Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C380  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 94 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 33.6
 LDTP10699  E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) 30.3
 LDTP03680  DNA replication licensing factor MCM4 (MCM4) 23.1
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 22.6
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 20.8
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 20.3
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 19.4
 LDTP06325  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) 17.9
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 17.5
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 17.0
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 16.7
 LDTP03540  Heme oxygenase 2 (HMOX2) 15.3
 LDTP12679  Trimethyllysine dioxygenase, mitochondrial (TMLHE) 15.2
 LDTP00697  Cytochrome b5 type B (CYB5B) 13.5
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 12.8
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 11.3
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 11.2
 LDTP02359  Heme oxygenase 1 (HMOX1) 11.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 10.5
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 10.4
 LDTP01300  Cartilage-associated protein (CRTAP) 9.7
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 9.7
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 9.7
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 9.6
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 9.6
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 9.1
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 8.8
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 8.7
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 8.7
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 8.6
 LDTP03787  Choline kinase alpha (CHKA) 8.4
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 8.3
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 8.2
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 8.1
 LDTP06427  Translin (TSN) 8.1
 LDTP00575  Glutathione S-transferase A4 (GSTA4) 8.0
 LDTP01769  Dihydrofolate reductase (DHFR) 7.8
 LDTP05905  Acid ceramidase (ASAH1) 7.7
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 7.6
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 7.5
 LDTP10329  Ceramide synthase 2 (CERS2) 7.4
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 7.3
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 7.3
 LDTP05493  Sulfotransferase 2A1 (SULT2A1) 7.1
 LDTP02837  Beta-galactosidase (GLB1) 7.0
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 7.0
 LDTP06849  Prolyl endopeptidase-like (PREPL) 6.9
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 6.8
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 6.7
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 6.6
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 6.5
 LDTP02505  Lysosomal protective protein (CTSA) 6.5
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 6.5
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 6.4
 LDTP11437  Peroxisomal trans-2-enoyl-CoA reductase (PECR) 6.4
 LDTP12020  Histone-lysine N-methyltransferase SMYD3 (SMYD3) 6.3
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 6.2
 LDTP06511  Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETFDH) 6.2
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 6.2
 LDTP01018  High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A) 6.1
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 6.1
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 6.1
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 6.1
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 6.1
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 6.1
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 6.0
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 5.9
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 5.9
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 5.9
 LDTP04581  Holocytochrome c-type synthase (HCCS) 5.8
 LDTP09799  DCN1-like protein 4 (DCUN1D4) 5.7
 LDTP13751  Exonuclease 1 (EXO1) 5.7
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 5.7
 LDTP11127  ADP-dependent glucokinase (ADPGK) 5.7
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 5.7
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 5.7
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 5.7
 LDTP13154  E3 ubiquitin-protein ligase RNF14 (RNF14) 5.7
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 5.6
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 5.5
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 5.5
 LDTP00988  Protein O-GlcNAcase (OGA) 5.5
 LDTP01803  Adenosine deaminase (ADA) 5.5
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 5.4
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 5.4
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 5.4
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 5.3
 LDTP01168  NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) 5.3
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 5.3
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 5.3
 LDTP16025  Ketosamine-3-kinase (FN3KRP) 5.1
 LDTP07989  Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) 5.1
 LDTP07417  Serine/threonine-protein phosphatase 4 regulatory subunit 3A (PPP4R3A) 5.1
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 5.1
Transporter and channel
Click to Show/Hide to Show 49 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 27.9
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 26.0
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 22.3
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 19.3
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 17.4
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 16.4
 LDTP01804  ATP synthase subunit a (MT-ATP6) 16.1
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 15.0
 LDTP00592  Surfeit locus protein 4 (SURF4) 14.7
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 14.4
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 13.6
 LDTP16813  Tetraspanin-3 (TSPAN3) 11.8
 LDTP05900  Metaxin-1 (MTX1) 11.2
 LDTP15948  Transmembrane protein 126A (TMEM126A) 9.9
 LDTP04463  H(+)/Cl(-) exchange transporter 7 (CLCN7) 9.8
 LDTP15967  Tetraspanin-10 (TSPAN10) 9.7
 LDTP03546  Translocator protein (TSPO) 9.3
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 9.2
 LDTP20002  Transmembrane protein 160 (TMEM160) 8.6
 LDTP08881  Transmembrane protein 199 (TMEM199) 7.9
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 7.8
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 7.7
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 7.5
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 7.5
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 7.4
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 7.4
 LDTP01217  Metaxin-2 (MTX2) 7.3
 LDTP02215  Prosaposin (PSAP) 7.1
 LDTP04293  Transmembrane emp24 domain-containing protein 10 (TMED10) 7.1
 LDTP11812  Protein ARV1 (ARV1) 6.9
 LDTP12383  Protein GPR108 (GPR108) 6.8
 LDTP15481  Transmembrane protein 87A (TMEM87A) 6.7
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 6.5
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 6.3
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 6.2
 LDTP00970  Gasdermin-E (GSDME) 6.1
 LDTP07531  Sideroflexin-4 (SFXN4) 6.1
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 6.1
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 6.1
 LDTP07236  Protein GPR107 (GPR107) 5.9
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 5.8
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 5.8
 LDTP11826  Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) 5.8
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 5.7
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 5.4
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 5.2
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.1
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 5.1
 LDTP11213  Nucleoporin NDC1 (NDC1) 5.0
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16717  Forkhead-associated domain-containing protein 1 (FHAD1) 31.3
Other
Click to Show/Hide to Show 57 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16099  p53 and DNA damage-regulated protein 1 (PDRG1) 39.9
 LDTP11076  Apolipoprotein L2 (APOL2) 27.5
 LDTP03729  General transcription factor IIF subunit 1 (GTF2F1) 25.3
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 19.0
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 17.4
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 14.4
 LDTP00105  Protein unc-119 homolog B (UNC119B) 12.6
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 12.1
 LDTP05160  Nucleobindin-2 (NUCB2) 11.7
 LDTP14458  Tetraspanin-6 (TSPAN6) 11.6
 LDTP05868  Protein unc-119 homolog A (UNC119) 11.1
 LDTP00199  HCLS1-associated protein X-1 (HAX1) 10.5
 LDTP07839  Capping protein-inhibiting regulator of actin dynamics (CRACD) 8.7
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 8.5
 LDTP01075  Protein CutA (CUTA) 8.3
 LDTP13402  Dynactin subunit 4 (DCTN4) 7.8
 LDTP06373  Mitochondrial import receptor subunit TOM20 homolog (TOMM20) 7.6
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 7.4
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 7.4
 LDTP01522  Reticulon-3 (RTN3) 7.4
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 7.0
 LDTP08793  Armadillo repeat-containing protein 10 (ARMC10) 6.9
 LDTP08130  Rab9 effector protein with kelch motifs (RABEPK) 6.8
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 6.5
 LDTP17715  S1 RNA-binding domain-containing protein 1 (SRBD1) 6.5
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 6.5
 LDTP16080  Protein FAM114A2 (FAM114A2) 6.1
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) 6.0
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 5.9
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 5.9
 LDTP01652  Centrosomal protein 43 (CEP43) 5.9
 LDTP18883  Protein CEBPZOS (CEBPZOS) 5.9
 LDTP06097  Reticulocalbin-2 (RCN2) 5.9
 LDTP15834  Integrator complex subunit 14 (INTS14) 5.8
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 5.8
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 5.7
 LDTP16006  Optic atrophy 3 protein (OPA3) 5.7
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 5.7
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 5.5
 LDTP18272  Transmembrane protein 209 (TMEM209) 5.5
 LDTP01358  Pre-mRNA-splicing factor SPF27 (BCAS2) 5.5
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 5.5
 LDTP09069  Kinetochore protein Spc24 (SPC24) 5.4
 LDTP12418  Mitochondrial dynamics protein MIEF1 (MIEF1) 5.3
 LDTP01167  Reticulon-2 (RTN2) 5.3
 LDTP14058  Rap guanine nucleotide exchange factor 2 (RAPGEF2) 5.2
 LDTP09644  m-AAA protease-interacting protein 1, mitochondrial (MAIP1) 5.2
 LDTP12412  Reticulon-4 (RTN4) 5.2
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 5.2
 LDTP13086  Syntaxin-18 (STX18) 5.1
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 5.1
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 5.1
 LDTP01359  Dynactin subunit 3 (DCTN3) 5.0
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 5.0
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) 5.0
 LDTP14263  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) 5.0
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 5.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587