Details of the Target

General Information of Target

Target ID LDTP13817
Target Name Nuclear migration protein nudC (NUDC)
Gene Name NUDC
Gene ID 10726
Synonyms
Nuclear migration protein nudC; Nuclear distribution protein C homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKK
MAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAI
GLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESL
QKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTL
HDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLF
VDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGIPLDLLDRVMI
IRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKIN
GKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK
Target Bioclass
Other
Family
NudC family
Subcellular location
Cytoplasm, cytoskeleton
Function Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
Uniprot ID
Q9Y266
Ensemble ID
ENST00000321265.10
HGNC ID
HGNC:8045

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P8
 Probe Info  		10.00  LDD0451  [2]
A-EBA
 Probe Info  		3.75  LDD0215  [3]
AZ-9
 Probe Info  		5.33  LDD0393  [4]
CY-1
 Probe Info  		100.00  LDD0243  [5]
TH211
 Probe Info  		Y292(11.63)  LDD0257  [6]
ONAyne
 Probe Info  		N.A.  LDD0273  [7]
Probe 1
 Probe Info  		Y172(15.63); Y223(19.17)  LDD3495  [8]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [9]
THZ1-DTB
 Probe Info  		C188(1.01)  LDD0460  [9]
DA-P3
 Probe Info  		8.15  LDD0183  [10]
AHL-Pu-1
 Probe Info  		C188(2.44)  LDD0169  [11]
EA-probe
 Probe Info  		C188(0.85)  LDD2210  [12]
HHS-482
 Probe Info  		Y292(0.84)  LDD0285  [13]
HHS-475
 Probe Info  		Y292(0.78); Y223(1.24)  LDD0264  [14]
HHS-465
 Probe Info  		Y292(8.79)  LDD2237  [15]
DBIA
 Probe Info  		C188(0.92)  LDD0078  [16]
5E-2FA
 Probe Info  		H128(0.00); H320(0.00); H61(0.00); H62(0.00)  LDD2235  [17]
AMP probe
 Probe Info  		N.A.  LDD0200  [18]
ATP probe
 Probe Info  		K68(0.00); K315(0.00); K196(0.00); K160(0.00)  LDD0199  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [19]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [20]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [19]
NAIA_4
 Probe Info  		N.A.  LDD2226  [21]
1d-yne
 Probe Info  		N.A.  LDD0356  [22]
IPM
 Probe Info  		N.A.  LDD0147  [23]
NHS
 Probe Info  		K267(0.00); K160(0.00); K68(0.00); K96(0.00)  LDD0010  [24]
STPyne
 Probe Info  		K39(0.00); K275(0.00)  LDD0009  [24]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [25]
Ox-W18
 Probe Info  		N.A.  LDD2175  [26]
1c-yne
 Probe Info  		K297(0.00); K315(0.00); K105(0.00); K160(0.00)  LDD0228  [22]
Acrolein
 Probe Info  		H62(0.00); H61(0.00); H244(0.00); H128(0.00)  LDD0217  [27]
Crotonaldehyde
 Probe Info  		H62(0.00); H61(0.00)  LDD0219  [27]
Methacrolein
 Probe Info  		N.A.  LDD0218  [27]
AOyne
 Probe Info  		15.00  LDD0443  [28]
NAIA_5
 Probe Info  		N.A.  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		24.25  LDD1865  [29]
C191
 Probe Info  		17.03  LDD1868  [29]
C193
 Probe Info  		7.73  LDD1869  [29]
FFF probe13
 Probe Info  		10.34  LDD0475  [30]
FFF probe14
 Probe Info  		12.46  LDD0477  [30]
FFF probe2
 Probe Info  		7.33  LDD0463  [30]
FFF probe3
 Probe Info  		12.52  LDD0464  [30]
FFF probe9
 Probe Info  		5.87  LDD0470  [30]
STS-1
 Probe Info  		N.A.  LDD0136  [31]
VE-P
 Probe Info  		N.A.  LDD0396  [32]
DA-2
 Probe Info  		N.A.  LDD0070  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C188(2.30)  LDD0172  [11]
 LDCM0026  4SU-RNA+native RNA HEK-293T C188(2.44)  LDD0169  [11]
 LDCM0214  AC1 HEK-293T C188(0.88)  LDD0812  [16]
 LDCM0215  AC10 HEK-293T C188(0.85)  LDD0813  [16]
 LDCM0216  AC100 HCT 116 C188(1.16)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C188(1.05)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C188(0.85)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C188(1.19)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C188(1.21)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C188(1.31)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C188(0.90)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C188(0.86)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C188(1.40)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C188(2.45)  LDD0542  [16]
 LDCM0226  AC11 HEK-293T C188(1.09)  LDD0824  [16]
 LDCM0227  AC110 HCT 116 C188(0.95)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C188(0.77)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C188(1.00)  LDD0546  [16]
 LDCM0230  AC113 PaTu 8988t C188(0.92)  LDD1109  [16]
 LDCM0231  AC114 PaTu 8988t C188(0.94)  LDD1110  [16]
 LDCM0232  AC115 PaTu 8988t C188(0.96)  LDD1111  [16]
 LDCM0233  AC116 PaTu 8988t C188(0.69)  LDD1112  [16]
 LDCM0234  AC117 PaTu 8988t C188(1.04)  LDD1113  [16]
 LDCM0235  AC118 PaTu 8988t C188(1.16)  LDD1114  [16]
 LDCM0236  AC119 PaTu 8988t C188(1.06)  LDD1115  [16]
 LDCM0237  AC12 HEK-293T C188(0.85)  LDD0835  [16]
 LDCM0238  AC120 PaTu 8988t C188(1.16)  LDD1117  [16]
 LDCM0239  AC121 PaTu 8988t C188(1.06)  LDD1118  [16]
 LDCM0240  AC122 PaTu 8988t C188(1.04)  LDD1119  [16]
 LDCM0241  AC123 PaTu 8988t C188(0.86)  LDD1120  [16]
 LDCM0242  AC124 PaTu 8988t C188(1.24)  LDD1121  [16]
 LDCM0243  AC125 PaTu 8988t C188(1.40)  LDD1122  [16]
 LDCM0244  AC126 PaTu 8988t C188(0.82)  LDD1123  [16]
 LDCM0245  AC127 PaTu 8988t C188(0.47)  LDD1124  [16]
 LDCM0246  AC128 HEK-293T C188(0.63)  LDD0844  [16]
 LDCM0247  AC129 HEK-293T C188(0.76)  LDD0845  [16]
 LDCM0249  AC130 HEK-293T C188(0.84)  LDD0847  [16]
 LDCM0250  AC131 HEK-293T C188(0.89)  LDD0848  [16]
 LDCM0251  AC132 HEK-293T C188(0.82)  LDD0849  [16]
 LDCM0252  AC133 HEK-293T C188(0.67)  LDD0850  [16]
 LDCM0253  AC134 HEK-293T C188(0.84)  LDD0851  [16]
 LDCM0254  AC135 HEK-293T C188(0.61)  LDD0852  [16]
 LDCM0255  AC136 HEK-293T C188(0.57)  LDD0853  [16]
 LDCM0256  AC137 HEK-293T C188(0.58)  LDD0854  [16]
 LDCM0257  AC138 HEK-293T C188(0.48)  LDD0855  [16]
 LDCM0258  AC139 HEK-293T C188(0.68)  LDD0856  [16]
 LDCM0259  AC14 HEK-293T C188(0.87)  LDD0857  [16]
 LDCM0260  AC140 HEK-293T C188(0.76)  LDD0858  [16]
 LDCM0261  AC141 HEK-293T C188(0.64)  LDD0859  [16]
 LDCM0262  AC142 HEK-293T C188(0.71)  LDD0860  [16]
 LDCM0263  AC143 HCT 116 C188(1.09)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C188(2.84)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C188(1.56)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C188(1.04)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C188(2.76)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C188(1.89)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C188(1.37)  LDD0586  [16]
 LDCM0270  AC15 HEK-293T C188(0.87)  LDD0868  [16]
 LDCM0271  AC150 HCT 116 C188(1.07)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C188(1.26)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C188(1.80)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C188(4.05)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C188(2.24)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C188(1.86)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C188(1.40)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C188(2.53)  LDD2161  [16]
 LDCM0276  AC17 HEK-293T C188(0.97)  LDD0874  [16]
 LDCM0277  AC18 HEK-293T C188(1.01)  LDD0875  [16]
 LDCM0278  AC19 HEK-293T C188(1.13)  LDD0876  [16]
 LDCM0279  AC2 HEK-293T C188(0.86)  LDD0877  [16]
 LDCM0280  AC20 HEK-293T C188(0.95)  LDD0878  [16]
 LDCM0281  AC21 HEK-293T C188(0.90)  LDD0879  [16]
 LDCM0282  AC22 HEK-293T C188(0.99)  LDD0880  [16]
 LDCM0283  AC23 HEK-293T C188(0.85)  LDD0881  [16]
 LDCM0284  AC24 HEK-293T C188(1.09)  LDD0882  [16]
 LDCM0285  AC25 HEK-293T C188(1.15)  LDD0883  [16]
 LDCM0286  AC26 HEK-293T C188(0.95)  LDD0884  [16]
 LDCM0287  AC27 HEK-293T C188(0.97)  LDD0885  [16]
 LDCM0288  AC28 HEK-293T C188(0.91)  LDD0886  [16]
 LDCM0289  AC29 HEK-293T C188(0.91)  LDD0887  [16]
 LDCM0290  AC3 HEK-293T C188(0.96)  LDD0888  [16]
 LDCM0291  AC30 HEK-293T C188(1.12)  LDD0889  [16]
 LDCM0292  AC31 HEK-293T C188(1.03)  LDD0890  [16]
 LDCM0293  AC32 HEK-293T C188(1.00)  LDD0891  [16]
 LDCM0294  AC33 HEK-293T C188(0.92)  LDD0892  [16]
 LDCM0295  AC34 HEK-293T C188(1.13)  LDD0893  [16]
 LDCM0296  AC35 PaTu 8988t C188(1.27)  LDD1175  [16]
 LDCM0297  AC36 PaTu 8988t C188(1.21)  LDD1176  [16]
 LDCM0298  AC37 PaTu 8988t C188(1.50)  LDD1177  [16]
 LDCM0299  AC38 PaTu 8988t C188(1.43)  LDD1178  [16]
 LDCM0300  AC39 PaTu 8988t C188(1.52)  LDD1179  [16]
 LDCM0301  AC4 HEK-293T C188(0.95)  LDD0899  [16]
 LDCM0302  AC40 PaTu 8988t C188(1.69)  LDD1181  [16]
 LDCM0303  AC41 PaTu 8988t C188(1.17)  LDD1182  [16]
 LDCM0304  AC42 PaTu 8988t C188(1.36)  LDD1183  [16]
 LDCM0305  AC43 PaTu 8988t C188(1.39)  LDD1184  [16]
 LDCM0306  AC44 PaTu 8988t C188(1.90)  LDD1185  [16]
 LDCM0307  AC45 PaTu 8988t C188(1.79)  LDD1186  [16]
 LDCM0308  AC46 HEK-293T C188(0.69)  LDD0906  [16]
 LDCM0309  AC47 HEK-293T C188(0.76)  LDD0907  [16]
 LDCM0310  AC48 HEK-293T C188(0.81)  LDD0908  [16]
 LDCM0311  AC49 HEK-293T C188(0.73)  LDD0909  [16]
 LDCM0312  AC5 HEK-293T C188(1.05)  LDD0910  [16]
 LDCM0313  AC50 HEK-293T C188(0.73)  LDD0911  [16]
 LDCM0314  AC51 HEK-293T C188(0.69)  LDD0912  [16]
 LDCM0315  AC52 HEK-293T C188(0.72)  LDD0913  [16]
 LDCM0316  AC53 HEK-293T C188(0.89)  LDD0914  [16]
 LDCM0317  AC54 HEK-293T C188(0.72)  LDD0915  [16]
 LDCM0318  AC55 HEK-293T C188(0.69)  LDD0916  [16]
 LDCM0319  AC56 HEK-293T C188(0.77)  LDD0917  [16]
 LDCM0320  AC57 HCT 116 C188(1.36)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C188(1.72)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C188(2.18)  LDD0639  [16]
 LDCM0323  AC6 HEK-293T C188(1.19)  LDD0921  [16]
 LDCM0324  AC60 HCT 116 C188(1.60)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C188(1.98)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C188(1.60)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C188(1.96)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C188(1.74)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C188(1.13)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C188(1.05)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C188(1.01)  LDD0648  [16]
 LDCM0332  AC68 HEK-293T C188(1.06)  LDD0930  [16]
 LDCM0333  AC69 HEK-293T C188(1.14)  LDD0931  [16]
 LDCM0334  AC7 HEK-293T C188(1.00)  LDD0932  [16]
 LDCM0335  AC70 HEK-293T C188(0.93)  LDD0933  [16]
 LDCM0336  AC71 HEK-293T C188(1.16)  LDD0934  [16]
 LDCM0337  AC72 HEK-293T C188(1.15)  LDD0935  [16]
 LDCM0338  AC73 HEK-293T C188(0.84)  LDD0936  [16]
 LDCM0339  AC74 HEK-293T C188(0.89)  LDD0937  [16]
 LDCM0340  AC75 HEK-293T C188(0.93)  LDD0938  [16]
 LDCM0341  AC76 HEK-293T C188(1.01)  LDD0939  [16]
 LDCM0342  AC77 HEK-293T C188(0.93)  LDD0940  [16]
 LDCM0343  AC78 HEK-293T C188(0.89)  LDD0941  [16]
 LDCM0344  AC79 HEK-293T C188(1.07)  LDD0942  [16]
 LDCM0345  AC8 HEK-293T C188(0.95)  LDD0943  [16]
 LDCM0346  AC80 HEK-293T C188(1.03)  LDD0944  [16]
 LDCM0347  AC81 HEK-293T C188(0.98)  LDD0945  [16]
 LDCM0348  AC82 HEK-293T C188(0.97)  LDD0946  [16]
 LDCM0349  AC83 HCT 116 C188(2.00)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C188(1.73)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C188(0.94)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C188(2.61)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C188(1.33)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C188(1.30)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C188(1.89)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C188(1.10)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C188(2.20)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C188(2.95)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C188(1.65)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C188(1.45)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C188(1.54)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C188(2.19)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C188(1.96)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C188(0.64)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C188(0.79)  LDD0683  [16]
 LDCM0248  AKOS034007472 HEK-293T C188(0.97)  LDD0846  [16]
 LDCM0356  AKOS034007680 HEK-293T C188(0.68)  LDD0954  [16]
 LDCM0275  AKOS034007705 HEK-293T C188(1.03)  LDD0873  [16]
 LDCM0156  Aniline NCI-H1299 12.63  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C188(0.92)  LDD0078  [16]
 LDCM0087  Capsaicin HEK-293T 7.72  LDD0185  [10]
 LDCM0630  CCW28-3 231MFP C188(1.17)  LDD2214  [34]
 LDCM0108  Chloroacetamide HeLa H62(0.00); H61(0.00); H128(0.00); H244(0.00)  LDD0222  [27]
 LDCM0367  CL1 HEK-293T C188(0.78)  LDD1571  [35]
 LDCM0368  CL10 HEK-293T C188(0.65)  LDD1572  [35]
 LDCM0369  CL100 HEK-293T C188(0.88)  LDD0967  [16]
 LDCM0370  CL101 HEK-293T C188(0.99)  LDD0968  [16]
 LDCM0371  CL102 HEK-293T C188(1.06)  LDD0969  [16]
 LDCM0372  CL103 HEK-293T C188(0.82)  LDD0970  [16]
 LDCM0373  CL104 HEK-293T C188(0.94)  LDD0971  [16]
 LDCM0374  CL105 HEK-293T C188(1.16)  LDD0972  [16]
 LDCM0375  CL106 HEK-293T C188(1.15)  LDD0973  [16]
 LDCM0376  CL107 HEK-293T C188(1.07)  LDD0974  [16]
 LDCM0377  CL108 HEK-293T C188(1.00)  LDD0975  [16]
 LDCM0378  CL109 HEK-293T C188(1.06)  LDD0976  [16]
 LDCM0380  CL110 HEK-293T C188(1.07)  LDD0978  [16]
 LDCM0381  CL111 HEK-293T C188(1.29)  LDD0979  [16]
 LDCM0382  CL112 HEK-293T C188(0.99)  LDD0980  [16]
 LDCM0383  CL113 HEK-293T C188(1.05)  LDD0981  [16]
 LDCM0384  CL114 HEK-293T C188(0.79)  LDD0982  [16]
 LDCM0385  CL115 HEK-293T C188(1.09)  LDD0983  [16]
 LDCM0386  CL116 HEK-293T C188(0.97)  LDD0984  [16]
 LDCM0387  CL117 PaTu 8988t C188(1.61)  LDD1266  [16]
 LDCM0388  CL118 PaTu 8988t C188(1.23)  LDD1267  [16]
 LDCM0389  CL119 PaTu 8988t C188(1.24)  LDD1268  [16]
 LDCM0390  CL12 HEK-293T C188(0.66)  LDD1594  [35]
 LDCM0391  CL120 PaTu 8988t C188(1.36)  LDD1270  [16]
 LDCM0392  CL121 HEK-293T C188(0.72)  LDD0990  [16]
 LDCM0393  CL122 HEK-293T C188(0.74)  LDD0991  [16]
 LDCM0394  CL123 HEK-293T C188(0.80)  LDD0992  [16]
 LDCM0395  CL124 HEK-293T C188(0.86)  LDD0993  [16]
 LDCM0396  CL125 HCT 116 C188(0.96)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C188(1.37)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C188(1.68)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C188(1.33)  LDD0716  [16]
 LDCM0400  CL13 HEK-293T C188(0.91)  LDD1604  [35]
 LDCM0401  CL14 HEK-293T C188(0.84)  LDD1605  [35]
 LDCM0402  CL15 HEK-293T C188(0.59)  LDD1606  [35]
 LDCM0403  CL16 PaTu 8988t C188(1.11)  LDD1282  [16]
 LDCM0404  CL17 PaTu 8988t C188(1.37)  LDD1283  [16]
 LDCM0405  CL18 PaTu 8988t C188(1.07)  LDD1284  [16]
 LDCM0406  CL19 PaTu 8988t C188(1.70)  LDD1285  [16]
 LDCM0407  CL2 HEK-293T C188(0.73)  LDD1611  [35]
 LDCM0408  CL20 PaTu 8988t C188(1.66)  LDD1287  [16]
 LDCM0409  CL21 PaTu 8988t C188(1.73)  LDD1288  [16]
 LDCM0410  CL22 PaTu 8988t C188(1.44)  LDD1289  [16]
 LDCM0411  CL23 PaTu 8988t C188(1.65)  LDD1290  [16]
 LDCM0412  CL24 PaTu 8988t C188(1.03)  LDD1291  [16]
 LDCM0413  CL25 PaTu 8988t C188(0.83)  LDD1292  [16]
 LDCM0414  CL26 PaTu 8988t C188(1.15)  LDD1293  [16]
 LDCM0415  CL27 PaTu 8988t C188(1.38)  LDD1294  [16]
 LDCM0416  CL28 PaTu 8988t C188(1.20)  LDD1295  [16]
 LDCM0417  CL29 PaTu 8988t C188(2.07)  LDD1296  [16]
 LDCM0418  CL3 HEK-293T C188(0.61)  LDD1622  [35]
 LDCM0419  CL30 PaTu 8988t C188(3.63)  LDD1298  [16]
 LDCM0420  CL31 HEK-293T C188(1.41)  LDD1018  [16]
 LDCM0421  CL32 HEK-293T C188(1.16)  LDD1019  [16]
 LDCM0422  CL33 HEK-293T C188(0.93)  LDD1020  [16]
 LDCM0423  CL34 HEK-293T C188(1.18)  LDD1021  [16]
 LDCM0424  CL35 HEK-293T C188(1.12)  LDD1022  [16]
 LDCM0425  CL36 HEK-293T C188(1.20)  LDD1023  [16]
 LDCM0426  CL37 HEK-293T C188(1.06)  LDD1024  [16]
 LDCM0428  CL39 HEK-293T C188(0.68)  LDD1026  [16]
 LDCM0429  CL4 HEK-293T C188(0.95)  LDD1633  [35]
 LDCM0430  CL40 HEK-293T C188(0.94)  LDD1028  [16]
 LDCM0431  CL41 HEK-293T C188(0.73)  LDD1029  [16]
 LDCM0432  CL42 HEK-293T C188(0.80)  LDD1030  [16]
 LDCM0433  CL43 HEK-293T C188(0.78)  LDD1031  [16]
 LDCM0434  CL44 HEK-293T C188(1.14)  LDD1032  [16]
 LDCM0435  CL45 HEK-293T C188(0.80)  LDD1033  [16]
 LDCM0436  CL46 HCT 116 C188(1.44)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C188(0.76)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C188(1.10)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C188(1.90)  LDD0756  [16]
 LDCM0440  CL5 HEK-293T C188(0.91)  LDD1644  [35]
 LDCM0441  CL50 HCT 116 C188(1.05)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C188(1.55)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C188(1.75)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C188(1.33)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C188(1.05)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C188(1.09)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C188(1.10)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C188(1.51)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C188(0.97)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C188(1.14)  LDD0767  [16]
 LDCM0451  CL6 HEK-293T C188(0.72)  LDD1654  [35]
 LDCM0452  CL60 HCT 116 C188(1.12)  LDD0769  [16]
 LDCM0453  CL61 PaTu 8988t C188(1.19)  LDD1332  [16]
 LDCM0454  CL62 PaTu 8988t C188(1.48)  LDD1333  [16]
 LDCM0455  CL63 PaTu 8988t C188(1.27)  LDD1334  [16]
 LDCM0456  CL64 PaTu 8988t C188(1.51)  LDD1335  [16]
 LDCM0457  CL65 PaTu 8988t C188(1.23)  LDD1336  [16]
 LDCM0458  CL66 PaTu 8988t C188(1.11)  LDD1337  [16]
 LDCM0459  CL67 PaTu 8988t C188(1.41)  LDD1338  [16]
 LDCM0460  CL68 PaTu 8988t C188(2.07)  LDD1339  [16]
 LDCM0461  CL69 PaTu 8988t C188(1.72)  LDD1340  [16]
 LDCM0462  CL7 HEK-293T C188(0.61)  LDD1665  [35]
 LDCM0463  CL70 PaTu 8988t C188(1.50)  LDD1342  [16]
 LDCM0464  CL71 PaTu 8988t C188(1.17)  LDD1343  [16]
 LDCM0465  CL72 PaTu 8988t C188(1.04)  LDD1344  [16]
 LDCM0466  CL73 PaTu 8988t C188(1.92)  LDD1345  [16]
 LDCM0467  CL74 PaTu 8988t C188(1.33)  LDD1346  [16]
 LDCM0469  CL76 HEK-293T C188(1.23)  LDD1067  [16]
 LDCM0470  CL77 HEK-293T C188(1.31)  LDD1068  [16]
 LDCM0471  CL78 HEK-293T C188(1.73)  LDD1069  [16]
 LDCM0472  CL79 HEK-293T C188(1.29)  LDD1070  [16]
 LDCM0473  CL8 HEK-293T C188(0.55)  LDD1676  [35]
 LDCM0474  CL80 HEK-293T C188(1.20)  LDD1072  [16]
 LDCM0475  CL81 HEK-293T C188(1.54)  LDD1073  [16]
 LDCM0476  CL82 HEK-293T C188(0.84)  LDD1074  [16]
 LDCM0477  CL83 HEK-293T C188(0.86)  LDD1075  [16]
 LDCM0478  CL84 HEK-293T C188(1.59)  LDD1076  [16]
 LDCM0479  CL85 HEK-293T C188(1.36)  LDD1077  [16]
 LDCM0480  CL86 HEK-293T C188(1.68)  LDD1078  [16]
 LDCM0481  CL87 HEK-293T C188(1.38)  LDD1079  [16]
 LDCM0482  CL88 HEK-293T C188(1.10)  LDD1080  [16]
 LDCM0483  CL89 HEK-293T C188(1.28)  LDD1081  [16]
 LDCM0484  CL9 HEK-293T C188(0.75)  LDD1687  [35]
 LDCM0485  CL90 HEK-293T C188(0.93)  LDD1083  [16]
 LDCM0486  CL91 HEK-293T C188(1.18)  LDD1084  [16]
 LDCM0487  CL92 HEK-293T C188(1.24)  LDD1085  [16]
 LDCM0488  CL93 HEK-293T C188(1.23)  LDD1086  [16]
 LDCM0489  CL94 HEK-293T C188(1.13)  LDD1087  [16]
 LDCM0490  CL95 HEK-293T C188(0.90)  LDD1088  [16]
 LDCM0491  CL96 HEK-293T C188(1.05)  LDD1089  [16]
 LDCM0492  CL97 HEK-293T C188(1.10)  LDD1090  [16]
 LDCM0493  CL98 HEK-293T C188(0.95)  LDD1091  [16]
 LDCM0494  CL99 HEK-293T C188(1.05)  LDD1092  [16]
 LDCM0191  Compound 21 HEK-293T 6.20  LDD0508  [30]
 LDCM0190  Compound 34 HEK-293T 7.63  LDD0510  [30]
 LDCM0192  Compound 35 HEK-293T 3.84  LDD0509  [30]
 LDCM0193  Compound 36 HEK-293T 4.97  LDD0511  [30]
 LDCM0495  E2913 HEK-293T C188(0.71)  LDD1698  [35]
 LDCM0031  Epigallocatechin gallate HEK-293T 8.15  LDD0183  [10]
 LDCM0175  Ethacrynic acid HeLa C188(0.85)  LDD2210  [12]
 LDCM0572  Fragment10 MDA-MB-231 C188(1.09)  LDD1389  [36]
 LDCM0573  Fragment11 MDA-MB-231 C188(1.34)  LDD1391  [36]
 LDCM0574  Fragment12 MDA-MB-231 C188(1.00)  LDD1393  [36]
 LDCM0575  Fragment13 MDA-MB-231 C188(0.96)  LDD1395  [36]
 LDCM0576  Fragment14 MDA-MB-231 C188(1.25)  LDD1397  [36]
 LDCM0577  Fragment15 Ramos C188(1.17)  LDD1400  [36]
 LDCM0579  Fragment20 MDA-MB-231 C188(1.24)  LDD1402  [36]
 LDCM0580  Fragment21 MDA-MB-231 C188(0.90)  LDD1404  [36]
 LDCM0581  Fragment22 MDA-MB-231 C188(1.15)  LDD1406  [36]
 LDCM0582  Fragment23 MDA-MB-231 C188(1.29)  LDD1408  [36]
 LDCM0583  Fragment24 Ramos C188(1.05)  LDD1410  [36]
 LDCM0584  Fragment25 MDA-MB-231 C188(0.94)  LDD1411  [36]
 LDCM0585  Fragment26 Ramos C188(0.66)  LDD1412  [36]
 LDCM0578  Fragment27 MDA-MB-231 C188(1.13)  LDD1401  [36]
 LDCM0586  Fragment28 MDA-MB-231 C188(0.88)  LDD1415  [36]
 LDCM0587  Fragment29 MDA-MB-231 C188(1.34)  LDD1417  [36]
 LDCM0588  Fragment30 MDA-MB-231 C188(0.93)  LDD1419  [36]
 LDCM0589  Fragment31 MDA-MB-231 C188(1.35)  LDD1421  [36]
 LDCM0590  Fragment32 MDA-MB-231 C188(1.01)  LDD1423  [36]
 LDCM0468  Fragment33 PaTu 8988t C188(1.52)  LDD1347  [16]
 LDCM0592  Fragment34 MDA-MB-231 C188(0.65)  LDD1427  [36]
 LDCM0593  Fragment35 MDA-MB-231 C188(0.77)  LDD1429  [36]
 LDCM0594  Fragment36 MDA-MB-231 C188(1.57)  LDD1431  [36]
 LDCM0595  Fragment37 Ramos C188(1.10)  LDD1432  [36]
 LDCM0596  Fragment38 MDA-MB-231 C188(0.97)  LDD1433  [36]
 LDCM0597  Fragment39 MDA-MB-231 C188(1.25)  LDD1435  [36]
 LDCM0566  Fragment4 MDA-MB-231 C188(1.20)  LDD1378  [36]
 LDCM0598  Fragment40 MDA-MB-231 C188(0.80)  LDD1436  [36]
 LDCM0599  Fragment41 MDA-MB-231 C188(1.15)  LDD1438  [36]
 LDCM0600  Fragment42 Ramos C188(0.84)  LDD1440  [36]
 LDCM0601  Fragment43 MDA-MB-231 C188(0.98)  LDD1441  [36]
 LDCM0602  Fragment44 MDA-MB-231 C188(0.81)  LDD1443  [36]
 LDCM0603  Fragment45 MDA-MB-231 C188(1.31)  LDD1444  [36]
 LDCM0604  Fragment46 MDA-MB-231 C188(1.05)  LDD1445  [36]
 LDCM0605  Fragment47 MDA-MB-231 C188(1.21)  LDD1446  [36]
 LDCM0606  Fragment48 MDA-MB-231 C188(1.23)  LDD1447  [36]
 LDCM0607  Fragment49 MDA-MB-231 C188(1.29)  LDD1448  [36]
 LDCM0608  Fragment50 MDA-MB-231 C188(1.05)  LDD1449  [36]
 LDCM0427  Fragment51 HEK-293T C188(1.01)  LDD1025  [16]
 LDCM0610  Fragment52 MDA-MB-231 C188(0.99)  LDD1452  [36]
 LDCM0611  Fragment53 MDA-MB-231 C188(0.86)  LDD1454  [36]
 LDCM0612  Fragment54 MDA-MB-231 C188(1.12)  LDD1456  [36]
 LDCM0613  Fragment55 MDA-MB-231 C188(0.93)  LDD1457  [36]
 LDCM0614  Fragment56 MDA-MB-231 C188(0.99)  LDD1458  [36]
 LDCM0568  Fragment6 MDA-MB-231 C188(1.23)  LDD1382  [36]
 LDCM0569  Fragment7 MDA-MB-231 C188(0.97)  LDD1383  [36]
 LDCM0570  Fragment8 MDA-MB-231 C188(1.16)  LDD1385  [36]
 LDCM0571  Fragment9 MDA-MB-231 C188(0.97)  LDD1387  [36]
 LDCM0116  HHS-0101 DM93 Y292(0.78); Y223(1.24)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y292(0.80); Y223(1.25)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y292(0.85); Y223(1.28)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y292(0.85); Y223(1.17)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y292(0.73); Y223(0.88)  LDD0268  [14]
 LDCM0107  IAA HeLa H128(0.00); H61(0.00); H62(0.00); H320(0.00)  LDD0221  [27]
 LDCM0123  JWB131 DM93 Y292(0.84)  LDD0285  [13]
 LDCM0124  JWB142 DM93 Y292(0.91)  LDD0286  [13]
 LDCM0125  JWB146 DM93 Y292(1.07)  LDD0287  [13]
 LDCM0126  JWB150 DM93 Y292(4.89)  LDD0288  [13]
 LDCM0127  JWB152 DM93 Y292(2.09)  LDD0289  [13]
 LDCM0128  JWB198 DM93 Y292(1.19)  LDD0290  [13]
 LDCM0129  JWB202 DM93 Y292(0.39)  LDD0291  [13]
 LDCM0130  JWB211 DM93 Y292(0.97)  LDD0292  [13]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [9]
 LDCM0022  KB02 HCT 116 C188(1.22)  LDD0080  [16]
 LDCM0023  KB03 HCT 116 C188(0.98)  LDD0081  [16]
 LDCM0024  KB05 HCT 116 C188(3.20)  LDD0082  [16]
 LDCM0109  NEM HeLa H61(0.00); H320(0.00); H62(0.00); H128(0.00)  LDD0223  [27]
 LDCM0627  NUDT7-COV-1 HEK-293T C188(2.46)  LDD2206  [37]
 LDCM0628  OTUB2-COV-1 HEK-293T C188(0.77)  LDD2207  [37]
 LDCM0131  RA190 MM1.R C188(1.12)  LDD0304  [38]
 LDCM0021  THZ1 HeLa S3 C188(1.01)  LDD0460  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytoplasmic dynein 2 intermediate chain 1 (DYNC2I1) Dynein light intermediate chain family Q8WVS4
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
POC1 centriolar protein homolog B (POC1B) WD repeat POC1 family Q8TC44
DnaJ homolog subfamily A member 2 (DNAJA2) . O60884
F-box/WD repeat-containing protein 2 (FBXW2) . Q9UKT8

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phenethyl Isothiocyanate Small molecular drug DB12695

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
10 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
13 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
14 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
15 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
17 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
18 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
19 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
20 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
24 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
25 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
26 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
27 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
28 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
29 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
30 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
31 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
32 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
33 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
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Mass spectrometry data entry: PXD044402
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