Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C376  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 114 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 67.6
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 47.8
 LDTP15886  Diphthine methyltransferase (DPH7) 39.1
 LDTP01562  Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) 30.9
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 30.3
 LDTP03540  Heme oxygenase 2 (HMOX2) 28.1
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 26.9
 LDTP13337  Leucine carboxyl methyltransferase 1 (LCMT1) 26.7
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 26.7
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 26.5
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 26.2
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 26.0
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 23.1
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 21.4
 LDTP02359  Heme oxygenase 1 (HMOX1) 19.3
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 19.0
 LDTP10329  Ceramide synthase 2 (CERS2) 18.9
 LDTP01769  Dihydrofolate reductase (DHFR) 18.6
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 18.5
 LDTP00697  Cytochrome b5 type B (CYB5B) 18.4
 LDTP05905  Acid ceramidase (ASAH1) 17.6
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 17.4
 LDTP12679  Trimethyllysine dioxygenase, mitochondrial (TMLHE) 17.0
 LDTP03394  Ceramide synthase 1 (CERS1) 16.9
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 16.9
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 16.8
 LDTP02505  Lysosomal protective protein (CTSA) 16.7
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 16.6
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 16.1
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 15.9
 LDTP02837  Beta-galactosidase (GLB1) 15.2
 LDTP05493  Sulfotransferase 2A1 (SULT2A1) 14.9
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 14.1
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 13.8
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 13.4
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 13.3
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 13.2
 LDTP06511  Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETFDH) 13.1
 LDTP07931  Heme A synthase COX15 (COX15) 12.7
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 12.7
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 12.6
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 12.6
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 12.5
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 12.4
 LDTP06849  Prolyl endopeptidase-like (PREPL) 12.3
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 12.1
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 11.7
 LDTP12163  Calcyclin-binding protein (CACYBP) 11.1
 LDTP11127  ADP-dependent glucokinase (ADPGK) 11.0
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 10.6
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 10.4
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 9.8
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 9.5
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 9.1
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 9.0
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 9.0
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 8.9
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 8.8
 LDTP00988  Protein O-GlcNAcase (OGA) 8.6
 LDTP00338  Lysosomal alpha-mannosidase (MAN2B1) 8.6
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 8.5
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 8.4
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 8.4
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 8.3
 LDTP11318  ADP-ribose pyrophosphatase, mitochondrial (NUDT9) 8.3
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 8.3
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 8.2
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 8.2
 LDTP05850  Probable methyltransferase TARBP1 (TARBP1) 8.2
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 8.0
 LDTP02141  Alpha-galactosidase A (GLA) 7.9
 LDTP01759  Histone-lysine N-methyltransferase NSD2 (NSD2) 7.9
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 7.9
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 7.9
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 7.8
 LDTP13751  Exonuclease 1 (EXO1) 7.8
 LDTP11081  NAD-capped RNA hydrolase NUDT12 (NUDT12) 7.7
 LDTP02539  Lysosomal acid phosphatase (ACP2) 7.6
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 7.5
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 7.5
 LDTP05372  Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4) 7.5
 LDTP04243  Fatty acid synthase (FASN) 7.4
 LDTP03024  Plasma membrane calcium-transporting ATPase 1 (ATP2B1) 7.4
 LDTP03060  Proteasome subunit beta type-1 (PSMB1) 7.4
 LDTP09799  DCN1-like protein 4 (DCUN1D4) 7.4
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 7.4
 LDTP00836  ATPase GET3 (GET3) 7.3
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 7.3
 LDTP01018  High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A) 7.3
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 7.2
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 7.1
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 7.1
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 6.9
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) 6.9
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 6.9
 LDTP03787  Choline kinase alpha (CHKA) 6.8
 LDTP11703  Histone deacetylase complex subunit SAP130 (SAP130) 6.8
 LDTP13814  Phospholipase A-2-activating protein (PLAA) 6.8
 LDTP01141  E3 ubiquitin-protein ligase BRE1B (RNF40) 6.8
 LDTP18087  Dephospho-CoA kinase domain-containing protein (DCAKD) 6.7
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 6.6
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 6.6
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 6.6
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 6.6
 LDTP10981  Mitochondrial intermediate peptidase (MIPEP) 6.5
 LDTP05877  Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) 6.5
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 6.5
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 6.5
 LDTP01168  NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) 6.5
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 6.5
 LDTP06142  Squalene monooxygenase (SQLE) 6.5
 LDTP04542  Thimet oligopeptidase (THOP1) 6.5
 LDTP10101  Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) 6.4
 LDTP01707  Thioredoxin domain-containing protein 12 (TXNDC12) 6.4
Transporter and channel
Click to Show/Hide to Show 67 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 89.9
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 33.1
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 30.9
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 30.5
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 30.1
 LDTP16813  Tetraspanin-3 (TSPAN3) 27.9
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 27.1
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 26.5
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 26.2
 LDTP20002  Transmembrane protein 160 (TMEM160) 24.9
 LDTP00592  Surfeit locus protein 4 (SURF4) 24.6
 LDTP01804  ATP synthase subunit a (MT-ATP6) 23.1
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 23.1
 LDTP11615  Protein tweety homolog 3 (TTYH3) 22.8
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 21.1
 LDTP02215  Prosaposin (PSAP) 20.0
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 18.4
 LDTP15948  Transmembrane protein 126A (TMEM126A) 16.9
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 16.6
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 15.8
 LDTP12383  Protein GPR108 (GPR108) 15.2
 LDTP08881  Transmembrane protein 199 (TMEM199) 15.0
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 14.0
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 14.0
 LDTP15967  Tetraspanin-10 (TSPAN10) 13.6
 LDTP00970  Gasdermin-E (GSDME) 11.8
 LDTP15481  Transmembrane protein 87A (TMEM87A) 11.6
 LDTP11812  Protein ARV1 (ARV1) 11.4
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 11.2
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 11.2
 LDTP04501  Importin subunit alpha-1 (KPNA2) 10.9
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 10.6
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 10.6
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 10.6
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 10.4
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 10.1
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 9.6
 LDTP11213  Nucleoporin NDC1 (NDC1) 9.6
 LDTP16190  Protein FAM8A1 (FAM8A1) 9.5
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 9.3
 LDTP07236  Protein GPR107 (GPR107) 8.9
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 8.8
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 8.6
 LDTP10065  Transmembrane protein 230 (TMEM230) 8.3
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 8.3
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 8.2
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 8.2
 LDTP09949  Transportin-1 (TNPO1) 8.2
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 7.9
 LDTP02655  Lysosome-associated membrane glycoprotein 2 (LAMP2) 7.8
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 7.8
 LDTP13393  Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) 7.7
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 7.7
 LDTP03380  Stomatin (STOM) 7.6
 LDTP04789  Synaptojanin-2-binding protein (SYNJ2BP) 7.6
 LDTP06499  V-type proton ATPase subunit S1 (ATP6AP1) 7.4
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 7.1
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 7.1
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 7.1
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 7.0
 LDTP09769  Zinc transporter SLC39A7 (SLC39A7) 6.9
 LDTP09515  Importin-4 (IPO4) 6.8
 LDTP09180  Zinc transporter 7 (SLC30A7) 6.8
 LDTP09651  Choline transporter-like protein 1 (SLC44A1) 6.7
 LDTP05690  Vesicular integral-membrane protein VIP36 (LMAN2) 6.7
 LDTP13262  Signal recognition particle subunit SRP68 (SRP68) 6.6
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 6.5
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16717  Forkhead-associated domain-containing protein 1 (FHAD1) 15.6
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 6.6
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 9.2
Other
Click to Show/Hide to Show 72 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 86.2
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 59.7
 LDTP05160  Nucleobindin-2 (NUCB2) 41.9
 LDTP14458  Tetraspanin-6 (TSPAN6) 39.4
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 38.3
 LDTP16099  p53 and DNA damage-regulated protein 1 (PDRG1) 24.6
 LDTP18883  Protein CEBPZOS (CEBPZOS) 24.6
 LDTP16006  Optic atrophy 3 protein (OPA3) 21.4
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 20.8
 LDTP07839  Capping protein-inhibiting regulator of actin dynamics (CRACD) 20.0
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 18.8
 LDTP06373  Mitochondrial import receptor subunit TOM20 homolog (TOMM20) 18.1
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 18.1
 LDTP13086  Syntaxin-18 (STX18) 15.9
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 15.5
 LDTP16080  Protein FAM114A2 (FAM114A2) 15.1
 LDTP00105  Protein unc-119 homolog B (UNC119B) 14.8
 LDTP01522  Reticulon-3 (RTN3) 14.6
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 14.5
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 14.3
 LDTP19963  TraB domain-containing protein (TRABD) 12.6
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 11.7
 LDTP05868  Protein unc-119 homolog A (UNC119) 11.3
 LDTP11421  Fanconi anemia group D2 protein (FANCD2) 11.2
 LDTP12412  Reticulon-4 (RTN4) 11.2
 LDTP05375  Nucleobindin-1 (NUCB1) 10.9
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 10.1
 LDTP01387  SEC14-like protein 2 (SEC14L2) 10.1
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) 9.8
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 9.7
 LDTP18272  Transmembrane protein 209 (TMEM209) 9.5
 LDTP15253  HEAT repeat-containing protein 3 (HEATR3) 9.3
 LDTP08606  Nurim (NRM) 9.1
 LDTP14263  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) 8.9
 LDTP07476  RAD50-interacting protein 1 (RINT1) 8.8
 LDTP02927  Ganglioside GM2 activator (GM2A) 8.7
 LDTP09787  Nicastrin (NCSTN) 8.6
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 8.5
 LDTP08248  NLR family member X1 (NLRX1) 8.3
 LDTP08224  Protein LYRIC (MTDH) 8.3
 LDTP11643  Superkiller complex protein 8 (SKIC8) 8.3
 LDTP04395  RNA-binding protein FXR1 (FXR1) 8.3
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 8.3
 LDTP07916  Protein MTSS 2 (MTSS2) 8.2
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 8.2
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 8.1
 LDTP10056  Protein FAM162A (FAM162A) 8.1
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 7.9
 LDTP16285  Transducin beta-like protein 2 (TBL2) 7.9
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 7.8
 LDTP01167  Reticulon-2 (RTN2) 7.8
 LDTP00417  Programmed cell death protein 5 (PDCD5) 7.7
 LDTP09054  Golgi membrane protein 1 (GOLM1) 7.7
 LDTP13813  Eukaryotic translation initiation factor 3 subunit L (EIF3L) 7.4
 LDTP08793  Armadillo repeat-containing protein 10 (ARMC10) 7.2
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 7.2
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 7.1
 LDTP03926  Centrin-2 (CETN2) 7.1
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 7.1
 LDTP09069  Kinetochore protein Spc24 (SPC24) 7.0
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 6.9
 LDTP00859  Synaptogyrin-2 (SYNGR2) 6.9
 LDTP13955  Calcium-binding protein 39 (CAB39) 6.9
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 6.8
 LDTP06097  Reticulocalbin-2 (RCN2) 6.8
 LDTP12830  U3 small nucleolar RNA-associated protein 6 homolog (UTP6) 6.7
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 6.6
 LDTP09644  m-AAA protease-interacting protein 1, mitochondrial (MAIP1) 6.6
 LDTP05545  TLE family member 5 (TLE5) 6.5
 LDTP09773  Protein FAM3C (FAM3C) 6.5
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 6.5
 LDTP01494  Protein YIF1A (YIF1A) 6.5

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587