Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment41  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cells (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 100 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) C436 4.5
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.9
 LDTP15290  5'-nucleotidase domain-containing protein 3 (NT5DC3) C276 1.7
 LDTP01220  Mitochondrial-processing peptidase subunit beta (PMPCB) C265 1.3
 LDTP15311  Deaminated glutathione amidase (NIT1) C203 1.3
 LDTP01141  E3 ubiquitin-protein ligase BRE1B (RNF40) C890 1.3
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C57 1.3
 LDTP11059  ADP-ribose glycohydrolase MACROD1 (MACROD1) C186 1.2
 LDTP13980  Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2) C105 1.2
 LDTP03163  Sterol carrier protein 2 (SCP2) C71 1.2
 LDTP10774  Elongation factor G, mitochondrial (GFM1) C153 1.1
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.1
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 1.1
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 1.1
 LDTP03163  Sterol carrier protein 2 (SCP2) C307 1.1
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 1.0
 LDTP01707  Thioredoxin domain-containing protein 12 (TXNDC12) C66 1.0
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.0
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 1.0
 LDTP12227  Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) C216 1.0
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.0
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C620 1.0
 LDTP18330  Haloacid dehalogenase-like hydrolase domain-containing 5 (HDHD5) C392 1.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.0
 LDTP03316  DNA replication licensing factor MCM3 (MCM3) C119 0.9
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) C207 0.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 0.9
 LDTP12960  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) C149 0.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 0.9
 LDTP12539  DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) C130 0.9
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 0.9
 LDTP08401  All trans-polyprenyl-diphosphate synthase PDSS2 (PDSS2) C71 0.9
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C190 0.9
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 0.9
 LDTP02074  Aldehyde dehydrogenase, mitochondrial (ALDH2) C319 0.9
 LDTP03770  Alpha-adducin (ADD1) C68 0.9
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 0.9
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C758 0.9
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 0.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 0.8
 LDTP08808  E3 SUMO-protein ligase PIAS4 (PIAS4) C326 0.8
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 0.8
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126 0.8
 LDTP00414  Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) C131 0.8
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) C317 0.8
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 0.8
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 0.8
 LDTP13527  Aspartyl aminopeptidase (DNPEP) C144 0.8
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 0.8
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) C138 0.8
 LDTP04232  4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) C288 0.8
 LDTP04262  Alanine--tRNA ligase, cytoplasmic (AARS1) C773 0.7
 LDTP07110  Putative transferase CAF17, mitochondrial (IBA57) C170 0.7
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 0.7
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 0.7
 LDTP03000  General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) C342 0.7
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 0.7
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 0.7
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 0.7
 LDTP18123  Isochorismatase domain-containing protein 2 (ISOC2) C114 0.7
 LDTP02055  Thymidylate synthase (TYMS) C199 0.7
 LDTP01055  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) C158 0.7
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 0.7
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 0.7
 LDTP03401  Multifunctional protein CAD (CAD) C73 0.7
 LDTP00013  Ubiquitin-like modifier-activating enzyme 6 (UBA6) C347 0.6
 LDTP12837  Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) C22 0.6
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 0.6
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 0.6
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) C623 0.6
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C114 0.6
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 0.6
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.6
 LDTP00479  Histone acetyltransferase type B catalytic subunit (HAT1) C101 0.6
 LDTP05859  Integrin-linked protein kinase (ILK) C346 0.6
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 0.6
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 0.6
 LDTP04374  Dynamin-2 (DNM2) C27 0.5
 LDTP03786  Glutaredoxin-1 (GLRX) C23 0.5
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 0.5
 LDTP10973  Thioredoxin, mitochondrial (TXN2) C90 0.5
 LDTP00481  Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6) C98 0.5
 LDTP05289  AMP deaminase 2 (AMPD2) C107 0.5
 LDTP06211  Caspase-8 (CASP8) C360 0.5
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 0.5
 LDTP12313  Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (ALG13) C86 0.5
 LDTP02502  Thioredoxin (TXN) C32 0.4
 LDTP10386  ERO1-like protein alpha (ERO1A) C37 0.4
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) C88 0.4
 LDTP14155  Serine/threonine-protein kinase MRCK beta (CDC42BPB) C1517 0.4
 LDTP02223  Cathepsin B (CTSB) C211 0.4
 LDTP03400  Deoxycytidine kinase (DCK) C9 0.4
 LDTP03496  Protein PML (PML) C389 0.4
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 0.4
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 0.3
 LDTP19750  RNA ligase 1 (RLIG1) C302 0.3
 LDTP03258  Thymidylate kinase (DTYMK) C163 0.2
 LDTP14092  Protein phosphatase methylesterase 1 (PPME1) C381 0.2
 LDTP10982  Aconitate hydratase, mitochondrial (ACO2) C385 0.1
Transporter and channel
Click to Show/Hide to Show 15 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) C65 1.4
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 1.1
 LDTP03777  Nuclear pore complex protein Nup214 (NUP214) C728 1.1
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) C100 1.0
 LDTP00501  Exportin-1 (XPO1) C528 0.9
 LDTP09204  Nucleoporin NUP35 (NUP35) C255 0.8
 LDTP13498  Nuclear pore complex protein Nup50 (NUP50) C151 0.8
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 0.8
 LDTP05591  Nuclear cap-binding protein subunit 1 (NCBP1) C44 0.8
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 0.6
 LDTP04801  Gasdermin-D (GSDMD) C268 0.6
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 0.6
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 0.6
 LDTP02735  G2/mitotic-specific cyclin-B1 (CCNB1) C238 0.5
 LDTP10642  Chloride intracellular channel protein 6 (CLIC6) C487 0.4
Transcription factor
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 1.2
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.1
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 1.0
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 0.9
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 0.9
 LDTP03280  COUP transcription factor 2 (NR2F2) C326 0.8
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 0.6
Other
Click to Show/Hide to Show 65 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP13906  Polymerase delta-interacting protein 2 (POLDIP2) C143 1.2
 LDTP07205  Telomere-associated protein RIF1 (RIF1) C2298 1.2
 LDTP04487  Cyclin-H (CCNH) C244 1.2
 LDTP13583  Targeting protein for Xklp2 (TPX2) C536 1.2
 LDTP05867  Treacle protein (TCOF1) C38 1.1
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) C267 1.0
 LDTP04078  Proliferation marker protein Ki-67 (MKI67) C903 1.0
 LDTP01299  WD repeat and HMG-box DNA-binding protein 1 (WDHD1) C773 1.0
 LDTP15896  Ashwin (C2orf49) C10 1.0
 LDTP12412  Reticulon-4 (RTN4) C1101 1.0
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 1.0
 LDTP05867  Treacle protein (TCOF1) C1298 1.0
 LDTP08094  Wings apart-like protein homolog (WAPL) C160 1.0
 LDTP13622  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) C213 0.9
 LDTP06330  Plectin (PLEC) C4574 0.9
 LDTP00306  Pescadillo homolog (PES1) C272 0.9
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 0.9
 LDTP13964  MOB-like protein phocein (MOB4) C134 0.9
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 0.9
 LDTP08018  Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) C645 0.9
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 0.8
 LDTP09650  LIM domain only protein 7 (LMO7) C228 0.8
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C439 0.8
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 0.8
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C532 0.8
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 0.8
 LDTP12800  Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2) C22 0.8
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 0.8
 LDTP13580  Coronin-1C (CORO1C) C420 0.8
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 0.8
 LDTP06362  Leucine-rich repeat-containing protein 41 (LRRC41) C297 0.8
 LDTP16117  Mediator of RNA polymerase II transcription subunit 9 (MED9) C139 0.8
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 0.7
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 0.7
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 0.7
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 0.7
 LDTP12443  Anillin (ANLN) C712 0.7
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 0.7
 LDTP14250  Cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1) C51 0.7
 LDTP10613  Dedicator of cytokinesis protein 7 (DOCK7) C2125 0.7
 LDTP13402  Dynactin subunit 4 (DCTN4) C258 0.7
 LDTP17182  Uncharacterized protein C3orf38 (C3orf38) C308 0.7
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 0.7
 LDTP07088  Formin-binding protein 1-like (FNBP1L) C69 0.6
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 0.6
 LDTP12571  LanC-like protein 2 (LANCL2) C187 0.6
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 0.6
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 0.6
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 0.6
 LDTP01532  ZW10 interactor (ZWINT) C54 0.6
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C819 0.6
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 0.6
 LDTP11235  Protein PAXX (PAXX) C180 0.6
 LDTP13705  LIM and calponin homology domains-containing protein 1 (LIMCH1) C140 0.5
 LDTP15861  Acyl-CoA-binding domain-containing protein 6 (ACBD6) C267 0.5
 LDTP10657  Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1) C900 0.5
 LDTP04434  Host cell factor 1 (HCFC1) C1872 0.5
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 0.5
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 0.5
 LDTP10864  Calponin-2 (CNN2) C164 0.4
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 0.3
 LDTP18494  Tropomodulin-3 (TMOD3) C132 0.3
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 0.3
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 0.3
 LDTP04560  Cytosolic Fe-S cluster assembly factor NUBP1 (NUBP1) C235 0.2

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.