Details of the Target

General Information of Target

Target ID LDTP16717
Target Name Forkhead-associated domain-containing protein 1 (FHAD1)
Gene Name FHAD1
Gene ID 114827
Synonyms
KIAA1937; Forkhead-associated domain-containing protein 1; FHA domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPHLLWCPTNGLGLGGSPAGQWGGGSHYRGLVPGEPAGRPPALPLPGLAGLHDHTQLLR
MAGQPWLAWGTAAARVSARPTRDCSCTSRCHHACDVVAVTLS
Target Bioclass
Transcription factor
Uniprot ID
B1AJZ9
Ensemble ID
ENST00000358897.8
HGNC ID
HGNC:29408

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K1374(1.20); K961(10.00)  LDD0277  [1]
ONAyne
 Probe Info  		K1374(5.88)  LDD0275  [1]
N1
 Probe Info  		N.A.  LDD0245  [2]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C008
 Probe Info  		10.06  LDD1717  [3]
C010
 Probe Info  		19.16  LDD1719  [3]
C011
 Probe Info  		9.78  LDD1720  [3]
C376
 Probe Info  		15.56  LDD2036  [3]
C380
 Probe Info  		31.34  LDD2039  [3]
C382
 Probe Info  		34.30  LDD2041  [3]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587