Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment28  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cells (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 34 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP03163  Sterol carrier protein 2 (SCP2) C94 20.0
 LDTP02502  Thioredoxin (TXN) C32 20.0
 LDTP03770  Alpha-adducin (ADD1) C68 1.7
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C57 1.6
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 1.4
 LDTP03786  Glutaredoxin-1 (GLRX) C23 1.4
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.3
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 1.2
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) C317 1.1
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.1
 LDTP10785  Ubiquitin carboxyl-terminal hydrolase 28 (USP28) C171 1.1
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 1.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.0
 LDTP18330  Haloacid dehalogenase-like hydrolase domain-containing 5 (HDHD5) C392 1.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.0
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) C223 1.0
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 1.0
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C758 1.0
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.8
 LDTP18123  Isochorismatase domain-containing protein 2 (ISOC2) C114 0.8
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 0.8
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 0.8
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 0.8
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 0.8
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 0.8
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 0.7
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 0.7
 LDTP01220  Mitochondrial-processing peptidase subunit beta (PMPCB) C265 0.6
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 0.6
 LDTP19750  RNA ligase 1 (RLIG1) C302 0.6
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 0.5
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 0.4
 LDTP03258  Thymidylate kinase (DTYMK) C163 0.4
Transporter and channel
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 2.7
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 1.3
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) C65 1.2
Transcription factor
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.1
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 0.9
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 0.9
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 0.8
Other
Click to Show/Hide to Show 29 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 1.7
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.1
 LDTP11235  Protein PAXX (PAXX) C180 1.1
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.1
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 1.0
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 1.0
 LDTP05867  Treacle protein (TCOF1) C38 1.0
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 1.0
 LDTP06276  MAD2L1-binding protein (MAD2L1BP) C124 1.0
 LDTP13583  Targeting protein for Xklp2 (TPX2) C536 1.0
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 0.9
 LDTP05867  Treacle protein (TCOF1) C1298 0.9
 LDTP15896  Ashwin (C2orf49) C10 0.9
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 0.9
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 0.9
 LDTP12443  Anillin (ANLN) C712 0.9
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C439 0.9
 LDTP10864  Calponin-2 (CNN2) C164 0.9
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 0.8
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 0.8
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 0.8
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 0.8
 LDTP13580  Coronin-1C (CORO1C) C420 0.7
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 0.7
 LDTP14250  Cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1) C51 0.7
 LDTP18494  Tropomodulin-3 (TMOD3) C132 0.7
 LDTP01532  ZW10 interactor (ZWINT) C54 0.7
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 0.7
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 0.7

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.