Details of the Target

General Information of Target

Target ID LDTP08808
Target Name E3 SUMO-protein ligase PIAS4 (PIAS4)
Gene Name PIAS4
Gene ID 51588
Synonyms
PIASG; E3 SUMO-protein ligase PIAS4; EC 2.3.2.27; PIASy; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; PIAS-gamma
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAELVEAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDCSPELFKKIKE
LYETRYAKKNSEPAPQPHRPLDPLTMHSTYDRAGAVPRTPLAGPNIDYPVLYGKYLNGLG
RLPAKTLKPEVRLVKLPFFNMLDELLKPTELVPQNNEKLQESPCIFALTPRQVELIRNSR
ELQPGVKAVQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGVEPKRPC
RPINLTHLMYLSSATNRITVTWGNYGKSYSVALYLVRQLTSSELLQRLKTIGVKHPELCK
ALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDAVFYLQMNEKK
PTWMCPVCDKPAPYDQLIIDGLLSKILSECEDADEIEYLVDGSWCPIRAEKERSCSPQGA
ILVLGPSDANGLLPAPSVNGSGALGSTGGGGPVGSMENGKPGADVVDLTLDSSSSSEDEE
EEEEEEEDEDEEGPRPKRRCPFQKGLVPAC
Target Bioclass
Enzyme
Family
PIAS family
Subcellular location
Nucleus, PML body
Function
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168 . Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Binds to AT-rich DNA sequences, known as matrix or scaffold attachment regions (MARs/SARs). Catalyzes conjugation of SUMO2 to KAT5 in response to DNA damage, facilitating repair of DNA double-strand breaks (DSBs) via homologous recombination (HR). Mediates sumoylation of PARP1 in response to PARP1 trapping to chromatin.
Uniprot ID
Q8N2W9
Ensemble ID
ENST00000262971.3
HGNC ID
HGNC:17002

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y62(25.81)  LDD3495  [1]
DBIA
 Probe Info  		C196(1.82); C202(1.82); C50(1.47)  LDD0080  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		C221(0.00); C326(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C164(0.00); C50(0.00)  LDD0037  [3]
Compound 10
 Probe Info  		C164(0.00); C326(0.00)  LDD2216  [4]
IPM
 Probe Info  		C164(0.00); C326(0.00)  LDD0147  [5]
NHS
 Probe Info  		N.A.  LDD0010  [6]
TFBX
 Probe Info  		C337(0.00); C299(0.00); C326(0.00); C164(0.00)  LDD0148  [5]
AOyne
 Probe Info  		15.00  LDD0443  [7]
NAIA_5
 Probe Info  		C50(0.00); C510(0.00); C164(0.00); C240(0.00)  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C326(0.83); C390(0.38); C405(0.38); C164(1.05)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C326(1.99); C390(0.88); C405(0.88); C196(1.07)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C326(1.15); C196(0.80); C202(0.80); C164(0.87)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C326(1.20); C196(0.83); C202(0.83); C164(0.76)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C326(1.13); C196(0.90); C202(0.90); C164(0.77)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C326(1.22); C196(0.84); C202(0.84); C164(0.76)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C326(1.06); C196(0.88); C202(0.88); C164(0.83)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C326(1.20); C196(0.69); C202(0.69); C164(0.76)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C326(1.15); C196(0.96); C202(0.96); C164(0.67)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C326(1.05); C196(0.83); C202(1.06); C164(0.74)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C326(1.18); C196(0.95); C202(0.88); C164(0.74)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C326(1.07); C196(1.15); C202(0.90); C164(0.83)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C326(0.95); C390(0.97); C405(0.97); C196(0.98)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C326(1.26); C196(0.83); C202(0.84); C164(0.74)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C326(1.17); C196(0.86); C202(0.82); C164(0.81)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C326(1.18); C196(0.79); C202(0.87); C164(0.71)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C326(0.95); C390(1.05); C405(1.05); C196(1.08)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C326(1.10); C390(0.81); C405(0.81); C196(0.67)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C326(1.06); C390(0.92); C405(0.92); C196(0.73)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C326(1.05); C390(1.04); C405(1.04); C196(0.76)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C326(1.02); C390(1.32); C405(1.32); C196(0.75)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C326(1.07); C390(1.00); C405(1.00); C196(0.76)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C326(1.21); C390(0.96); C405(0.96); C196(0.81)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C326(0.92); C390(0.82); C405(0.82); C196(1.22)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C326(1.20); C390(1.15); C405(1.15); C196(0.83)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C326(0.88); C390(0.98); C405(0.98); C196(0.79)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C326(1.17); C390(0.88); C405(0.88); C196(0.81)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C326(0.90); C390(0.80); C405(0.80); C196(0.70)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C326(0.98); C390(0.98); C405(0.98); C196(0.80)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C326(1.18); C390(0.90); C405(0.90); C196(0.80)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C326(1.09); C390(0.94); C405(0.94); C196(0.74)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C326(1.05); C390(0.88); C405(0.88); C196(0.71)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C326(0.83); C390(0.82); C405(0.82); C164(1.40)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C326(0.93); C390(0.76); C405(0.76); C164(0.92)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C326(0.91); C390(1.01); C405(1.01); C164(0.86)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C326(0.97); C390(0.98); C405(0.98); C164(1.49)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C326(1.09); C390(0.85); C405(0.85); C164(0.63)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C326(1.11); C390(0.79); C405(0.79); C164(0.66)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C326(1.03); C390(0.75); C405(0.75); C164(0.91)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C326(0.94); C390(0.89); C405(0.89); C164(0.88)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C326(1.06); C390(1.00); C405(1.00); C164(0.69)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C326(1.12); C390(0.77); C405(0.77); C164(0.70)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C326(1.28); C390(0.92); C405(0.92); C164(1.33)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C326(1.29); C390(1.13); C405(1.13); C164(0.70)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C326(0.87); C390(1.02); C405(1.02); C196(1.11)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C326(1.66); C390(0.78); C405(0.78); C164(0.76)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C326(1.42); C390(0.87); C405(0.87); C164(1.11)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C326(1.14); C390(0.97); C405(0.97); C164(0.51)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C326(1.01); C390(0.76); C405(0.76); C196(1.07)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C202(0.57); C365(0.80); C196(0.81); C390(0.89)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C202(0.52); C326(0.90); C365(0.98); C368(1.02)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C202(0.70); C368(0.75); C365(0.75); C326(0.97)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C202(0.65); C326(0.84); C390(0.90); C405(0.90)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C202(0.74); C365(0.88); C368(0.93); C326(1.05)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C202(0.47); C365(0.82); C368(0.86); C196(0.96)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C326(0.87); C390(0.91); C405(0.91); C365(0.91)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C390(0.81); C405(0.81); C164(0.96); C368(0.97)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C365(0.72); C164(0.76); C368(0.80); C326(0.95)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C365(0.96); C326(0.99); C368(1.00); C390(1.03)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C202(0.51); C368(0.86); C365(0.87); C196(0.97)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C326(0.96); C390(1.12); C405(1.12); C196(1.53)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C326(1.01); C390(1.12); C405(1.12); C196(1.18)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C326(0.98); C390(1.06); C405(1.06); C196(1.33)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C326(0.96); C390(1.07); C405(1.07); C196(0.98)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C164(0.97); C365(1.04); C368(1.04); C326(1.05)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C164(0.94); C365(0.96); C368(0.96); C326(1.42)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C365(1.00); C368(1.00); C164(1.07); C326(1.12)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C390(0.35); C405(0.35); C164(0.64); C326(0.88)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C365(0.77); C368(0.77); C326(1.16); C164(1.53)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C365(0.79); C368(0.79); C326(1.16); C164(1.26)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C365(0.75); C368(0.75); C164(0.98); C326(1.05)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C365(0.69); C368(0.69); C326(1.07); C164(1.09)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C365(0.89); C368(0.89); C326(0.96); C164(1.32)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C390(0.83); C405(0.83); C326(0.92); C196(1.16)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C390(0.74); C405(0.74); C196(1.06); C202(1.06)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C390(0.93); C405(0.93); C196(1.11); C202(1.11)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C390(0.77); C405(0.77); C196(1.21); C202(1.21)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C390(1.06); C405(1.06); C196(1.08); C202(1.08)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C390(0.36); C405(0.36); C164(0.57); C326(0.73)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C196(1.06); C202(1.06); C390(1.09); C405(1.09)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C390(0.87); C405(0.87); C196(1.12); C202(1.12)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C390(0.86); C405(0.86); C196(0.99); C202(0.99)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C390(0.89); C405(0.89); C326(0.90); C196(0.99)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C365(0.79); C368(0.79); C390(0.83); C405(0.83)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C196(0.58); C202(0.58); C390(0.75); C405(0.75)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C390(0.73); C405(0.73); C196(1.06); C202(1.06)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C196(0.52); C202(0.52); C390(0.64); C405(0.64)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C196(0.55); C202(0.55); C390(0.87); C405(0.87)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C196(0.56); C202(0.56); C390(0.80); C405(0.80)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C390(0.43); C405(0.43); C164(0.61); C326(0.68)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C196(0.74); C202(0.74); C365(1.00); C368(1.00)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C196(0.65); C202(0.65); C390(0.76); C405(0.76)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C196(0.76); C202(0.76); C365(0.86); C368(0.86)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C196(0.65); C202(0.65); C365(0.82); C368(0.82)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C196(0.53); C202(0.53); C390(0.80); C405(0.80)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C196(0.52); C202(0.52); C390(0.77); C405(0.77)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C164(0.79); C196(0.83); C202(0.83); C390(0.89)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C196(0.82); C202(0.82); C390(0.94); C405(0.94)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C164(0.73); C390(0.79); C405(0.79); C365(1.06)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C164(0.76); C365(0.85); C368(0.85); C390(0.98)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C390(0.33); C405(0.33); C164(0.62); C326(0.72)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C390(0.80); C405(0.80); C365(1.07); C368(1.07)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C196(0.80); C202(0.80); C390(0.83); C405(0.83)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C196(0.60); C202(0.60); C390(0.87); C405(0.87)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C196(0.65); C202(0.65); C390(0.77); C405(0.77)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C365(0.92); C368(0.92); C390(0.97); C405(0.97)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C164(0.87); C390(0.98); C405(0.98); C365(1.02)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C365(0.60); C368(0.60); C196(0.83); C202(0.83)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C196(0.84); C202(0.84); C164(0.86); C365(0.95)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C196(0.82); C202(0.82); C365(0.94); C368(0.94)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C164(0.85); C196(0.87); C202(0.87); C365(0.96)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C390(0.82); C405(0.82); C365(0.94); C368(0.94)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C196(0.85); C202(0.85); C164(0.89); C365(0.94)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C164(0.79); C196(0.85); C202(0.85); C365(1.09)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C164(0.90); C196(0.90); C202(0.90); C365(0.95)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C196(0.82); C202(0.82); C164(0.98); C365(1.27)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C164(0.90); C196(1.04); C202(1.04); C365(1.15)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C164(0.70); C196(0.96); C202(0.96); C365(1.23)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C164(0.89); C196(0.90); C202(0.90); C365(1.08)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C164(0.69); C196(0.99); C202(0.99); C365(1.07)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C365(0.64); C368(0.64); C326(0.95); C164(0.96)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C365(0.80); C368(0.80); C326(0.90); C196(0.96)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C390(1.00); C405(1.00); C365(1.05); C368(1.05)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C365(0.71); C368(0.71); C164(0.83); C196(0.90)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C326(0.78); C365(0.83); C368(0.83); C164(0.95)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C365(0.75); C368(0.75); C326(0.93); C196(0.97)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C365(0.78); C368(0.78); C326(1.01); C164(1.13)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C365(0.74); C368(0.74); C326(0.89); C196(1.11)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C365(0.92); C368(0.92); C326(0.96); C164(1.13)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C365(0.75); C368(0.75); C326(0.90); C196(0.97)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C365(0.82); C368(0.82); C326(0.88); C196(1.02)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C326(0.91); C196(0.91); C202(0.91); C164(0.93)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C365(0.81); C368(0.81); C326(0.91); C164(0.94)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C365(0.90); C368(0.90); C390(1.00); C405(1.00)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C326(0.92); C164(0.97); C365(1.04); C368(1.04)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C365(0.70); C368(0.70); C164(0.84); C326(0.86)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C365(0.68); C368(0.68); C164(0.91); C326(0.94)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C164(0.60); C365(0.64); C368(0.64); C196(0.77)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C164(0.50); C365(0.61); C368(0.61); C196(0.77)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C196(0.42); C202(0.42); C164(0.48); C365(0.72)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C164(0.53); C196(0.56); C202(0.56); C365(0.80)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C196(0.45); C202(0.45); C164(0.52); C365(0.91)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C196(0.66); C202(0.66); C164(0.69); C365(0.92)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C196(0.63); C202(0.63); C365(0.81); C368(0.81)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C164(0.78); C365(1.14); C368(1.14); C326(1.16)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C196(0.52); C202(0.52); C164(0.58); C365(1.00)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C196(0.70); C202(0.70); C164(0.72); C365(0.99)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C196(0.68); C202(0.68); C164(0.71); C365(0.87)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C196(0.62); C202(0.62); C164(0.70); C326(1.14)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C196(0.51); C202(0.51); C164(0.55); C365(1.12)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C196(0.59); C202(0.59); C164(0.85); C326(1.03)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C164(0.77); C196(0.81); C202(0.81); C365(1.03)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C164(0.81); C365(0.93); C368(0.93); C196(1.01)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C164(0.71); C196(1.07); C202(1.07); C326(1.18)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C326(0.96); C390(1.12); C405(1.12); C196(1.25)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C164(0.94); C390(1.04); C405(1.04); C365(1.06)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C365(0.94); C368(0.94); C326(1.04); C390(1.05)  LDD0592  [2]
 LDCM0632  CL-Sc Hep-G2 C221(3.99); C326(1.00); C50(0.77)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C164(1.22); C365(1.32); C368(1.32); C390(3.10)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C164(0.23); C365(1.45); C368(1.45); C390(3.30)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C390(0.35); C405(0.35); C164(0.66); C326(0.87)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C390(0.78); C405(0.78); C365(1.06); C368(1.06)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C164(0.82); C365(1.07); C368(1.07); C390(1.09)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C326(0.91); C365(1.31); C368(1.31); C196(1.41)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C326(0.90); C365(0.93); C368(0.93); C390(1.08)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C365(0.83); C368(0.83); C164(0.85); C326(1.31)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C365(0.76); C368(0.76); C164(0.92); C326(1.49)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C365(0.76); C368(0.76); C164(0.77); C326(1.37)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C164(0.82); C365(0.91); C368(0.91); C326(1.42)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C365(0.78); C368(0.78); C164(1.21); C326(1.30)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C164(0.33); C365(1.39); C368(1.39); C390(1.66)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C164(0.78); C365(0.81); C368(0.81); C326(1.30)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C365(0.80); C368(0.80); C164(0.89); C326(1.22)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C326(0.99); C196(1.05); C202(1.05); C365(1.11)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C390(0.67); C405(0.67); C365(0.91); C368(0.91)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C365(0.84); C368(0.84); C196(0.99); C202(0.99)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C365(0.83); C368(0.83); C196(0.93); C202(0.93)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C390(0.73); C405(0.73); C365(0.83); C368(0.83)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C196(1.01); C202(1.01); C365(1.07); C368(1.07)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C196(0.49); C202(0.49); C390(0.96); C405(0.96)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C196(0.45); C202(0.45); C390(0.75); C405(0.75)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C164(0.21); C390(1.26); C405(1.26); C365(1.39)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C196(0.45); C202(0.45); C390(0.84); C405(0.84)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C390(0.93); C405(0.93); C164(0.99); C365(1.15)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C196(0.79); C202(0.79); C365(0.90); C368(0.90)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C365(0.94); C368(0.94); C164(1.56); C390(1.59)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C196(0.76); C202(0.76); C164(0.85); C390(0.91)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C164(0.85); C196(0.85); C202(0.85); C365(0.94)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C365(0.97); C368(0.97); C164(1.04); C196(1.04)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C365(0.78); C368(0.78); C196(0.90); C202(0.90)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C196(0.87); C202(0.87); C164(0.91); C365(0.95)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C164(0.97); C365(1.14); C368(1.14); C390(1.91)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C164(0.87); C365(1.22); C368(1.22); C390(2.06)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C164(1.18); C365(1.33); C368(1.33); C390(1.79)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C164(0.81); C196(0.85); C202(0.85); C326(1.10)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C164(0.62); C196(1.08); C202(1.08); C365(1.14)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C164(0.74); C196(0.74); C202(0.74); C390(0.81)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C164(0.68); C196(0.96); C202(0.96); C326(0.99)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C365(1.06); C368(1.06); C164(1.29); C390(1.36)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C390(0.97); C405(0.97); C196(1.03); C202(1.03)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C164(1.09); C365(1.27); C368(1.27); C196(1.48)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C365(0.88); C368(0.88); C164(1.55); C196(1.57)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C365(0.81); C368(0.81); C196(0.97); C202(0.97)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C164(0.93); C196(0.96); C202(0.96); C326(1.06)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C326(1.15); C390(1.27); C405(1.27); C196(0.98)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C326(1.03); C390(1.65); C405(1.65); C196(0.90)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C326(1.01); C390(1.44); C405(1.44); C196(0.85)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C326(1.20); C390(1.06); C405(1.06); C196(0.94)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C326(1.01); C390(1.48); C405(1.48); C196(1.06)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C390(1.01); C405(1.01); C164(0.98); C365(1.02)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C326(0.90); C390(0.91); C405(0.91); C196(0.93)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C326(0.95); C390(0.87); C405(0.87); C164(0.67)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C390(0.67); C405(0.67); C196(0.88); C202(0.88)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C390(20.00); C405(20.00); C196(1.64); C202(1.64)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C390(1.57); C405(1.57); C196(1.14); C202(1.14)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C390(1.49); C405(1.49); C196(0.99); C202(0.99)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C390(1.09); C405(1.09); C196(1.15); C202(1.15)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C390(0.88); C405(0.88); C196(1.11); C202(1.11)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C390(2.52); C405(2.52); C196(0.83); C202(0.83)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C390(1.13); C405(1.13); C164(1.03); C365(1.73)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C390(0.67); C405(0.67); C196(1.19); C202(1.19)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C390(0.97); C405(0.97); C196(1.01); C202(1.01)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C390(0.95); C405(0.95); C196(1.21); C202(1.21)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C390(1.11); C405(1.11); C196(0.82); C202(0.82)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C390(1.70); C405(1.70); C196(0.95); C202(0.95)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C390(1.18); C405(1.18); C196(1.06); C202(1.06)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C326(3.46); C390(1.50); C405(1.50); C196(1.15)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C326(2.48); C390(1.07); C405(1.07); C196(1.27)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C326(1.12); C390(1.39); C405(1.39); C196(1.13)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C326(1.02); C390(1.03); C405(1.03); C196(0.99)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C390(0.88); C405(0.88); C164(1.12); C365(1.22)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C326(1.14); C390(1.06); C405(1.06); C196(0.99)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C326(1.23); C390(0.88); C405(0.88); C196(0.99)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C326(1.20); C390(0.70); C405(0.70); C196(1.04)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C326(1.35); C390(0.85); C405(0.85); C196(1.08)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C326(3.29); C390(1.68); C405(1.68); C196(1.31)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C326(1.14); C390(0.83); C405(0.83); C196(1.01)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C326(2.23); C390(1.09); C405(1.09); C196(0.96)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C326(9.21); C390(1.32); C405(1.32); C196(1.50)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C326(1.18); C390(1.03); C405(1.03); C196(1.14)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C326(1.18); C390(0.90); C405(0.90); C196(1.10)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C390(1.12); C405(1.12); C164(1.16); C365(1.23)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C326(1.26); C390(0.93); C405(0.93); C196(1.05)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C326(0.99); C390(1.20); C405(1.20); C196(0.86)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C326(1.20); C390(1.08); C405(1.08); C196(0.90)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C326(1.11); C390(0.99); C405(0.99); C196(0.82)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C326(1.21); C390(0.93); C405(0.93); C196(0.86)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C326(0.98); C390(1.01); C405(1.01); C196(0.86)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C326(2.17); C390(1.75); C405(1.75); C196(1.11)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C326(1.15); C390(1.07); C405(1.07); C196(0.83)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C326(3.03); C390(1.23); C405(1.23); C196(1.01)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C326(4.24); C390(1.21); C405(1.21); C196(1.17)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C390(1.18); C405(1.18); C164(0.38); C365(1.39)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C326(1.09); C390(0.92); C405(0.92); C196(0.79)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C326(1.10); C390(1.02); C405(1.02); C196(0.87)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C326(1.09); C390(1.13); C405(1.13); C196(0.98)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C326(1.18); C390(0.92); C405(0.92); C196(0.86)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C326(1.13); C390(1.07); C405(1.07); C196(0.81)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C326(1.32); C196(1.04); C202(1.04); C164(1.11)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C326(1.57); C196(1.02); C202(1.02); C164(0.87)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C326(1.53); C196(0.96); C202(0.96); C164(0.87)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C326(0.90); C196(0.98); C202(0.98); C164(1.03)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C390(4.99); C405(4.99); C164(1.22); C365(1.53)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C326(0.94); C196(1.09); C202(1.09); C164(0.69)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C326(0.99); C196(1.16); C202(1.16); C164(0.92)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C326(0.85); C196(1.12); C202(1.12); C164(0.93)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C326(1.02); C196(1.01); C202(1.01); C164(1.07)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C326(1.24); C196(1.02); C202(1.02); C164(0.90)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C326(0.88); C196(0.96); C202(0.96); C164(1.12)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C326(0.91); C196(0.84); C202(0.84); C164(0.84)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C326(0.99); C196(1.34); C202(1.34); C164(0.99)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C326(0.81); C196(1.13); C202(1.13); C164(1.11)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C326(0.89); C196(1.05); C202(1.05); C164(1.16)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C390(0.93); C405(0.93); C164(0.97); C365(1.22)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C326(5.17); C196(1.66); C202(1.66); C164(1.48)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C326(0.75); C390(0.39); C405(0.39); C164(3.33)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C326(2.22); C390(0.42); C405(0.42); C164(3.47)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C326(2.54); C390(0.65); C405(0.65); C164(0.66)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C326(1.10); C390(0.52); C405(0.52); C164(1.02)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C326(0.85); C390(0.29); C405(0.29); C164(1.41)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C326(0.89); C390(0.35); C405(0.35); C164(0.82)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C326(0.88); C390(0.33); C405(0.33); C164(1.05)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C326(2.12); C390(0.44); C405(0.44); C164(1.16)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C326(1.52); C390(0.42); C405(0.42); C164(1.03)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C326(7.38); C164(0.85); C50(0.96)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C299(1.90); C337(1.00); C326(0.98)  LDD1702  [10]
 LDCM0625  F8 Ramos C326(1.11)  LDD2187  [11]
 LDCM0572  Fragment10 MDA-MB-231 C326(4.50)  LDD1465  [12]
 LDCM0573  Fragment11 Ramos C50(0.54)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C326(0.54)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C326(20.00)  LDD1470  [12]
 LDCM0576  Fragment14 Ramos C326(0.70); C50(0.75)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C326(0.50)  LDD2194  [11]
 LDCM0580  Fragment21 MDA-MB-231 C326(0.97)  LDD1473  [12]
 LDCM0578  Fragment27 Ramos C326(0.96)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C326(0.90); C50(1.02)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C326(1.06)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C326(0.99)  LDD2200  [11]
 LDCM0468  Fragment33 HCT 116 C326(2.43); C390(1.12); C405(1.12); C196(0.95)  LDD0785  [2]
 LDCM0596  Fragment38 MDA-MB-231 C326(0.88)  LDD1480  [12]
 LDCM0599  Fragment41 MDA-MB-231 C326(0.83)  LDD1481  [12]
 LDCM0427  Fragment51 HCT 116 C390(0.93); C405(0.93); C196(1.13); C202(1.13)  LDD0744  [2]
 LDCM0569  Fragment7 Ramos C326(0.59)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C326(2.61)  LDD1464  [12]
 LDCM0022  KB02 HCT 116 C196(1.82); C202(1.82); C50(1.47)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C196(1.45); C202(1.45); C50(2.26)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C196(2.27); C202(2.27); C50(1.46)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) 2-oxoacid dehydrogenase family P36957
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) Adenosylhomocysteinase family O43865
Poly [ADP-ribose] polymerase 1 (PARP1) ARTD/PARP family P09874
Phosphatidate phosphatase LPIN1 (LPIN1) Lipin family Q14693
Transcriptional adapter 3 (TADA3) NGG1 family O75528
Glycylpeptide N-tetradecanoyltransferase 2 (NMT2) NMT family O60551
Serine/threonine-protein kinase Nek7 (NEK7) NEK Ser/Thr protein kinase family Q8TDX7
E3 ubiquitin-protein ligase TRIM38 (TRIM38) . O00635
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Beclin-1 (BECN1) Beclin family Q14457
Calreticulin (CALR) Calreticulin family P27797
Huntingtin (HTT) Huntingtin family P42858
Cellular tumor antigen p53 (TP53) P53 family P04637
Cadherin-1 (CDH1) . P12830
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C4 (HOXC4) Antp homeobox family P09017
Steroid hormone receptor ERR1 (ESRRA) Nuclear hormone receptor family P11474
Krueppel-like factor 15 (KLF15) Sp1 C2H2-type zinc-finger protein family Q9UIH9
Hypoxia-inducible factor 1-alpha (HIF1A) . Q16665
Transcription factor p65 (RELA) . Q04206
Zinc finger and BTB domain-containing protein 34 (ZBTB34) . Q8NCN2
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 141 (CCDC141) . Q6ZP82
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytokine receptor-like factor 3 (CRLF3) Cytokine receptor-like factor 3 family Q8IUI8
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (KCTD13) BACURD family Q8WZ19
Cyclin-dependent kinase 5 activator 1 (CDK5R1) Cyclin-dependent kinase 5 activator family Q15078
RNA polymerase II elongation factor ELL2 (ELL2) ELL/occludin family O00472
Late cornified envelope protein 1D (LCE1D) LCE family Q5T752
Myozenin-1 (MYOZ1) Myozenin family Q9NP98
Histone deacetylase complex subunit SAP30 (SAP30) SAP30 family O75446
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Small ubiquitin-related modifier 2 (SUMO2) Ubiquitin family P61956
G-protein-signaling modulator 3 (GPSM3) . Q9Y4H4
GA-binding protein subunit beta-2 (GABPB2) . Q8TAK5
La-related protein 4B (LARP4B) . Q92615
Mitochondrial nucleoid-associated protein 1 (MTNAP1) . Q9BSJ5
Protein FAM117B (FAM117B) . Q6P1L5
Splicing regulator RBM11 (RBM11) . P57052
WW domain binding protein 1-like (WBP1L) . Q9NX94

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.