Details of the Target

General Information of Target

Target ID LDTP13402
Target Name Dynactin subunit 4 (DCTN4)
Gene Name DCTN4
Gene ID 51164
Synonyms
Dynactin subunit 4; Dyn4; Dynactin subunit p62
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEESEPERKRARTDEVPAGGSRSEAEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGAAE
EEQQDSGSEPRGDEDDIPLGPQSNVSLLDQHQHLKEKAEARKESAKEKQLKEEEKILESV
AEGRALMSVKEMAKGITYDDPIKTSWTPPRYVLSMSEERHERVRKKYHILVEGDGIPPPI
KSFKEMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVI
MFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSSPLLRCALCIGG
MSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRT
IFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEAK
MVYLLECLQKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFRE
GKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINKAC
DESVLMDLKALLLEAKQKVPPVLQVLHCGDESMLDIGGERGCAFCGGLGHRITDCPKLEA
MQTKQVSNIGRKDYLAHSSMDF
Target Bioclass
Other
Family
Dynactin subunit 4 family
Subcellular location
Cytoplasm, cytoskeleton
Function Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
Uniprot ID
Q9UJW0
Ensemble ID
ENST00000424236.5
HGNC ID
HGNC:15518

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.K420N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DA-P2
 Probe Info  		5.60  LDD0348  [2]
TH211
 Probe Info  		Y150(14.41); Y173(5.01)  LDD0257  [3]
TH216
 Probe Info  		Y150(18.91)  LDD0259  [3]
STPyne
 Probe Info  		K105(10.00); K181(7.94)  LDD0277  [4]
AZ-9
 Probe Info  		E17(10.00)  LDD2209  [5]
DBIA
 Probe Info  		C30(1.20); C425(1.49); C265(2.94)  LDD3312  [6]
YY4-yne
 Probe Info  		3.14  LDD0400  [7]
DA-P3
 Probe Info  		22.53  LDD0179  [2]
AHL-Pu-1
 Probe Info  		C258(2.52)  LDD0168  [8]
HPAP
 Probe Info  		3.17  LDD0062  [9]
EA-probe
 Probe Info  		C258(1.06); C258(0.98)  LDD2210  [10]
HHS-475
 Probe Info  		Y173(0.43); Y232(0.64); Y32(0.88); Y150(0.88)  LDD0264  [11]
HHS-465
 Probe Info  		Y150(3.93); Y173(10.00)  LDD2237  [12]
Acrolein
 Probe Info  		C258(0.00); C418(0.00)  LDD0222  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C30(0.00); C280(0.00); C344(0.00); C258(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C30(0.00); C280(0.00); C258(0.00); C418(0.00)  LDD0036  [14]
Lodoacetamide azide
 Probe Info  		C30(0.00); C280(0.00); C344(0.00); C258(0.00)  LDD0037  [14]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [15]
NAIA_4
 Probe Info  		N.A.  LDD2226  [16]
TFBX
 Probe Info  		N.A.  LDD0027  [15]
Compound 10
 Probe Info  		N.A.  LDD2216  [17]
Compound 11
 Probe Info  		N.A.  LDD2213  [17]
ENE
 Probe Info  		N.A.  LDD0006  [18]
IPM
 Probe Info  		C258(0.00); C70(0.00)  LDD0005  [18]
PF-06672131
 Probe Info  		N.A.  LDD0017  [19]
VSF
 Probe Info  		N.A.  LDD0007  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [20]
W1
 Probe Info  		C258(0.00); C30(0.00)  LDD0236  [21]
AOyne
 Probe Info  		15.00  LDD0443  [22]
NAIA_5
 Probe Info  		C30(0.00); C280(0.00); C258(0.00); C418(0.00)  LDD2223  [16]
HHS-482
 Probe Info  		Y173(1.42)  LDD2239  [12]
PAL-AfBPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.87  LDD1714  [23]
C010
 Probe Info  		5.10  LDD1719  [23]
C064
 Probe Info  		9.13  LDD1761  [23]
C085
 Probe Info  		9.45  LDD1777  [23]
C106
 Probe Info  		21.86  LDD1793  [23]
C120
 Probe Info  		5.58  LDD1806  [23]
C143
 Probe Info  		15.14  LDD1825  [23]
C145
 Probe Info  		8.57  LDD1827  [23]
C147
 Probe Info  		10.48  LDD1829  [23]
C159
 Probe Info  		7.16  LDD1839  [23]
C191
 Probe Info  		11.24  LDD1868  [23]
C193
 Probe Info  		5.39  LDD1869  [23]
C206
 Probe Info  		46.21  LDD1881  [23]
C228
 Probe Info  		15.35  LDD1901  [23]
C284
 Probe Info  		35.51  LDD1954  [23]
C293
 Probe Info  		16.56  LDD1963  [23]
C322
 Probe Info  		16.00  LDD1988  [23]
C380
 Probe Info  		7.84  LDD2039  [23]
FFF probe13
 Probe Info  		18.39  LDD0475  [24]
FFF probe15
 Probe Info  		6.11  LDD0478  [24]
FFF probe2
 Probe Info  		20.00  LDD0463  [24]
FFF probe3
 Probe Info  		20.00  LDD0464  [24]
JN0003
 Probe Info  		20.00  LDD0469  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C258(2.52)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C258(3.76)  LDD0169  [8]
 LDCM0214  AC1 HEK-293T C280(1.00); C258(0.99); C30(0.94); C41(0.80)  LDD1507  [25]
 LDCM0215  AC10 HEK-293T C280(0.98); C258(1.07); C418(1.21); C30(1.11)  LDD1508  [25]
 LDCM0226  AC11 HEK-293T C280(1.00); C258(1.08); C418(0.96); C30(0.97)  LDD1509  [25]
 LDCM0237  AC12 HEK-293T C280(0.99); C258(1.05); C418(0.90); C30(1.03)  LDD1510  [25]
 LDCM0259  AC14 HEK-293T C280(0.91); C258(0.93); C30(1.24); C41(1.04)  LDD1512  [25]
 LDCM0270  AC15 HEK-293T C280(1.03); C258(1.15); C418(1.04); C30(0.99)  LDD1513  [25]
 LDCM0276  AC17 HEK-293T C280(0.95); C258(1.20); C30(0.97); C41(0.69)  LDD1515  [25]
 LDCM0277  AC18 HEK-293T C280(0.98); C258(0.98); C418(1.10); C30(1.02)  LDD1516  [25]
 LDCM0278  AC19 HEK-293T C280(0.94); C258(0.89); C418(0.95); C30(0.72)  LDD1517  [25]
 LDCM0279  AC2 HEK-293T C280(0.96); C258(0.94); C418(1.04); C30(1.10)  LDD1518  [25]
 LDCM0280  AC20 HEK-293T C280(0.93); C258(1.01); C418(1.02); C30(1.01)  LDD1519  [25]
 LDCM0281  AC21 HEK-293T C280(1.03); C258(0.93); C418(1.09); C30(0.97)  LDD1520  [25]
 LDCM0282  AC22 HEK-293T C280(0.88); C258(0.97); C30(1.03); C41(1.02)  LDD1521  [25]
 LDCM0283  AC23 HEK-293T C280(0.98); C258(0.98); C418(0.99); C30(0.96)  LDD1522  [25]
 LDCM0284  AC24 HEK-293T C280(1.04); C258(0.97); C418(0.97); C30(1.05)  LDD1523  [25]
 LDCM0285  AC25 HEK-293T C280(0.98); C258(1.16); C30(1.01); C41(0.72)  LDD1524  [25]
 LDCM0286  AC26 HEK-293T C280(0.97); C258(1.10); C418(1.12); C30(1.10)  LDD1525  [25]
 LDCM0287  AC27 HEK-293T C280(0.96); C258(1.29); C418(1.06); C30(0.92)  LDD1526  [25]
 LDCM0288  AC28 HEK-293T C280(0.94); C258(1.05); C418(1.08); C30(1.13)  LDD1527  [25]
 LDCM0289  AC29 HEK-293T C280(0.93); C258(1.28); C418(1.09); C30(1.12)  LDD1528  [25]
 LDCM0290  AC3 HEK-293T C280(0.94); C258(1.12); C418(1.01); C30(1.01)  LDD1529  [25]
 LDCM0291  AC30 HEK-293T C280(0.91); C258(1.01); C30(1.12); C41(0.92)  LDD1530  [25]
 LDCM0292  AC31 HEK-293T C280(1.06); C258(0.97); C418(1.12); C30(1.03)  LDD1531  [25]
 LDCM0293  AC32 HEK-293T C280(0.99); C258(1.02); C418(1.02); C30(1.06)  LDD1532  [25]
 LDCM0294  AC33 HEK-293T C280(0.94); C258(1.05); C30(0.98); C41(0.85)  LDD1533  [25]
 LDCM0295  AC34 HEK-293T C280(0.99); C258(1.05); C418(1.11); C30(1.07)  LDD1534  [25]
 LDCM0296  AC35 HEK-293T C280(0.95); C258(1.17); C418(1.14); C30(1.07)  LDD1535  [25]
 LDCM0297  AC36 HEK-293T C280(0.93); C258(1.16); C418(0.96); C30(1.00)  LDD1536  [25]
 LDCM0298  AC37 HEK-293T C280(0.94); C258(0.92); C418(1.17); C30(1.07)  LDD1537  [25]
 LDCM0299  AC38 HEK-293T C280(0.91); C258(0.97); C30(1.13); C41(1.05)  LDD1538  [25]
 LDCM0300  AC39 HEK-293T C280(1.02); C258(1.02); C418(1.09); C30(1.07)  LDD1539  [25]
 LDCM0301  AC4 HEK-293T C280(0.92); C258(1.16); C418(0.96); C30(1.07)  LDD1540  [25]
 LDCM0302  AC40 HEK-293T C280(1.02); C258(1.14); C418(0.92); C30(0.98)  LDD1541  [25]
 LDCM0303  AC41 HEK-293T C280(0.94); C258(1.06); C30(0.93); C41(0.78)  LDD1542  [25]
 LDCM0304  AC42 HEK-293T C280(0.93); C258(1.10); C418(1.08); C30(1.11)  LDD1543  [25]
 LDCM0305  AC43 HEK-293T C280(1.02); C258(0.98); C418(1.17); C30(1.03)  LDD1544  [25]
 LDCM0306  AC44 HEK-293T C280(0.99); C258(0.96); C418(1.04); C30(1.06)  LDD1545  [25]
 LDCM0307  AC45 HEK-293T C280(0.93); C258(1.13); C418(1.14); C30(1.00)  LDD1546  [25]
 LDCM0308  AC46 HEK-293T C280(0.97); C258(1.06); C30(1.01); C41(1.02)  LDD1547  [25]
 LDCM0309  AC47 HEK-293T C280(0.99); C258(1.06); C418(1.19); C30(1.00)  LDD1548  [25]
 LDCM0310  AC48 HEK-293T C280(1.05); C258(1.06); C418(1.01); C30(1.03)  LDD1549  [25]
 LDCM0311  AC49 HEK-293T C280(0.97); C258(1.10); C30(1.06); C41(0.77)  LDD1550  [25]
 LDCM0312  AC5 HEK-293T C280(0.92); C258(0.94); C418(1.16); C30(1.12)  LDD1551  [25]
 LDCM0313  AC50 HEK-293T C280(1.02); C258(1.13); C418(1.23); C30(1.01)  LDD1552  [25]
 LDCM0314  AC51 HEK-293T C280(0.98); C258(1.10); C418(1.07); C30(1.09)  LDD1553  [25]
 LDCM0315  AC52 HEK-293T C280(0.97); C258(1.02); C418(0.98); C30(1.12)  LDD1554  [25]
 LDCM0316  AC53 HEK-293T C280(0.95); C258(1.01); C418(1.15); C30(0.97)  LDD1555  [25]
 LDCM0317  AC54 HEK-293T C280(0.94); C258(1.04); C30(1.02); C41(0.97)  LDD1556  [25]
 LDCM0318  AC55 HEK-293T C280(1.02); C258(1.08); C418(1.06); C30(1.13)  LDD1557  [25]
 LDCM0319  AC56 HEK-293T C280(1.02); C258(0.93); C418(0.98); C30(0.97)  LDD1558  [25]
 LDCM0320  AC57 HEK-293T C280(0.96); C258(1.05); C30(0.99); C41(0.76)  LDD1559  [25]
 LDCM0321  AC58 HEK-293T C280(0.98); C258(1.01); C418(1.16); C30(1.08)  LDD1560  [25]
 LDCM0322  AC59 HEK-293T C280(0.93); C258(1.24); C418(1.07); C30(1.07)  LDD1561  [25]
 LDCM0323  AC6 HEK-293T C280(0.88); C258(1.08); C30(0.99); C41(0.99)  LDD1562  [25]
 LDCM0324  AC60 HEK-293T C280(0.90); C258(1.11); C418(1.04); C30(0.97)  LDD1563  [25]
 LDCM0325  AC61 HEK-293T C280(0.85); C258(1.00); C418(1.01); C30(1.08)  LDD1564  [25]
 LDCM0326  AC62 HEK-293T C280(0.90); C258(1.03); C30(1.04); C41(0.99)  LDD1565  [25]
 LDCM0327  AC63 HEK-293T C280(0.88); C258(1.04); C418(1.02); C30(1.04)  LDD1566  [25]
 LDCM0328  AC64 HEK-293T C280(0.95); C258(0.97); C418(1.21); C30(1.08)  LDD1567  [25]
 LDCM0334  AC7 HEK-293T C280(0.97); C258(1.07); C418(0.96); C30(1.14)  LDD1568  [25]
 LDCM0345  AC8 HEK-293T C280(0.95); C258(0.99); C418(0.98); C30(1.12)  LDD1569  [25]
 LDCM0248  AKOS034007472 HEK-293T C280(0.96); C258(1.04); C418(1.10); C30(1.14)  LDD1511  [25]
 LDCM0356  AKOS034007680 HEK-293T C280(0.99); C258(1.24); C30(0.98); C41(0.78)  LDD1570  [25]
 LDCM0275  AKOS034007705 HEK-293T C280(1.06); C258(0.98); C418(1.00); C30(1.07)  LDD1514  [25]
 LDCM0156  Aniline NCI-H1299 12.05  LDD0403  [1]
 LDCM0200  BPK-25 T cell C258(14.58)  LDD0529  [26]
 LDCM0630  CCW28-3 231MFP C258(1.14)  LDD2214  [27]
 LDCM0108  Chloroacetamide HeLa C258(0.00); C418(0.00)  LDD0222  [13]
 LDCM0632  CL-Sc Hep-G2 C258(0.53)  LDD2227  [16]
 LDCM0367  CL1 HEK-293T C280(0.92); C258(1.28); C418(0.98); C30(0.85)  LDD1571  [25]
 LDCM0368  CL10 HEK-293T C280(1.21); C258(0.93); C30(0.80); C41(1.01)  LDD1572  [25]
 LDCM0369  CL100 HEK-293T C280(0.97); C258(1.05); C30(0.93); C41(0.87)  LDD1573  [25]
 LDCM0370  CL101 HEK-293T C280(0.95); C258(1.18); C418(0.98); C30(1.05)  LDD1574  [25]
 LDCM0371  CL102 HEK-293T C280(0.99); C258(1.12); C418(1.11); C30(0.86)  LDD1575  [25]
 LDCM0372  CL103 HEK-293T C280(0.93); C258(1.05); C30(1.05); C41(0.81)  LDD1576  [25]
 LDCM0373  CL104 HEK-293T C280(0.94); C258(0.94); C30(1.02); C41(0.93)  LDD1577  [25]
 LDCM0374  CL105 HEK-293T C280(0.93); C258(1.19); C418(0.98); C30(0.98)  LDD1578  [25]
 LDCM0375  CL106 HEK-293T C280(1.04); C258(0.90); C418(0.99); C30(1.07)  LDD1579  [25]
 LDCM0376  CL107 HEK-293T C280(0.97); C258(1.03); C30(0.96); C41(0.86)  LDD1580  [25]
 LDCM0377  CL108 HEK-293T C280(0.93); C258(0.98); C30(1.00); C41(0.87)  LDD1581  [25]
 LDCM0378  CL109 HEK-293T C280(0.95); C258(1.00); C418(0.97); C30(1.02)  LDD1582  [25]
 LDCM0379  CL11 HEK-293T C280(1.32); C258(0.98); C418(0.82); C30(0.74)  LDD1583  [25]
 LDCM0380  CL110 HEK-293T C280(1.02); C258(1.19); C418(0.99); C30(0.82)  LDD1584  [25]
 LDCM0381  CL111 HEK-293T C280(0.94); C258(1.36); C30(1.02); C41(0.82)  LDD1585  [25]
 LDCM0382  CL112 HEK-293T C280(0.91); C258(1.04); C30(0.87); C41(0.89)  LDD1586  [25]
 LDCM0383  CL113 HEK-293T C280(0.90); C258(0.98); C418(1.02); C30(1.01)  LDD1587  [25]
 LDCM0384  CL114 HEK-293T C280(0.91); C258(0.99); C418(1.22); C30(1.09)  LDD1588  [25]
 LDCM0385  CL115 HEK-293T C280(0.94); C258(1.00); C30(1.04); C41(0.81)  LDD1589  [25]
 LDCM0386  CL116 HEK-293T C280(0.95); C258(1.15); C30(0.96); C41(0.90)  LDD1590  [25]
 LDCM0387  CL117 HEK-293T C280(0.90); C258(1.16); C418(0.94); C30(0.98)  LDD1591  [25]
 LDCM0388  CL118 HEK-293T C280(1.06); C258(1.09); C418(1.15); C30(1.03)  LDD1592  [25]
 LDCM0389  CL119 HEK-293T C280(1.07); C258(1.06); C30(1.05); C41(0.98)  LDD1593  [25]
 LDCM0390  CL12 HEK-293T C280(1.46); C258(1.00); C418(0.88); C30(0.92)  LDD1594  [25]
 LDCM0391  CL120 HEK-293T C280(0.91); C258(1.07); C30(1.00); C41(0.89)  LDD1595  [25]
 LDCM0392  CL121 HEK-293T C280(0.93); C258(1.08); C418(0.96); C30(1.00)  LDD1596  [25]
 LDCM0393  CL122 HEK-293T C280(1.06); C258(1.14); C418(1.19); C30(0.97)  LDD1597  [25]
 LDCM0394  CL123 HEK-293T C280(0.96); C258(0.89); C30(1.07); C41(0.72)  LDD1598  [25]
 LDCM0395  CL124 HEK-293T C280(1.06); C258(1.13); C30(0.97); C41(0.81)  LDD1599  [25]
 LDCM0396  CL125 HEK-293T C280(0.84); C258(1.27); C418(1.33); C30(0.94)  LDD1600  [25]
 LDCM0397  CL126 HEK-293T C280(0.87); C258(1.08); C418(1.03); C30(1.03)  LDD1601  [25]
 LDCM0398  CL127 HEK-293T C280(0.80); C258(1.26); C30(0.96); C41(0.82)  LDD1602  [25]
 LDCM0399  CL128 HEK-293T C280(0.87); C258(1.03); C30(1.03); C41(0.89)  LDD1603  [25]
 LDCM0400  CL13 HEK-293T C280(0.85); C258(1.12); C418(1.03); C30(0.98)  LDD1604  [25]
 LDCM0401  CL14 HEK-293T C280(1.03); C258(1.14); C418(1.05); C30(0.96)  LDD1605  [25]
 LDCM0402  CL15 HEK-293T C280(0.94); C258(1.66); C30(0.95); C41(0.79)  LDD1606  [25]
 LDCM0403  CL16 HEK-293T C280(0.96); C258(1.01); C30(1.02); C41(0.83)  LDD1607  [25]
 LDCM0404  CL17 HEK-293T C280(0.84); C258(1.28); C30(0.77); C41(1.09)  LDD1608  [25]
 LDCM0405  CL18 HEK-293T C280(1.20); C258(1.05); C418(1.06); C30(0.94)  LDD1609  [25]
 LDCM0406  CL19 HEK-293T C280(1.16); C258(0.95); C418(1.17); C30(0.85)  LDD1610  [25]
 LDCM0407  CL2 HEK-293T C280(0.97); C258(1.18); C418(0.87); C30(0.91)  LDD1611  [25]
 LDCM0408  CL20 HEK-293T C280(1.23); C258(1.25); C418(0.76); C30(0.94)  LDD1612  [25]
 LDCM0409  CL21 HEK-293T C280(1.19); C258(1.29); C418(1.36); C30(0.76)  LDD1613  [25]
 LDCM0410  CL22 HEK-293T C280(1.37); C258(1.07); C30(0.88); C41(1.04)  LDD1614  [25]
 LDCM0411  CL23 HEK-293T C280(1.32); C258(1.11); C418(0.91); C30(0.86)  LDD1615  [25]
 LDCM0412  CL24 HEK-293T C280(1.49); C258(1.01); C418(0.82); C30(0.80)  LDD1616  [25]
 LDCM0413  CL25 HEK-293T C280(0.89); C258(1.19); C418(1.34); C30(0.90)  LDD1617  [25]
 LDCM0414  CL26 HEK-293T C280(1.05); C258(1.02); C418(1.07); C30(1.09)  LDD1618  [25]
 LDCM0415  CL27 HEK-293T C280(1.01); C258(1.07); C30(1.00); C41(0.82)  LDD1619  [25]
 LDCM0416  CL28 HEK-293T C280(0.94); C258(0.92); C30(0.93); C41(0.82)  LDD1620  [25]
 LDCM0417  CL29 HEK-293T C280(1.00); C258(0.97); C30(0.89); C41(0.75)  LDD1621  [25]
 LDCM0418  CL3 HEK-293T C280(0.97); C258(1.04); C30(0.98); C41(0.95)  LDD1622  [25]
 LDCM0419  CL30 HEK-293T C280(1.19); C258(1.00); C418(1.07); C30(1.00)  LDD1623  [25]
 LDCM0420  CL31 HEK-293T C280(1.07); C258(1.46); C418(0.82); C30(0.85)  LDD1624  [25]
 LDCM0421  CL32 HEK-293T C280(1.16); C258(1.24); C418(0.93); C30(0.85)  LDD1625  [25]
 LDCM0422  CL33 HEK-293T C280(1.12); C258(0.87); C418(1.20); C30(0.77)  LDD1626  [25]
 LDCM0423  CL34 HEK-293T C280(1.43); C258(1.00); C30(0.91); C41(1.01)  LDD1627  [25]
 LDCM0424  CL35 HEK-293T C280(1.33); C258(1.36); C418(0.89); C30(0.77)  LDD1628  [25]
 LDCM0425  CL36 HEK-293T C280(1.55); C258(0.89); C418(0.77); C30(0.91)  LDD1629  [25]
 LDCM0426  CL37 HEK-293T C280(0.91); C258(1.26); C418(1.27); C30(0.99)  LDD1630  [25]
 LDCM0428  CL39 HEK-293T C280(0.99); C258(1.05); C30(1.04); C41(0.98)  LDD1632  [25]
 LDCM0429  CL4 HEK-293T C280(0.90); C258(1.01); C30(0.99); C41(0.90)  LDD1633  [25]
 LDCM0430  CL40 HEK-293T C280(0.95); C258(1.04); C30(0.93); C41(0.92)  LDD1634  [25]
 LDCM0431  CL41 HEK-293T C280(0.95); C258(0.88); C30(0.91); C41(0.80)  LDD1635  [25]
 LDCM0432  CL42 HEK-293T C280(1.25); C258(1.08); C418(1.20); C30(0.97)  LDD1636  [25]
 LDCM0433  CL43 HEK-293T C280(1.21); C258(1.03); C418(0.90); C30(0.92)  LDD1637  [25]
 LDCM0434  CL44 HEK-293T C280(1.08); C258(1.10); C418(0.88); C30(0.89)  LDD1638  [25]
 LDCM0435  CL45 HEK-293T C280(0.98); C258(0.98); C418(1.13); C30(0.86)  LDD1639  [25]
 LDCM0436  CL46 HEK-293T C280(1.25); C258(1.03); C30(0.86); C41(1.09)  LDD1640  [25]
 LDCM0437  CL47 HEK-293T C280(1.30); C258(1.13); C418(0.81); C30(0.81)  LDD1641  [25]
 LDCM0438  CL48 HEK-293T C280(1.68); C258(0.89); C418(0.84); C30(0.82)  LDD1642  [25]
 LDCM0439  CL49 HEK-293T C280(0.88); C258(1.18); C418(1.16); C30(1.01)  LDD1643  [25]
 LDCM0440  CL5 HEK-293T C280(0.89); C258(1.08); C30(1.04); C41(0.72)  LDD1644  [25]
 LDCM0441  CL50 HEK-293T C280(1.01); C258(1.12); C418(1.10); C30(1.11)  LDD1645  [25]
 LDCM0443  CL52 HEK-293T C280(1.02); C258(0.99); C30(0.95); C41(0.86)  LDD1646  [25]
 LDCM0444  CL53 HEK-293T C280(0.92); C258(1.02); C30(0.87); C41(0.87)  LDD1647  [25]
 LDCM0445  CL54 HEK-293T C280(1.15); C258(1.08); C418(1.23); C30(0.91)  LDD1648  [25]
 LDCM0446  CL55 HEK-293T C280(1.16); C258(1.29); C418(0.86); C30(0.95)  LDD1649  [25]
 LDCM0447  CL56 HEK-293T C280(1.17); C258(1.08); C418(0.82); C30(0.89)  LDD1650  [25]
 LDCM0448  CL57 HEK-293T C280(1.13); C258(0.82); C418(1.11); C30(0.87)  LDD1651  [25]
 LDCM0449  CL58 HEK-293T C280(1.42); C258(0.99); C30(0.85); C41(1.01)  LDD1652  [25]
 LDCM0450  CL59 HEK-293T C280(1.39); C258(1.09); C418(0.90); C30(0.83)  LDD1653  [25]
 LDCM0451  CL6 HEK-293T C280(1.04); C258(1.12); C418(1.34); C30(0.88)  LDD1654  [25]
 LDCM0452  CL60 HEK-293T C280(1.56); C258(1.02); C418(0.82); C30(0.85)  LDD1655  [25]
 LDCM0453  CL61 HEK-293T C280(0.83); C258(1.11); C418(1.36); C30(1.06)  LDD1656  [25]
 LDCM0454  CL62 HEK-293T C280(0.94); C258(0.97); C418(1.00); C30(1.11)  LDD1657  [25]
 LDCM0455  CL63 HEK-293T C280(1.06); C258(1.11); C30(0.97); C41(0.81)  LDD1658  [25]
 LDCM0456  CL64 HEK-293T C280(0.87); C258(0.98); C30(1.03); C41(0.84)  LDD1659  [25]
 LDCM0457  CL65 HEK-293T C280(0.94); C258(1.11); C30(0.96); C41(0.71)  LDD1660  [25]
 LDCM0458  CL66 HEK-293T C280(1.12); C258(0.89); C418(1.13); C30(1.02)  LDD1661  [25]
 LDCM0459  CL67 HEK-293T C280(1.06); C258(1.17); C418(1.10); C30(0.97)  LDD1662  [25]
 LDCM0460  CL68 HEK-293T C280(1.20); C258(0.98); C418(0.93); C30(0.99)  LDD1663  [25]
 LDCM0461  CL69 HEK-293T C280(1.23); C258(0.89); C418(1.21); C30(0.91)  LDD1664  [25]
 LDCM0462  CL7 HEK-293T C280(0.97); C258(1.15); C418(1.23); C30(1.01)  LDD1665  [25]
 LDCM0463  CL70 HEK-293T C280(1.29); C258(1.12); C30(0.86); C41(1.02)  LDD1666  [25]
 LDCM0464  CL71 HEK-293T C280(1.30); C258(1.14); C418(0.91); C30(0.84)  LDD1667  [25]
 LDCM0465  CL72 HEK-293T C280(1.51); C258(0.96); C418(0.83); C30(1.00)  LDD1668  [25]
 LDCM0466  CL73 HEK-293T C280(0.87); C258(1.48); C418(1.26); C30(0.94)  LDD1669  [25]
 LDCM0467  CL74 HEK-293T C280(0.98); C258(1.06); C418(1.23); C30(1.04)  LDD1670  [25]
 LDCM0469  CL76 HEK-293T C280(0.92); C258(1.02); C30(1.04); C41(0.85)  LDD1672  [25]
 LDCM0470  CL77 HEK-293T C280(0.88); C258(1.05); C30(0.77); C41(0.87)  LDD1673  [25]
 LDCM0471  CL78 HEK-293T C280(1.14); C258(1.02); C418(1.02); C30(0.99)  LDD1674  [25]
 LDCM0472  CL79 HEK-293T C280(1.16); C258(1.09); C418(1.34); C30(1.00)  LDD1675  [25]
 LDCM0473  CL8 HEK-293T C280(0.93); C258(1.24); C418(0.83); C30(0.82)  LDD1676  [25]
 LDCM0474  CL80 HEK-293T C280(1.26); C258(1.09); C418(1.00); C30(1.01)  LDD1677  [25]
 LDCM0475  CL81 HEK-293T C280(1.23); C258(1.09); C418(1.25); C30(1.02)  LDD1678  [25]
 LDCM0476  CL82 HEK-293T C280(1.31); C258(1.03); C30(0.95); C41(0.99)  LDD1679  [25]
 LDCM0477  CL83 HEK-293T C280(1.23); C258(1.04); C418(1.05); C30(0.83)  LDD1680  [25]
 LDCM0478  CL84 HEK-293T C280(1.31); C258(1.06); C418(0.92); C30(0.95)  LDD1681  [25]
 LDCM0479  CL85 HEK-293T C280(0.81); C258(1.33); C418(1.48); C30(0.99)  LDD1682  [25]
 LDCM0480  CL86 HEK-293T C280(0.80); C258(1.16); C418(1.34); C30(1.10)  LDD1683  [25]
 LDCM0481  CL87 HEK-293T C280(0.80); C258(1.09); C30(0.95); C41(0.80)  LDD1684  [25]
 LDCM0482  CL88 HEK-293T C280(0.84); C258(1.15); C30(1.00); C41(0.85)  LDD1685  [25]
 LDCM0483  CL89 HEK-293T C280(1.02); C258(1.02); C30(1.15); C41(0.72)  LDD1686  [25]
 LDCM0484  CL9 HEK-293T C280(1.15); C258(1.05); C418(1.20); C30(0.81)  LDD1687  [25]
 LDCM0485  CL90 HEK-293T C280(0.89); C258(1.00); C418(1.20); C30(0.69)  LDD1688  [25]
 LDCM0486  CL91 HEK-293T C280(1.12); C258(1.00); C418(1.03); C30(1.03)  LDD1689  [25]
 LDCM0487  CL92 HEK-293T C280(1.06); C258(1.12); C418(0.99); C30(0.89)  LDD1690  [25]
 LDCM0488  CL93 HEK-293T C280(1.08); C258(1.09); C418(1.17); C30(0.93)  LDD1691  [25]
 LDCM0489  CL94 HEK-293T C280(1.15); C258(1.06); C30(0.87); C41(1.09)  LDD1692  [25]
 LDCM0490  CL95 HEK-293T C280(0.96); C258(0.90); C418(1.08); C30(0.70)  LDD1693  [25]
 LDCM0491  CL96 HEK-293T C280(1.00); C258(0.99); C418(1.23); C30(0.89)  LDD1694  [25]
 LDCM0492  CL97 HEK-293T C280(0.85); C258(1.09); C418(0.91); C30(1.01)  LDD1695  [25]
 LDCM0493  CL98 HEK-293T C280(0.95); C258(1.18); C418(0.94); C30(0.99)  LDD1696  [25]
 LDCM0494  CL99 HEK-293T C280(0.89); C258(1.02); C30(0.93); C41(1.10)  LDD1697  [25]
 LDCM0191  Compound 21 HEK-293T 5.63  LDD0508  [24]
 LDCM0192  Compound 35 HEK-293T 5.99  LDD0509  [24]
 LDCM0193  Compound 36 HEK-293T 8.47  LDD0511  [24]
 LDCM0027  Dopamine HEK-293T 22.53  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C280(1.08); C258(1.18); C30(0.96); C41(0.88)  LDD1698  [25]
 LDCM0175  Ethacrynic acid HeLa C258(1.06); C258(0.98)  LDD2210  [10]
 LDCM0206  EV-99 T cell C258(8.10)  LDD0521  [26]
 LDCM0625  F8 Ramos C30(0.90); C258(1.43)  LDD2187  [28]
 LDCM0572  Fragment10 MDA-MB-231 C258(20.00)  LDD1465  [29]
 LDCM0573  Fragment11 MDA-MB-231 C258(20.00)  LDD1467  [29]
 LDCM0574  Fragment12 MDA-MB-231 C258(20.00)  LDD1468  [29]
 LDCM0575  Fragment13 Ramos C258(1.88)  LDD1470  [29]
 LDCM0576  Fragment14 MDA-MB-231 C258(2.98)  LDD1471  [29]
 LDCM0579  Fragment20 Ramos C30(0.53)  LDD2194  [28]
 LDCM0580  Fragment21 Ramos C258(0.99)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C30(0.85); C258(0.79)  LDD2196  [28]
 LDCM0578  Fragment27 MDA-MB-231 C258(0.82)  LDD1474  [29]
 LDCM0586  Fragment28 Ramos C30(0.91); C258(1.93)  LDD2198  [28]
 LDCM0587  Fragment29 Ramos C258(20.00)  LDD1476  [29]
 LDCM0588  Fragment30 Ramos C30(1.06); C258(1.02)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C258(1.13)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C30(0.41); C258(2.41)  LDD2201  [28]
 LDCM0468  Fragment33 HEK-293T C280(0.91); C258(1.04); C30(1.05); C41(0.88)  LDD1671  [25]
 LDCM0596  Fragment38 Ramos C30(0.84); C258(0.57)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C30(0.51); C258(0.87)  LDD2184  [28]
 LDCM0599  Fragment41 MDA-MB-231 C258(0.66)  LDD1481  [29]
 LDCM0603  Fragment45 MDA-MB-231 C258(2.69)  LDD1482  [29]
 LDCM0427  Fragment51 MDA-MB-231 C258(1.08)  LDD1483  [29]
 LDCM0610  Fragment52 Ramos C258(0.81)  LDD2204  [28]
 LDCM0614  Fragment56 MDA-MB-231 C258(1.25)  LDD1484  [29]
 LDCM0569  Fragment7 Ramos C30(0.55); C258(7.47)  LDD2186  [28]
 LDCM0570  Fragment8 MDA-MB-231 C258(20.00)  LDD1462  [29]
 LDCM0571  Fragment9 Ramos C258(20.00)  LDD1464  [29]
 LDCM0116  HHS-0101 DM93 Y173(0.43); Y232(0.64); Y32(0.88); Y150(0.88)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y173(0.53); Y150(0.89); Y32(1.65)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y150(0.61); Y173(1.29); Y32(1.31)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y150(1.28); Y32(1.29); Y173(1.67); Y232(1.75)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y173(0.75); Y32(0.84); Y150(1.06)  LDD0268  [11]
 LDCM0015  HNE MDA-MB-231 C258(0.99)  LDD0346  [28]
 LDCM0022  KB02 MDA-MB-231 C258(3.98)  LDD1460  [29]
 LDCM0023  KB03 HEK-293T C280(1.01); C30(0.95); C258(1.10); C41(0.93)  LDD1497  [25]
 LDCM0024  KB05 HMCB C30(1.20); C425(1.49); C265(2.94)  LDD3312  [6]
 LDCM0030  Luteolin HEK-293T 16.02  LDD0182  [2]
 LDCM0109  NEM HeLa N.A.  LDD0231  [13]
 LDCM0627  NUDT7-COV-1 HEK-293T C258(0.15)  LDD2206  [30]
 LDCM0032  Oleacein HEK-293T 5.55  LDD0184  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C258(0.69)  LDD2207  [30]
 LDCM0014  Panhematin HEK-293T 3.17  LDD0062  [9]
 LDCM0029  Quercetin HEK-293T 5.90  LDD0181  [2]
 LDCM0131  RA190 MM1.R C258(1.63)  LDD0304  [31]
 LDCM0112  W16 Hep-G2 C258(1.19)  LDD0239  [21]
 LDCM0154  YY4 T cell 3.14  LDD0400  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Actin-related protein 10 (ACTR10) Actin family Q9NZ32
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
10 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
27 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
29 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
30 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
31 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.