Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FFF probe3  Probe Info 
Probe concentration 200 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Compound 21  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 68 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00890  S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) 12.1
 LDTP15879  Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) 11.7
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 11.6
 LDTP00886  Nardilysin (NRDC) 10.7
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 10.6
 LDTP03592  Ribonucleoside-diphosphate reductase subunit M2 (RRM2) 10.4
 LDTP15236  TRMT1-like protein (TRMT1L) 10.3
 LDTP03540  Heme oxygenase 2 (HMOX2) 10.1
 LDTP05193  ADP-ribosylation factor 5 (ARF5) 9.8
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 9.8
 LDTP12851  UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1) 9.6
 LDTP10020  Ras-related protein Rab-24 (RAB24) 9.2
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 9.2
 LDTP06142  Squalene monooxygenase (SQLE) 9.1
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 9.0
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 8.8
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 8.8
 LDTP09569  Ras-related protein Rab-2B (RAB2B) 8.7
 LDTP04384  Cyclin-dependent kinase 9 (CDK9) 8.5
 LDTP00988  Protein O-GlcNAcase (OGA) 8.4
 LDTP03682  DNA replication licensing factor MCM7 (MCM7) 8.2
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 8.2
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) 8.1
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 8.1
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 7.8
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 7.8
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 7.7
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 7.7
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 7.5
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 7.3
 LDTP11127  ADP-dependent glucokinase (ADPGK) 7.1
 LDTP06371  GTP-binding protein Rheb (RHEB) 7.1
 LDTP04962  26S proteasome regulatory subunit 4 (PSMC1) 7.1
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) 6.8
 LDTP09388  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (STT3B) 6.8
 LDTP03523  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) 6.8
 LDTP11819  STE20-like serine/threonine-protein kinase (SLK) 6.7
 LDTP00697  Cytochrome b5 type B (CYB5B) 6.6
 LDTP01986  NADH-ubiquinone oxidoreductase chain 5 (MT-ND5) 6.6
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 6.5
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 6.3
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 6.2
 LDTP13959  Dehydrogenase/reductase SDR family member 7 (DHRS7) 6.2
 LDTP04542  Thimet oligopeptidase (THOP1) 6.1
 LDTP09495  Probable glutathione peroxidase 8 (GPX8) 5.6
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2) 5.5
 LDTP02868  Fumarylacetoacetase (FAH) 5.5
 LDTP02743  Insulin-degrading enzyme (IDE) 5.2
 LDTP04963  26S proteasome regulatory subunit 8 (PSMC5) 5.0
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 4.7
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 4.7
 LDTP02602  Histidine--tRNA ligase, cytoplasmic (HARS1) 4.7
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 4.2
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 4.2
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 4.1
 LDTP06849  Prolyl endopeptidase-like (PREPL) 4.1
 LDTP12610  Obg-like ATPase 1 (OLA1) 4.0
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) 3.9
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 3.9
 LDTP04878  Eukaryotic initiation factor 4A-I (EIF4A1) 3.7
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) 3.6
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 3.6
 LDTP06294  Lysine--tRNA ligase (KARS1) 3.6
 LDTP02616  Creatine kinase B-type (CKB) 3.5
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) 3.4
 LDTP03753  Cystathionine beta-synthase (CBS) 3.3
 LDTP11601  (E3-independent) E2 ubiquitin-conjugating enzyme (UBE2O) 3.1
 LDTP07015  Alanine--tRNA ligase, mitochondrial (AARS2) 3.1
Transporter and channel
Click to Show/Hide to Show 19 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09149  ATP-binding cassette sub-family F member 1 (ABCF1) 11.6
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 9.7
 LDTP00310  Syntenin-1 (SDCBP) 9.4
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 8.6
 LDTP05938  Sorting nexin-1 (SNX1) 8.2
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 8.2
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 8.1
 LDTP01601  Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) 7.4
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 6.6
 LDTP11250  MICOS complex subunit MIC26 (APOO) 6.6
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 6.5
 LDTP03405  Calnexin (CANX) 6.5
 LDTP04501  Importin subunit alpha-1 (KPNA2) 6.4
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 6.1
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 5.5
 LDTP09949  Transportin-1 (TNPO1) 4.0
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 3.5
 LDTP09515  Importin-4 (IPO4) 3.4
 LDTP06549  Hsp90 co-chaperone Cdc37 (CDC37) 3.3
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02870  Y-box-binding protein 3 (YBX3) 9.0
Other
Click to Show/Hide to Show 57 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16006  Optic atrophy 3 protein (OPA3) 12.7
 LDTP04558  Arfaptin-1 (ARFIP1) 12.3
 LDTP08594  Negative elongation factor C/D (NELFCD) 12.0
 LDTP00849  17S U2 SnRNP complex component HTATSF1 (HTATSF1) 11.6
 LDTP05922  Dynactin subunit 2 (DCTN2) 11.5
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 11.4
 LDTP14172  Sorting nexin-9 (SNX9) 11.4
 LDTP06268  Condensin complex subunit 2 (NCAPH) 11.3
 LDTP13044  Ribosome-binding protein 1 (RRBP1) 11.2
 LDTP02756  Junction plakoglobin (JUP) 10.4
 LDTP13532  Malignant T-cell-amplified sequence 1 (MCTS1) 10.1
 LDTP05160  Nucleobindin-2 (NUCB2) 10.0
 LDTP05375  Nucleobindin-1 (NUCB1) 10.0
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 9.8
 LDTP00934  C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9) 9.4
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 9.3
 LDTP15887  Lipase maturation factor 2 (LMF2) 9.0
 LDTP05068  Tropomyosin alpha-4 chain (TPM4) 9.0
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 8.8
 LDTP12412  Reticulon-4 (RTN4) 8.6
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 8.5
 LDTP04570  Coatomer subunit beta (COPB1) 8.5
 LDTP03030  Annexin A7 (ANXA7) 8.3
 LDTP00105  Protein unc-119 homolog B (UNC119B) 8.1
 LDTP16080  Protein FAM114A2 (FAM114A2) 8.1
 LDTP01522  Reticulon-3 (RTN3) 8.1
 LDTP04518  DNA mismatch repair protein Msh6 (MSH6) 7.5
 LDTP13086  Syntaxin-18 (STX18) 7.2
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) 7.0
 LDTP10860  Tubulin-folding cofactor B (TBCB) 7.0
 LDTP04092  Crk-like protein (CRKL) 6.7
 LDTP14085  Protein PRRC2C (PRRC2C) 6.6
 LDTP06121  Caprin-1 (CAPRIN1) 6.6
 LDTP13908  AP-3 complex subunit mu-1 (AP3M1) 6.2
 LDTP13817  Nuclear migration protein nudC (NUDC) 6.2
 LDTP06280  Squamous cell carcinoma antigen recognized by T-cells 3 (SART3) 6.1
 LDTP09878  Symplekin (SYMPK) 6.0
 LDTP08224  Protein LYRIC (MTDH) 5.8
 LDTP04078  Proliferation marker protein Ki-67 (MKI67) 5.7
 LDTP13402  Dynactin subunit 4 (DCTN4) 5.6
 LDTP03520  Phosphatidylethanolamine-binding protein 1 (PEBP1) 5.2
 LDTP04199  Protein PRRC2A (PRRC2A) 5.1
 LDTP04917  Proteasome activator complex subunit 3 (PSME3) 5.0
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 4.9
 LDTP06281  Condensin complex subunit 1 (NCAPD2) 4.7
 LDTP00223  26S proteasome non-ATPase regulatory subunit 11 (PSMD11) 4.7
 LDTP04853  Eukaryotic translation initiation factor 3 subunit E (EIF3E) 4.5
 LDTP05277  Protein SET (SET) 4.5
 LDTP06809  Tubulin beta-8 chain (TUBB8) 4.4
 LDTP13813  Eukaryotic translation initiation factor 3 subunit L (EIF3L) 4.3
 LDTP06301  Eukaryotic translation initiation factor 4H (EIF4H) 4.2
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) 3.8
 LDTP06181  Structural maintenance of chromosomes protein 1A (SMC1A) 3.7
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 3.6
 LDTP04241  Nuclear autoantigenic sperm protein (NASP) 3.5
 LDTP04049  Ran-specific GTPase-activating protein (RANBP1) 3.3
 LDTP03283  Elongation factor 1-beta (EEF1B2) 3.0

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.