Details of the Target

General Information of Target

Target ID	LDTP13086
Target Name	Syntaxin-18 (STX18)
Gene Name	STX18
Gene ID	53407
Synonyms	Syntaxin-18; Cell growth-inhibiting gene 9 protein
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MPKRRDILAIVLIVLPWTLLITVWHQSTLAPLLAVHKDEGSDPRRETPPGADPREYCTSD RDIVEVVRTEYVYTRPPPWSDTLPTIHVVTPTYSRPVQKAELTRMANTLLHVPNLHWLVV EDAPRRTPLTARLLRDTGLNYTHLHVETPRNYKLRGDARDPRIPRGTMQRNLALRWLRET FPRNSSQPGVVYFADDDNTYSLELFEEMRSTRRVSVWPVAFVGGLRYEAPRVNGAGKVVG WKTVFDPHRPFAIDMAGFAVNLRLILQRSQAYFKLRGVKGGYQESSLLRELVTLNDLEPK AANCTKILVWHTRTEKPVLVNEGKKGFTDPSVEI
Target Bioclass	Other
Family	Syntaxin family
Subcellular location	Endoplasmic reticulum membrane
Function	Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.
Uniprot ID	Q9P2W9
Ensemble ID	ENST00000306200.7
HGNC ID	HGNC:15942

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 11 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
STPyne Probe Info	K62(7.14)	LDD0277	[1]
m-APA Probe Info	9.17	LDD0403	[2]
DBIA Probe Info	C107(2.64)	LDD3319	[3]
BTD Probe Info	C107(0.84)	LDD2140	[4]
Curcusone 37 Probe Info	2.03	LDD0188	[5]
IPM Probe Info	C107(0.86)	LDD1701	[4]
4-Iodoacetamidophenylacetylene Probe Info	N.A.	LDD0038	[6]
IA-alkyne Probe Info	N.A.	LDD0165	[7]
Lodoacetamide azide Probe Info	N.A.	LDD0037	[6]
TFBX Probe Info	C146(0.00); C107(0.00)	LDD0027	[8]
AOyne Probe Info	15.00	LDD0443	[9]

PAL-AfBPP Probe

Click To Hide/Show 145 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
C004 Probe Info	7.89	LDD1714	[10]
C010 Probe Info	5.58	LDD1719	[10]
C017 Probe Info	9.58	LDD1725	[10]
C040 Probe Info	39.12	LDD1740	[10]
C041 Probe Info	14.62	LDD1741	[10]
C049 Probe Info	6.96	LDD1747	[10]
C053 Probe Info	6.96	LDD1751	[10]
C055 Probe Info	23.59	LDD1752	[10]
C056 Probe Info	68.59	LDD1753	[10]
C063 Probe Info	17.88	LDD1760	[10]
C064 Probe Info	9.58	LDD1761	[10]
C067 Probe Info	6.15	LDD1763	[10]
C070 Probe Info	25.99	LDD1766	[10]
C072 Probe Info	11.79	LDD1768	[10]
C082 Probe Info	8.82	LDD1774	[10]
C085 Probe Info	4.99	LDD1777	[10]
C087 Probe Info	8.34	LDD1779	[10]
C091 Probe Info	38.05	LDD1782	[10]
C092 Probe Info	41.07	LDD1783	[10]
C094 Probe Info	54.95	LDD1785	[10]
C095 Probe Info	8.28	LDD1786	[10]
C100 Probe Info	11.24	LDD1789	[10]
C106 Probe Info	50.21	LDD1793	[10]
C107 Probe Info	11.63	LDD1794	[10]
C108 Probe Info	15.78	LDD1795	[10]
C112 Probe Info	59.71	LDD1799	[10]
C129 Probe Info	6.59	LDD1811	[10]
C130 Probe Info	8.34	LDD1812	[10]
C134 Probe Info	62.25	LDD1816	[10]
C135 Probe Info	20.68	LDD1817	[10]
C141 Probe Info	17.03	LDD1823	[10]
C143 Probe Info	31.56	LDD1825	[10]
C153 Probe Info	43.71	LDD1834	[10]
C158 Probe Info	10.06	LDD1838	[10]
C159 Probe Info	22.01	LDD1839	[10]
C160 Probe Info	14.72	LDD1840	[10]
C161 Probe Info	37.27	LDD1841	[10]
C163 Probe Info	15.45	LDD1843	[10]
C165 Probe Info	21.11	LDD1845	[10]
C166 Probe Info	8.46	LDD1846	[10]
C169 Probe Info	97.68	LDD1849	[10]
C170 Probe Info	9.51	LDD1850	[10]
C173 Probe Info	9.06	LDD1853	[10]
C174 Probe Info	6.28	LDD1854	[10]
C177 Probe Info	9.06	LDD1856	[10]
C178 Probe Info	41.07	LDD1857	[10]
C183 Probe Info	5.94	LDD1861	[10]
C186 Probe Info	9.71	LDD1864	[10]
C187 Probe Info	70.52	LDD1865	[10]
C191 Probe Info	34.54	LDD1868	[10]
C193 Probe Info	13.09	LDD1869	[10]
C194 Probe Info	19.16	LDD1870	[10]
C196 Probe Info	21.71	LDD1872	[10]
C198 Probe Info	22.78	LDD1874	[10]
C201 Probe Info	99.73	LDD1877	[10]
C204 Probe Info	5.21	LDD1879	[10]
C205 Probe Info	5.43	LDD1880	[10]
C206 Probe Info	72.50	LDD1881	[10]
C207 Probe Info	29.86	LDD1882	[10]
C210 Probe Info	87.43	LDD1884	[10]
C213 Probe Info	21.11	LDD1887	[10]
C218 Probe Info	50.91	LDD1892	[10]
C219 Probe Info	10.06	LDD1893	[10]
C220 Probe Info	38.32	LDD1894	[10]
C225 Probe Info	7.36	LDD1898	[10]
C226 Probe Info	6.73	LDD1899	[10]
C228 Probe Info	41.93	LDD1901	[10]
C229 Probe Info	8.51	LDD1902	[10]
C231 Probe Info	41.64	LDD1904	[10]
C232 Probe Info	48.50	LDD1905	[10]
C233 Probe Info	13.93	LDD1906	[10]
C234 Probe Info	8.34	LDD1907	[10]
C235 Probe Info	44.02	LDD1908	[10]
C238 Probe Info	22.94	LDD1911	[10]
C240 Probe Info	9.92	LDD1913	[10]
C243 Probe Info	21.86	LDD1916	[10]
C244 Probe Info	16.68	LDD1917	[10]
C246 Probe Info	34.30	LDD1919	[10]
C249 Probe Info	26.54	LDD1922	[10]
C252 Probe Info	10.85	LDD1925	[10]
C258 Probe Info	5.35	LDD1931	[10]
C264 Probe Info	34.06	LDD1935	[10]
C265 Probe Info	17.15	LDD1936	[10]
C270 Probe Info	6.77	LDD1940	[10]
C271 Probe Info	5.10	LDD1941	[10]
C273 Probe Info	5.94	LDD1943	[10]
C277 Probe Info	34.06	LDD1947	[10]
C278 Probe Info	87.43	LDD1948	[10]
C282 Probe Info	23.75	LDD1952	[10]
C284 Probe Info	28.44	LDD1954	[10]
C285 Probe Info	57.28	LDD1955	[10]
C287 Probe Info	20.39	LDD1957	[10]
C288 Probe Info	13.00	LDD1958	[10]
C289 Probe Info	89.26	LDD1959	[10]
C293 Probe Info	49.18	LDD1963	[10]
C296 Probe Info	27.47	LDD1966	[10]
C299 Probe Info	11.39	LDD1968	[10]
C305 Probe Info	19.56	LDD1974	[10]
C307 Probe Info	5.24	LDD1975	[10]
C310 Probe Info	17.03	LDD1977	[10]
C313 Probe Info	13.45	LDD1980	[10]
C314 Probe Info	20.39	LDD1981	[10]
C317 Probe Info	6.63	LDD1983	[10]
C322 Probe Info	9.51	LDD1988	[10]
C326 Probe Info	18.00	LDD1990	[10]
C343 Probe Info	49.87	LDD2005	[10]
C348 Probe Info	16.91	LDD2009	[10]
C349 Probe Info	42.81	LDD2010	[10]
C350 Probe Info	89.88	LDD2011	[10]
C355 Probe Info	52.71	LDD2016	[10]
C356 Probe Info	11.63	LDD2017	[10]
C357 Probe Info	5.90	LDD2018	[10]
C362 Probe Info	99.73	LDD2023	[10]
C363 Probe Info	86.82	LDD2024	[10]
C364 Probe Info	99.73	LDD2025	[10]
C366 Probe Info	40.50	LDD2027	[10]
C367 Probe Info	30.70	LDD2028	[10]
C373 Probe Info	8.63	LDD2033	[10]
C376 Probe Info	15.89	LDD2036	[10]
C378 Probe Info	7.89	LDD2037	[10]
C380 Probe Info	5.13	LDD2039	[10]
C382 Probe Info	20.82	LDD2041	[10]
C383 Probe Info	14.03	LDD2042	[10]
C386 Probe Info	7.46	LDD2045	[10]
C388 Probe Info	99.73	LDD2047	[10]
C390 Probe Info	99.73	LDD2049	[10]
C391 Probe Info	14.03	LDD2050	[10]
C397 Probe Info	14.22	LDD2056	[10]
C399 Probe Info	19.70	LDD2058	[10]
C403 Probe Info	54.19	LDD2061	[10]
C407 Probe Info	32.67	LDD2064	[10]
C413 Probe Info	16.56	LDD2069	[10]
C419 Probe Info	13.36	LDD2074	[10]
C420 Probe Info	21.26	LDD2075	[10]
C424 Probe Info	13.27	LDD2079	[10]
C426 Probe Info	18.77	LDD2081	[10]
C429 Probe Info	15.03	LDD2084	[10]
C431 Probe Info	26.35	LDD2086	[10]
FFF probe11 Probe Info	20.00	LDD0471	[11]
FFF probe13 Probe Info	20.00	LDD0475	[11]
FFF probe14 Probe Info	20.00	LDD0477	[11]
FFF probe2 Probe Info	20.00	LDD0463	[11]
FFF probe3 Probe Info	20.00	LDD0464	[11]
JN0003 Probe Info	20.00	LDD0469	[11]
OEA-DA Probe Info	20.00	LDD0046	[12]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0214	AC1	HEK-293T	C107(0.95)	LDD1507	[13]
LDCM0215	AC10	HEK-293T	C107(1.21)	LDD0813	[14]
LDCM0226	AC11	HEK-293T	C107(1.18)	LDD0824	[14]
LDCM0230	AC113	HEK-293T	C107(0.91)	LDD0828	[14]
LDCM0231	AC114	HEK-293T	C107(1.24)	LDD0829	[14]
LDCM0232	AC115	HEK-293T	C107(1.33)	LDD0830	[14]
LDCM0233	AC116	HEK-293T	C107(1.23)	LDD0831	[14]
LDCM0234	AC117	HEK-293T	C107(1.36)	LDD0832	[14]
LDCM0235	AC118	HEK-293T	C107(1.13)	LDD0833	[14]
LDCM0236	AC119	HEK-293T	C107(1.19)	LDD0834	[14]
LDCM0237	AC12	HEK-293T	C107(1.21)	LDD0835	[14]
LDCM0238	AC120	HEK-293T	C107(1.24)	LDD0836	[14]
LDCM0239	AC121	HEK-293T	C107(1.43)	LDD0837	[14]
LDCM0240	AC122	HEK-293T	C107(1.80)	LDD0838	[14]
LDCM0241	AC123	HEK-293T	C107(1.42)	LDD0839	[14]
LDCM0242	AC124	HEK-293T	C107(1.38)	LDD0840	[14]
LDCM0243	AC125	HEK-293T	C107(1.60)	LDD0841	[14]
LDCM0244	AC126	HEK-293T	C107(2.25)	LDD0842	[14]
LDCM0245	AC127	HEK-293T	C107(2.43)	LDD0843	[14]
LDCM0259	AC14	HEK-293T	C107(0.93)	LDD0857	[14]
LDCM0270	AC15	HEK-293T	C107(1.29)	LDD0868	[14]
LDCM0276	AC17	HEK-293T	C107(0.88)	LDD1515	[13]
LDCM0277	AC18	HEK-293T	C107(1.02)	LDD1516	[13]
LDCM0279	AC2	HEK-293T	C107(1.10)	LDD1518	[13]
LDCM0281	AC21	HEK-293T	C107(0.94)	LDD1520	[13]
LDCM0282	AC22	HEK-293T	C107(0.69)	LDD1521	[13]
LDCM0283	AC23	HEK-293T	C107(0.85)	LDD1522	[13]
LDCM0284	AC24	HEK-293T	C107(1.10)	LDD1523	[13]
LDCM0285	AC25	HEK-293T	C107(1.18)	LDD0883	[14]
LDCM0286	AC26	HEK-293T	C107(0.92)	LDD0884	[14]
LDCM0287	AC27	HEK-293T	C107(1.04)	LDD0885	[14]
LDCM0288	AC28	HEK-293T	C107(1.07)	LDD0886	[14]
LDCM0289	AC29	HEK-293T	C107(1.54)	LDD0887	[14]
LDCM0291	AC30	HEK-293T	C107(1.44)	LDD0889	[14]
LDCM0292	AC31	HEK-293T	C107(1.04)	LDD0890	[14]
LDCM0293	AC32	HEK-293T	C107(1.01)	LDD0891	[14]
LDCM0294	AC33	HEK-293T	C107(1.40)	LDD0892	[14]
LDCM0295	AC34	HEK-293T	C107(1.02)	LDD0893	[14]
LDCM0298	AC37	HEK-293T	C107(1.10)	LDD1537	[13]
LDCM0299	AC38	HEK-293T	C107(0.64)	LDD1538	[13]
LDCM0300	AC39	HEK-293T	C107(0.88)	LDD1539	[13]
LDCM0302	AC40	HEK-293T	C107(0.99)	LDD1541	[13]
LDCM0303	AC41	HEK-293T	C107(0.89)	LDD1542	[13]
LDCM0304	AC42	HEK-293T	C107(0.85)	LDD1543	[13]
LDCM0307	AC45	HEK-293T	C107(0.94)	LDD1546	[13]
LDCM0308	AC46	HEK-293T	C107(0.73)	LDD1547	[13]
LDCM0309	AC47	HEK-293T	C107(0.91)	LDD1548	[13]
LDCM0310	AC48	HEK-293T	C107(0.85)	LDD1549	[13]
LDCM0311	AC49	HEK-293T	C107(0.89)	LDD1550	[13]
LDCM0312	AC5	HEK-293T	C107(0.93)	LDD1551	[13]
LDCM0313	AC50	HEK-293T	C107(0.81)	LDD1552	[13]
LDCM0316	AC53	HEK-293T	C107(0.96)	LDD1555	[13]
LDCM0317	AC54	HEK-293T	C107(0.64)	LDD1556	[13]
LDCM0318	AC55	HEK-293T	C107(0.73)	LDD1557	[13]
LDCM0319	AC56	HEK-293T	C107(0.85)	LDD1558	[13]
LDCM0320	AC57	HEK-293T	C107(0.93)	LDD1559	[13]
LDCM0321	AC58	HEK-293T	C107(1.14)	LDD1560	[13]
LDCM0323	AC6	HEK-293T	C107(0.89)	LDD0921	[14]
LDCM0325	AC61	HEK-293T	C107(1.01)	LDD1564	[13]
LDCM0326	AC62	HEK-293T	C107(0.62)	LDD1565	[13]
LDCM0327	AC63	HEK-293T	C107(0.97)	LDD1566	[13]
LDCM0328	AC64	HEK-293T	C107(0.97)	LDD1567	[13]
LDCM0332	AC68	HEK-293T	C107(0.86)	LDD0930	[14]
LDCM0333	AC69	HEK-293T	C107(0.70)	LDD0931	[14]
LDCM0334	AC7	HEK-293T	C107(1.07)	LDD0932	[14]
LDCM0335	AC70	HEK-293T	C107(1.37)	LDD0933	[14]
LDCM0336	AC71	HEK-293T	C107(1.28)	LDD0934	[14]
LDCM0337	AC72	HEK-293T	C107(1.38)	LDD0935	[14]
LDCM0338	AC73	HEK-293T	C107(0.67)	LDD0936	[14]
LDCM0339	AC74	HEK-293T	C107(0.58)	LDD0937	[14]
LDCM0340	AC75	HEK-293T	C107(1.11)	LDD0938	[14]
LDCM0341	AC76	HEK-293T	C107(1.23)	LDD0939	[14]
LDCM0342	AC77	HEK-293T	C107(0.90)	LDD0940	[14]
LDCM0343	AC78	HEK-293T	C107(0.69)	LDD0941	[14]
LDCM0344	AC79	HEK-293T	C107(0.66)	LDD0942	[14]
LDCM0345	AC8	HEK-293T	C107(1.31)	LDD0943	[14]
LDCM0346	AC80	HEK-293T	C107(1.23)	LDD0944	[14]
LDCM0347	AC81	HEK-293T	C107(1.40)	LDD0945	[14]
LDCM0348	AC82	HEK-293T	C107(1.29)	LDD0946	[14]
LDCM0248	AKOS034007472	HEK-293T	C107(0.96)	LDD0846	[14]
LDCM0356	AKOS034007680	HEK-293T	C107(1.30)	LDD0954	[14]
LDCM0275	AKOS034007705	HEK-293T	C107(1.38)	LDD0873	[14]
LDCM0156	Aniline	NCI-H1299	9.17	LDD0403	[2]
LDCM0367	CL1	HEK-293T	C107(1.14)	LDD1571	[13]
LDCM0368	CL10	HEK-293T	C107(0.85)	LDD1572	[13]
LDCM0369	CL100	HEK-293T	C107(0.97)	LDD1573	[13]
LDCM0370	CL101	HEK-293T	C107(0.97)	LDD0968	[14]
LDCM0371	CL102	HEK-293T	C107(1.31)	LDD0969	[14]
LDCM0372	CL103	HEK-293T	C107(0.94)	LDD0970	[14]
LDCM0373	CL104	HEK-293T	C107(1.29)	LDD0971	[14]
LDCM0374	CL105	HEK-293T	C107(0.99)	LDD1578	[13]
LDCM0375	CL106	HEK-293T	C107(0.91)	LDD1579	[13]
LDCM0376	CL107	HEK-293T	C107(0.77)	LDD1580	[13]
LDCM0377	CL108	HEK-293T	C107(1.01)	LDD1581	[13]
LDCM0378	CL109	HEK-293T	C107(0.96)	LDD1582	[13]
LDCM0379	CL11	HEK-293T	C107(1.08)	LDD1583	[13]
LDCM0380	CL110	HEK-293T	C107(0.89)	LDD1584	[13]
LDCM0381	CL111	HEK-293T	C107(0.83)	LDD1585	[13]
LDCM0382	CL112	HEK-293T	C107(1.39)	LDD0980	[14]
LDCM0383	CL113	HEK-293T	C107(1.22)	LDD0981	[14]
LDCM0384	CL114	HEK-293T	C107(3.19)	LDD0982	[14]
LDCM0385	CL115	HEK-293T	C107(1.18)	LDD0983	[14]
LDCM0386	CL116	HEK-293T	C107(1.18)	LDD0984	[14]
LDCM0387	CL117	HEK-293T	C107(0.95)	LDD1591	[13]
LDCM0388	CL118	HEK-293T	C107(0.94)	LDD1592	[13]
LDCM0389	CL119	HEK-293T	C107(0.84)	LDD1593	[13]
LDCM0390	CL12	HEK-293T	C107(1.13)	LDD1594	[13]
LDCM0391	CL120	HEK-293T	C107(0.92)	LDD1595	[13]
LDCM0392	CL121	HEK-293T	C107(0.94)	LDD1596	[13]
LDCM0393	CL122	HEK-293T	C107(0.96)	LDD1597	[13]
LDCM0394	CL123	HEK-293T	C107(0.71)	LDD1598	[13]
LDCM0395	CL124	HEK-293T	C107(0.72)	LDD1599	[13]
LDCM0396	CL125	HEK-293T	C107(0.96)	LDD1600	[13]
LDCM0397	CL126	HEK-293T	C107(0.88)	LDD1601	[13]
LDCM0398	CL127	HEK-293T	C107(0.99)	LDD1602	[13]
LDCM0399	CL128	HEK-293T	C107(0.88)	LDD1603	[13]
LDCM0400	CL13	HEK-293T	C107(0.96)	LDD1604	[13]
LDCM0401	CL14	HEK-293T	C107(1.00)	LDD1605	[13]
LDCM0402	CL15	HEK-293T	C107(0.83)	LDD1606	[13]
LDCM0403	CL16	HEK-293T	C107(1.02)	LDD1607	[13]
LDCM0404	CL17	HEK-293T	C107(0.75)	LDD1608	[13]
LDCM0405	CL18	HEK-293T	C107(0.92)	LDD1609	[13]
LDCM0407	CL2	HEK-293T	C107(0.74)	LDD1611	[13]
LDCM0409	CL21	HEK-293T	C107(1.02)	LDD1613	[13]
LDCM0410	CL22	HEK-293T	C107(0.92)	LDD1614	[13]
LDCM0411	CL23	HEK-293T	C107(1.00)	LDD1615	[13]
LDCM0412	CL24	HEK-293T	C107(1.13)	LDD1616	[13]
LDCM0413	CL25	HEK-293T	C107(0.97)	LDD1617	[13]
LDCM0414	CL26	HEK-293T	C107(0.98)	LDD1618	[13]
LDCM0415	CL27	HEK-293T	C107(0.91)	LDD1619	[13]
LDCM0416	CL28	HEK-293T	C107(0.79)	LDD1620	[13]
LDCM0417	CL29	HEK-293T	C107(1.06)	LDD1621	[13]
LDCM0418	CL3	HEK-293T	C107(1.05)	LDD1622	[13]
LDCM0419	CL30	HEK-293T	C107(0.87)	LDD1623	[13]
LDCM0422	CL33	HEK-293T	C107(0.91)	LDD1626	[13]
LDCM0423	CL34	HEK-293T	C107(1.00)	LDD1627	[13]
LDCM0424	CL35	HEK-293T	C107(1.04)	LDD1628	[13]
LDCM0425	CL36	HEK-293T	C107(1.06)	LDD1629	[13]
LDCM0426	CL37	HEK-293T	C107(1.10)	LDD1630	[13]
LDCM0428	CL39	HEK-293T	C107(1.01)	LDD1632	[13]
LDCM0429	CL4	HEK-293T	C107(0.91)	LDD1633	[13]
LDCM0430	CL40	HEK-293T	C107(1.09)	LDD1634	[13]
LDCM0431	CL41	HEK-293T	C107(0.95)	LDD1635	[13]
LDCM0432	CL42	HEK-293T	C107(1.10)	LDD1636	[13]
LDCM0435	CL45	HEK-293T	C107(1.03)	LDD1639	[13]
LDCM0436	CL46	HEK-293T	C107(1.16)	LDD1640	[13]
LDCM0437	CL47	HEK-293T	C107(1.08)	LDD1641	[13]
LDCM0438	CL48	HEK-293T	C107(1.12)	LDD1642	[13]
LDCM0439	CL49	HEK-293T	C107(1.05)	LDD1643	[13]
LDCM0440	CL5	HEK-293T	C107(1.09)	LDD1644	[13]
LDCM0441	CL50	HEK-293T	C107(0.93)	LDD1645	[13]
LDCM0443	CL52	HEK-293T	C107(1.10)	LDD1646	[13]
LDCM0444	CL53	HEK-293T	C107(0.98)	LDD1647	[13]
LDCM0445	CL54	HEK-293T	C107(0.67)	LDD1648	[13]
LDCM0448	CL57	HEK-293T	C107(1.02)	LDD1651	[13]
LDCM0449	CL58	HEK-293T	C107(0.69)	LDD1652	[13]
LDCM0450	CL59	HEK-293T	C107(0.99)	LDD1653	[13]
LDCM0451	CL6	HEK-293T	C107(1.05)	LDD1654	[13]
LDCM0452	CL60	HEK-293T	C107(1.27)	LDD1655	[13]
LDCM0453	CL61	HEK-293T	C107(1.14)	LDD1656	[13]
LDCM0454	CL62	HEK-293T	C107(1.09)	LDD1657	[13]
LDCM0455	CL63	HEK-293T	C107(0.98)	LDD1658	[13]
LDCM0456	CL64	HEK-293T	C107(0.86)	LDD1659	[13]
LDCM0457	CL65	HEK-293T	C107(0.95)	LDD1660	[13]
LDCM0458	CL66	HEK-293T	C107(1.00)	LDD1661	[13]
LDCM0461	CL69	HEK-293T	C107(1.12)	LDD1664	[13]
LDCM0463	CL70	HEK-293T	C107(1.05)	LDD1666	[13]
LDCM0464	CL71	HEK-293T	C107(0.86)	LDD1667	[13]
LDCM0465	CL72	HEK-293T	C107(1.02)	LDD1668	[13]
LDCM0466	CL73	HEK-293T	C107(1.00)	LDD1669	[13]
LDCM0467	CL74	HEK-293T	C107(0.94)	LDD1670	[13]
LDCM0469	CL76	HEK-293T	C107(0.89)	LDD1672	[13]
LDCM0470	CL77	HEK-293T	C107(0.77)	LDD1673	[13]
LDCM0471	CL78	HEK-293T	C107(0.90)	LDD1674	[13]
LDCM0475	CL81	HEK-293T	C107(1.07)	LDD1678	[13]
LDCM0476	CL82	HEK-293T	C107(1.00)	LDD1679	[13]
LDCM0477	CL83	HEK-293T	C107(0.97)	LDD1680	[13]
LDCM0478	CL84	HEK-293T	C107(1.17)	LDD1681	[13]
LDCM0479	CL85	HEK-293T	C107(0.97)	LDD1682	[13]
LDCM0480	CL86	HEK-293T	C107(0.92)	LDD1683	[13]
LDCM0481	CL87	HEK-293T	C107(0.95)	LDD1684	[13]
LDCM0482	CL88	HEK-293T	C107(1.03)	LDD1685	[13]
LDCM0483	CL89	HEK-293T	C107(0.97)	LDD1686	[13]
LDCM0484	CL9	HEK-293T	C107(1.12)	LDD1687	[13]
LDCM0485	CL90	HEK-293T	C107(0.82)	LDD1688	[13]
LDCM0488	CL93	HEK-293T	C107(0.87)	LDD1691	[13]
LDCM0489	CL94	HEK-293T	C107(1.09)	LDD1692	[13]
LDCM0490	CL95	HEK-293T	C107(0.76)	LDD1693	[13]
LDCM0491	CL96	HEK-293T	C107(1.10)	LDD1694	[13]
LDCM0492	CL97	HEK-293T	C107(0.89)	LDD1695	[13]
LDCM0493	CL98	HEK-293T	C107(0.92)	LDD1696	[13]
LDCM0494	CL99	HEK-293T	C107(0.99)	LDD1697	[13]
LDCM0185	Compound 17	HEK-293T	5.80	LDD0512	[11]
LDCM0191	Compound 21	HEK-293T	7.17	LDD0508	[11]
LDCM0190	Compound 34	HEK-293T	9.90	LDD0510	[11]
LDCM0192	Compound 35	HEK-293T	8.44	LDD0509	[11]
LDCM0193	Compound 36	HEK-293T	13.07	LDD0511	[11]
LDCM0033	Curcusone1d	MCF-7	2.03	LDD0188	[5]
LDCM0495	E2913	HEK-293T	C107(0.87)	LDD1698	[13]
LDCM0468	Fragment33	HEK-293T	C107(0.92)	LDD1671	[13]
LDCM0427	Fragment51	HEK-293T	C107(1.03)	LDD1631	[13]
LDCM0022	KB02	A2780	C107(1.17)	LDD2254	[3]
LDCM0023	KB03	MDA-MB-231	C107(0.86)	LDD1701	[4]
LDCM0024	KB05	MEWO	C107(2.64)	LDD3319	[3]
LDCM0546	Nucleophilic fragment 40	MDA-MB-231	C107(0.84)	LDD2140	[4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other

Click To Hide/Show 2 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Vesicle-trafficking protein SEC22b (SEC22B)				Synaptobrevin family	O75396
Vesicle transport protein USE1 (USE1)				USE1 family	Q9NZ43

References

1	A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10. Mass spectrometry data entry: PXD028270
2	Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3	DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22. Mass spectrometry data entry: PXD047840
4	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
5	Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
6	Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23. Mass spectrometry data entry: PXD028853
7	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
9	Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
11	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
13	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
14	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.

Details of the Target

Citation

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Correspondence

Prof. Feng Zhu

Prof. Feng Ni