Details of the Target

General Information of Target

Target ID LDTP05396
Target Name Histone-lysine N-methyltransferase 2A (KMT2A)
Gene Name KMT2A
Gene ID 4297
Synonyms
ALL1; CXXC7; HRX; HTRX; MLL; MLL1; TRX1; Histone-lysine N-methyltransferase 2A; Lysine N-methyltransferase 2A; EC 2.1.1.364; ALL-1; CXXC-type zinc finger protein 7; Cysteine methyltransferase KMT2A; EC 2.1.1.-; Myeloid/lymphoid or mixed-lineage leukemia; Myeloid/lymphoid or mixed-lineage leukemia protein 1; Trithorax-like protein; Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320; N-terminal cleavage product of 320 kDa; p320; MLL cleavage product C180; C-terminal cleavage product of 180 kDa; p180)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAPPSPPAV
AAAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSASSGPALLRVGPGFDAALQVSA
AIGTNLRRFRAVFGESGGGGGSGEDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPR
SGSDRNSAILSDPSVFSPLNKSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKD
ISELPKGNKEDSLKKIKRTPSATFQQATKIKKLRAGKLSPLKSKFKTGKLQIGRKGVQIV
RRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPRRIKPVRI
IPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPVVSAISSR
IIKTPRRFIEDEDYDPPIKIARLESTPNSRFSAPSCGSSEKSSAASQHSSQMSSDSSRSS
SPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGS
RTTKKLSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPAS
TAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSSAKYAKEGLIRKPIFDNFRPPPLTPED
VGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSN
RTSAGTSSSGVSNRKRKRKVFSPIRSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVSSSL
SISVSPLATSALNPTFTFPSHSLTQSGESAEKNQRPRKQTSAPAEPFSSSSPTPLFPWFT
PGSQTERGRNKDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTLGDTTAVKTKI
LIKKGRGNLEKTNLDLGPTAPSLEKEKTLCLSTPSSSTVKHSTSSIGSMLAQADKLPMTD
KRVASLLKKAKAQLCKIEKSKSLKQTDQPKAQGQESDSSETSVRGPRIKHVCRRAAVALG
RKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKA
PQEPPVKKGRRSRRCGQCPGCQVPEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQNLQWM
PSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSSE
PPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVP
KTTPSEPKKKQPPPPESGPEQSKQKKVAPRPSIPVKQKPKEKEKPPPVNKQENAGTLNIL
STLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASS
GHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNK
CRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCA
KLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYT
CVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESI
PSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINS
DGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDH
NYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPE
LNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKN
VHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDL
IKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDC
EDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPT
SFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCR
PLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYS
RNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHL
DGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTS
RELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVK
TLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNL
KPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTV
KVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSC
QDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSY
GEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASH
NLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPED
AGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNL
LDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEG
LGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPT
VPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMD
ADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQIS
NAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTS
VLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNP
PSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTP
SNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAP
LLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPG
HVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAI
TAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQV
SNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKT
KRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSS
QKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESI
TEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRML
GILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNF
LASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHG
RGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGN
AARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCG
AKKCRKFLN
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, TRX/MLL subfamily
Subcellular location
Nucleus
Function
Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-BMAL1 to chromatin. Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate.
TTD ID
T25462
Uniprot ID
Q03164
DrugMap ID
TT1GNDM
Ensemble ID
ENST00000389506.10
HGNC ID
HGNC:7132
ChEMBL ID
CHEMBL1293299

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C2786(1.23)  LDD3310  [2]
IA-alkyne
 Probe Info  		C456(0.00); C2074(0.00); C990(0.00); C1498(0.00)  LDD0165  [3]
NAIA_4
 Probe Info  		C990(0.00); C2159(0.00)  LDD2226  [4]
NAIA_5
 Probe Info  		C3604(0.00); C2433(0.00)  LDD2224  [4]
ENE
 Probe Info  		N.A.  LDD0006  [5]
IPM
 Probe Info  		C2783(0.00); C5(0.00); C2159(0.00)  LDD0005  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
VSF
 Probe Info  		N.A.  LDD0007  [5]
Phosphinate-6
 Probe Info  		C456(0.00); C2159(0.00); C2783(0.00); C2709(0.00)  LDD0018  [7]
AOyne
 Probe Info  		14.40  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		8.22  LDD1728  [9]
C026
 Probe Info  		8.11  LDD1732  [9]
C063
 Probe Info  		10.85  LDD1760  [9]
C129
 Probe Info  		9.19  LDD1811  [9]
C138
 Probe Info  		5.24  LDD1820  [9]
C139
 Probe Info  		12.91  LDD1821  [9]
C141
 Probe Info  		12.82  LDD1823  [9]
C145
 Probe Info  		8.06  LDD1827  [9]
C173
 Probe Info  		6.73  LDD1853  [9]
C180
 Probe Info  		6.41  LDD1859  [9]
C187
 Probe Info  		26.72  LDD1865  [9]
C193
 Probe Info  		5.78  LDD1869  [9]
C198
 Probe Info  		11.63  LDD1874  [9]
C216
 Probe Info  		15.89  LDD1890  [9]
C218
 Probe Info  		22.32  LDD1892  [9]
C220
 Probe Info  		12.82  LDD1894  [9]
C225
 Probe Info  		5.46  LDD1898  [9]
C288
 Probe Info  		7.36  LDD1958  [9]
C290
 Probe Info  		6.02  LDD1960  [9]
C313
 Probe Info  		13.55  LDD1980  [9]
C317
 Probe Info  		12.82  LDD1983  [9]
C319
 Probe Info  		5.13  LDD1985  [9]
C326
 Probe Info  		11.88  LDD1990  [9]
C337
 Probe Info  		4.92  LDD2000  [9]
C338
 Probe Info  		28.44  LDD2001  [9]
C348
 Probe Info  		32.22  LDD2009  [9]
C349
 Probe Info  		33.59  LDD2010  [9]
C350
 Probe Info  		31.34  LDD2011  [9]
C351
 Probe Info  		8.63  LDD2012  [9]
C353
 Probe Info  		6.68  LDD2014  [9]
C376
 Probe Info  		8.34  LDD2036  [9]
C380
 Probe Info  		6.45  LDD2039  [9]
C382
 Probe Info  		12.91  LDD2041  [9]
C408
 Probe Info  		8.51  LDD2065  [9]
C413
 Probe Info  		17.27  LDD2069  [9]
C419
 Probe Info  		22.47  LDD2074  [9]
C420
 Probe Info  		14.93  LDD2075  [9]
C422
 Probe Info  		11.16  LDD2077  [9]
C423
 Probe Info  		10.34  LDD2078  [9]
C424
 Probe Info  		7.57  LDD2079  [9]
C428
 Probe Info  		7.94  LDD2083  [9]
C429
 Probe Info  		16.56  LDD2084  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C2783(0.95); C3882(1.20); C3604(1.05); C1509(0.98)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C2783(0.98); C3882(1.08); C3604(0.88); C1964(0.98)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C2783(1.02); C3882(1.07); C3604(1.14); C1964(1.06)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C2783(1.01); C3882(1.04); C3604(0.94); C1964(1.06)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C2783(0.96); C3882(1.04); C3604(0.92); C1509(1.31)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C2783(1.00); C3882(0.99); C3604(1.00); C1509(1.24)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C2783(1.06); C3882(1.09); C3604(0.94); C1509(1.06)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C2783(1.02); C3882(1.03); C3604(1.20); C1964(0.93)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C2783(1.54); C3882(1.30); C3604(1.04); C1964(1.27)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C2783(0.97); C3882(1.22); C3604(0.95); C1964(1.01)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C2783(0.99); C3882(1.08); C3604(1.06); C1964(1.01)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C2783(0.99); C3882(1.14); C3604(1.07); C1509(0.97)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C2783(0.97); C3882(1.12); C3604(0.91); C1509(1.01)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C2783(0.97); C3882(1.03); C3604(1.09); C1509(1.26)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C2783(1.03); C3882(1.06); C3604(1.00); C1509(1.19)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C2783(1.01); C3882(1.08); C3604(0.94); C1509(1.18)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C2783(1.00); C3882(1.05); C3604(0.99); C1964(0.97)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C2783(1.04); C3882(1.16); C3604(0.77); C1964(1.07)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C2783(0.95); C3882(0.97); C3604(0.96); C1964(0.97)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C2783(0.96); C3882(1.19); C3604(0.91); C1509(1.05)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C2783(1.06); C3882(1.14); C3604(1.14); C1964(1.00)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C2783(0.96); C3882(0.96); C3604(0.95); C1509(0.94)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C2783(0.96); C3882(1.03); C3604(1.00); C1509(1.15)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C2783(1.00); C3882(1.02); C3604(0.90); C1509(1.11)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C2783(1.09); C3882(1.05); C3604(0.87); C1509(1.15)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C2783(1.03); C3882(1.12); C3604(0.99); C1964(1.10)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C2783(1.08); C3882(1.14); C3604(1.14); C1964(0.96)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C2783(1.04); C3882(1.03); C3604(0.82); C1964(1.05)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C2783(0.92); C3882(1.13); C3604(1.21); C1509(0.93)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C2783(0.97); C3882(1.12); C3604(0.95); C1509(1.27)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C2783(1.03); C3882(1.12); C3604(0.98); C1509(1.18)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C2783(0.97); C3882(0.98); C3604(0.92); C1964(1.08)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C2783(1.06); C3882(1.05); C3604(0.90); C1509(1.08)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C2783(1.03); C3882(1.16); C3604(1.03); C1509(1.01)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C2783(1.06); C3882(1.16); C3604(1.09); C1964(1.05)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C2783(1.09); C3882(1.17); C3604(0.83); C1964(1.11)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C2783(1.02); C3882(0.95); C3604(0.96); C1964(0.97)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C2783(1.00); C3882(1.13); C3604(1.09); C1509(1.01)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C2783(1.03); C3882(1.06); C3604(1.04); C1509(1.15)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C2783(1.00); C3882(1.17); C3604(0.93); C1509(1.11)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C2783(1.01); C3882(1.12); C3604(1.05); C1509(1.32)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C2783(1.04); C3882(1.11); C3604(1.06); C1509(1.27)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C2783(0.97); C3882(1.19); C3604(1.08); C1509(1.03)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C2783(0.97); C3882(1.07); C3604(1.04); C1964(0.97)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C2783(1.01); C3882(1.11); C3604(1.21); C1964(1.08)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C2783(1.04); C3882(1.00); C3604(1.01); C1964(1.00)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C2783(1.01); C3882(1.17); C3604(1.08); C1509(0.98)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C2783(1.02); C3882(1.09); C3604(0.96); C1509(1.11)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C2783(1.00); C3882(1.10); C3604(1.03); C1509(1.32)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C2783(1.03); C3882(1.11); C3604(1.00); C1509(1.25)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C2783(1.01); C3882(1.07); C3604(0.88); C1509(0.97)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C2783(0.99); C3882(1.20); C3604(1.11); C1964(0.94)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C2783(0.98); C3882(1.16); C3604(0.90); C1964(1.00)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C2783(1.00); C3882(1.14); C3604(0.95); C1509(0.94)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C2783(0.98); C3882(1.07); C3604(0.83); C1964(1.06)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C2783(0.98); C3882(1.26); C3604(1.07); C1509(0.90)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C2783(1.01); C3882(1.18); C3604(1.03); C1509(0.93)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C2783(1.04); C3882(1.11); C3604(1.02); C1509(1.12)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C2783(0.97); C3882(1.11); C3604(0.93); C1509(1.14)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C2783(0.95); C3882(1.16); C3604(0.89); C1509(1.01)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C2783(1.00); C3882(1.14); C3604(0.99); C1509(1.07)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C2783(0.95); C3882(1.23); C3604(1.11); C1509(0.94)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C2783(0.99); C3882(0.99); C3604(1.02); C1509(1.21)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C2783(1.01); C3882(1.03); C3604(1.01); C1509(1.26)  LDD1514  [10]
 LDCM0156  Aniline NCI-H1299 12.36  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C2074(0.57)  LDD2227  [4]
 LDCM0367  CL1 HEK-293T C2783(0.85); C3882(1.38); C3604(1.10); C1509(0.96)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C2783(0.88); C3882(1.03); C3604(0.70); C1509(1.08)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C2783(1.05); C3882(1.14); C3604(0.97); C1509(0.99)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C2783(0.92); C3882(1.30); C3604(1.18); C1509(1.11)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C2783(0.99); C3882(1.01); C3604(1.04); C1964(1.02)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C2783(1.12); C3882(1.14); C3604(1.00); C2159(1.09)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C2783(1.05); C3882(1.20); C3604(1.08); C1509(1.10)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C2783(1.03); C3882(1.20); C3604(1.11); C1509(0.94)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C2783(1.00); C3882(1.03); C3604(1.10); C1964(0.92)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C2783(1.02); C3882(1.11); C3604(0.91); C2159(1.09)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C2783(1.03); C3882(1.13); C3604(0.92); C1509(1.18)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C2783(0.95); C3882(1.26); C3604(0.89); C1509(0.95)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C2783(0.94); C3882(1.11); C3604(1.00); C1509(1.17)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C2783(0.96); C3882(1.01); C3604(0.80); C1964(0.98)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C2783(1.01); C3882(1.04); C3604(1.06); C2159(0.92)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C2783(1.10); C3882(1.07); C3604(1.09); C1509(1.11)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C2783(0.99); C3882(1.35); C3604(1.11); C1509(1.05)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C2783(1.03); C3882(1.14); C3604(1.05); C1964(0.99)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C2783(0.97); C3882(1.22); C3604(1.07); C2159(1.13)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C2783(1.04); C3882(1.17); C3604(1.26); C1509(1.10)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C2783(1.05); C3882(1.41); C3604(1.18); C1509(1.12)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C2783(1.09); C3882(1.05); C3604(1.17); C1964(0.83)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C2783(1.01); C3882(1.07); C3604(0.97); C2159(1.05)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C2783(1.04); C3882(1.04); C3604(0.87); C1509(1.05)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C2783(0.99); C3882(1.19); C3604(0.98); C1509(1.13)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C2783(1.03); C3882(1.34); C3604(1.08); C1509(1.15)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C2783(1.04); C3882(1.04); C3604(0.89); C1964(0.87)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C2783(0.90); C3882(1.15); C3604(0.93); C2159(0.98)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C2783(0.95); C3882(1.12); C3604(1.05); C1509(1.09)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C2783(0.94); C3882(1.43); C3604(0.98); C1509(0.94)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C2783(1.00); C3882(1.10); C3604(1.09); C1964(1.00)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C2783(1.04); C3882(1.14); C3604(0.92); C2159(0.87)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C2783(1.04); C3882(1.24); C3604(1.14); C1509(0.86)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C2783(1.02); C3882(1.41); C3604(1.13); C1509(1.16)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C2783(1.02); C3882(1.15); C3604(1.08); C1964(1.11)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C2783(0.96); C3882(1.14); C3604(0.95); C2159(1.12)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C2783(0.98); C3882(1.10); C3604(1.26); C1509(0.99)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C2783(0.94); C3882(0.90); C3604(0.89); C1509(1.10)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C2783(0.92); C3882(1.07); C3604(1.17); C1964(1.26)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C2783(1.05); C3882(1.01); C3604(1.13); C1964(0.85)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C2783(1.02); C3882(1.02); C3604(1.21); C1964(1.26)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C2783(1.07); C3882(0.91); C3604(0.87); C1964(0.95)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C2783(0.94); C3882(1.03); C3604(1.09); C1509(1.03)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C2783(0.93); C3882(1.15); C3604(0.89); C1509(1.05)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C2783(0.99); C3882(1.06); C3604(0.96); C1509(1.20)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C2783(1.02); C3882(1.06); C3604(0.99); C1509(1.23)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C2783(0.86); C3882(1.37); C3604(1.12); C1509(0.92)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C2783(1.06); C3882(1.10); C3604(0.77); C1964(0.98)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C2783(1.02); C3882(1.16); C3604(1.05); C2159(0.92)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C2783(0.93); C3882(1.18); C3604(1.01); C1509(0.97)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C2783(0.99); C3882(1.10); C3604(0.94); C1509(1.34)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C2783(0.95); C3882(1.17); C3604(0.97); C2159(1.10)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C2783(0.98); C3882(1.00); C3604(1.14); C1964(1.04)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C2783(1.06); C3882(1.21); C3604(0.70); C1964(0.94)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C2783(1.01); C3882(0.96); C3604(0.89); C1964(0.93)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C2783(0.82); C3882(1.09); C3604(0.94); C1509(0.75)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C2783(0.91); C3882(1.12); C3604(1.06); C1509(1.11)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C2783(0.97); C3882(1.02); C3604(1.07); C1509(1.16)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C2783(1.01); C3882(1.08); C3604(1.03); C1509(1.34)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C2783(0.96); C3882(1.25); C3604(1.13); C1509(1.04)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C2783(1.01); C3882(1.24); C3604(0.89); C2159(0.97)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C2783(0.98); C3882(1.18); C3604(1.16); C1509(0.81)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C2783(1.11); C3882(1.18); C3604(1.22); C1509(1.06)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C2783(1.00); C3882(1.04); C3604(0.95); C1509(1.18)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C2783(0.96); C3882(1.05); C3604(0.95); C1964(1.12)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C2783(1.03); C3882(1.15); C3604(1.05); C1964(0.97)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C2783(0.99); C3882(0.99); C3604(0.82); C1964(0.87)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C2783(0.97); C3882(1.09); C3604(1.00); C1509(0.93)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C2783(0.96); C3882(0.96); C3604(0.89); C1509(1.22)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C2783(1.00); C3882(1.01); C3604(0.94); C1509(1.23)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C2783(1.10); C3882(1.09); C3604(1.01); C1509(1.10)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C2783(0.91); C3882(1.42); C3604(1.01); C1509(0.97)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C2783(0.91); C3882(1.00); C3604(0.97); C1509(0.93)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C2783(1.04); C3882(1.10); C3604(0.92); C1964(1.05)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C2783(1.09); C3882(1.23); C3604(1.13); C1509(1.48)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C2783(1.02); C3882(1.11); C3604(0.96); C1509(1.07)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C2783(0.85); C3882(1.04); C3604(0.87); C1964(1.08)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C2783(1.05); C3882(1.10); C3604(1.00); C1964(0.90)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C2783(1.01); C3882(0.98); C3604(0.91); C1964(0.87)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C2783(1.07); C3882(1.23); C3604(1.01); C1509(1.15)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C2783(0.94); C3882(1.05); C3604(0.84); C1509(1.16)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C2783(1.02); C3882(0.99); C3604(0.77); C1509(1.21)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C2783(0.82); C3882(1.09); C3604(1.13); C1964(1.26)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C2783(1.05); C3882(1.03); C3604(0.83); C1509(1.16)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C2783(1.02); C3882(1.34); C3604(1.17); C1509(1.03)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C2783(1.06); C3882(1.07); C3604(1.25); C1964(1.03)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C2783(1.03); C3882(1.11); C3604(1.15); C2159(1.00)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C2783(0.94); C3882(1.08); C3604(1.08); C1509(0.95)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C2783(1.05); C3882(1.05); C3604(0.99); C1509(1.08)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C2783(1.00); C3882(1.05); C3604(1.03); C1964(1.10)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C2783(1.05); C3882(1.06); C3604(0.88); C1964(0.97)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C2783(1.02); C3882(0.92); C3604(0.87); C1964(0.96)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C2783(0.91); C3882(1.10); C3604(1.04); C1509(0.93)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C2783(0.97); C3882(1.13); C3604(1.01); C1964(0.99)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C2783(1.00); C3882(1.03); C3604(0.93); C1509(1.13)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C2783(0.98); C3882(0.95); C3604(1.06); C1509(1.24)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C2783(1.15); C3882(1.03); C3604(0.98); C1509(1.03)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C2783(0.85); C3882(1.26); C3604(1.32); C1509(1.07)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C2783(1.02); C3882(1.12); C3604(1.06); C1964(0.89)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C2783(0.95); C3882(1.22); C3604(1.16); C1509(1.04)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C2783(0.89); C3882(1.04); C3604(0.90); C1509(0.98)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C2783(0.94); C3882(1.04); C3604(1.13); C1964(1.14)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C2783(1.00); C3882(1.18); C3604(0.79); C1964(0.98)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C2783(0.86); C3882(0.89); C3604(0.63); C1964(0.99)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C2783(0.95); C3882(0.97); C3604(0.85); C1964(1.01)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C2783(0.95); C3882(1.07); C3604(1.27); C1509(0.93)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C2783(0.95); C3882(1.03); C3604(0.89); C1509(1.10)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C2783(0.94); C3882(1.07); C3604(1.05); C1509(1.14)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C2783(0.93); C3882(0.97); C3604(0.92); C1509(1.03)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C2783(0.93); C3882(1.40); C3604(1.04); C1509(0.91)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C2783(1.01); C3882(1.23); C3604(0.96); C1964(0.95)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C2783(1.00); C3882(1.22); C3604(0.92); C2159(1.02)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C2783(0.97); C3882(1.14); C3604(1.08); C1509(0.79)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C2783(0.95); C3882(1.14); C3604(1.00); C1509(0.91)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C2783(0.91); C3882(1.03); C3604(1.05); C1509(0.91)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C2783(0.80); C3882(1.08); C3604(0.84); C1964(1.20)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C2783(0.99); C3882(1.22); C3604(0.92); C1964(0.85)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C2783(0.96); C3882(0.99); C3604(1.03); C1964(1.05)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C2783(0.93); C3882(1.33); C3604(1.00); C1509(0.81)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C2783(1.00); C3882(0.98); C3604(0.87); C1509(1.09)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C2783(0.95); C3882(0.97); C3604(0.82); C1509(0.94)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C2783(0.96); C3882(1.08); C3604(0.98); C1509(0.90)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C2783(0.97); C3882(1.31); C3604(1.12); C1509(1.15)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C2783(1.01); C3882(1.06); C3604(1.07); C1964(1.05)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C2783(1.01); C3882(1.36); C3604(0.94); C2159(0.90)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C2783(1.09); C3882(1.33); C3604(1.07); C2159(0.99)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C2783(1.53); C456(1.36); C990(1.35); C1536(1.06)  LDD1702  [11]
 LDCM0468  Fragment33 HEK-293T C2783(0.98); C3882(1.16); C3604(1.04); C2159(1.02)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C2783(1.03); C3882(1.03); C3604(0.75); C1964(1.06)  LDD1631  [10]
 LDCM0022  KB02 HEK-293T C2783(0.89); C1536(0.73); C1575(1.06); C1509(0.99)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C2783(1.02); C1536(0.93); C1575(1.07); C1509(1.00)  LDD1497  [10]
 LDCM0024  KB05 COLO792 C2786(1.23)  LDD3310  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase 2A (KMT2A) Histone-lysine methyltransferase family Q03164
Peptidyl-prolyl cis-trans isomerase E (PPIE) Cyclophilin-type PPIase family Q9UNP9
Histone acetyltransferase KAT6A (KAT6A) MYST (SAS/MOZ) family Q92794
Histone acetyltransferase KAT8 (KAT8) MYST (SAS/MOZ) family Q9H7Z6
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) Sirtuin family Q96EB6
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Androgen receptor (AR) Nuclear hormone receptor family P10275
Paired box protein Pax-5 (PAX5) . Q02548
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Parafibromin (CDC73) CDC73 family Q6P1J9
Histone H3.1 (H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12) Histone H3 family P68431
RNA polymerase II-associated factor 1 homolog (PAF1) PAF1 family Q8N7H5
WD repeat-containing protein 5 (WDR5) WD repeat WDR5/wds family P61964
Retinoblastoma-binding protein 5 (RBBP5) . Q15291
RNA polymerase-associated protein CTR9 homolog (CTR9) . Q6PD62

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761