); C1038(1.34)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C1216(1.10); C1323(1.11); C1128(1.20); C1038(1.27)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C933(1.36); C1323(1.39); C1216(1.46); C1038(1.52)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C1216(1.28); C1038(1.37); C1128(1.40); C1323(1.72)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C1038(0.81); C1216(0.84); C1323(1.00); C1128(1.14)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C1038(0.83); C933(0.90); C1323(0.99); C1216(1.13)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C1216(0.98); C933(0.99); C1038(1.05); C1128(1.11)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C1038(1.04); C1128(1.31); C1323(1.32); C1216(1.34)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C1038(1.07); C1216(1.14); C1128(1.20); C1323(1.34)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C1038(0.94); C1216(0.96); C1323(1.02); C1128(1.09)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C1323(1.12); C1038(1.13); C1216(1.15); C1128(1.24)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C1216(1.08); C1323(1.13); C1128(1.64)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C933(1.00); C1216(1.03); C1323(1.22); C1128(1.82)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C933(0.93); C1216(1.13); C1323(1.17); C1128(1.85)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C933(0.93); C1216(1.16); C1323(1.31); C1128(1.70)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C1216(0.93); C1038(0.94); C1323(0.96); C1128(1.05)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C933(1.18); C1216(1.26); C1128(1.31); C1323(1.54)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C933(0.95); C1216(1.30); C1323(1.78); C1128(2.12)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C933(0.78); C1216(1.80); C1128(2.32); C1323(2.92)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C933(0.89); C1128(0.97); C1216(1.09); C1323(1.34)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C1323(2.01); C1128(1.23); C1216(1.47); C933(1.03)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C1323(1.65); C1128(1.97); C1216(1.36); C933(0.64)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C1323(1.37); C1128(1.40); C1216(1.19); C933(0.77)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C1323(1.38); C1128(2.34); C1216(1.10); C933(1.15)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C1323(1.59); C1128(1.71); C1216(1.19); C933(0.93)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C1323(1.62); C1128(1.23); C1216(1.21); C933(0.91)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C1323(0.92); C1038(1.01); C1128(1.10); C1216(0.97)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C1323(1.30); C1128(1.09); C1216(0.94); C933(0.79)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C1323(1.14); C1038(1.11); C1128(1.09); C1216(1.08)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C1323(1.32); C1038(0.98); C1128(1.38); C1216(1.20)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C1323(1.33); C1038(1.06); C1128(1.10); C1216(1.14)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C1323(1.93); C1038(1.25); C1128(1.19); C1216(1.37)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C1323(1.50); C1038(1.20); C1128(1.26); C1216(1.33)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C1323(1.49); C1038(1.25); C1128(1.09); C1216(1.24)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C1323(1.84); C1038(1.24); C1128(1.26); C1216(1.42)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C1323(1.75); C1038(1.34); C1128(1.16); C1216(1.43)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C1323(1.06); C1038(1.06); C1128(1.15); C1216(0.95)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C1323(1.72); C1038(1.11); C1128(1.13); C1216(1.35)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C1323(1.55); C1038(1.24); C1128(1.25); C1216(1.17)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C1323(5.05); C1038(1.35); C1128(1.38); C1216(1.94)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C1323(2.53); C1038(1.29); C1128(1.21); C1216(1.52)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C1323(1.91); C1038(1.20); C1128(1.23); C1216(1.26)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C1323(2.22); C1038(1.33); C1128(1.48); C1216(1.41)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C1323(0.87); C1128(1.03); C1216(0.82)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C1323(0.84); C1128(0.92); C1216(0.86)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C1323(0.89); C1128(1.01); C1216(0.81)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C1323(1.08); C1128(1.02); C1216(0.85)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C1323(1.14); C1038(0.99); C1128(1.09); C1216(0.97)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C1323(0.83); C1128(1.01); C1216(0.85)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C1323(0.84); C1128(0.95); C1216(0.81)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C1323(1.04); C1128(0.99); C1216(0.76)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C1323(1.01); C1128(0.98); C1216(0.82)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C1323(0.86); C1128(1.08); C1216(0.75)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C1323(0.83); C1128(1.05); C1216(0.78)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C1323(1.03); C1128(1.10); C1216(0.97)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C1323(0.90); C1128(1.22); C1216(0.87)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C1323(0.94); C1128(0.91); C1216(0.81)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C1323(1.10); C1128(0.94); C1216(0.88)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C1323(1.13); C1038(1.07); C1128(1.27); C1216(1.08)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C1323(1.04); C1128(1.04); C1216(0.91)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C1323(1.07); C1038(0.99); C1128(1.23); C1216(1.02)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C1323(1.19); C1038(1.01); C1128(1.22); C1216(1.05)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C1323(1.35); C1038(1.08); C1128(1.22); C1216(1.17)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C1323(1.74); C1038(1.25); C1128(1.02); C1216(1.19)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C1323(1.18); C1038(1.13); C1128(1.02); C1216(1.07)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C1323(2.11); C1038(1.43); C1128(1.52); C1216(1.51)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C1323(1.69); C1038(1.27); C1128(1.08); C1216(1.31)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C1323(1.44); C1038(1.23); C1128(1.32); C1216(1.17)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C1323(1.01); C1038(0.93); C1128(1.13); C1216(0.95)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C1323(1.27); C1038(1.13); C1128(1.30); C1216(1.13)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C1323(1.41); C1038(1.04); C1128(0.97); C1216(1.10)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C1323(1.46); C1038(1.14); C1128(1.05); C1216(1.14)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C1323(1.09); C1038(0.98); C1128(0.91); C1216(1.01)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C1323(1.39); C1038(1.09); C1128(0.92); C1216(1.09)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C1323(1.33); C1038(1.18); C1128(0.91); C1216(1.09)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C1323(1.10); C1038(1.01); C1128(1.06); C1216(1.14)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C1323(1.14); C1038(1.01); C1128(0.87); C1216(1.06)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C1323(1.44); C1038(1.06); C1128(0.98); C1216(1.15)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C1323(1.50); C1038(1.12); C1128(1.09); C1216(1.32)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C1323(2.19); C1038(1.24); C1128(1.22); C1216(1.32)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C1323(0.99); C1038(1.17); C1128(1.17); C1216(1.09)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C1323(1.50); C1038(1.09); C1128(1.06); C1216(1.17)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C1323(2.05); C1038(1.30); C1128(1.40); C1216(1.59)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C1323(1.66); C1038(1.30); C1128(1.30); C1216(1.41)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C1323(2.26); C1038(1.30); C1128(1.40); C1216(1.72)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C1323(1.42); C1038(1.11); C1128(1.07); C1216(1.22)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C1323(1.28); C1038(1.02); C1128(1.00); C1216(1.06)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C1323(1.75); C1038(1.18); C1128(1.22); C1216(1.13)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C1323(1.79); C1038(1.16); C1128(1.27); C1216(1.32)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C1323(3.17); C1038(1.44); C1128(1.39); C1216(2.05)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C1323(1.30); C1038(1.20); C1128(1.12); C1216(1.09)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C1323(0.94); C1038(1.22); C1128(0.86); C1216(1.03)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C1323(1.10); C1038(1.10); C1128(1.36); C1216(1.26)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C1323(1.09); C1038(0.99); C1128(1.34); C1216(1.26)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C1323(1.07); C1038(0.90); C1128(1.29); C1216(1.13)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C1323(1.32); C1038(1.11); C1128(1.34); C1216(1.21)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C1323(1.34); C1038(1.03); C1128(1.43); C1216(1.29)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C1323(1.25); C1038(1.17); C1128(1.39); C1216(1.21)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C1323(1.09); C1038(1.17); C1128(1.48); C1216(1.30)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C1323(1.12); C1038(1.09); C1128(1.35); C1216(1.38)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C1323(1.22); C1038(0.95); C1128(1.40); C1216(1.35)  LDD0811  [12]
 LDCM0191  Compound 21 HEK-293T 11.24  LDD0508  [26]
 LDCM0192  Compound 35 HEK-293T 6.17  LDD0509  [26]
 LDCM0193  Compound 36 HEK-293T 13.61  LDD0511  [26]
 LDCM0634  CY-0357 Hep-G2 C1038(0.73)  LDD2228  [17]
 LDCM0495  E2913 HEK-293T C892(0.99); C1216(1.02); C1038(0.93); C1128(1.09)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1323(1.58); C892(1.18); C1216(0.93); C1038(0.64)  LDD1702  [8]
 LDCM0573  Fragment11 Ramos C892(0.65); C1216(20.00)  LDD2190  [30]
 LDCM0576  Fragment14 Ramos C1216(1.22)  LDD2193  [30]
 LDCM0468  Fragment33 HCT 116 C1323(1.44); C1038(1.07); C1128(1.25); C1216(1.19)  LDD0785  [12]
 LDCM0427  Fragment51 HCT 116 C1323(3.11); C1038(1.32); C1128(1.25); C1216(1.70)  LDD0744  [12]
 LDCM0569  Fragment7 Ramos C892(0.47)  LDD2186  [30]
 LDCM0116  HHS-0101 DM93 Y647(1.57)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y647(2.31)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y1219(1.32); Y647(5.04)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y647(0.86)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y647(0.10)  LDD0268  [11]
 LDCM0107  IAA HeLa H1208(0.00); H919(0.00); H1099(0.00); H898(0.00)  LDD0221  [24]
 LDCM0022  KB02 HCT 116 C1216(1.24); C933(1.47)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C1216(1.09); C933(1.21)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C1216(1.31); C933(1.27)  LDD0082  [12]
 LDCM0030  Luteolin HEK-293T 4.62  LDD0182  [9]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1323(1.20); C933(0.88); C892(1.00)  LDD2102  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C1323(0.70); C1216(0.54)  LDD2121  [8]
 LDCM0109  NEM HeLa H1099(0.00); H1176(0.00); H919(0.00)  LDD0223  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C1323(0.79); C892(0.52)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C1323(1.20)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1323(0.97); C933(0.72); C892(0.95); C1216(0.98)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1038(1.43); C933(1.16); C892(1.30); C1216(0.80)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C1323(0.96); C933(1.03); C892(1.06)  LDD2094  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C933(1.06); C892(0.49)  LDD2096  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C933(1.03); C892(1.14); C1216(0.92)  LDD2097  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C933(0.82); C892(0.93); C1216(0.71)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1323(1.04); C1038(1.18); C933(1.05); C892(0.88)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1323(0.94); C933(0.63); C892(0.54)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1038(0.98); C933(0.72); C892(1.10); C1216(0.77)  LDD2101  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1323(0.89); C1216(0.30)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1323(0.98); C892(1.32); C1216(1.64)  LDD2105  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C1323(0.72)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1323(1.15); C1038(1.12); C933(1.29); C892(0.80)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1323(0.83); C933(0.74); C892(0.71)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1323(1.04); C1038(1.80); C933(0.97); C892(0.84)  LDD2109  [8]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C1323(1.97); C1128(0.48)  LDD2110  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1323(1.24); C933(1.03); C892(1.04); C1216(0.88)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1323(0.80); C892(0.38); C1216(0.53); C1128(0.36)  LDD2114  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C1323(0.54); C1038(0.46); C933(0.34); C892(0.44)  LDD2115  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C933(0.94); C892(0.70)  LDD2116  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C892(0.58)  LDD2118  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1323(2.42); C1038(2.24); C892(2.85); C1216(2.56)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1323(1.16); C933(0.82); C892(0.52); C1216(0.67)  LDD2120  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C933(0.82); C892(0.56)  LDD2122  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1323(1.01); C1038(1.14); C933(0.96); C892(0.86)  LDD2123  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C933(0.76); C892(0.70)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1323(0.94); C1038(0.84); C933(0.88); C892(0.85)  LDD2125  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C1323(0.35); C933(1.14); C892(1.00)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1323(1.23); C1038(1.22); C933(0.89); C892(0.89)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1323(1.19); C933(0.76)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1038(1.25); C933(0.91); C892(0.89); C1216(0.80)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1038(0.34); C933(0.28); C892(0.60); C1216(0.44)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1323(0.71); C1038(0.48); C933(0.46); C892(0.58)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1323(0.96); C1038(1.40); C933(1.14); C892(0.76)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1323(1.65); C1038(1.46); C933(1.27); C1216(1.05)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1323(1.12); C1038(1.23); C933(1.09); C892(0.90)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1323(1.09); C933(1.03)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1323(1.06); C1038(1.01); C933(0.93); C892(1.01)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C933(1.26); C1216(0.42)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C892(0.63); C1216(1.19)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1323(3.15); C1038(3.23); C933(3.27); C1216(1.87)  LDD2144  [8]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C933(1.98); C892(2.16)  LDD2145  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1038(1.33); C892(1.02); C1216(0.79)  LDD2146  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C1038(0.38); C933(0.35); C892(0.46); C1216(0.39)  LDD2148  [8]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C892(0.90)  LDD2149  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C1323(0.49); C933(0.37); C892(0.37)  LDD2150  [8]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C933(1.49); C892(1.13)  LDD2151  [8]
 LDCM0029  Quercetin HEK-293T 5.30  LDD0181  [9]
 LDCM0131  RA190 MM1.R C1128(1.34); C1323(1.30); C1038(1.11)  LDD0304  [31]
 LDCM0021  THZ1 HCT 116 C1323(1.13); C1216(1.05)  LDD2173  [12]
 LDCM0110  W12 Hep-G2 C1038(1.29)  LDD0237  [4]
 LDCM0111  W14 Hep-G2 K779(0.58); C1038(1.77); C892(5.91)  LDD0238  [4]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Radezolid . DB12339

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD033004
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