Details of the Target

General Information of Target

Target ID LDTP06314
Target Name Protein disulfide-isomerase A6 (PDIA6)
Gene Name PDIA6
Gene ID 10130
Synonyms
ERP5; P5; TXNDC7; Protein disulfide-isomerase A6; EC 5.3.4.1; Endoplasmic reticulum protein 5; ER protein 5; ERp5; Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALLVLGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQR
LTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTG
EAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDV
WMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTI
KIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVA
VLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMA
AINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELP
VEDDIDLSDVELDDLGKDEL
Target Bioclass
Enzyme
Family
Protein disulfide isomerase family
Subcellular location
Endoplasmic reticulum lumen
Function
May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.
Uniprot ID
Q15084
Ensemble ID
ENST00000272227.8
HGNC ID
HGNC:30168
ChEMBL ID
CHEMBL2146308

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HUH1 SNV: p.S377G .
MM1S SNV: p.D167E .
NCIH1155 SNV: p.A127V .
NCIH446 SNV: p.A360S .
SKMEL30 SNV: p.P99L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.64  LDD0402  [1]
P8
 Probe Info  		10.00  LDD0451  [2]
A-EBA
 Probe Info  		3.45  LDD0215  [3]
DAyne
 Probe Info  		3.03  LDD0261  [4]
W1
 Probe Info  		22.13  LDD0235  [5]
TH211
 Probe Info  		Y146(14.69)  LDD0260  [6]
YN-1
 Probe Info  		18.68  LDD0444  [7]
YN-4
 Probe Info  		100.00  LDD0445  [7]
STPyne
 Probe Info  		K108(9.02); K150(7.63); K208(5.56); K212(1.59)  LDD0277  [8]
ONAyne
 Probe Info  		K66(0.00); K150(0.00); K73(0.00); K245(0.00)  LDD0273  [8]
OPA-S-S-alkyne
 Probe Info  		K245(1.95); K150(4.09)  LDD3494  [9]
Probe 1
 Probe Info  		Y114(55.61); Y146(55.97); Y252(16.23)  LDD3495  [10]
P12
 Probe Info  		16.45  LDD0202  [11]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [12]
THZ1-DTB
 Probe Info  		C297(1.01); C55(0.99); C58(0.95)  LDD0460  [12]
AHL-Pu-1
 Probe Info  		C193(4.67); C190(2.11)  LDD0170  [13]
DBIA
 Probe Info  		C190(9.42); C190(4.45)  LDD0209  [14]
HHS-475
 Probe Info  		Y146(0.97)  LDD0264  [15]
IPM
 Probe Info  		C55(0.98)  LDD1702  [16]
Acrolein
 Probe Info  		H87(0.00); H304(0.00)  LDD0221  [17]
5E-2FA
 Probe Info  		H86(0.00); H304(0.00); H294(0.00); H87(0.00)  LDD2235  [18]
ATP probe
 Probe Info  		K85(0.00); K208(0.00); K212(0.00); K245(0.00)  LDD0199  [19]
4-Iodoacetamidophenylacetylene
 Probe Info  		C291(0.00); C297(0.00)  LDD0038  [20]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [21]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [22]
Lodoacetamide azide
 Probe Info  		C55(0.00); C58(0.00); C291(0.00); C297(0.00)  LDD0037  [20]
ATP probe
 Probe Info  		K373(0.00); K216(0.00); K150(0.00); K73(0.00)  LDD0035  [23]
1d-yne
 Probe Info  		N.A.  LDD0356  [24]
NHS
 Probe Info  		K160(0.00); K85(0.00); K208(0.00); K245(0.00)  LDD0010  [25]
SF
 Probe Info  		K150(0.00); K326(0.00)  LDD0028  [26]
Phosphinate-6
 Probe Info  		C55(0.00); C58(0.00); C190(0.00)  LDD0018  [27]
Ox-W18
 Probe Info  		W65(0.00); W200(0.00)  LDD2175  [28]
1c-yne
 Probe Info  		K245(0.00); K160(0.00); K102(0.00); K288(0.00)  LDD0228  [24]
NAIA_5
 Probe Info  		C297(0.00); C291(0.00)  LDD2223  [29]
TPP-AC
 Probe Info  		N.A.  LDD0427  [30]
HHS-465
 Probe Info  		K150(0.00); K368(0.00); Y146(0.00)  LDD2240  [31]
HHS-482
 Probe Info  		Y146(0.69); Y316(0.50)  LDD2239  [32]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		6.45  LDD0475  [33]
FFF probe2
 Probe Info  		5.12  LDD0463  [33]
FFF probe3
 Probe Info  		6.11  LDD0464  [33]
JN0003
 Probe Info  		6.87  LDD0469  [33]
DA-2
 Probe Info  		N.A.  LDD0070  [34]
OEA-DA
 Probe Info  		3.10  LDD0046  [35]
STS-1
 Probe Info  		N.A.  LDD0069  [36]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C193(4.67); C190(2.11)  LDD0170  [13]
 LDCM0026  4SU-RNA+native RNA DM93 C190(3.85)  LDD0171  [13]
 LDCM0214  AC1 HEK-293T C190(1.14); C55(1.13); C190(1.08); C193(1.08)  LDD1507  [37]
 LDCM0215  AC10 HEK-293T C190(1.11); C297(1.02); C55(0.93); C190(1.05)  LDD1508  [37]
 LDCM0226  AC11 HEK-293T C190(1.04); C291(0.97); C297(1.03); C55(0.96)  LDD1509  [37]
 LDCM0237  AC12 HEK-293T C190(1.00); C291(0.85); C55(0.97); C190(1.04)  LDD1510  [37]
 LDCM0259  AC14 HEK-293T C190(0.97); C193(1.03); C291(0.94); C55(0.98)  LDD1512  [37]
 LDCM0270  AC15 HEK-293T C190(0.94); C193(1.14); C291(0.97); C297(0.96)  LDD1513  [37]
 LDCM0276  AC17 HEK-293T C190(1.07); C55(1.03); C190(0.84); C193(0.84)  LDD1515  [37]
 LDCM0277  AC18 HEK-293T C190(1.06); C297(1.19); C55(0.97); C190(1.15)  LDD1516  [37]
 LDCM0278  AC19 HEK-293T C190(0.95); C291(1.09); C297(0.94); C55(0.80)  LDD1517  [37]
 LDCM0279  AC2 HEK-293T C190(1.07); C297(1.01); C55(1.14); C190(1.22)  LDD1518  [37]
 LDCM0280  AC20 HEK-293T C190(1.01); C291(0.82); C55(1.07); C190(1.08)  LDD1519  [37]
 LDCM0281  AC21 HEK-293T C190(1.02); C291(1.10); C297(1.02); C55(0.89)  LDD1520  [37]
 LDCM0282  AC22 HEK-293T C190(0.94); C193(1.11); C291(0.89); C55(1.09)  LDD1521  [37]
 LDCM0283  AC23 HEK-293T C190(0.97); C193(1.06); C291(1.03); C297(1.02)  LDD1522  [37]
 LDCM0284  AC24 HEK-293T C190(0.97); C193(0.87); C291(0.96); C297(0.97)  LDD1523  [37]
 LDCM0285  AC25 HEK-293T C190(1.09); C55(1.07); C190(0.77); C193(0.77)  LDD1524  [37]
 LDCM0286  AC26 HEK-293T C190(1.02); C297(1.10); C55(1.25); C190(1.01)  LDD1525  [37]
 LDCM0287  AC27 HEK-293T C190(1.04); C291(1.03); C297(0.96); C55(0.92)  LDD1526  [37]
 LDCM0288  AC28 HEK-293T C190(0.99); C291(0.99); C55(0.96); C190(1.03)  LDD1527  [37]
 LDCM0289  AC29 HEK-293T C190(0.95); C291(1.02); C297(0.96); C55(0.87)  LDD1528  [37]
 LDCM0290  AC3 HEK-293T C190(1.17); C291(1.08); C297(1.11); C55(1.04)  LDD1529  [37]
 LDCM0291  AC30 HEK-293T C190(0.99); C193(1.11); C291(0.91); C55(1.03)  LDD1530  [37]
 LDCM0292  AC31 HEK-293T C190(0.99); C193(1.23); C291(1.04); C297(1.11)  LDD1531  [37]
 LDCM0293  AC32 HEK-293T C190(0.97); C193(1.11); C291(1.00); C297(1.21)  LDD1532  [37]
 LDCM0294  AC33 HEK-293T C190(1.07); C55(1.10); C190(0.89); C193(0.89)  LDD1533  [37]
 LDCM0295  AC34 HEK-293T C190(1.03); C297(1.12); C55(1.15); C190(0.99)  LDD1534  [37]
 LDCM0296  AC35 HEK-293T C190(1.03); C291(1.15); C297(1.00); C55(1.04)  LDD1535  [37]
 LDCM0297  AC36 HEK-293T C190(1.03); C291(0.93); C55(1.08); C190(1.09)  LDD1536  [37]
 LDCM0298  AC37 HEK-293T C190(0.87); C291(1.06); C297(0.90); C55(0.87)  LDD1537  [37]
 LDCM0299  AC38 HEK-293T C190(0.91); C193(1.05); C291(0.96); C55(1.03)  LDD1538  [37]
 LDCM0300  AC39 HEK-293T C190(0.95); C193(1.16); C291(0.88); C297(1.14)  LDD1539  [37]
 LDCM0301  AC4 HEK-293T C190(1.07); C291(1.02); C55(1.17); C190(1.13)  LDD1540  [37]
 LDCM0302  AC40 HEK-293T C190(0.95); C193(0.88); C291(1.01); C297(1.02)  LDD1541  [37]
 LDCM0303  AC41 HEK-293T C190(1.09); C55(1.06); C190(1.03); C193(1.03)  LDD1542  [37]
 LDCM0304  AC42 HEK-293T C190(1.07); C297(1.00); C55(1.15); C190(1.01)  LDD1543  [37]
 LDCM0305  AC43 HEK-293T C190(1.07); C291(0.89); C297(1.03); C55(1.03)  LDD1544  [37]
 LDCM0306  AC44 HEK-293T C190(1.02); C291(0.93); C55(1.04); C190(0.98)  LDD1545  [37]
 LDCM0307  AC45 HEK-293T C190(1.02); C291(0.99); C297(1.06); C55(1.00)  LDD1546  [37]
 LDCM0308  AC46 HEK-293T C190(0.95); C193(0.96); C291(0.90); C55(0.96)  LDD1547  [37]
 LDCM0309  AC47 HEK-293T C190(0.97); C193(1.31); C291(0.88); C297(1.31)  LDD1548  [37]
 LDCM0310  AC48 HEK-293T C190(1.04); C193(0.93); C291(0.93); C297(1.10)  LDD1549  [37]
 LDCM0311  AC49 HEK-293T C190(1.13); C55(1.15); C190(0.93); C193(0.93)  LDD1550  [37]
 LDCM0312  AC5 HEK-293T C190(0.98); C291(1.06); C297(1.11); C55(0.85)  LDD1551  [37]
 LDCM0313  AC50 HEK-293T C190(1.06); C297(1.34); C55(1.02); C190(0.95)  LDD1552  [37]
 LDCM0314  AC51 HEK-293T C190(1.07); C291(1.10); C297(1.26); C55(0.92)  LDD1553  [37]
 LDCM0315  AC52 HEK-293T C190(0.99); C291(0.89); C55(0.99); C190(1.07)  LDD1554  [37]
 LDCM0316  AC53 HEK-293T C190(1.00); C291(1.13); C297(0.94); C55(0.92)  LDD1555  [37]
 LDCM0317  AC54 HEK-293T C190(0.96); C193(1.11); C291(0.96); C55(1.04)  LDD1556  [37]
 LDCM0318  AC55 HEK-293T C190(0.99); C193(1.12); C291(0.98); C297(1.13)  LDD1557  [37]
 LDCM0319  AC56 HEK-293T C190(0.97); C193(1.10); C291(0.92); C297(1.22)  LDD1558  [37]
 LDCM0320  AC57 HEK-293T C190(1.10); C55(1.06); C190(1.12); C193(1.12)  LDD1559  [37]
 LDCM0321  AC58 HEK-293T C190(1.03); C297(1.15); C55(0.93); C190(0.96)  LDD1560  [37]
 LDCM0322  AC59 HEK-293T C190(1.02); C291(1.12); C297(1.12); C55(0.92)  LDD1561  [37]
 LDCM0323  AC6 HEK-293T C190(1.02); C193(1.01); C291(0.95); C55(0.98)  LDD1562  [37]
 LDCM0324  AC60 HEK-293T C190(1.05); C291(0.97); C55(1.15); C190(1.07)  LDD1563  [37]
 LDCM0325  AC61 HEK-293T C190(1.01); C291(1.05); C297(1.07); C55(1.09)  LDD1564  [37]
 LDCM0326  AC62 HEK-293T C190(0.97); C193(1.14); C291(0.95); C55(1.11)  LDD1565  [37]
 LDCM0327  AC63 HEK-293T C190(0.99); C193(1.18); C291(0.98); C297(0.90)  LDD1566  [37]
 LDCM0328  AC64 HEK-293T C190(1.03); C193(1.20); C291(1.03); C297(1.05)  LDD1567  [37]
 LDCM0334  AC7 HEK-293T C190(0.99); C193(1.15); C291(0.93); C297(0.93)  LDD1568  [37]
 LDCM0345  AC8 HEK-293T C190(1.01); C193(1.05); C291(1.06); C297(1.00)  LDD1569  [37]
 LDCM0248  AKOS034007472 HEK-293T C190(0.96); C291(1.02); C297(1.05); C55(0.84)  LDD1511  [37]
 LDCM0356  AKOS034007680 HEK-293T C190(1.07); C55(1.11); C190(0.90); C193(0.90)  LDD1570  [37]
 LDCM0275  AKOS034007705 HEK-293T C190(0.98); C193(0.87); C291(1.01); C297(0.99)  LDD1514  [37]
 LDCM0156  Aniline NCI-H1299 11.60  LDD0403  [1]
 LDCM0088  C45 HEK-293T 16.45  LDD0202  [11]
 LDCM0630  CCW28-3 231MFP C58(1.65); C193(1.59); C190(1.38); C55(1.23)  LDD2214  [38]
 LDCM0108  Chloroacetamide HeLa H87(0.00); C58(0.00)  LDD0222  [17]
 LDCM0367  CL1 HEK-293T C190(1.10); C55(1.01)  LDD1571  [37]
 LDCM0368  CL10 HEK-293T C190(1.72); C193(0.60); C291(0.63); C55(1.22)  LDD1572  [37]
 LDCM0369  CL100 HEK-293T C190(1.03); C297(1.01); C55(1.08); C190(1.06)  LDD1573  [37]
 LDCM0370  CL101 HEK-293T C190(1.14); C55(1.01)  LDD1574  [37]
 LDCM0371  CL102 HEK-293T C190(1.19); C297(1.14); C55(1.21); C190(1.22)  LDD1575  [37]
 LDCM0372  CL103 HEK-293T C190(1.05); C291(0.82); C55(0.99)  LDD1576  [37]
 LDCM0373  CL104 HEK-293T C190(0.97); C297(1.11); C55(1.14); C190(1.24)  LDD1577  [37]
 LDCM0374  CL105 HEK-293T C190(1.17); C55(1.03)  LDD1578  [37]
 LDCM0375  CL106 HEK-293T C190(1.00); C297(1.01); C55(1.06); C190(1.02)  LDD1579  [37]
 LDCM0376  CL107 HEK-293T C190(1.02); C291(0.94); C55(0.93)  LDD1580  [37]
 LDCM0377  CL108 HEK-293T C190(1.20); C297(1.13); C55(1.35); C190(1.37)  LDD1581  [37]
 LDCM0378  CL109 HEK-293T C190(1.06); C55(0.98)  LDD1582  [37]
 LDCM0379  CL11 HEK-293T C190(1.24); C193(1.37); C291(0.82); C297(0.74)  LDD1583  [37]
 LDCM0380  CL110 HEK-293T C190(1.17); C297(1.06); C55(1.19); C190(0.63)  LDD1584  [37]
 LDCM0381  CL111 HEK-293T C190(1.03); C291(1.06); C55(0.96)  LDD1585  [37]
 LDCM0382  CL112 HEK-293T C190(1.10); C297(1.10); C55(1.07); C190(1.11)  LDD1586  [37]
 LDCM0383  CL113 HEK-293T C190(1.05); C55(0.90)  LDD1587  [37]
 LDCM0384  CL114 HEK-293T C190(0.99); C297(1.04); C55(0.91); C190(1.04)  LDD1588  [37]
 LDCM0385  CL115 HEK-293T C190(1.30); C291(1.02); C55(1.34)  LDD1589  [37]
 LDCM0386  CL116 HEK-293T C190(1.05); C297(1.06); C55(1.11); C190(1.18)  LDD1590  [37]
 LDCM0387  CL117 HEK-293T C190(1.12); C55(0.89)  LDD1591  [37]
 LDCM0388  CL118 HEK-293T C190(1.03); C297(1.17); C55(1.05); C190(1.29)  LDD1592  [37]
 LDCM0389  CL119 HEK-293T C190(0.99); C291(0.99); C55(0.93)  LDD1593  [37]
 LDCM0390  CL12 HEK-293T C190(0.82); C193(0.72); C291(0.82); C297(0.78)  LDD1594  [37]
 LDCM0391  CL120 HEK-293T C190(1.02); C297(1.11); C55(0.96); C190(1.09)  LDD1595  [37]
 LDCM0392  CL121 HEK-293T C190(1.08); C55(1.12)  LDD1596  [37]
 LDCM0393  CL122 HEK-293T C190(1.12); C297(1.01); C55(1.17); C190(1.06)  LDD1597  [37]
 LDCM0394  CL123 HEK-293T C190(1.43); C291(0.94); C55(1.36)  LDD1598  [37]
 LDCM0395  CL124 HEK-293T C190(1.03); C297(1.13); C55(0.99); C190(1.08)  LDD1599  [37]
 LDCM0396  CL125 HEK-293T C190(1.07); C55(0.99)  LDD1600  [37]
 LDCM0397  CL126 HEK-293T C190(1.13); C297(1.26); C55(1.11); C190(1.11)  LDD1601  [37]
 LDCM0398  CL127 HEK-293T C190(1.18); C291(1.21); C55(1.08)  LDD1602  [37]
 LDCM0399  CL128 HEK-293T C190(1.11); C297(1.14); C55(1.29); C190(1.18)  LDD1603  [37]
 LDCM0400  CL13 HEK-293T C190(1.45); C55(1.51)  LDD1604  [37]
 LDCM0401  CL14 HEK-293T C190(1.38); C297(1.14); C55(1.41); C190(1.58)  LDD1605  [37]
 LDCM0402  CL15 HEK-293T C190(0.99); C291(0.87); C55(0.90)  LDD1606  [37]
 LDCM0403  CL16 HEK-293T C190(1.06); C297(0.94); C55(0.93); C190(1.01)  LDD1607  [37]
 LDCM0404  CL17 HEK-293T C190(1.17); C55(0.94); C190(1.03); C193(1.03)  LDD1608  [37]
 LDCM0405  CL18 HEK-293T C190(0.91); C297(0.85); C55(0.94); C190(0.95)  LDD1609  [37]
 LDCM0406  CL19 HEK-293T C190(0.93); C291(0.74); C297(0.93); C55(0.89)  LDD1610  [37]
 LDCM0407  CL2 HEK-293T C190(1.28); C297(1.19); C55(1.36); C190(1.30)  LDD1611  [37]
 LDCM0408  CL20 HEK-293T C190(0.91); C291(0.77); C55(0.83); C190(0.90)  LDD1612  [37]
 LDCM0409  CL21 HEK-293T C190(0.77); C291(0.73); C297(0.55); C55(0.72)  LDD1613  [37]
 LDCM0410  CL22 HEK-293T C190(0.94); C193(1.18); C291(0.67); C55(1.11)  LDD1614  [37]
 LDCM0411  CL23 HEK-293T C190(0.77); C193(1.18); C291(0.84); C297(0.75)  LDD1615  [37]
 LDCM0412  CL24 HEK-293T C190(0.82); C193(0.81); C291(0.81); C297(0.97)  LDD1616  [37]
 LDCM0413  CL25 HEK-293T C190(1.11); C55(0.87)  LDD1617  [37]
 LDCM0414  CL26 HEK-293T C190(1.08); C297(0.94); C55(0.99); C190(1.18)  LDD1618  [37]
 LDCM0415  CL27 HEK-293T C190(1.03); C291(1.14); C55(0.94)  LDD1619  [37]
 LDCM0416  CL28 HEK-293T C190(1.75); C297(0.87); C55(1.55); C190(1.68)  LDD1620  [37]
 LDCM0417  CL29 HEK-293T C190(0.96); C55(0.96); C190(1.04); C193(1.04)  LDD1621  [37]
 LDCM0418  CL3 HEK-293T C190(0.95); C291(0.99); C55(0.92)  LDD1622  [37]
 LDCM0419  CL30 HEK-293T C190(0.92); C297(0.89); C55(0.98); C190(0.90)  LDD1623  [37]
 LDCM0420  CL31 HEK-293T C190(1.19); C291(0.64); C297(0.84); C55(0.87)  LDD1624  [37]
 LDCM0421  CL32 HEK-293T C190(0.94); C291(0.79); C55(0.93); C190(0.92)  LDD1625  [37]
 LDCM0422  CL33 HEK-293T C190(0.97); C291(0.81); C297(0.64); C55(0.85)  LDD1626  [37]
 LDCM0423  CL34 HEK-293T C190(0.95); C193(1.59); C291(0.63); C55(0.89)  LDD1627  [37]
 LDCM0424  CL35 HEK-293T C190(0.76); C193(1.02); C291(0.74); C297(0.76)  LDD1628  [37]
 LDCM0425  CL36 HEK-293T C190(0.99); C193(0.92); C291(0.81); C297(0.91)  LDD1629  [37]
 LDCM0426  CL37 HEK-293T C190(1.02); C55(1.09)  LDD1630  [37]
 LDCM0428  CL39 HEK-293T C190(2.59); C291(1.02); C55(1.53)  LDD1632  [37]
 LDCM0429  CL4 HEK-293T C190(1.06); C297(0.92); C55(1.03); C190(0.96)  LDD1633  [37]
 LDCM0430  CL40 HEK-293T C190(0.97); C297(0.97); C55(1.16); C190(1.02)  LDD1634  [37]
 LDCM0431  CL41 HEK-293T C190(0.91); C55(0.84); C190(0.81); C193(0.81)  LDD1635  [37]
 LDCM0432  CL42 HEK-293T C190(0.97); C297(0.92); C55(0.78); C190(1.12)  LDD1636  [37]
 LDCM0433  CL43 HEK-293T C190(1.03); C291(0.86); C297(0.92); C55(0.92)  LDD1637  [37]
 LDCM0434  CL44 HEK-293T C190(0.89); C291(0.79); C55(0.88); C190(0.80)  LDD1638  [37]
 LDCM0435  CL45 HEK-293T C190(1.71); C291(0.77); C297(0.65); C55(1.15)  LDD1639  [37]
 LDCM0436  CL46 HEK-293T C190(1.03); C193(1.28); C291(0.67); C55(0.93)  LDD1640  [37]
 LDCM0437  CL47 HEK-293T C190(0.93); C193(1.04); C291(0.72); C297(0.79)  LDD1641  [37]
 LDCM0438  CL48 HEK-293T C190(0.81); C193(0.82); C291(0.82); C297(1.08)  LDD1642  [37]
 LDCM0439  CL49 HEK-293T C190(0.96); C55(1.05)  LDD1643  [37]
 LDCM0440  CL5 HEK-293T C190(1.07); C55(1.01); C190(0.86); C193(0.86)  LDD1644  [37]
 LDCM0441  CL50 HEK-293T C190(1.15); C297(0.74); C55(1.22); C190(1.16)  LDD1645  [37]
 LDCM0443  CL52 HEK-293T C190(0.94); C297(0.93); C55(0.86); C190(0.94)  LDD1646  [37]
 LDCM0444  CL53 HEK-293T C190(0.88); C55(0.92); C190(0.81); C193(0.81)  LDD1647  [37]
 LDCM0445  CL54 HEK-293T C190(1.39); C297(0.81); C55(1.20); C190(1.52)  LDD1648  [37]
 LDCM0446  CL55 HEK-293T C190(0.91); C291(0.74); C297(0.82); C55(0.93)  LDD1649  [37]
 LDCM0447  CL56 HEK-293T C190(1.47); C291(0.82); C55(1.17); C190(1.22)  LDD1650  [37]
 LDCM0448  CL57 HEK-293T C190(1.70); C291(0.89); C297(0.76); C55(0.98)  LDD1651  [37]
 LDCM0449  CL58 HEK-293T C190(0.95); C193(1.05); C291(0.64); C55(0.86)  LDD1652  [37]
 LDCM0450  CL59 HEK-293T C190(0.80); C193(1.10); C291(0.83); C297(0.76)  LDD1653  [37]
 LDCM0451  CL6 HEK-293T C190(0.89); C297(0.76); C55(0.78); C190(0.79)  LDD1654  [37]
 LDCM0452  CL60 HEK-293T C190(0.99); C193(0.92); C291(0.82); C297(0.81)  LDD1655  [37]
 LDCM0453  CL61 HEK-293T C190(0.98); C55(0.71)  LDD1656  [37]
 LDCM0454  CL62 HEK-293T C190(1.15); C297(1.07); C55(1.21); C190(1.34)  LDD1657  [37]
 LDCM0455  CL63 HEK-293T C190(1.07); C291(0.97); C55(1.12)  LDD1658  [37]
 LDCM0456  CL64 HEK-293T C190(0.96); C297(0.86); C55(0.96); C190(1.00)  LDD1659  [37]
 LDCM0457  CL65 HEK-293T C190(1.11); C55(1.04); C190(1.02); C193(1.02)  LDD1660  [37]
 LDCM0458  CL66 HEK-293T C190(1.59); C297(0.90); C55(1.17); C190(1.69)  LDD1661  [37]
 LDCM0459  CL67 HEK-293T C190(0.93); C291(0.80); C297(0.94); C55(0.86)  LDD1662  [37]
 LDCM0460  CL68 HEK-293T C190(0.91); C291(0.72); C55(0.98); C190(0.68)  LDD1663  [37]
 LDCM0461  CL69 HEK-293T C190(0.97); C291(0.80); C297(0.68); C55(0.96)  LDD1664  [37]
 LDCM0462  CL7 HEK-293T C190(0.95); C291(0.68); C297(0.92); C55(0.94)  LDD1665  [37]
 LDCM0463  CL70 HEK-293T C190(0.79); C193(0.96); C291(0.65); C55(0.82)  LDD1666  [37]
 LDCM0464  CL71 HEK-293T C190(0.79); C193(1.15); C291(0.84); C297(0.82)  LDD1667  [37]
 LDCM0465  CL72 HEK-293T C190(0.86); C193(0.80); C291(0.82); C297(0.99)  LDD1668  [37]
 LDCM0466  CL73 HEK-293T C190(1.06); C55(0.98)  LDD1669  [37]
 LDCM0467  CL74 HEK-293T C190(1.06); C297(1.25); C55(1.07); C190(1.20)  LDD1670  [37]
 LDCM0469  CL76 HEK-293T C190(1.04); C297(0.99); C55(1.03); C190(1.10)  LDD1672  [37]
 LDCM0470  CL77 HEK-293T C190(1.35); C55(1.01); C190(1.35); C193(1.35)  LDD1673  [37]
 LDCM0471  CL78 HEK-293T C190(0.94); C297(0.99); C55(0.78); C190(1.13)  LDD1674  [37]
 LDCM0472  CL79 HEK-293T C190(0.89); C291(0.88); C297(1.05); C55(0.79)  LDD1675  [37]
 LDCM0473  CL8 HEK-293T C190(0.89); C291(0.71); C55(0.79); C190(0.91)  LDD1676  [37]
 LDCM0474  CL80 HEK-293T C190(0.87); C291(0.82); C55(0.83); C190(0.98)  LDD1677  [37]
 LDCM0475  CL81 HEK-293T C190(0.84); C291(0.89); C297(0.76); C55(0.81)  LDD1678  [37]
 LDCM0476  CL82 HEK-293T C190(0.81); C193(1.10); C291(0.85); C55(0.83)  LDD1679  [37]
 LDCM0477  CL83 HEK-293T C190(0.75); C193(1.24); C291(0.92); C297(0.91)  LDD1680  [37]
 LDCM0478  CL84 HEK-293T C190(0.84); C193(0.73); C291(0.84); C297(1.03)  LDD1681  [37]
 LDCM0479  CL85 HEK-293T C190(1.00); C55(0.80)  LDD1682  [37]
 LDCM0480  CL86 HEK-293T C190(1.18); C297(1.44); C55(1.29); C190(1.36)  LDD1683  [37]
 LDCM0481  CL87 HEK-293T C190(2.46); C291(0.95); C55(2.56)  LDD1684  [37]
 LDCM0482  CL88 HEK-293T C190(1.02); C297(1.42); C55(0.99); C190(1.10)  LDD1685  [37]
 LDCM0483  CL89 HEK-293T C190(1.02); C55(1.10); C190(0.94); C193(0.94)  LDD1686  [37]
 LDCM0484  CL9 HEK-293T C190(0.97); C291(0.87); C297(0.73); C55(0.90)  LDD1687  [37]
 LDCM0485  CL90 HEK-293T C190(1.50); C297(0.84); C55(1.11); C190(1.36)  LDD1688  [37]
 LDCM0486  CL91 HEK-293T C190(1.09); C291(0.91); C297(0.96); C55(0.90)  LDD1689  [37]
 LDCM0487  CL92 HEK-293T C190(1.11); C291(0.70); C55(1.08); C190(1.08)  LDD1690  [37]
 LDCM0488  CL93 HEK-293T C190(1.02); C291(0.85); C297(0.76); C55(0.84)  LDD1691  [37]
 LDCM0489  CL94 HEK-293T C190(1.54); C193(1.32); C291(0.70); C55(1.19)  LDD1692  [37]
 LDCM0490  CL95 HEK-293T C190(0.71); C193(0.93); C291(0.85); C297(0.71)  LDD1693  [37]
 LDCM0491  CL96 HEK-293T C190(0.79); C193(0.69); C291(0.93); C297(0.96)  LDD1694  [37]
 LDCM0492  CL97 HEK-293T C190(1.21); C55(1.78)  LDD1695  [37]
 LDCM0493  CL98 HEK-293T C190(1.29); C297(1.03); C55(1.32); C190(1.17)  LDD1696  [37]
 LDCM0494  CL99 HEK-293T C190(2.15); C291(1.15); C55(1.45)  LDD1697  [37]
 LDCM0495  E2913 HEK-293T C190(4.53); C291(0.92); C55(1.82)  LDD1698  [37]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C55(0.98)  LDD1702  [16]
 LDCM0572  Fragment10 MDA-MB-231 C55(20.00)  LDD1389  [39]
 LDCM0573  Fragment11 MDA-MB-231 C55(20.00)  LDD1391  [39]
 LDCM0574  Fragment12 MDA-MB-231 C55(3.72)  LDD1393  [39]
 LDCM0575  Fragment13 MDA-MB-231 C55(1.91)  LDD1395  [39]
 LDCM0576  Fragment14 MDA-MB-231 C55(0.96)  LDD1397  [39]
 LDCM0577  Fragment15 MDA-MB-231 C55(0.81)  LDD1399  [39]
 LDCM0579  Fragment20 MDA-MB-231 C55(1.65)  LDD1402  [39]
 LDCM0580  Fragment21 MDA-MB-231 C55(1.11)  LDD1404  [39]
 LDCM0581  Fragment22 MDA-MB-231 C55(2.13)  LDD1406  [39]
 LDCM0582  Fragment23 MDA-MB-231 C55(0.77)  LDD1408  [39]
 LDCM0583  Fragment24 Ramos C55(1.32)  LDD1410  [39]
 LDCM0584  Fragment25 MDA-MB-231 C55(0.99)  LDD1411  [39]
 LDCM0585  Fragment26 Ramos C55(0.90)  LDD1412  [39]
 LDCM0578  Fragment27 MDA-MB-231 C55(0.79)  LDD1401  [39]
 LDCM0586  Fragment28 MDA-MB-231 C55(1.10)  LDD1415  [39]
 LDCM0587  Fragment29 MDA-MB-231 C55(1.04)  LDD1417  [39]
 LDCM0588  Fragment30 MDA-MB-231 C55(2.17)  LDD1419  [39]
 LDCM0589  Fragment31 MDA-MB-231 C55(1.22)  LDD1421  [39]
 LDCM0590  Fragment32 MDA-MB-231 C55(20.00)  LDD1423  [39]
 LDCM0468  Fragment33 MDA-MB-231 C55(3.28)  LDD1425  [39]
 LDCM0592  Fragment34 MDA-MB-231 C55(0.90)  LDD1427  [39]
 LDCM0593  Fragment35 MDA-MB-231 C55(0.89)  LDD1429  [39]
 LDCM0595  Fragment37 Ramos C55(0.95)  LDD1432  [39]
 LDCM0596  Fragment38 MDA-MB-231 C55(0.98)  LDD1433  [39]
 LDCM0597  Fragment39 MDA-MB-231 C55(3.93)  LDD1435  [39]
 LDCM0566  Fragment4 MDA-MB-231 C55(1.29)  LDD1378  [39]
 LDCM0598  Fragment40 MDA-MB-231 C55(0.79)  LDD1436  [39]
 LDCM0599  Fragment41 MDA-MB-231 C55(0.91)  LDD1438  [39]
 LDCM0600  Fragment42 Ramos C55(0.90)  LDD1440  [39]
 LDCM0601  Fragment43 MDA-MB-231 C55(20.00)  LDD1441  [39]
 LDCM0602  Fragment44 MDA-MB-231 C55(1.01)  LDD1443  [39]
 LDCM0603  Fragment45 MDA-MB-231 C55(1.98); C190(2.78)  LDD1482  [39]
 LDCM0604  Fragment46 MDA-MB-231 C55(0.84)  LDD1445  [39]
 LDCM0605  Fragment47 MDA-MB-231 C55(0.92)  LDD1446  [39]
 LDCM0606  Fragment48 MDA-MB-231 C55(0.95)  LDD1447  [39]
 LDCM0607  Fragment49 MDA-MB-231 C55(12.84)  LDD1448  [39]
 LDCM0608  Fragment50 MDA-MB-231 C55(1.27)  LDD1449  [39]
 LDCM0427  Fragment51 MDA-MB-231 C55(2.46)  LDD1450  [39]
 LDCM0610  Fragment52 MDA-MB-231 C55(1.13)  LDD1452  [39]
 LDCM0611  Fragment53 MDA-MB-231 C55(0.90)  LDD1454  [39]
 LDCM0612  Fragment54 MDA-MB-231 C55(1.22)  LDD1456  [39]
 LDCM0613  Fragment55 MDA-MB-231 C55(0.85)  LDD1457  [39]
 LDCM0614  Fragment56 MDA-MB-231 C55(0.96)  LDD1458  [39]
 LDCM0568  Fragment6 MDA-MB-231 C55(0.97)  LDD1382  [39]
 LDCM0569  Fragment7 MDA-MB-231 C55(0.98)  LDD1383  [39]
 LDCM0570  Fragment8 MDA-MB-231 C55(4.67)  LDD1385  [39]
 LDCM0571  Fragment9 MDA-MB-231 C55(1.38)  LDD1387  [39]
 LDCM0116  HHS-0101 DM93 Y146(0.97)  LDD0264  [15]
 LDCM0117  HHS-0201 DM93 Y146(0.84)  LDD0265  [15]
 LDCM0118  HHS-0301 DM93 Y146(0.87)  LDD0266  [15]
 LDCM0119  HHS-0401 DM93 Y146(0.96)  LDD0267  [15]
 LDCM0120  HHS-0701 DM93 Y146(0.67)  LDD0268  [15]
 LDCM0107  IAA HeLa H87(0.00); H304(0.00)  LDD0221  [17]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [12]
 LDCM0022  KB02 MDA-MB-231 C55(6.28)  LDD1374  [39]
 LDCM0023  KB03 Jurkat C190(9.42); C190(4.45)  LDD0209  [14]
 LDCM0024  KB05 UACC257 C349(2.64)  LDD3325  [40]
 LDCM0109  NEM HeLa H86(0.00); K85(0.00)  LDD0223  [17]
 LDCM0627  NUDT7-COV-1 HEK-293T C55(1.01); C190(0.80)  LDD2206  [41]
 LDCM0628  OTUB2-COV-1 HEK-293T C190(0.55); C55(0.13)  LDD2207  [41]
 LDCM0131  RA190 MM1.R C190(1.26); C193(1.26); C55(1.15); C58(1.15)  LDD0304  [42]
 LDCM0021  THZ1 HeLa S3 C297(1.01); C55(0.99); C58(0.95)  LDD0460  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATPase GET3 (GET3) ArsA ATPase family O43681
Endoplasmic reticulum chaperone BiP (HSPA5) Heat shock protein 70 family P11021
Peroxiredoxin-4 (PRDX4) Peroxiredoxin family Q13162
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) SGT family Q96EQ0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine. ACS Chem Biol. 2021 Nov 19;16(11):2581-2594. doi: 10.1021/acschembio.1c00629. Epub 2021 Nov 2.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
12 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
13 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
14 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
15 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
16 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
19 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
20 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
21 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
22 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
23 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
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Mass spectrometry data entry: PXD001377 , PXD005252
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