Details of the Target

General Information of Target

Target ID LDTP05346
Target Name Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1)
Gene Name ALDH6A1
Gene ID 4329
Synonyms
MMSDH; Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial; MMSDH; EC 1.2.1.27; Aldehyde dehydrogenase family 6 member A1; Malonate-semialdehyde dehydrogenase [acylating]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIH
NPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIA
KLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCA
GIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHG
QHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKEN
TLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLIT
PQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFG
PVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLP
MFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR
Target Bioclass
Enzyme
Family
Aldehyde dehydrogenase family
Subcellular location
Mitochondrion
Function Malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine.
Uniprot ID
Q02252
Ensemble ID
ENST00000350259.8
HGNC ID
HGNC:7179

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
D283MED SNV: p.A132G .
NCIH1703 Deletion: p.L193FfsTer15 DBIA    Probe Info 
SKNMC SNV: p.R107C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH216
 Probe Info  		Y498(11.32)  LDD0259  [1]
STPyne
 Probe Info  		K264(0.75); K287(10.00); K47(3.71)  LDD0277  [2]
Probe 1
 Probe Info  		Y108(5.57); Y170(30.61); Y268(14.81); Y498(140.19)  LDD3495  [3]
m-APA
 Probe Info  		12.77  LDD0403  [4]
Backus_15
 Probe Info  		2.43  LDD0423  [5]
BTD
 Probe Info  		C368(1.16)  LDD2090  [6]
Sulforaphane-probe2
 Probe Info  		3.50  LDD0042  [7]
Johansson_61
 Probe Info  		_(4.80)  LDD1487  [8]
DBIA
 Probe Info  		C368(6.47)  LDD0209  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C86(0.00); C317(0.00); C149(0.00); C249(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C86(0.00); C317(0.00); C149(0.00); C249(0.00)  LDD0037  [11]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
WYneO
 Probe Info  		N.A.  LDD0022  [14]
IPM
 Probe Info  		N.A.  LDD0005  [14]
NHS
 Probe Info  		K47(0.00); K264(0.00)  LDD0010  [14]
TFBX
 Probe Info  		C317(0.00); C368(0.00)  LDD0148  [13]
VSF
 Probe Info  		N.A.  LDD0007  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
AOyne
 Probe Info  		14.20  LDD0443  [16]
NAIA_5
 Probe Info  		C86(0.00); C317(0.00); C368(0.00); C149(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C153
 Probe Info  		21.26  LDD1834  [18]
C160
 Probe Info  		35.02  LDD1840  [18]
C194
 Probe Info  		12.55  LDD1870  [18]
C198
 Probe Info  		13.74  LDD1874  [18]
C208
 Probe Info  		6.82  LDD1883  [18]
C233
 Probe Info  		13.36  LDD1906  [18]
C238
 Probe Info  		11.00  LDD1911  [18]
C361
 Probe Info  		26.35  LDD2022  [18]
C402
 Probe Info  		5.28  LDD2060  [18]
FFF probe14
 Probe Info  		20.00  LDD0477  [19]
FFF probe4
 Probe Info  		20.00  LDD0466  [19]
STS-1
 Probe Info  		N.A.  LDD0137  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C413(0.91); C86(0.92); C368(0.96); C317(1.05)  LDD1507  [21]
 LDCM0215  AC10 HEK-293T C413(0.87); C86(1.02); C368(0.96); C317(1.09)  LDD1508  [21]
 LDCM0216  AC100 HCT 116 C317(0.81)  LDD0533  [22]
 LDCM0217  AC101 HCT 116 C317(0.87)  LDD0534  [22]
 LDCM0218  AC102 HCT 116 C317(0.74)  LDD0535  [22]
 LDCM0219  AC103 HCT 116 C317(0.99)  LDD0536  [22]
 LDCM0220  AC104 HCT 116 C317(0.86)  LDD0537  [22]
 LDCM0221  AC105 HCT 116 C317(0.87)  LDD0538  [22]
 LDCM0222  AC106 HCT 116 C317(0.83)  LDD0539  [22]
 LDCM0223  AC107 HCT 116 C317(0.74)  LDD0540  [22]
 LDCM0224  AC108 HCT 116 C317(0.68)  LDD0541  [22]
 LDCM0225  AC109 HCT 116 C317(0.61)  LDD0542  [22]
 LDCM0226  AC11 HEK-293T C413(0.92); C86(1.01); C368(1.10); C317(1.09)  LDD1509  [21]
 LDCM0227  AC110 HCT 116 C317(0.63)  LDD0544  [22]
 LDCM0228  AC111 HCT 116 C317(0.53)  LDD0545  [22]
 LDCM0229  AC112 HCT 116 C317(0.66)  LDD0546  [22]
 LDCM0237  AC12 HEK-293T C413(0.96); C86(1.01); C368(1.08); C317(1.05)  LDD1510  [21]
 LDCM0259  AC14 HEK-293T C413(0.82); C86(1.06); C368(1.14); C317(1.02)  LDD1512  [21]
 LDCM0270  AC15 HEK-293T C413(0.93); C86(1.05); C368(1.13); C317(1.06)  LDD1513  [21]
 LDCM0276  AC17 HCT 116 C317(1.21)  LDD0593  [22]
 LDCM0277  AC18 HCT 116 C317(1.00)  LDD0594  [22]
 LDCM0278  AC19 HCT 116 C317(1.09)  LDD0595  [22]
 LDCM0279  AC2 HEK-293T C413(0.96); C86(1.14); C368(0.93); C317(1.00)  LDD1518  [21]
 LDCM0280  AC20 HCT 116 C317(1.14)  LDD0597  [22]
 LDCM0281  AC21 HCT 116 C317(1.01)  LDD0598  [22]
 LDCM0282  AC22 HCT 116 C317(1.16)  LDD0599  [22]
 LDCM0283  AC23 HCT 116 C317(1.06)  LDD0600  [22]
 LDCM0284  AC24 HCT 116 C317(1.19)  LDD0601  [22]
 LDCM0285  AC25 HEK-293T C413(0.86); C86(0.98); C368(0.95); C317(1.06)  LDD1524  [21]
 LDCM0286  AC26 HEK-293T C413(0.82); C86(1.08); C368(0.96); C317(0.98)  LDD1525  [21]
 LDCM0287  AC27 HEK-293T C413(0.86); C86(1.03); C368(1.08); C317(1.03)  LDD1526  [21]
 LDCM0288  AC28 HEK-293T C413(0.93); C86(1.02); C368(1.06); C317(1.12)  LDD1527  [21]
 LDCM0289  AC29 HEK-293T C413(1.25); C86(1.22); C368(1.36); C317(1.70)  LDD1528  [21]
 LDCM0290  AC3 HEK-293T C413(0.93); C86(1.07); C368(1.08); C317(1.07)  LDD1529  [21]
 LDCM0291  AC30 HEK-293T C413(0.91); C86(1.08); C368(1.04); C317(1.03)  LDD1530  [21]
 LDCM0292  AC31 HEK-293T C413(0.93); C86(1.04); C368(1.09); C317(1.02)  LDD1531  [21]
 LDCM0293  AC32 HEK-293T C413(0.94); C86(0.95); C368(1.09); C317(1.01)  LDD1532  [21]
 LDCM0294  AC33 HEK-293T C413(0.83); C86(0.90); C368(1.00); C317(1.00)  LDD1533  [21]
 LDCM0295  AC34 HEK-293T C413(0.85); C86(1.02); C368(0.86); C317(1.01)  LDD1534  [21]
 LDCM0296  AC35 HCT 116 C317(1.05)  LDD0613  [22]
 LDCM0297  AC36 HCT 116 C317(1.39)  LDD0614  [22]
 LDCM0298  AC37 HCT 116 C317(1.28)  LDD0615  [22]
 LDCM0299  AC38 HCT 116 C317(1.33)  LDD0616  [22]
 LDCM0300  AC39 HCT 116 C317(1.12)  LDD0617  [22]
 LDCM0301  AC4 HEK-293T C413(1.05); C86(1.06); C368(1.09); C317(1.02)  LDD1540  [21]
 LDCM0302  AC40 HCT 116 C317(1.19)  LDD0619  [22]
 LDCM0303  AC41 HCT 116 C317(1.47)  LDD0620  [22]
 LDCM0304  AC42 HCT 116 C317(1.14)  LDD0621  [22]
 LDCM0305  AC43 HCT 116 C317(1.18)  LDD0622  [22]
 LDCM0306  AC44 HCT 116 C317(1.16)  LDD0623  [22]
 LDCM0307  AC45 HCT 116 C317(1.14)  LDD0624  [22]
 LDCM0308  AC46 HEK-293T C413(0.87); C86(1.06); C368(1.16); C317(1.03)  LDD1547  [21]
 LDCM0309  AC47 HEK-293T C413(1.00); C86(0.96); C368(1.21); C317(1.04)  LDD1548  [21]
 LDCM0310  AC48 HEK-293T C413(1.03); C86(0.99); C368(1.15); C317(1.03)  LDD1549  [21]
 LDCM0311  AC49 HEK-293T C413(0.86); C86(0.99); C368(1.03); C317(1.08)  LDD1550  [21]
 LDCM0312  AC5 HEK-293T C413(0.97); C86(1.14); C368(1.07); C317(0.98)  LDD1551  [21]
 LDCM0313  AC50 HEK-293T C413(0.97); C86(1.04); C368(0.87); C317(1.02)  LDD1552  [21]
 LDCM0314  AC51 HEK-293T C413(0.93); C86(1.03); C368(1.11); C317(1.03)  LDD1553  [21]
 LDCM0315  AC52 HEK-293T C413(1.04); C86(1.02); C368(1.06); C317(1.02)  LDD1554  [21]
 LDCM0316  AC53 HEK-293T C413(1.01); C86(1.12); C368(1.07); C317(0.99)  LDD1555  [21]
 LDCM0317  AC54 HEK-293T C413(0.96); C86(1.00); C368(1.10); C317(0.98)  LDD1556  [21]
 LDCM0318  AC55 HEK-293T C413(1.00); C86(1.01); C368(1.11); C317(1.07)  LDD1557  [21]
 LDCM0319  AC56 HEK-293T C413(1.01); C86(0.96); C368(1.10); C317(1.12)  LDD1558  [21]
 LDCM0320  AC57 HCT 116 C317(1.11)  LDD0637  [22]
 LDCM0321  AC58 HCT 116 C317(1.19)  LDD0638  [22]
 LDCM0322  AC59 HCT 116 C317(1.17)  LDD0639  [22]
 LDCM0323  AC6 HEK-293T C413(0.96); C86(0.97); C368(1.03); C317(1.00)  LDD1562  [21]
 LDCM0324  AC60 HCT 116 C317(1.12)  LDD0641  [22]
 LDCM0325  AC61 HCT 116 C317(1.05)  LDD0642  [22]
 LDCM0326  AC62 HCT 116 C317(1.43)  LDD0643  [22]
 LDCM0327  AC63 HCT 116 C317(1.06)  LDD0644  [22]
 LDCM0328  AC64 HCT 116 C317(1.38)  LDD0645  [22]
 LDCM0329  AC65 HCT 116 C317(1.02)  LDD0646  [22]
 LDCM0330  AC66 HCT 116 C317(1.04)  LDD0647  [22]
 LDCM0331  AC67 HCT 116 C317(1.06)  LDD0648  [22]
 LDCM0334  AC7 HEK-293T C413(0.99); C86(1.05); C368(1.11); C317(1.01)  LDD1568  [21]
 LDCM0345  AC8 HEK-293T C413(0.99); C86(1.03); C368(1.12); C317(1.03)  LDD1569  [21]
 LDCM0349  AC83 HCT 116 C317(1.64)  LDD0666  [22]
 LDCM0350  AC84 HCT 116 C317(1.47)  LDD0667  [22]
 LDCM0351  AC85 HCT 116 C317(1.19)  LDD0668  [22]
 LDCM0352  AC86 HCT 116 C317(1.14)  LDD0669  [22]
 LDCM0353  AC87 HCT 116 C317(1.05)  LDD0670  [22]
 LDCM0354  AC88 HCT 116 C317(1.13)  LDD0671  [22]
 LDCM0355  AC89 HCT 116 C317(1.56)  LDD0672  [22]
 LDCM0357  AC90 HCT 116 C317(1.06)  LDD0674  [22]
 LDCM0358  AC91 HCT 116 C317(1.77)  LDD0675  [22]
 LDCM0359  AC92 HCT 116 C317(1.56)  LDD0676  [22]
 LDCM0360  AC93 HCT 116 C317(1.18)  LDD0677  [22]
 LDCM0361  AC94 HCT 116 C317(1.23)  LDD0678  [22]
 LDCM0362  AC95 HCT 116 C317(1.34)  LDD0679  [22]
 LDCM0363  AC96 HCT 116 C317(1.35)  LDD0680  [22]
 LDCM0364  AC97 HCT 116 C317(1.56)  LDD0681  [22]
 LDCM0365  AC98 HCT 116 C317(1.28)  LDD0682  [22]
 LDCM0366  AC99 HCT 116 C317(0.90)  LDD0683  [22]
 LDCM0248  AKOS034007472 HEK-293T C413(1.01); C86(1.13); C368(1.08); C317(1.06)  LDD1511  [21]
 LDCM0356  AKOS034007680 HEK-293T C413(0.85); C86(1.00); C368(1.03); C317(1.11)  LDD1570  [21]
 LDCM0275  AKOS034007705 HEK-293T C413(0.95); C86(1.02); C368(1.12); C317(1.11)  LDD1514  [21]
 LDCM0156  Aniline NCI-H1299 12.77  LDD0403  [4]
 LDCM0632  CL-Sc Hep-G2 C86(1.34); C86(0.94); C368(0.79); C317(0.49)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C317(1.27)  LDD0684  [22]
 LDCM0368  CL10 HCT 116 C317(1.19)  LDD0685  [22]
 LDCM0369  CL100 HEK-293T C413(0.88); C86(0.92); C368(1.00); C317(3.85)  LDD1573  [21]
 LDCM0370  CL101 HEK-293T C413(0.93); C86(1.42); C368(1.03); C317(3.69)  LDD1574  [21]
 LDCM0371  CL102 HEK-293T C413(1.14); C86(1.16); C368(1.34); C317(7.27)  LDD1575  [21]
 LDCM0372  CL103 HEK-293T C413(0.89); C86(1.19); C368(1.12); C317(1.60)  LDD1576  [21]
 LDCM0373  CL104 HEK-293T C413(1.02); C86(1.06); C368(1.27); C317(3.38)  LDD1577  [21]
 LDCM0374  CL105 HCT 116 C317(1.35)  LDD0691  [22]
 LDCM0375  CL106 HCT 116 C317(1.64)  LDD0692  [22]
 LDCM0376  CL107 HCT 116 C317(1.40)  LDD0693  [22]
 LDCM0377  CL108 HCT 116 C317(1.53)  LDD0694  [22]
 LDCM0378  CL109 HCT 116 C317(1.30)  LDD0695  [22]
 LDCM0379  CL11 HCT 116 C317(1.39)  LDD0696  [22]
 LDCM0380  CL110 HCT 116 C317(1.21)  LDD0697  [22]
 LDCM0381  CL111 HCT 116 C317(1.27)  LDD0698  [22]
 LDCM0382  CL112 HEK-293T C413(0.76); C86(0.92); C368(0.93); C317(3.73)  LDD1586  [21]
 LDCM0383  CL113 HEK-293T C413(0.94); C86(0.98); C368(1.09); C317(0.97)  LDD1587  [21]
 LDCM0384  CL114 HEK-293T C413(0.92); C86(0.91); C368(1.11); C317(6.70)  LDD1588  [21]
 LDCM0385  CL115 HEK-293T C413(0.94); C86(0.98); C368(1.09); C317(1.54)  LDD1589  [21]
 LDCM0386  CL116 HEK-293T C413(0.96); C86(1.12); C368(1.15); C317(1.32)  LDD1590  [21]
 LDCM0387  CL117 HCT 116 C317(1.28)  LDD0704  [22]
 LDCM0388  CL118 HCT 116 C317(1.42)  LDD0705  [22]
 LDCM0389  CL119 HCT 116 C317(1.28)  LDD0706  [22]
 LDCM0390  CL12 HCT 116 C317(1.12)  LDD0707  [22]
 LDCM0391  CL120 HCT 116 C317(1.21)  LDD0708  [22]
 LDCM0392  CL121 HEK-293T C413(0.94); C86(0.68); C368(1.04); C317(3.24)  LDD1596  [21]
 LDCM0393  CL122 HEK-293T C413(1.15); C86(1.07); C368(1.19); C317(4.36)  LDD1597  [21]
 LDCM0394  CL123 HEK-293T C413(1.21); C86(1.06); C368(1.24); C317(3.55)  LDD1598  [21]
 LDCM0395  CL124 HEK-293T C413(1.03); C86(1.01); C368(1.11); C317(4.40)  LDD1599  [21]
 LDCM0396  CL125 HCT 116 C317(0.92)  LDD0713  [22]
 LDCM0397  CL126 HCT 116 C317(1.59)  LDD0714  [22]
 LDCM0398  CL127 HCT 116 C317(1.03)  LDD0715  [22]
 LDCM0399  CL128 HCT 116 C317(1.31)  LDD0716  [22]
 LDCM0400  CL13 HCT 116 C317(1.56)  LDD0717  [22]
 LDCM0401  CL14 HCT 116 C317(1.24)  LDD0718  [22]
 LDCM0402  CL15 HCT 116 C317(1.22)  LDD0719  [22]
 LDCM0403  CL16 HCT 116 C317(1.17)  LDD0720  [22]
 LDCM0404  CL17 HCT 116 C317(1.38)  LDD0721  [22]
 LDCM0405  CL18 HCT 116 C317(0.92)  LDD0722  [22]
 LDCM0406  CL19 HCT 116 C317(0.98)  LDD0723  [22]
 LDCM0407  CL2 HCT 116 C317(1.21)  LDD0724  [22]
 LDCM0408  CL20 HCT 116 C317(1.12)  LDD0725  [22]
 LDCM0409  CL21 HCT 116 C317(1.36)  LDD0726  [22]
 LDCM0410  CL22 HCT 116 C317(1.21)  LDD0727  [22]
 LDCM0411  CL23 HCT 116 C317(1.02)  LDD0728  [22]
 LDCM0412  CL24 HCT 116 C317(1.08)  LDD0729  [22]
 LDCM0413  CL25 HCT 116 C317(1.15)  LDD0730  [22]
 LDCM0414  CL26 HCT 116 C317(1.11)  LDD0731  [22]
 LDCM0415  CL27 HCT 116 C317(1.00)  LDD0732  [22]
 LDCM0416  CL28 HCT 116 C317(1.14)  LDD0733  [22]
 LDCM0417  CL29 HCT 116 C317(1.00)  LDD0734  [22]
 LDCM0418  CL3 HCT 116 C317(1.28)  LDD0735  [22]
 LDCM0419  CL30 HCT 116 C317(1.04)  LDD0736  [22]
 LDCM0420  CL31 HEK-293T C413(1.23); C86(1.16); C368(1.36); C317(2.16)  LDD1624  [21]
 LDCM0421  CL32 HEK-293T C413(1.59); C86(1.29); C368(1.54); C317(3.77)  LDD1625  [21]
 LDCM0422  CL33 HEK-293T C413(1.17); C86(1.04); C368(1.18); C317(3.58)  LDD1626  [21]
 LDCM0423  CL34 HEK-293T C413(1.55); C86(1.28); C368(1.40); C317(4.50)  LDD1627  [21]
 LDCM0424  CL35 HEK-293T C413(1.78); C86(1.10); C368(1.22); C317(1.85)  LDD1628  [21]
 LDCM0425  CL36 HEK-293T C413(1.79); C86(1.17); C368(1.37); C317(4.86)  LDD1629  [21]
 LDCM0426  CL37 HEK-293T C413(1.20); C86(1.03); C368(1.45); C317(4.94)  LDD1630  [21]
 LDCM0428  CL39 HEK-293T C413(1.43); C86(1.35); C368(1.67); C317(4.70)  LDD1632  [21]
 LDCM0429  CL4 HCT 116 C317(1.25)  LDD0746  [22]
 LDCM0430  CL40 HEK-293T C413(0.95); C86(1.16); C368(1.10); C317(0.99)  LDD1634  [21]
 LDCM0431  CL41 HEK-293T C413(0.80); C86(1.03); C368(0.96); C317(4.89)  LDD1635  [21]
 LDCM0432  CL42 HEK-293T C413(1.19); C86(1.05); C368(0.93); C317(1.19)  LDD1636  [21]
 LDCM0433  CL43 HEK-293T C413(1.66); C86(1.38); C368(1.70); C317(3.11)  LDD1637  [21]
 LDCM0434  CL44 HEK-293T C413(1.02); C86(1.03); C368(1.16); C317(1.97)  LDD1638  [21]
 LDCM0435  CL45 HEK-293T C413(1.26); C86(1.09); C368(1.28); C317(3.43)  LDD1639  [21]
 LDCM0436  CL46 HEK-293T C413(1.58); C86(1.27); C368(1.45); C317(4.02)  LDD1640  [21]
 LDCM0437  CL47 HEK-293T C413(2.58); C86(1.56); C368(1.86); C317(4.24)  LDD1641  [21]
 LDCM0438  CL48 HEK-293T C413(1.85); C86(1.10); C368(1.27); C317(1.78)  LDD1642  [21]
 LDCM0439  CL49 HEK-293T C413(1.17); C86(0.99); C368(1.36); C317(2.10)  LDD1643  [21]
 LDCM0440  CL5 HCT 116 C317(1.13)  LDD0757  [22]
 LDCM0441  CL50 HEK-293T C413(0.92); C86(1.01); C368(1.10); C317(5.86)  LDD1645  [21]
 LDCM0443  CL52 HEK-293T C413(1.03); C86(1.19); C368(1.26); C317(1.74)  LDD1646  [21]
 LDCM0444  CL53 HEK-293T C413(0.92); C86(0.91); C368(1.19); C317(4.94)  LDD1647  [21]
 LDCM0445  CL54 HEK-293T C413(1.14); C86(0.95); C368(1.05); C317(3.63)  LDD1648  [21]
 LDCM0446  CL55 HEK-293T C413(0.94); C86(1.10); C368(1.17); C317(1.23)  LDD1649  [21]
 LDCM0447  CL56 HEK-293T C413(1.73); C86(1.43); C368(1.61); C317(3.84)  LDD1650  [21]
 LDCM0448  CL57 HEK-293T C413(1.34); C86(1.20); C368(1.39); C317(3.72)  LDD1651  [21]
 LDCM0449  CL58 HEK-293T C413(2.13); C86(1.50); C368(2.07); C317(4.11)  LDD1652  [21]
 LDCM0450  CL59 HEK-293T C413(1.51); C86(1.06); C368(1.29); C317(2.12)  LDD1653  [21]
 LDCM0451  CL6 HCT 116 C317(1.14)  LDD0768  [22]
 LDCM0452  CL60 HEK-293T C413(1.71); C86(1.10); C368(1.44); C317(4.80)  LDD1655  [21]
 LDCM0453  CL61 HEK-293T C413(0.95); C86(1.12); C368(1.18); C317(0.96)  LDD1656  [21]
 LDCM0454  CL62 HEK-293T C413(1.51); C86(1.28); C368(1.85); C317(6.47)  LDD1657  [21]
 LDCM0455  CL63 HEK-293T C413(0.84); C86(1.02); C368(1.02); C317(1.74)  LDD1658  [21]
 LDCM0456  CL64 HEK-293T C413(0.92); C86(0.96); C368(1.04); C317(3.86)  LDD1659  [21]
 LDCM0457  CL65 HEK-293T C413(0.88); C86(1.06); C368(1.06); C317(1.18)  LDD1660  [21]
 LDCM0458  CL66 HEK-293T C413(1.12); C86(1.04); C368(0.99); C317(3.80)  LDD1661  [21]
 LDCM0459  CL67 HEK-293T C413(0.86); C86(1.02); C368(1.05); C317(1.02)  LDD1662  [21]
 LDCM0460  CL68 HEK-293T C413(1.42); C86(1.28); C368(1.56); C317(3.83)  LDD1663  [21]
 LDCM0461  CL69 HEK-293T C413(1.33); C86(1.16); C368(1.27); C317(3.72)  LDD1664  [21]
 LDCM0462  CL7 HCT 116 C317(1.35)  LDD0779  [22]
 LDCM0463  CL70 HEK-293T C413(1.23); C86(1.11); C368(1.21); C317(1.96)  LDD1666  [21]
 LDCM0464  CL71 HEK-293T C413(1.16); C86(0.90); C368(1.00); C317(3.47)  LDD1667  [21]
 LDCM0465  CL72 HEK-293T C413(1.35); C86(1.00); C368(1.26); C317(1.47)  LDD1668  [21]
 LDCM0466  CL73 HEK-293T C413(1.00); C86(0.77); C368(1.17); C317(4.15)  LDD1669  [21]
 LDCM0467  CL74 HEK-293T C413(0.85); C86(0.95); C368(0.92); C317(2.62)  LDD1670  [21]
 LDCM0469  CL76 HEK-293T C413(1.38); C86(1.34); C368(1.60); C317(3.53)  LDD1672  [21]
 LDCM0470  CL77 HEK-293T C413(0.94); C86(0.98); C368(1.00); C317(5.57)  LDD1673  [21]
 LDCM0471  CL78 HEK-293T C413(1.00); C86(1.07); C368(0.96); C317(1.06)  LDD1674  [21]
 LDCM0472  CL79 HEK-293T C413(1.22); C86(1.21); C368(1.27); C317(1.84)  LDD1675  [21]
 LDCM0473  CL8 HCT 116 C317(1.30)  LDD0790  [22]
 LDCM0474  CL80 HEK-293T C413(1.06); C86(1.04); C368(1.07); C317(1.05)  LDD1677  [21]
 LDCM0475  CL81 HEK-293T C413(1.11); C86(1.03); C368(1.13); C317(2.25)  LDD1678  [21]
 LDCM0476  CL82 HEK-293T C413(1.47); C86(1.23); C368(1.42); C317(2.35)  LDD1679  [21]
 LDCM0477  CL83 HEK-293T C413(1.53); C86(1.18); C368(1.33); C317(2.96)  LDD1680  [21]
 LDCM0478  CL84 HEK-293T C413(1.25); C86(0.94); C368(1.21); C317(5.10)  LDD1681  [21]
 LDCM0479  CL85 HEK-293T C413(1.14); C86(0.69); C368(1.32); C317(1.41)  LDD1682  [21]
 LDCM0480  CL86 HEK-293T C413(1.50); C86(1.18); C368(1.62); C317(4.49)  LDD1683  [21]
 LDCM0481  CL87 HEK-293T C413(1.27); C86(1.20); C368(1.55); C317(4.58)  LDD1684  [21]
 LDCM0482  CL88 HEK-293T C413(1.05); C86(1.13); C368(1.16); C317(1.35)  LDD1685  [21]
 LDCM0483  CL89 HEK-293T C413(1.09); C86(1.01); C368(1.20); C317(1.53)  LDD1686  [21]
 LDCM0484  CL9 HCT 116 C317(1.72)  LDD0801  [22]
 LDCM0485  CL90 HEK-293T C413(1.16); C86(1.06); C368(1.00); C317(3.84)  LDD1688  [21]
 LDCM0486  CL91 HEK-293T C413(1.39); C86(1.32); C368(1.42); C317(2.51)  LDD1689  [21]
 LDCM0487  CL92 HEK-293T C413(1.43); C86(1.13); C368(1.50); C317(3.89)  LDD1690  [21]
 LDCM0488  CL93 HEK-293T C413(1.43); C86(1.22); C368(1.48); C317(4.24)  LDD1691  [21]
 LDCM0489  CL94 HEK-293T C413(1.39); C86(1.19); C368(1.41); C317(4.24)  LDD1692  [21]
 LDCM0490  CL95 HEK-293T C413(1.21); C86(0.75); C368(1.05); C317(4.27)  LDD1693  [21]
 LDCM0491  CL96 HEK-293T C413(1.33); C86(0.91); C368(1.30); C317(6.19)  LDD1694  [21]
 LDCM0492  CL97 HEK-293T C413(0.97); C86(0.96); C368(1.14); C317(4.48)  LDD1695  [21]
 LDCM0493  CL98 HEK-293T C413(1.25); C86(1.23); C368(1.40); C317(6.42)  LDD1696  [21]
 LDCM0494  CL99 HEK-293T C413(1.20); C86(1.27); C368(1.26); C317(1.75)  LDD1697  [21]
 LDCM0495  E2913 HEK-293T C413(1.42); C86(1.26); C368(1.82); C317(4.31)  LDD1698  [21]
 LDCM0625  F8 Ramos C86(1.43); C368(0.82)  LDD2187  [23]
 LDCM0572  Fragment10 MDA-MB-231 C317(1.45)  LDD1465  [8]
 LDCM0573  Fragment11 MDA-MB-231 C317(0.94)  LDD1467  [8]
 LDCM0574  Fragment12 MDA-MB-231 C317(3.24)  LDD1468  [8]
 LDCM0575  Fragment13 MDA-MB-231 C317(1.29)  LDD1469  [8]
 LDCM0576  Fragment14 MDA-MB-231 C317(1.11)  LDD1471  [8]
 LDCM0579  Fragment20 Ramos C86(1.05); C368(2.68)  LDD2194  [23]
 LDCM0580  Fragment21 MDA-MB-231 C317(1.51)  LDD1473  [8]
 LDCM0582  Fragment23 Ramos C86(0.82); C368(1.40)  LDD2196  [23]
 LDCM0578  Fragment27 MDA-MB-231 C317(2.04)  LDD1474  [8]
 LDCM0586  Fragment28 MDA-MB-231 C317(1.13)  LDD1475  [8]
 LDCM0587  Fragment29 Ramos C317(1.17)  LDD1476  [8]
 LDCM0588  Fragment30 Ramos C86(1.60); C368(1.12)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C86(1.09); C368(0.96)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C86(0.94); C368(1.83)  LDD2201  [23]
 LDCM0468  Fragment33 MDA-MB-231 C317(2.31)  LDD1479  [8]
 LDCM0596  Fragment38 MDA-MB-231 C317(2.41)  LDD1480  [8]
 LDCM0566  Fragment4 MDA-MB-231 C317(14.36)  LDD1461  [8]
 LDCM0599  Fragment41 MDA-MB-231 C317(0.81)  LDD1481  [8]
 LDCM0603  Fragment45 MDA-MB-231 C317(2.58)  LDD1482  [8]
 LDCM0427  Fragment51 HEK-293T C413(1.69); C86(1.36); C368(1.90); C317(6.06)  LDD1631  [21]
 LDCM0610  Fragment52 Ramos C86(1.81); C368(1.01)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C86(1.43); C368(0.93)  LDD2205  [23]
 LDCM0615  Fragment63-R Jurkat _(4.80)  LDD1487  [8]
 LDCM0569  Fragment7 Ramos C86(1.05); C368(0.86)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C317(2.61)  LDD1464  [8]
 LDCM0167  HOIPIN 11a HEK-293T 2.43  LDD0423  [5]
 LDCM0022  KB02 MDA-MB-231 C317(10.27)  LDD1460  [8]
 LDCM0023  KB03 Jurkat C368(6.47)  LDD0209  [9]
 LDCM0024  KB05 G361 C317(3.83)  LDD3311  [24]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C368(1.16)  LDD2090  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C368(0.94)  LDD2127  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C368(2.23)  LDD2153  [6]
 LDCM0003  Sulforaphane MCF-7 3.50  LDD0042  [7]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP. J Am Chem Soc. 2019 Feb 13;141(6):2703-2712. doi: 10.1021/jacs.8b13193. Epub 2019 Feb 4.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
8 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
9 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840