Details of the Target

General Information of Target

Target ID LDTP04917
Target Name Proteasome activator complex subunit 3 (PSME3)
Gene Name PSME3
Gene ID 10197
Synonyms
Proteasome activator complex subunit 3; 11S regulator complex subunit gamma; REG-gamma; Activator of multicatalytic protease subunit 3; Ki nuclear autoantigen; Proteasome activator 28 subunit gamma; PA28g; PA28gamma
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
KVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQIS
RYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIE
KIKRPRSSNAETLY
Target Bioclass
Other
Family
PA28 family
Subcellular location
Nucleus
Function
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition.
Uniprot ID
P61289
Ensemble ID
ENST00000293362.7
HGNC ID
HGNC:9570
ChEMBL ID
CHEMBL4296023

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.E27Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 38 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
W1
 Probe Info  		14.48  LDD0235  [2]
TH211
 Probe Info  		Y196(5.18)  LDD0257  [3]
TH216
 Probe Info  		Y196(20.00); Y175(6.86)  LDD0259  [3]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
Probe 1
 Probe Info  		Y175(14.08)  LDD3495  [5]
BTD
 Probe Info  		C133(1.57); C92(1.16)  LDD1700  [6]
AHL-Pu-1
 Probe Info  		C92(2.37)  LDD0169  [7]
EA-probe
 Probe Info  		N.A.  LDD0440  [8]
DBIA
 Probe Info  		C92(4.26)  LDD0209  [9]
HHS-475
 Probe Info  		Y196(5.24)  LDD0264  [10]
HHS-465
 Probe Info  		Y196(4.31)  LDD2237  [11]
ATP probe
 Probe Info  		K132(0.00); K195(0.00); K36(0.00); K37(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [13]
JW-RF-010
 Probe Info  		C92(0.00); C133(0.00)  LDD0026  [16]
TFBX
 Probe Info  		C92(0.00); C133(0.00)  LDD0027  [16]
WYneN
 Probe Info  		N.A.  LDD0021  [17]
WYneO
 Probe Info  		N.A.  LDD0022  [17]
Compound 10
 Probe Info  		N.A.  LDD2216  [18]
Compound 11
 Probe Info  		N.A.  LDD2213  [18]
ENE
 Probe Info  		N.A.  LDD0006  [17]
IPM
 Probe Info  		N.A.  LDD0005  [17]
NHS
 Probe Info  		N.A.  LDD0010  [17]
SF
 Probe Info  		Y196(0.00); K12(0.00); Y202(0.00)  LDD0028  [19]
STPyne
 Probe Info  		K6(0.00); K100(0.00)  LDD0009  [17]
VSF
 Probe Info  		N.A.  LDD0007  [17]
Phosphinate-6
 Probe Info  		C133(0.00); C92(0.00)  LDD0018  [20]
1c-yne
 Probe Info  		K110(0.00); K100(0.00); K121(0.00)  LDD0228  [21]
Acrolein
 Probe Info  		C92(0.00); H232(0.00); H198(0.00)  LDD0217  [22]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [22]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [22]
Methacrolein
 Probe Info  		N.A.  LDD0218  [22]
AOyne
 Probe Info  		6.10  LDD0443  [23]
NAIA_5
 Probe Info  		C92(0.00); C133(0.00)  LDD2223  [24]
HHS-482
 Probe Info  		Y196(0.87)  LDD2239  [11]
PAL-AfBPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C064
 Probe Info  		7.31  LDD1761  [25]
C106
 Probe Info  		16.22  LDD1793  [25]
C153
 Probe Info  		15.45  LDD1834  [25]
C201
 Probe Info  		30.48  LDD1877  [25]
C228
 Probe Info  		17.15  LDD1901  [25]
C284
 Probe Info  		29.45  LDD1954  [25]
C285
 Probe Info  		19.56  LDD1955  [25]
C296
 Probe Info  		12.47  LDD1966  [25]
C310
 Probe Info  		7.84  LDD1977  [25]
C348
 Probe Info  		14.72  LDD2009  [25]
C350
 Probe Info  		24.93  LDD2011  [25]
C363
 Probe Info  		25.63  LDD2024  [25]
C364
 Probe Info  		15.78  LDD2025  [25]
C388
 Probe Info  		41.64  LDD2047  [25]
FFF probe11
 Probe Info  		5.13  LDD0472  [26]
FFF probe13
 Probe Info  		20.00  LDD0475  [26]
FFF probe14
 Probe Info  		12.81  LDD0477  [26]
FFF probe2
 Probe Info  		7.39  LDD0463  [26]
FFF probe3
 Probe Info  		9.38  LDD0464  [26]
FFF probe4
 Probe Info  		20.00  LDD0466  [26]
JN0003
 Probe Info  		13.75  LDD0469  [26]
VE-P
 Probe Info  		N.A.  LDD0396  [27]
LD-F
 Probe Info  		E171(0.00); E169(0.00)  LDD0015  [28]
DA-2
 Probe Info  		N.A.  LDD0070  [29]
STS-1
 Probe Info  		N.A.  LDD0068  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C92(0.69); C133(0.33)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C133(0.58)  LDD2112  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C133(1.70)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C92(0.98); C133(0.62)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C133(1.03)  LDD2152  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C133(1.51)  LDD2131  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C92(2.37)  LDD0169  [7]
 LDCM0214  AC1 HEK-293T C92(0.95)  LDD1507  [31]
 LDCM0215  AC10 HEK-293T C92(0.94)  LDD1508  [31]
 LDCM0226  AC11 HEK-293T C92(1.02)  LDD1509  [31]
 LDCM0237  AC12 HEK-293T C92(0.97)  LDD1510  [31]
 LDCM0259  AC14 HEK-293T C92(1.00)  LDD1512  [31]
 LDCM0270  AC15 HEK-293T C92(1.01)  LDD1513  [31]
 LDCM0276  AC17 HEK-293T C92(1.04)  LDD1515  [31]
 LDCM0277  AC18 HEK-293T C92(0.99)  LDD1516  [31]
 LDCM0278  AC19 HEK-293T C92(1.15)  LDD1517  [31]
 LDCM0279  AC2 HEK-293T C92(0.88)  LDD1518  [31]
 LDCM0280  AC20 HEK-293T C92(0.96)  LDD1519  [31]
 LDCM0281  AC21 HEK-293T C92(1.04)  LDD1520  [31]
 LDCM0282  AC22 HEK-293T C92(1.07)  LDD1521  [31]
 LDCM0283  AC23 HEK-293T C92(1.00)  LDD1522  [31]
 LDCM0284  AC24 HEK-293T C92(0.97)  LDD1523  [31]
 LDCM0285  AC25 HEK-293T C92(1.06)  LDD1524  [31]
 LDCM0286  AC26 HEK-293T C92(1.01)  LDD1525  [31]
 LDCM0287  AC27 HEK-293T C92(1.04)  LDD1526  [31]
 LDCM0288  AC28 HEK-293T C92(0.98)  LDD1527  [31]
 LDCM0289  AC29 HEK-293T C92(1.01)  LDD1528  [31]
 LDCM0290  AC3 HEK-293T C92(0.99)  LDD1529  [31]
 LDCM0291  AC30 HEK-293T C92(1.16)  LDD1530  [31]
 LDCM0292  AC31 HEK-293T C92(1.10)  LDD1531  [31]
 LDCM0293  AC32 HEK-293T C92(0.99)  LDD1532  [31]
 LDCM0294  AC33 HEK-293T C92(0.98)  LDD1533  [31]
 LDCM0295  AC34 HEK-293T C92(0.93)  LDD1534  [31]
 LDCM0296  AC35 HEK-293T C92(1.01)  LDD1535  [31]
 LDCM0297  AC36 HEK-293T C92(0.91)  LDD1536  [31]
 LDCM0298  AC37 HEK-293T C92(0.94)  LDD1537  [31]
 LDCM0299  AC38 HEK-293T C92(0.94)  LDD1538  [31]
 LDCM0300  AC39 HEK-293T C92(0.93)  LDD1539  [31]
 LDCM0301  AC4 HEK-293T C92(0.94)  LDD1540  [31]
 LDCM0302  AC40 HEK-293T C92(1.04)  LDD1541  [31]
 LDCM0303  AC41 HEK-293T C92(0.96)  LDD1542  [31]
 LDCM0304  AC42 HEK-293T C92(0.93)  LDD1543  [31]
 LDCM0305  AC43 HEK-293T C92(1.02)  LDD1544  [31]
 LDCM0306  AC44 HEK-293T C92(0.95)  LDD1545  [31]
 LDCM0307  AC45 HEK-293T C92(1.00)  LDD1546  [31]
 LDCM0308  AC46 HEK-293T C92(0.99)  LDD1547  [31]
 LDCM0309  AC47 HEK-293T C92(0.93)  LDD1548  [31]
 LDCM0310  AC48 HEK-293T C92(1.01)  LDD1549  [31]
 LDCM0311  AC49 HEK-293T C92(0.99)  LDD1550  [31]
 LDCM0312  AC5 HEK-293T C92(0.96)  LDD1551  [31]
 LDCM0313  AC50 HEK-293T C92(0.93)  LDD1552  [31]
 LDCM0314  AC51 HEK-293T C92(0.99)  LDD1553  [31]
 LDCM0315  AC52 HEK-293T C92(0.91)  LDD1554  [31]
 LDCM0316  AC53 HEK-293T C92(0.94)  LDD1555  [31]
 LDCM0317  AC54 HEK-293T C92(1.01)  LDD1556  [31]
 LDCM0318  AC55 HEK-293T C92(0.99)  LDD1557  [31]
 LDCM0319  AC56 HEK-293T C92(1.01)  LDD1558  [31]
 LDCM0320  AC57 HEK-293T C92(0.98)  LDD1559  [31]
 LDCM0321  AC58 HEK-293T C92(0.92)  LDD1560  [31]
 LDCM0322  AC59 HEK-293T C92(0.97)  LDD1561  [31]
 LDCM0323  AC6 HEK-293T C92(0.95)  LDD1562  [31]
 LDCM0324  AC60 HEK-293T C92(0.93)  LDD1563  [31]
 LDCM0325  AC61 HEK-293T C92(0.96)  LDD1564  [31]
 LDCM0326  AC62 HEK-293T C92(0.90)  LDD1565  [31]
 LDCM0327  AC63 HEK-293T C92(0.98)  LDD1566  [31]
 LDCM0328  AC64 HEK-293T C92(0.98)  LDD1567  [31]
 LDCM0334  AC7 HEK-293T C92(0.97)  LDD1568  [31]
 LDCM0345  AC8 HEK-293T C92(1.06)  LDD1569  [31]
 LDCM0545  Acetamide MDA-MB-231 C92(0.57); C133(0.38)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C133(0.54)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C92(0.95)  LDD1511  [31]
 LDCM0356  AKOS034007680 HEK-293T C92(0.93)  LDD1570  [31]
 LDCM0275  AKOS034007705 HEK-293T C92(1.01)  LDD1514  [31]
 LDCM0156  Aniline NCI-H1299 12.52  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C92(0.63); C133(0.46)  LDD2091  [6]
 LDCM0630  CCW28-3 231MFP C92(1.29)  LDD2214  [32]
 LDCM0108  Chloroacetamide HeLa C92(0.00); H232(0.00); H198(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C92(20.00); C92(1.32); C92(0.91); C92(0.88)  LDD2227  [24]
 LDCM0367  CL1 HEK-293T C92(1.01)  LDD1571  [31]
 LDCM0368  CL10 HEK-293T C92(1.33)  LDD1572  [31]
 LDCM0369  CL100 HEK-293T C92(0.94)  LDD1573  [31]
 LDCM0370  CL101 HEK-293T C92(0.95)  LDD1574  [31]
 LDCM0371  CL102 HEK-293T C92(0.89)  LDD1575  [31]
 LDCM0372  CL103 HEK-293T C92(1.09)  LDD1576  [31]
 LDCM0373  CL104 HEK-293T C92(0.99)  LDD1577  [31]
 LDCM0374  CL105 HEK-293T C92(0.93)  LDD1578  [31]
 LDCM0375  CL106 HEK-293T C92(0.97)  LDD1579  [31]
 LDCM0376  CL107 HEK-293T C92(1.00)  LDD1580  [31]
 LDCM0377  CL108 HEK-293T C92(1.00)  LDD1581  [31]
 LDCM0378  CL109 HEK-293T C92(0.91)  LDD1582  [31]
 LDCM0379  CL11 HEK-293T C92(1.13)  LDD1583  [31]
 LDCM0380  CL110 HEK-293T C92(0.96)  LDD1584  [31]
 LDCM0381  CL111 HEK-293T C92(1.03)  LDD1585  [31]
 LDCM0382  CL112 HEK-293T C92(1.04)  LDD1586  [31]
 LDCM0383  CL113 HEK-293T C92(0.92)  LDD1587  [31]
 LDCM0384  CL114 HEK-293T C92(0.84)  LDD1588  [31]
 LDCM0385  CL115 HEK-293T C92(1.00)  LDD1589  [31]
 LDCM0386  CL116 HEK-293T C92(0.90)  LDD1590  [31]
 LDCM0387  CL117 HEK-293T C92(0.93)  LDD1591  [31]
 LDCM0388  CL118 HEK-293T C92(0.95)  LDD1592  [31]
 LDCM0389  CL119 HEK-293T C92(0.98)  LDD1593  [31]
 LDCM0390  CL12 HEK-293T C92(1.22)  LDD1594  [31]
 LDCM0391  CL120 HEK-293T C92(0.91)  LDD1595  [31]
 LDCM0392  CL121 HEK-293T C92(0.96)  LDD1596  [31]
 LDCM0393  CL122 HEK-293T C92(0.90)  LDD1597  [31]
 LDCM0394  CL123 HEK-293T C92(0.92)  LDD1598  [31]
 LDCM0395  CL124 HEK-293T C92(0.95)  LDD1599  [31]
 LDCM0396  CL125 HEK-293T C92(0.93)  LDD1600  [31]
 LDCM0397  CL126 HEK-293T C92(0.91)  LDD1601  [31]
 LDCM0398  CL127 HEK-293T C92(0.91)  LDD1602  [31]
 LDCM0399  CL128 HEK-293T C92(0.93)  LDD1603  [31]
 LDCM0400  CL13 HEK-293T C92(1.10)  LDD1604  [31]
 LDCM0401  CL14 HEK-293T C92(0.91)  LDD1605  [31]
 LDCM0402  CL15 HEK-293T C92(1.04)  LDD1606  [31]
 LDCM0403  CL16 HEK-293T C92(0.98)  LDD1607  [31]
 LDCM0404  CL17 HEK-293T C92(1.08)  LDD1608  [31]
 LDCM0405  CL18 HEK-293T C92(0.99)  LDD1609  [31]
 LDCM0406  CL19 HEK-293T C92(1.19)  LDD1610  [31]
 LDCM0407  CL2 HEK-293T C92(0.95)  LDD1611  [31]
 LDCM0408  CL20 HEK-293T C92(1.17)  LDD1612  [31]
 LDCM0409  CL21 HEK-293T C92(1.20)  LDD1613  [31]
 LDCM0410  CL22 HEK-293T C92(1.21)  LDD1614  [31]
 LDCM0411  CL23 HEK-293T C92(1.20)  LDD1615  [31]
 LDCM0412  CL24 HEK-293T C92(1.27)  LDD1616  [31]
 LDCM0413  CL25 HEK-293T C92(0.89)  LDD1617  [31]
 LDCM0414  CL26 HEK-293T C92(0.98)  LDD1618  [31]
 LDCM0415  CL27 HEK-293T C92(1.05)  LDD1619  [31]
 LDCM0416  CL28 HEK-293T C92(0.98)  LDD1620  [31]
 LDCM0417  CL29 HEK-293T C92(1.05)  LDD1621  [31]
 LDCM0418  CL3 HEK-293T C92(0.98)  LDD1622  [31]
 LDCM0419  CL30 HEK-293T C92(1.08)  LDD1623  [31]
 LDCM0420  CL31 HEK-293T C92(1.12)  LDD1624  [31]
 LDCM0421  CL32 HEK-293T C92(1.16)  LDD1625  [31]
 LDCM0422  CL33 HEK-293T C92(1.10)  LDD1626  [31]
 LDCM0423  CL34 HEK-293T C92(1.16)  LDD1627  [31]
 LDCM0424  CL35 HEK-293T C92(1.16)  LDD1628  [31]
 LDCM0425  CL36 HEK-293T C92(1.13)  LDD1629  [31]
 LDCM0426  CL37 HEK-293T C92(0.90)  LDD1630  [31]
 LDCM0428  CL39 HEK-293T C92(1.01)  LDD1632  [31]
 LDCM0429  CL4 HEK-293T C92(1.01)  LDD1633  [31]
 LDCM0430  CL40 HEK-293T C92(1.05)  LDD1634  [31]
 LDCM0431  CL41 HEK-293T C92(1.01)  LDD1635  [31]
 LDCM0432  CL42 HEK-293T C92(1.03)  LDD1636  [31]
 LDCM0433  CL43 HEK-293T C92(1.09)  LDD1637  [31]
 LDCM0434  CL44 HEK-293T C92(1.17)  LDD1638  [31]
 LDCM0435  CL45 HEK-293T C92(1.14)  LDD1639  [31]
 LDCM0436  CL46 HEK-293T C92(1.36)  LDD1640  [31]
 LDCM0437  CL47 HEK-293T C92(1.19)  LDD1641  [31]
 LDCM0438  CL48 HEK-293T C92(1.12)  LDD1642  [31]
 LDCM0439  CL49 HEK-293T C92(0.93)  LDD1643  [31]
 LDCM0440  CL5 HEK-293T C92(1.07)  LDD1644  [31]
 LDCM0441  CL50 HEK-293T C92(0.92)  LDD1645  [31]
 LDCM0443  CL52 HEK-293T C92(1.00)  LDD1646  [31]
 LDCM0444  CL53 HEK-293T C92(1.01)  LDD1647  [31]
 LDCM0445  CL54 HEK-293T C92(0.88)  LDD1648  [31]
 LDCM0446  CL55 HEK-293T C92(1.10)  LDD1649  [31]
 LDCM0447  CL56 HEK-293T C92(1.14)  LDD1650  [31]
 LDCM0448  CL57 HEK-293T C92(1.16)  LDD1651  [31]
 LDCM0449  CL58 HEK-293T C92(1.18)  LDD1652  [31]
 LDCM0450  CL59 HEK-293T C92(0.97)  LDD1653  [31]
 LDCM0451  CL6 HEK-293T C92(0.92)  LDD1654  [31]
 LDCM0452  CL60 HEK-293T C92(1.19)  LDD1655  [31]
 LDCM0453  CL61 HEK-293T C92(0.92)  LDD1656  [31]
 LDCM0454  CL62 HEK-293T C92(0.90)  LDD1657  [31]
 LDCM0455  CL63 HEK-293T C92(0.96)  LDD1658  [31]
 LDCM0456  CL64 HEK-293T C92(0.87)  LDD1659  [31]
 LDCM0457  CL65 HEK-293T C92(1.00)  LDD1660  [31]
 LDCM0458  CL66 HEK-293T C92(0.97)  LDD1661  [31]
 LDCM0459  CL67 HEK-293T C92(1.05)  LDD1662  [31]
 LDCM0460  CL68 HEK-293T C92(1.09)  LDD1663  [31]
 LDCM0461  CL69 HEK-293T C92(1.12)  LDD1664  [31]
 LDCM0462  CL7 HEK-293T C92(1.08)  LDD1665  [31]
 LDCM0463  CL70 HEK-293T C92(1.29)  LDD1666  [31]
 LDCM0464  CL71 HEK-293T C92(1.06)  LDD1667  [31]
 LDCM0465  CL72 HEK-293T C92(1.11)  LDD1668  [31]
 LDCM0466  CL73 HEK-293T C92(0.92)  LDD1669  [31]
 LDCM0467  CL74 HEK-293T C92(0.88)  LDD1670  [31]
 LDCM0469  CL76 HEK-293T C92(0.96)  LDD1672  [31]
 LDCM0470  CL77 HEK-293T C92(0.96)  LDD1673  [31]
 LDCM0471  CL78 HEK-293T C92(1.00)  LDD1674  [31]
 LDCM0472  CL79 HEK-293T C92(1.08)  LDD1675  [31]
 LDCM0473  CL8 HEK-293T C92(1.04)  LDD1676  [31]
 LDCM0474  CL80 HEK-293T C92(1.09)  LDD1677  [31]
 LDCM0475  CL81 HEK-293T C92(1.14)  LDD1678  [31]
 LDCM0476  CL82 HEK-293T C92(1.18)  LDD1679  [31]
 LDCM0477  CL83 HEK-293T C92(1.11)  LDD1680  [31]
 LDCM0478  CL84 HEK-293T C92(1.01)  LDD1681  [31]
 LDCM0479  CL85 HEK-293T C92(0.94)  LDD1682  [31]
 LDCM0480  CL86 HEK-293T C92(0.89)  LDD1683  [31]
 LDCM0481  CL87 HEK-293T C92(0.85)  LDD1684  [31]
 LDCM0482  CL88 HEK-293T C92(0.92)  LDD1685  [31]
 LDCM0483  CL89 HEK-293T C92(0.88)  LDD1686  [31]
 LDCM0484  CL9 HEK-293T C92(1.12)  LDD1687  [31]
 LDCM0485  CL90 HEK-293T C92(0.88)  LDD1688  [31]
 LDCM0486  CL91 HEK-293T C92(0.99)  LDD1689  [31]
 LDCM0487  CL92 HEK-293T C92(0.93)  LDD1690  [31]
 LDCM0488  CL93 HEK-293T C92(0.99)  LDD1691  [31]
 LDCM0489  CL94 HEK-293T C92(1.01)  LDD1692  [31]
 LDCM0490  CL95 HEK-293T C92(0.90)  LDD1693  [31]
 LDCM0491  CL96 HEK-293T C92(0.97)  LDD1694  [31]
 LDCM0492  CL97 HEK-293T C92(0.92)  LDD1695  [31]
 LDCM0493  CL98 HEK-293T C92(0.92)  LDD1696  [31]
 LDCM0494  CL99 HEK-293T C92(0.90)  LDD1697  [31]
 LDCM0185  Compound 17 HEK-293T 3.21  LDD0512  [26]
 LDCM0191  Compound 21 HEK-293T 5.04  LDD0508  [26]
 LDCM0190  Compound 34 HEK-293T 4.74  LDD0510  [26]
 LDCM0192  Compound 35 HEK-293T 3.30  LDD0509  [26]
 LDCM0193  Compound 36 HEK-293T 4.58  LDD0511  [26]
 LDCM0634  CY-0357 Hep-G2 C92(1.07); C92(0.86)  LDD2228  [24]
 LDCM0495  E2913 HEK-293T C92(0.93)  LDD1698  [31]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C92(1.19)  LDD1702  [6]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [8]
 LDCM0625  F8 Ramos C92(1.41)  LDD2187  [33]
 LDCM0572  Fragment10 Ramos C92(1.23)  LDD2189  [33]
 LDCM0573  Fragment11 Ramos C92(0.08)  LDD2190  [33]
 LDCM0574  Fragment12 Ramos C92(1.10)  LDD2191  [33]
 LDCM0575  Fragment13 Ramos C92(1.07)  LDD2192  [33]
 LDCM0576  Fragment14 Ramos C92(1.03)  LDD2193  [33]
 LDCM0579  Fragment20 Ramos C92(1.25)  LDD2194  [33]
 LDCM0580  Fragment21 Ramos C92(1.02)  LDD2195  [33]
 LDCM0582  Fragment23 Ramos C92(1.10)  LDD2196  [33]
 LDCM0578  Fragment27 Ramos C92(0.93)  LDD2197  [33]
 LDCM0586  Fragment28 Ramos C92(0.85)  LDD2198  [33]
 LDCM0588  Fragment30 Ramos C92(1.23)  LDD2199  [33]
 LDCM0589  Fragment31 Ramos C92(1.08)  LDD2200  [33]
 LDCM0590  Fragment32 Ramos C92(1.66)  LDD2201  [33]
 LDCM0468  Fragment33 HEK-293T C92(1.00)  LDD1671  [31]
 LDCM0596  Fragment38 Ramos C92(1.32)  LDD2203  [33]
 LDCM0566  Fragment4 Ramos C92(1.34)  LDD2184  [33]
 LDCM0427  Fragment51 HEK-293T C92(0.99)  LDD1631  [31]
 LDCM0610  Fragment52 Ramos C92(1.07)  LDD2204  [33]
 LDCM0614  Fragment56 Ramos C92(1.29)  LDD2205  [33]
 LDCM0569  Fragment7 Ramos C92(1.45)  LDD2186  [33]
 LDCM0571  Fragment9 Ramos C92(1.41)  LDD2188  [33]
 LDCM0116  HHS-0101 DM93 Y196(5.24)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y196(5.27)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y196(4.95)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y196(5.36)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y196(2.93)  LDD0268  [10]
 LDCM0015  HNE MDA-MB-231 C92(1.12)  LDD0346  [33]
 LDCM0107  IAA HeLa H232(0.00); H198(0.00)  LDD0221  [22]
 LDCM0022  KB02 HEK-293T C92(0.97)  LDD1492  [31]
 LDCM0023  KB03 Jurkat C92(4.26)  LDD0209  [9]
 LDCM0024  KB05 RPMI-7951 C92(1.40)  LDD3410  [34]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C133(1.48)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C133(0.61)  LDD2121  [6]
 LDCM0109  NEM HeLa H232(0.00); H198(0.00)  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C133(0.60)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C92(1.08); C133(1.26)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C92(0.79); C133(0.86)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C133(1.59)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C92(1.22); C133(4.02)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C133(0.10)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C92(0.75); C133(0.67)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C92(0.51); C133(0.68)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C92(1.02); C133(0.73)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C92(0.73); C133(0.32)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C92(0.97); C133(0.68)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C92(0.66); C133(0.45)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C92(1.51)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C92(0.71); C133(0.35)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C92(0.93); C133(0.73)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C92(0.88); C133(0.33)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C133(0.41)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C133(0.83)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C92(1.34); C133(0.92)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C133(0.68)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C92(0.95); C133(0.39)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C133(0.27)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C92(0.89); C133(0.27)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C92(2.37); C133(3.51)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C133(0.67)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C92(0.72); C133(0.18)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C92(0.97); C133(0.67)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C133(0.16)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C92(0.99); C133(0.62)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C92(0.97); C133(0.16)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C92(1.26); C133(0.75)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C92(0.76); C133(0.85)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C92(1.61); C133(0.85)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C92(0.62); C133(0.48)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C92(0.58); C133(0.47)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C92(1.03); C133(0.94)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C92(1.48); C133(0.90)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C92(0.80); C133(0.82)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C133(1.57); C92(1.16)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C92(1.15); C133(0.63)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C92(1.14); C133(0.32)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C133(0.86)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C92(2.20); C133(2.93)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C92(3.97); C133(0.10)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C92(1.15); C133(0.66)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C133(3.17)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C92(0.48); C133(0.44)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C133(0.20)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C92(0.73); C133(0.52)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C133(0.35)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C133(2.60)  LDD2153  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C92(0.87); C92(0.33)  LDD2206  [35]
 LDCM0628  OTUB2-COV-1 HEK-293T C92(0.96); C92(0.62); C92(0.58)  LDD2207  [35]
 LDCM0131  RA190 MM1.R C92(2.30)  LDD0304  [36]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Paraplegin (SPG7) AAA ATPase family; Peptidase M41 family Q9UQ90
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) Inositol 1,4,5-trisphosphate 5-phosphatase type II family Q15735
E3 ubiquitin-protein ligase Mdm2 (MDM2) MDM2/MDM4 family Q00987
M-phase inducer phosphatase 2 (CDC25B) MPI phosphatase family P30305
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Nuclear receptor coactivator 3 (NCOA3) SRC/p160 nuclear receptor coactivator family Q9Y6Q9
Thioredoxin, mitochondrial (TXN2) Thioredoxin family Q99757
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
E3 ubiquitin-protein ligase SMURF1 (SMURF1) . Q9HCE7
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Bardet-Biedl syndrome 2 protein (BBS2) . Q9BXC9
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Doublesex- and mab-3-related transcription factor 3 (DMRT3) DMRT family Q9NQL9
Forkhead box protein D4-like 1 (FOXD4L1) . Q9NU39
THAP domain-containing protein 10 (THAP10) . Q9P2Z0
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
Coilin (COIL) Coilin family P38432
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
ELL-associated factor 1 (EAF1) EAF family Q96JC9
ELL-associated factor 2 (EAF2) EAF family Q96CJ1
Small ribosomal subunit protein eS27 (RPS27) Eukaryotic ribosomal protein eS27 family P42677
Proteasome activator complex subunit 3 (PSME3) PA28 family P61289
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Tumor necrosis factor alpha-induced protein 8-like protein 1 (TNFAIP8L1) TNFAIP8 family Q8WVP5
Atrophin-1 (ATN1) . P54259
F-box only protein 7 (FBXO7) . Q9Y3I1
Kelch repeat and BTB domain-containing protein 7 (KBTBD7) . Q8WVZ9
PRKCA-binding protein (PICK1) . Q9NRD5
Proline-rich protein 13 (PRR13) . Q9NZ81
Rab effector Noc2 (RPH3AL) . Q9UNE2
Zinc finger CCHC domain-containing protein 10 (ZCCHC10) . Q8TBK6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
9 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
25 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
28 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
29 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
30 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
31 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
32 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
33 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
34 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
35 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
36 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.