Details of the Probe-central Interaction Altas
General Information of Experiment
| Probe Name | C378 | Probe Info | ||||
|---|---|---|---|---|---|---|
| Probe concentration | Probe:50uM; negative probe:50uM | |||||
| Criteria | Quantification: AfBPP Probe vs Negative Probe | |||||
| Quantitative Method |
TMT
|
|||||
| In Vivo Experiment Model | Model Type |
|
Living cell | |||
| Derived Tissue |
|
Peripheral blood | ||||
| Disease Model | Normal | |||||
| Model Name | Human normal cells (HEK-293T) | |||||
| Note | Negative probe:C#CCCC1(CCC(NC)=O)N=N1 | |||||
Interaction Altas of This Experiment [1]
Enzyme
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP16007 | Lipid droplet-associated hydrolase (LDAH) | 28.8 | ||||
| LDTP05905 | Acid ceramidase (ASAH1) | 23.1 | ||||
| LDTP06325 | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) | 17.3 | ||||
| LDTP09256 | Putative phospholipase B-like 2 (PLBD2) | 16.4 | ||||
| LDTP02359 | Heme oxygenase 1 (HMOX1) | 15.6 | ||||
| LDTP03198 | Ferrochelatase, mitochondrial (FECH) | 15.0 | ||||
| LDTP02837 | Beta-galactosidase (GLB1) | 14.9 | ||||
| LDTP03540 | Heme oxygenase 2 (HMOX2) | 14.6 | ||||
| LDTP01803 | Adenosine deaminase (ADA) | 14.5 | ||||
| LDTP13282 | Prenylcysteine oxidase 1 (PCYOX1) | 12.6 | ||||
| LDTP04388 | Palmitoyl-protein thioesterase 1 (PPT1) | 11.9 | ||||
| LDTP15988 | Probable serine carboxypeptidase CPVL (CPVL) | 11.7 | ||||
| LDTP00697 | Cytochrome b5 type B (CYB5B) | 11.1 | ||||
| LDTP02175 | Epoxide hydrolase 1 (EPHX1) | 10.9 | ||||
| LDTP10032 | 7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) | 10.9 | ||||
| LDTP01982 | NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) | 10.9 | ||||
| LDTP08728 | Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) | 10.6 | ||||
| LDTP00907 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) | 10.3 | ||||
| LDTP10329 | Ceramide synthase 2 (CERS2) | 10.3 | ||||
| LDTP05724 | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) | 10.2 | ||||
| LDTP04004 | Lysosomal Pro-X carboxypeptidase (PRCP) | 10.1 | ||||
| LDTP06648 | Lanosterol 14-alpha demethylase (CYP51A1) | 9.5 | ||||
| LDTP13189 | Cytochrome b-c1 complex subunit 9 (UQCR10) | 9.1 | ||||
| LDTP02216 | Beta-hexosaminidase subunit beta (HEXB) | 9.0 | ||||
| LDTP00486 | Cytochrome b-c1 complex subunit 8 (UQCRQ) | 8.9 | ||||
| LDTP06333 | Serum paraoxonase/arylesterase 2 (PON2) | 8.9 | ||||
| LDTP04051 | Nicotinamide phosphoribosyltransferase (NAMPT) | 8.8 | ||||
| LDTP10188 | FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) | 8.7 | ||||
| LDTP04712 | Puromycin-sensitive aminopeptidase (NPEPPS) | 8.7 | ||||
| LDTP00832 | NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) | 8.6 | ||||
| LDTP12279 | Endoplasmic reticulum transmembrane helix translocase (ATP13A1) | 8.6 | ||||
| LDTP04008 | Endothelin-converting enzyme 1 (ECE1) | 8.5 | ||||
| LDTP10699 | E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) | 8.4 | ||||
| LDTP16032 | Retinoid-inducible serine carboxypeptidase (SCPEP1) | 8.4 | ||||
| LDTP01328 | CAAX prenyl protease 1 homolog (ZMPSTE24) | 8.3 | ||||
| LDTP01687 | Apoptosis-inducing factor 1, mitochondrial (AIFM1) | 8.2 | ||||
| LDTP09096 | Carbohydrate sulfotransferase 14 (CHST14) | 8.2 | ||||
| LDTP01039 | Protein-S-isoprenylcysteine O-methyltransferase (ICMT) | 8.1 | ||||
| LDTP02713 | Macrophage migration inhibitory factor (MIF) | 7.9 | ||||
| LDTP11690 | RNA cytidine acetyltransferase (NAT10) | 7.9 | ||||
| LDTP03787 | Choline kinase alpha (CHKA) | 7.8 | ||||
| LDTP15484 | Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) | 7.8 | ||||
| LDTP00589 | Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) | 7.6 | ||||
| LDTP05493 | Sulfotransferase 2A1 (SULT2A1) | 7.4 | ||||
| LDTP07831 | Transmembrane protein with metallophosphoesterase domain (TMPPE) | 7.4 | ||||
| LDTP09088 | Phospholipase A2 group XV (PLA2G15) | 7.3 | ||||
| LDTP01241 | Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) | 7.3 | ||||
| LDTP01462 | Endonuclease domain-containing 1 protein (ENDOD1) | 7.1 | ||||
| LDTP08476 | 5'-3' exonuclease PLD3 (PLD3) | 7.0 | ||||
| LDTP02169 | Beta-hexosaminidase subunit alpha (HEXA) | 7.0 | ||||
| LDTP05862 | NAD(P) transhydrogenase, mitochondrial (NNT) | 7.0 | ||||
| LDTP04437 | Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) | 6.9 | ||||
| LDTP09799 | DCN1-like protein 4 (DCUN1D4) | 6.8 | ||||
| LDTP02254 | ATP-dependent translocase ABCB1 (ABCB1) | 6.7 | ||||
| LDTP03257 | Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) | 6.7 | ||||
| LDTP04634 | Alpha-N-acetylglucosaminidase (NAGLU) | 6.6 | ||||
| LDTP02074 | Aldehyde dehydrogenase, mitochondrial (ALDH2) | 6.5 | ||||
| LDTP10550 | Dehydrogenase/reductase SDR family member 1 (DHRS1) | 6.5 | ||||
| LDTP02721 | Farnesyl pyrophosphate synthase (FDPS) | 6.5 | ||||
| LDTP00325 | Pirin (PIR) | 6.5 | ||||
| LDTP11127 | ADP-dependent glucokinase (ADPGK) | 6.5 | ||||
| LDTP06787 | Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) | 6.5 | ||||
| LDTP09355 | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP4K2C) | 6.4 | ||||
| LDTP12679 | Trimethyllysine dioxygenase, mitochondrial (TMLHE) | 6.3 | ||||
| LDTP11273 | N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) | 6.3 | ||||
| LDTP04285 | Proteasome subunit beta type-2 (PSMB2) | 6.3 | ||||
| LDTP12020 | Histone-lysine N-methyltransferase SMYD3 (SMYD3) | 6.1 | ||||
| LDTP13358 | Leucyl-cystinyl aminopeptidase (LNPEP) | 6.1 | ||||
| LDTP05066 | Signal peptidase complex catalytic subunit SEC11A (SEC11A) | 6.1 | ||||
| LDTP01613 | Sphingosine-1-phosphate lyase 1 (SGPL1) | 6.1 | ||||
| LDTP02505 | Lysosomal protective protein (CTSA) | 6.0 | ||||
| LDTP06142 | Squalene monooxygenase (SQLE) | 6.0 | ||||
| LDTP12105 | L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) | 5.9 | ||||
| LDTP01018 | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A) | 5.9 | ||||
| LDTP15422 | Prostaglandin reductase 3 (PTGR3) | 5.9 | ||||
Transporter and channel
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP03277 | ER lumen protein-retaining receptor 1 (KDELR1) | 31.1 | ||||
| LDTP01059 | Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) | 26.5 | ||||
| LDTP03132 | Voltage-dependent anion-selective channel protein 1 (VDAC1) | 26.5 | ||||
| LDTP04071 | Voltage-dependent anion-selective channel protein 2 (VDAC2) | 20.3 | ||||
| LDTP10913 | Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) | 19.7 | ||||
| LDTP15948 | Transmembrane protein 126A (TMEM126A) | 15.8 | ||||
| LDTP16813 | Tetraspanin-3 (TSPAN3) | 14.7 | ||||
| LDTP20002 | Transmembrane protein 160 (TMEM160) | 14.7 | ||||
| LDTP06034 | Lysosome membrane protein 2 (SCARB2) | 13.3 | ||||
| LDTP06221 | StAR-related lipid transfer protein 3 (STARD3) | 12.9 | ||||
| LDTP00592 | Surfeit locus protein 4 (SURF4) | 12.6 | ||||
| LDTP04033 | Translocon-associated protein subunit alpha (SSR1) | 12.6 | ||||
| LDTP03064 | Cytochrome c oxidase subunit 5A, mitochondrial (COX5A) | 11.8 | ||||
| LDTP00547 | Secretory carrier-associated membrane protein 2 (SCAMP2) | 10.9 | ||||
| LDTP02215 | Prosaposin (PSAP) | 10.3 | ||||
| LDTP17362 | Magnesium transporter NIPA3 (NIPAL1) | 9.9 | ||||
| LDTP08881 | Transmembrane protein 199 (TMEM199) | 9.7 | ||||
| LDTP00562 | Membrane-associated progesterone receptor component 2 (PGRMC2) | 9.6 | ||||
| LDTP12383 | Protein GPR108 (GPR108) | 9.5 | ||||
| LDTP01804 | ATP synthase subunit a (MT-ATP6) | 8.6 | ||||
| LDTP06365 | Transmembrane emp24 domain-containing protein 2 (TMED2) | 8.6 | ||||
| LDTP09328 | Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) | 8.3 | ||||
| LDTP13174 | Mitochondrial dicarboxylate carrier (SLC25A10) | 8.1 | ||||
| LDTP15967 | Tetraspanin-10 (TSPAN10) | 7.9 | ||||
| LDTP16190 | Protein FAM8A1 (FAM8A1) | 7.6 | ||||
| LDTP11844 | Protein spinster homolog 1 (SPNS1) | 7.5 | ||||
| LDTP06945 | Sigma intracellular receptor 2 (TMEM97) | 7.4 | ||||
| LDTP00541 | NPC intracellular cholesterol transporter 1 (NPC1) | 7.3 | ||||
| LDTP07236 | Protein GPR107 (GPR107) | 7.2 | ||||
| LDTP09547 | Scavenger receptor class B member 1 (SCARB1) | 7.2 | ||||
| LDTP10958 | Sigma non-opioid intracellular receptor 1 (SIGMAR1) | 7.2 | ||||
| LDTP08878 | ER membrane protein complex subunit 5 (MMGT1) | 7.1 | ||||
| LDTP04463 | H(+)/Cl(-) exchange transporter 7 (CLCN7) | 7.0 | ||||
| LDTP11213 | Nucleoporin NDC1 (NDC1) | 6.7 | ||||
| LDTP02655 | Lysosome-associated membrane glycoprotein 2 (LAMP2) | 6.6 | ||||
| LDTP01671 | STARD3 N-terminal-like protein (STARD3NL) | 6.6 | ||||
| LDTP18448 | Transmembrane 9 superfamily member 3 (TM9SF3) | 6.6 | ||||
| LDTP11813 | Solute carrier family 25 member 32 (SLC25A32) | 6.5 | ||||
| LDTP00865 | Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) | 6.3 | ||||
| LDTP09769 | Zinc transporter SLC39A7 (SLC39A7) | 6.3 | ||||
| LDTP14511 | ATP synthase subunit g, mitochondrial (ATP5MG) | 6.2 | ||||
| LDTP05900 | Metaxin-1 (MTX1) | 6.2 | ||||
| LDTP09968 | V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) | 6.1 | ||||
| LDTP07885 | Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) | 6.1 | ||||
| LDTP13823 | Mitochondrial chaperone BCS1 (BCS1L) | 6.1 | ||||
| LDTP02724 | Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) | 6.0 | ||||
| LDTP14952 | Mpv17-like protein 2 (MPV17L2) | 6.0 | ||||
| LDTP17641 | Solute carrier family 35 member F2 (SLC35F2) | 5.9 | ||||
Other
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP11076 | Apolipoprotein L2 (APOL2) | 45.9 | ||||
| LDTP12565 | Mitochondrial import receptor subunit TOM22 homolog (TOMM22) | 25.3 | ||||
| LDTP15067 | Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) | 20.1 | ||||
| LDTP13606 | Mammalian ependymin-related protein 1 (EPDR1) | 15.3 | ||||
| LDTP14458 | Tetraspanin-6 (TSPAN6) | 13.5 | ||||
| LDTP04094 | Large proline-rich protein BAG6 (BAG6) | 13.1 | ||||
| LDTP00871 | Microtubule nucleation factor SSNA1 (SSNA1) | 12.9 | ||||
| LDTP01249 | Polycomb protein EED (EED) | 12.8 | ||||
| LDTP13902 | Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) | 12.3 | ||||
| LDTP05160 | Nucleobindin-2 (NUCB2) | 11.8 | ||||
| LDTP00105 | Protein unc-119 homolog B (UNC119B) | 10.7 | ||||
| LDTP13245 | Zinc finger CCCH domain-containing protein 7B (ZC3H7B) | 10.3 | ||||
| LDTP16006 | Optic atrophy 3 protein (OPA3) | 10.1 | ||||
| LDTP08364 | Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) | 9.8 | ||||
| LDTP18883 | Protein CEBPZOS (CEBPZOS) | 9.5 | ||||
| LDTP15420 | Mitochondrial import receptor subunit TOM5 homolog (TOMM5) | 8.9 | ||||
| LDTP05868 | Protein unc-119 homolog A (UNC119) | 8.6 | ||||
| LDTP14486 | Clustered mitochondria protein homolog (CLUH) | 8.5 | ||||
| LDTP09069 | Kinetochore protein Spc24 (SPC24) | 8.5 | ||||
| LDTP16323 | Signal recognition particle receptor subunit beta (SRPRB) | 7.9 | ||||
| LDTP13086 | Syntaxin-18 (STX18) | 7.9 | ||||
| LDTP16080 | Protein FAM114A2 (FAM114A2) | 7.4 | ||||
| LDTP02205 | Tubulin beta chain (TUBB) | 6.8 | ||||
| LDTP06373 | Mitochondrial import receptor subunit TOM20 homolog (TOMM20) | 6.6 | ||||
| LDTP01522 | Reticulon-3 (RTN3) | 6.6 | ||||
| LDTP00281 | Golgi integral membrane protein 4 (GOLIM4) | 6.5 | ||||
| LDTP01296 | Protein XRP2 (RP2) | 6.5 | ||||
| LDTP05076 | Tubulin beta-4B chain (TUBB4B) | 6.5 | ||||
| LDTP12412 | Reticulon-4 (RTN4) | 6.4 | ||||
| LDTP13311 | Poly(U)-binding-splicing factor PUF60 (PUF60) | 6.3 | ||||
| LDTP01075 | Protein CutA (CUTA) | 6.1 | ||||
| LDTP04652 | Eukaryotic translation initiation factor 5 (EIF5) | 6.0 | ||||
| LDTP01652 | Centrosomal protein 43 (CEP43) | 6.0 | ||||
| LDTP02927 | Ganglioside GM2 activator (GM2A) | 5.9 | ||||
| LDTP01167 | Reticulon-2 (RTN2) | 5.9 | ||||
| LDTP11277 | Tubulin beta-2B chain (TUBB2B) | 5.9 | ||||
| LDTP08606 | Nurim (NRM) | 5.9 | ||||
| LDTP15623 | Neuferricin (CYB5D2) | 5.9 | ||||
| LDTP18272 | Transmembrane protein 209 (TMEM209) | 5.9 | ||||