Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment24  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 93 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 12.6
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 11.4
 LDTP09912  DNA repair protein RAD50 (RAD50) C1296 10.5
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 5.3
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 2.9
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 2.8
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C217 2.5
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 2.3
 LDTP09912  DNA repair protein RAD50 (RAD50) C1302 2.2
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 2.1
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 2.0
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 2.0
 LDTP05859  Integrin-linked protein kinase (ILK) C346 1.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.9
 LDTP03786  Glutaredoxin-1 (GLRX) C23 1.8
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 1.8
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.8
 LDTP07098  Probable ATP-dependent RNA helicase DDX59 (DDX59) C453 1.7
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.7
 LDTP07098  Probable ATP-dependent RNA helicase DDX59 (DDX59) C414 1.7
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 1.7
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 1.7
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.7
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 1.7
 LDTP04374  Dynamin-2 (DNM2) C27 1.6
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 1.6
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 1.6
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C322 1.6
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.5
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 1.5
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 1.5
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 1.5
 LDTP10774  Elongation factor G, mitochondrial (GFM1) C153 1.5
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 1.5
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 1.5
 LDTP12166  Ras-related GTP-binding protein C (RRAGC) C377 1.5
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 1.4
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 1.4
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 1.4
 LDTP02502  Thioredoxin (TXN) C32 1.4
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.4
 LDTP06211  Caspase-8 (CASP8) C360 1.4
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.4
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 1.4
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.3
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 1.3
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.3
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.3
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 1.3
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 1.3
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.3
 LDTP05289  AMP deaminase 2 (AMPD2) C107 1.3
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 1.3
 LDTP00273  Dynamin-1-like protein (DNM1L) C367 1.3
 LDTP02672  Elongation factor 2 (EEF2) C136 1.3
 LDTP04424  Galactokinase (GALK1) C182 1.3
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 1.3
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.2
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 1.2
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 1.2
 LDTP13147  Cathepsin Z (CTSZ) C92 1.2
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C301 1.2
 LDTP10929  Cell cycle checkpoint control protein RAD9A (RAD9A) C114 1.2
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 1.2
 LDTP12960  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) C149 1.2
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.2
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 1.2
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.1
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 1.1
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126 1.1
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) C84 1.1
 LDTP03400  Deoxycytidine kinase (DCK) C45 1.1
 LDTP02672  Elongation factor 2 (EEF2) C41 1.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.1
 LDTP01495  E3 ubiquitin-protein ligase UBR5 (UBR5) C2267 1.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 1.1
 LDTP11340  Cyclin-dependent kinase 19 (CDK19) C349 1.1
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C620 1.1
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.0
 LDTP04689  Adenosine kinase (ADK) C353 1.0
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.0
 LDTP02733  Pyruvate kinase PKM (PKM) C423 1.0
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C863 1.0
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.0
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.0
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) C17 1.0
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 1.0
 LDTP09338  NEDD8-activating enzyme E1 catalytic subunit (UBA3) C237 1.0
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) C623 0.9
 LDTP12166  Ras-related GTP-binding protein C (RRAGC) C358 0.9
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 0.9
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) C269 0.9
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) C210 0.5
Transporter and channel
Click to Show/Hide to Show 14 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00501  Exportin-1 (XPO1) C528 20.0
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 2.6
 LDTP04801  Gasdermin-D (GSDMD) C268 1.9
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.5
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 1.4
 LDTP03777  Nuclear pore complex protein Nup214 (NUP214) C728 1.4
 LDTP13661  Sorting nexin-6 (SNX6) C264 1.2
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 1.2
 LDTP01574  Importin-7 (IPO7) C757 1.1
 LDTP04662  Exportin-2 (CSE1L) C842 1.1
 LDTP00501  Exportin-1 (XPO1) C34 1.1
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.1
 LDTP13490  Apoptotic chromatin condensation inducer in the nucleus (ACIN1) C1223 1.0
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 1.0
Transcription factor
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 5.4
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 1.7
 LDTP05284  Transcription factor RelB (RELB) C109 1.5
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.2
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.2
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 1.1
Other
Click to Show/Hide to Show 68 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12737  BRISC and BRCA1-A complex member 1 (BABAM1) C222 20.0
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 20.0
 LDTP07755  Dynamin-binding protein (DNMBP) C691 20.0
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 6.0
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 6.0
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 3.7
 LDTP06082  Dynactin subunit 1 (DCTN1) C1252 3.2
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 2.1
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 2.0
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 1.9
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.9
 LDTP05867  Treacle protein (TCOF1) C1298 1.8
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.7
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 1.7
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 1.7
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 1.7
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.6
 LDTP18494  Tropomodulin-3 (TMOD3) C132 1.6
 LDTP15677  Ribosomal protein eL42-like (RPL36AL) C88 1.6
 LDTP06083  Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) C1999 1.6
 LDTP10700  KH domain-containing RNA-binding protein QKI (QKI) C35 1.6
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.5
 LDTP10864  Calponin-2 (CNN2) C164 1.5
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 1.5
 LDTP06268  Condensin complex subunit 2 (NCAPH) C418 1.4
 LDTP04092  Crk-like protein (CRKL) C249 1.4
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.4
 LDTP05930  SNW domain-containing protein 1 (SNW1) C250 1.4
 LDTP04902  Actin-related protein 3 (ACTR3) C235 1.4
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 1.4
 LDTP02205  Tubulin beta chain (TUBB) C239 1.4
 LDTP10864  Calponin-2 (CNN2) C215 1.3
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 1.3
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 1.3
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 1.3
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 1.3
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.3
 LDTP02205  Tubulin beta chain (TUBB) C354 1.3
 LDTP13580  Coronin-1C (CORO1C) C420 1.3
 LDTP00202  AH receptor-interacting protein (AIP) C122 1.3
 LDTP14195  FH1/FH2 domain-containing protein 1 (FHOD1) C502 1.3
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.3
 LDTP08573  Ankyrin repeat and KH domain-containing protein 1 (ANKHD1) C615 1.2
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4) C34 1.2
 LDTP11239  Protein misato homolog 1 (MSTO1) C403 1.2
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 1.2
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 1.2
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 1.2
 LDTP14337  Protein strawberry notch homolog 1 (SBNO1) C445 1.2
 LDTP12685  Integrator complex subunit 13 (INTS13) C349 1.2
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.2
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 1.1
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) C18 1.1
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 1.1
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.1
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 1.1
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 1.1
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.1
 LDTP01299  WD repeat and HMG-box DNA-binding protein 1 (WDHD1) C773 1.1
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 1.1
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.1
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 1.0
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 1.0
 LDTP11212  Tubulin-specific chaperone D (TBCD) C850 0.9
 LDTP11239  Protein misato homolog 1 (MSTO1) C485 0.8
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C122 0.8
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 0.6
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1) C781 0.3

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.