Details of the Probe

General Information of Probe

Probe ID
LDPC0599
Probe Name
C380
Synonyms
Z3426081186
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 313.4
Lipid-water partition coefficient (xlogp) 2
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C15H15N5OS
IUPAC Name
N-(2,1,3-benzothiadiazol-4-ylmethyl)-3-(3-but-3-ynyldiazirin-3-yl)propanamide
Canonical SMILES
C#CCCC1(N=N1)CCC(=O)NCC2=CC=CC3=NSN=C32
InChI
InChI=1S/C15H15N5OS/c1-2-3-8-15(19-20-15)9-7-13(21)16-10-11-5-4-6-12-14(11)18-22-17-12/h1,4-6H,3,7-10H2,(H,16,21)
InChIKey
HSXXVYDCFYNAGO-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

94 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) LDTP06325 17.88  LDD2039 
3-ketodihydrosphingosine reductase (KDSR) LDTP05476 5.62  LDD2039 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 6.11  LDD2039 
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 7.31  LDD2039 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 6.50  LDD2039 
Acid ceramidase (ASAH1) LDTP05905 7.73  LDD2039 
Adenosine deaminase (ADA) LDTP01803 5.46  LDD2039 
ADP-dependent glucokinase (ADPGK) LDTP11127 5.70  LDD2039 
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) LDTP00186 5.31  LDD2039 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 6.11  LDD2039 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 17.51  LDD2039 
Beta-1,4-glucuronyltransferase 1 (B4GAT1) LDTP00783 9.58  LDD2039 
Beta-galactosidase (GLB1) LDTP02837 7.01  LDD2039 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 8.69  LDD2039 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 8.69  LDD2039 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 6.06  LDD2039 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 20.25  LDD2039 
Cartilage-associated protein (CRTAP) LDTP01300 9.71  LDD2039 
Ceramide synthase 2 (CERS2) LDTP10329 7.36  LDD2039 
Choline kinase alpha (CHKA) LDTP03787 8.40  LDD2039 
Cytochrome b-c1 complex subunit 8 (UQCRQ) LDTP00486 6.73  LDD2039 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 5.28  LDD2039 
Cytochrome b5 type B (CYB5B) LDTP00697 13.45  LDD2039 
Cytochrome c oxidase subunit 2 (MT-CO2) LDTP01773 8.22  LDD2039 
DCN1-like protein 4 (DCUN1D4) LDTP09799 5.74  LDD2039 
Delta(14)-sterol reductase LBR (LBR) LDTP06200 5.66  LDD2039 
Delta(24)-sterol reductase (DHCR24) LDTP06375 17.03  LDD2039 
Dihydrofolate reductase (DHFR) LDTP01769 7.78  LDD2039 
DNA replication licensing factor MCM4 (MCM4) LDTP03680 23.10  LDD2039 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 9.06  LDD2039 
E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) LDTP10699 30.27  LDD2039 
E3 ubiquitin-protein ligase RNF14 (RNF14) LDTP13154 5.66  LDD2039 
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETFDH) LDTP06511 6.19  LDD2039 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 11.24  LDD2039 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 6.96  LDD2039 
Exonuclease 1 (EXO1) LDTP13751 5.74  LDD2039 
FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) LDTP10188 5.90  LDD2039 
Ferrochelatase, mitochondrial (FECH) LDTP03198 5.90  LDD2039 
Glutathione S-transferase A4 (GSTA4) LDTP00575 8.00  LDD2039 
Heme oxygenase 1 (HMOX1) LDTP02359 11.00  LDD2039 
Heme oxygenase 2 (HMOX2) LDTP03540 15.35  LDD2039 
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A) LDTP01018 6.15  LDD2039 
Histone-lysine N-methyltransferase 2A (KMT2A) LDTP05396 6.45  LDD2039 
Histone-lysine N-methyltransferase SMYD3 (SMYD3) LDTP12020 6.32  LDD2039 
Holocytochrome c-type synthase (HCCS) LDTP04581 5.82  LDD2039 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 5.35  LDD2039 
Ketosamine-3-kinase (FN3KRP) LDTP16025 5.13  LDD2039 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 8.63  LDD2039 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 11.31  LDD2039 
Lipid droplet-associated hydrolase (LDAH) LDTP16007 19.43  LDD2039 
Lysine-specific histone demethylase 2 (KDM1B) LDTP09043 5.50  LDD2039 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 9.71  LDD2039 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 5.28  LDD2039 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 5.70  LDD2039 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 8.06  LDD2039 
Lysosomal protective protein (CTSA) LDTP02505 6.50  LDD2039 
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) LDTP11273 9.71  LDD2039 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 12.82  LDD2039 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 5.54  LDD2039 
NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) LDTP01168 5.31  LDD2039 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 10.41  LDD2039 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 8.75  LDD2039 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 8.28  LDD2039 
Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) LDTP12720 6.06  LDD2039 
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) LDTP05029 5.06  LDD2039 
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) LDTP14218 7.52  LDD2039 
Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) LDTP00589 6.23  LDD2039 
Peroxisomal trans-2-enoyl-CoA reductase (PECR) LDTP11437 6.36  LDD2039 
Phospholipase A2 group XV (PLA2G15) LDTP09088 5.70  LDD2039 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 5.90  LDD2039 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 9.58  LDD2039 
Prolyl endopeptidase-like (PREPL) LDTP06849 6.92  LDD2039 
Prostaglandin reductase 3 (PTGR3) LDTP15422 22.63  LDD2039 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 6.41  LDD2039 
Protein O-GlcNAcase (OGA) LDTP00988 5.50  LDD2039 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 20.82  LDD2039 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 6.59  LDD2039 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 6.19  LDD2039 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) LDTP00907 33.59  LDD2039 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 10.48  LDD2039 
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) LDTP07989 5.13  LDD2039 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 7.31  LDD2039 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 5.98  LDD2039 
Serine/threonine-protein phosphatase 4 regulatory subunit 3A (PPP4R3A) LDTP07417 5.10  LDD2039 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 5.74  LDD2039 
Signal peptide peptidase-like 2A (SPPL2A) LDTP09395 6.82  LDD2039 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 5.39  LDD2039 
Sphingosine-1-phosphate lyase 1 (SGPL1) LDTP01613 5.43  LDD2039 
Sulfotransferase 2A1 (SULT2A1) LDTP05493 7.11  LDD2039 
Translin (TSN) LDTP06427 8.06  LDD2039 
Transmembrane protein with metallophosphoesterase domain (TMPPE) LDTP07831 6.11  LDD2039 
Trimethyllysine dioxygenase, mitochondrial (TMLHE) LDTP12679 15.24  LDD2039 
Very-long-chain enoyl-CoA reductase (TECR) LDTP12867 7.57  LDD2039 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 16.68  LDD2039 
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⏷ Show the Full List of 94 Enzyme
49 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 6.06  LDD2039 
ATP synthase subunit a (MT-ATP6) LDTP01804 16.11  LDD2039 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 7.46  LDD2039 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 15.03  LDD2039 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 27.86  LDD2039 
ER membrane protein complex subunit 5 (MMGT1) LDTP08878 5.39  LDD2039 
Gasdermin-E (GSDME) LDTP00970 6.11  LDD2039 
H(+)/Cl(-) exchange transporter 7 (CLCN7) LDTP04463 9.85  LDD2039 
Lysosome membrane protein 2 (SCARB2) LDTP06034 13.64  LDD2039 
Magnesium transporter NIPA3 (NIPAL1) LDTP17362 9.19  LDD2039 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 6.19  LDD2039 
Metaxin-1 (MTX1) LDTP05900 11.16  LDD2039 
Metaxin-2 (MTX2) LDTP01217 7.31  LDD2039 
MFS-type transporter SLC18B1 (SLC18B1) LDTP07462 7.78  LDD2039 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 16.45  LDD2039 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 25.99  LDD2039 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 5.17  LDD2039 
Mpv17-like protein 2 (MPV17L2) LDTP14952 7.73  LDD2039 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 7.41  LDD2039 
Nucleoporin NDC1 (NDC1) LDTP11213 5.03  LDD2039 
Prosaposin (PSAP) LDTP02215 7.11  LDD2039 
Protein ARV1 (ARV1) LDTP11812 6.87  LDD2039 
Protein GPR107 (GPR107) LDTP07236 5.90  LDD2039 
Protein GPR108 (GPR108) LDTP12383 6.77  LDD2039 
Putative divalent cation/proton antiporter TMEM165 (TMEM165) LDTP12207 5.70  LDD2039 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 7.36  LDD2039 
Sideroflexin-4 (SFXN4) LDTP07531 6.11  LDD2039 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 5.78  LDD2039 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 19.29  LDD2039 
Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) LDTP11826 5.78  LDD2039 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 5.82  LDD2039 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 5.10  LDD2039 
StAR-related lipid transfer protein 3 (STARD3) LDTP06221 6.11  LDD2039 
Surfeit locus protein 4 (SURF4) LDTP00592 14.72  LDD2039 
Tetraspanin-10 (TSPAN10) LDTP15967 9.71  LDD2039 
Tetraspanin-3 (TSPAN3) LDTP16813 11.79  LDD2039 
Translocator protein (TSPO) LDTP03546 9.32  LDD2039 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 7.52  LDD2039 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 6.45  LDD2039 
Transmembrane emp24 domain-containing protein 10 (TMED10) LDTP04293 7.06  LDD2039 
Transmembrane emp24 domain-containing protein 2 (TMED2) LDTP06365 14.42  LDD2039 
Transmembrane emp24 domain-containing protein 7 (TMED7) LDTP13969 5.06  LDD2039 
Transmembrane protein 126A (TMEM126A) LDTP15948 9.92  LDD2039 
Transmembrane protein 160 (TMEM160) LDTP20002 8.63  LDD2039 
Transmembrane protein 199 (TMEM199) LDTP08881 7.89  LDD2039 
Transmembrane protein 87A (TMEM87A) LDTP15481 6.68  LDD2039 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 6.32  LDD2039 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 22.32  LDD2039 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 17.39  LDD2039 
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⏷ Show the Full List of 49 Transporter and channel
1 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Forkhead-associated domain-containing protein 1 (FHAD1) LDTP16717 31.34  LDD2039 
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57 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Apolipoprotein L2 (APOL2) LDTP11076 27.47  LDD2039 
Armadillo repeat-containing protein 10 (ARMC10) LDTP08793 6.87  LDD2039 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 5.06  LDD2039 
Capping protein-inhibiting regulator of actin dynamics (CRACD) LDTP07839 8.69  LDD2039 
Centrosomal protein 43 (CEP43) LDTP01652 5.86  LDD2039 
Clustered mitochondria protein homolog (CLUH) LDTP14486 12.13  LDD2039 
Cold-inducible RNA-binding protein (CIRBP) LDTP06022 5.54  LDD2039 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 7.36  LDD2039 
Dynactin subunit 3 (DCTN3) LDTP01359 4.99  LDD2039 
Dynactin subunit 4 (DCTN4) LDTP13402 7.84  LDD2039 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 5.78  LDD2039 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 6.50  LDD2039 
Eukaryotic translation initiation factor 5 (EIF5) LDTP04652 5.90  LDD2039 
General transcription factor IIF subunit 1 (GTF2F1) LDTP03729 25.28  LDD2039 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 5.94  LDD2039 
HCLS1-associated protein X-1 (HAX1) LDTP00199 10.48  LDD2039 
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) LDTP00500 5.66  LDD2039 
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) LDTP04714 5.74  LDD2039 
Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) LDTP03614 4.99  LDD2039 
Integrator complex subunit 14 (INTS14) LDTP15834 5.82  LDD2039 
Kinetochore protein Spc24 (SPC24) LDTP09069 5.43  LDD2039 
Large proline-rich protein BAG6 (BAG6) LDTP04094 6.96  LDD2039 
Large ribosomal subunit protein uL10m (MRPL10) LDTP08154 5.98  LDD2039 
m-AAA protease-interacting protein 1, mitochondrial (MAIP1) LDTP09644 5.21  LDD2039 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 8.46  LDD2039 
Mitochondrial dynamics protein MIEF1 (MIEF1) LDTP12418 5.28  LDD2039 
Mitochondrial import receptor subunit TOM20 homolog (TOMM20) LDTP06373 7.62  LDD2039 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 14.42  LDD2039 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 7.41  LDD2039 
Nucleobindin-2 (NUCB2) LDTP05160 11.71  LDD2039 
Nucleosome assembly protein 1-like 1 (NAP1L1) LDTP04684 5.06  LDD2039 
Nucleosome assembly protein 1-like 4 (NAP1L4) LDTP10965 5.17  LDD2039 
Optic atrophy 3 protein (OPA3) LDTP16006 5.70  LDD2039 
p53 and DNA damage-regulated protein 1 (PDRG1) LDTP16099 39.95  LDD2039 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 6.54  LDD2039 
Pre-mRNA-splicing factor SPF27 (BCAS2) LDTP01358 5.46  LDD2039 
Protein CEBPZOS (CEBPZOS) LDTP18883 5.86  LDD2039 
Protein CutA (CUTA) LDTP01075 8.28  LDD2039 
Protein FAM114A2 (FAM114A2) LDTP16080 6.11  LDD2039 
Protein unc-119 homolog A (UNC119) LDTP05868 11.08  LDD2039 
Protein unc-119 homolog B (UNC119B) LDTP00105 12.55  LDD2039 
Rab9 effector protein with kelch motifs (RABEPK) LDTP08130 6.77  LDD2039 
Rap guanine nucleotide exchange factor 2 (RAPGEF2) LDTP14058 5.24  LDD2039 
Reticulocalbin-2 (RCN2) LDTP06097 5.86  LDD2039 
Reticulon-2 (RTN2) LDTP01167 5.28  LDD2039 
Reticulon-3 (RTN3) LDTP01522 7.36  LDD2039 
Reticulon-4 (RTN4) LDTP12412 5.21  LDD2039 
S1 RNA-binding domain-containing protein 1 (SRBD1) LDTP17715 6.54  LDD2039 
Sister chromatid cohesion protein PDS5 homolog A (PDS5A) LDTP06684 4.99  LDD2039 
Syntaxin-18 (STX18) LDTP13086 5.13  LDD2039 
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) LDTP14263 4.99  LDD2039 
TATA-binding protein-associated factor 2N (TAF15) LDTP09881 5.46  LDD2039 
Tetraspanin-6 (TSPAN6) LDTP14458 11.63  LDD2039 
Tetratricopeptide repeat protein 38 (TTC38) LDTP19372 19.03  LDD2039 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 4.99  LDD2039 
Transmembrane protein 209 (TMEM209) LDTP18272 5.50  LDD2039 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 17.39  LDD2039 
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⏷ Show the Full List of 57 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD2039 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587