Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment13  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cells (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 59 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 20.0
 LDTP08808  E3 SUMO-protein ligase PIAS4 (PIAS4) C326 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP13302  Nuclear prelamin A recognition factor (NARF) C99 20.0
 LDTP12784  Pyroglutamyl-peptidase 1 (PGPEP1) C149 20.0
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) C623 20.0
 LDTP14159  Ubiquitin carboxyl-terminal hydrolase 16 (USP16) C205 20.0
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 12.4
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 12.2
 LDTP04232  4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) C288 12.0
 LDTP10320  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (TRMT61A) C209 6.8
 LDTP11617  Myotubularin-related protein 12 (MTMR12) C152 6.5
 LDTP03401  Multifunctional protein CAD (CAD) C73 5.0
 LDTP02502  Thioredoxin (TXN) C32 4.1
 LDTP07407  Desumoylating isopeptidase 1 (DESI1) C108 4.0
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 3.3
 LDTP13719  Ubiquitin carboxyl-terminal hydrolase 22 (USP22) C171 3.2
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 2.8
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 2.2
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 2.2
 LDTP05859  Integrin-linked protein kinase (ILK) C346 2.1
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 2.0
 LDTP05480  Amidophosphoribosyltransferase (PPAT) C100 2.0
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 2.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 2.0
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 1.9
 LDTP08401  All trans-polyprenyl-diphosphate synthase PDSS2 (PDSS2) C71 1.8
 LDTP12227  Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) C216 1.8
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 1.7
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C57 1.6
 LDTP00414  Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) C131 1.6
 LDTP01470  Lysine-specific demethylase 4B (KDM4B) C694 1.5
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 1.5
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C161 1.5
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 1.4
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 1.4
 LDTP10386  ERO1-like protein alpha (ERO1A) C37 1.4
 LDTP12313  Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (ALG13) C86 1.4
 LDTP03316  DNA replication licensing factor MCM3 (MCM3) C119 1.3
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.3
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.3
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C54 1.3
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) C223 1.3
 LDTP04438  Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) C340 1.3
 LDTP00479  Histone acetyltransferase type B catalytic subunit (HAT1) C101 1.2
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C114 1.2
 LDTP06603  Cyclin-dependent kinase inhibitor 3 (CDKN3) C39 1.2
 LDTP05954  GDP-L-fucose synthase (GFUS) C116 1.2
 LDTP04262  Alanine--tRNA ligase, cytoplasmic (AARS1) C773 1.1
 LDTP04374  Dynamin-2 (DNM2) C27 1.0
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.0
 LDTP02493  Serine/threonine-protein kinase A-Raf (ARAF) C597 1.0
 LDTP03770  Alpha-adducin (ADD1) C68 1.0
 LDTP01055  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) C158 0.9
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.9
 LDTP11639  RNA exonuclease 4 (REXO4) C382 0.9
 LDTP10774  Elongation factor G, mitochondrial (GFM1) C153 0.8
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 0.8
 LDTP17384  Lysine-specific demethylase RSBN1L (RSBN1L) C280 0.8
Transporter and channel
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 5.2
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 3.2
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 2.2
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 1.8
 LDTP02735  G2/mitotic-specific cyclin-B1 (CCNB1) C238 1.5
 LDTP04801  Gasdermin-D (GSDMD) C268 1.5
 LDTP00501  Exportin-1 (XPO1) C528 1.1
Transcription factor
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 20.0
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 1.6
 LDTP05362  Interferon regulatory factor 8 (IRF8) C306 1.5
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.1
Other
Click to Show/Hide to Show 37 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP17802  Glutathione S-transferase C-terminal domain-containing protein (GSTCD) C140 20.0
 LDTP13515  Zinc finger protein 346 (ZNF346) C68 20.0
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 2.0
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 2.0
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C532 2.0
 LDTP13402  Dynactin subunit 4 (DCTN4) C258 1.9
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.9
 LDTP04092  Crk-like protein (CRKL) C249 1.8
 LDTP10252  Elongator complex protein 4 (ELP4) C218 1.7
 LDTP17182  Uncharacterized protein C3orf38 (C3orf38) C308 1.7
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.6
 LDTP14250  Cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1) C51 1.5
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.5
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) C72 1.5
 LDTP12800  Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2) C22 1.5
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 1.4
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 1.4
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 1.4
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.4
 LDTP01532  ZW10 interactor (ZWINT) C54 1.4
 LDTP10864  Calponin-2 (CNN2) C164 1.3
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.3
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.2
 LDTP07624  Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC1S3) C168 1.2
 LDTP04487  Cyclin-H (CCNH) C244 1.2
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) C267 1.2
 LDTP13580  Coronin-1C (CORO1C) C420 1.1
 LDTP12571  LanC-like protein 2 (LANCL2) C187 1.1
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 1.1
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.1
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 1.0
 LDTP09650  LIM domain only protein 7 (LMO7) C228 1.0
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.0
 LDTP08018  Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) C645 0.9
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 0.9
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 0.9

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.