Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FFF probe3  Probe Info 
Probe concentration 200 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Compound 34  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 53 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06142  Squalene monooxygenase (SQLE) 13.2
 LDTP09495  Probable glutathione peroxidase 8 (GPX8) 12.7
 LDTP00697  Cytochrome b5 type B (CYB5B) 12.3
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 12.2
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 12.2
 LDTP09569  Ras-related protein Rab-2B (RAB2B) 11.8
 LDTP11127  ADP-dependent glucokinase (ADPGK) 10.9
 LDTP09388  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (STT3B) 10.8
 LDTP06371  GTP-binding protein Rheb (RHEB) 10.5
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 10.4
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 9.5
 LDTP00886  Nardilysin (NRDC) 9.4
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 9.3
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 9.1
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 8.8
 LDTP04384  Cyclin-dependent kinase 9 (CDK9) 8.6
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 8.5
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 8.4
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 8.2
 LDTP06903  Ubiquitin carboxyl-terminal hydrolase 39 (USP39) 7.9
 LDTP03682  DNA replication licensing factor MCM7 (MCM7) 7.7
 LDTP03523  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) 7.2
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 7.2
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 7.2
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) 7.1
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 6.8
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) 6.7
 LDTP00988  Protein O-GlcNAcase (OGA) 6.7
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 6.3
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 6.2
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 6.2
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 6.1
 LDTP03540  Heme oxygenase 2 (HMOX2) 5.8
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 5.7
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2) 5.0
 LDTP02743  Insulin-degrading enzyme (IDE) 4.6
 LDTP04963  26S proteasome regulatory subunit 8 (PSMC5) 4.1
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 4.0
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 3.8
 LDTP12610  Obg-like ATPase 1 (OLA1) 3.7
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) 3.6
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 3.5
 LDTP04878  Eukaryotic initiation factor 4A-I (EIF4A1) 3.5
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 3.5
 LDTP06849  Prolyl endopeptidase-like (PREPL) 3.4
 LDTP02602  Histidine--tRNA ligase, cytoplasmic (HARS1) 3.4
 LDTP07015  Alanine--tRNA ligase, mitochondrial (AARS2) 3.4
 LDTP02868  Fumarylacetoacetase (FAH) 3.3
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) 3.3
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 3.2
 LDTP11601  (E3-independent) E2 ubiquitin-conjugating enzyme (UBE2O) 3.1
 LDTP06294  Lysine--tRNA ligase (KARS1) 3.1
 LDTP12163  Calcyclin-binding protein (CACYBP) 3.0
Transporter and channel
Click to Show/Hide to Show 15 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11250  MICOS complex subunit MIC26 (APOO) 18.3
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 13.8
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 13.7
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 13.6
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 12.1
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 11.6
 LDTP09149  ATP-binding cassette sub-family F member 1 (ABCF1) 11.4
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 11.3
 LDTP03405  Calnexin (CANX) 10.2
 LDTP00310  Syntenin-1 (SDCBP) 9.4
 LDTP04501  Importin subunit alpha-1 (KPNA2) 7.2
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 6.2
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 5.9
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 4.6
 LDTP09949  Transportin-1 (TNPO1) 3.9
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02870  Y-box-binding protein 3 (YBX3) 10.3
Other
Click to Show/Hide to Show 43 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15887  Lipase maturation factor 2 (LMF2) 14.7
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 12.6
 LDTP05160  Nucleobindin-2 (NUCB2) 12.3
 LDTP01522  Reticulon-3 (RTN3) 11.8
 LDTP08224  Protein LYRIC (MTDH) 11.7
 LDTP14172  Sorting nexin-9 (SNX9) 11.7
 LDTP16006  Optic atrophy 3 protein (OPA3) 11.6
 LDTP04570  Coatomer subunit beta (COPB1) 10.8
 LDTP00849  17S U2 SnRNP complex component HTATSF1 (HTATSF1) 10.5
 LDTP12412  Reticulon-4 (RTN4) 9.9
 LDTP13086  Syntaxin-18 (STX18) 9.9
 LDTP01456  Pre-mRNA-processing factor 6 (PRPF6) 9.9
 LDTP05375  Nucleobindin-1 (NUCB1) 9.8
 LDTP08594  Negative elongation factor C/D (NELFCD) 9.1
 LDTP04078  Proliferation marker protein Ki-67 (MKI67) 9.1
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) 8.7
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 8.6
 LDTP05922  Dynactin subunit 2 (DCTN2) 8.1
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 8.1
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 8.0
 LDTP06268  Condensin complex subunit 2 (NCAPH) 7.9
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 7.8
 LDTP13817  Nuclear migration protein nudC (NUDC) 7.6
 LDTP09878  Symplekin (SYMPK) 7.4
 LDTP06121  Caprin-1 (CAPRIN1) 7.3
 LDTP04518  DNA mismatch repair protein Msh6 (MSH6) 7.3
 LDTP04092  Crk-like protein (CRKL) 6.5
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 6.3
 LDTP02756  Junction plakoglobin (JUP) 5.8
 LDTP16080  Protein FAM114A2 (FAM114A2) 5.8
 LDTP04199  Protein PRRC2A (PRRC2A) 5.5
 LDTP00105  Protein unc-119 homolog B (UNC119B) 5.2
 LDTP04853  Eukaryotic translation initiation factor 3 subunit E (EIF3E) 4.9
 LDTP13813  Eukaryotic translation initiation factor 3 subunit L (EIF3L) 4.9
 LDTP04917  Proteasome activator complex subunit 3 (PSME3) 4.7
 LDTP06281  Condensin complex subunit 1 (NCAPD2) 4.6
 LDTP00223  26S proteasome non-ATPase regulatory subunit 11 (PSMD11) 4.5
 LDTP06181  Structural maintenance of chromosomes protein 1A (SMC1A) 4.2
 LDTP05277  Protein SET (SET) 3.8
 LDTP03520  Phosphatidylethanolamine-binding protein 1 (PEBP1) 3.5
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) 3.4
 LDTP04241  Nuclear autoantigenic sperm protein (NASP) 3.1
 LDTP04049  Ran-specific GTPase-activating protein (RANBP1) 3.0

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.