Details of the Target

General Information of Target

Target ID LDTP05493
Target Name Sulfotransferase 2A1 (SULT2A1)
Gene Name SULT2A1
Gene ID 6822
Synonyms
HST; STD; Sulfotransferase 2A1; ST2A1; EC 2.8.2.2; Bile salt sulfotransferase; EC 2.8.2.14; Dehydroepiandrosterone sulfotransferase; DHEA-ST; DHEA-ST8; Hydroxysteroid Sulfotransferase; HST; ST2; SULT2A3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSK
GDAKWIQSVPIWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLM
RNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFL
LLSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVV
DKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRELFPWE
Target Bioclass
Enzyme
Family
Sulfotransferase 1 family
Subcellular location
Cytoplasm
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism. In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols.
Uniprot ID
Q06520
Ensemble ID
ENST00000222002.4
HGNC ID
HGNC:11458
ChEMBL ID
CHEMBL2077

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
IPM
 Probe Info  		C199(0.00); C55(0.00)  LDD0241  [2]
DBIA
 Probe Info  		C199(1.90)  LDD3424  [3]
W1
 Probe Info  		S97(0.00); S98(0.00); H99(0.00)  LDD0236  [2]
PAL-AfBPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		14.22  LDD1711  [4]
C004
 Probe Info  		7.52  LDD1714  [4]
C277
 Probe Info  		50.21  LDD1947  [4]
C279
 Probe Info  		5.82  LDD1949  [4]
C280
 Probe Info  		9.00  LDD1950  [4]
C284
 Probe Info  		37.01  LDD1954  [4]
C307
 Probe Info  		19.43  LDD1975  [4]
C311
 Probe Info  		6.45  LDD1978  [4]
C326
 Probe Info  		33.82  LDD1990  [4]
C376
 Probe Info  		14.93  LDD2036  [4]
C378
 Probe Info  		7.41  LDD2037  [4]
C380
 Probe Info  		7.11  LDD2039  [4]
C382
 Probe Info  		9.32  LDD2041  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CCK-81 C199(2.42)  LDD2297  [3]
 LDCM0023  KB03 CCK-81 C199(3.57)  LDD2714  [3]
 LDCM0024  KB05 SK-HEP1 C199(1.90)  LDD3424  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
Sulfotransferase 1B1 (SULT1B1) Sulfotransferase 1 family O43704
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Signal transducer and activator of transcription 3 (STAT3) Transcription factor STAT family P40763

The Drug(s) Related To This Target

Approved
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Abiraterone Small molecular drug DB05812
Ibrexafungerp Small molecular drug DB12471
Methyldopa Small molecular drug DB00968
Palbociclib Small molecular drug DB09073
Pindolol Small molecular drug DB00960
Prasterone Small molecular drug DB01708
Ritodrine Small molecular drug DB00867
Tamoxifen Small molecular drug DB00675
Terbutaline Small molecular drug DB00871
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adenosine 3'5'-diphosphate Small molecular drug DB01812
Aetiocholanolone Small molecular drug DB02854
Mercuric Iodide . DB04445
Propacetamol . DB09288

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587