Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FFF probe3  Probe Info 
Probe concentration 200 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Compound 35  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 53 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06142  Squalene monooxygenase (SQLE) 10.8
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 9.4
 LDTP09495  Probable glutathione peroxidase 8 (GPX8) 9.1
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 9.1
 LDTP00697  Cytochrome b5 type B (CYB5B) 9.0
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 8.7
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 8.5
 LDTP11127  ADP-dependent glucokinase (ADPGK) 8.5
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 7.7
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 7.1
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 7.1
 LDTP00886  Nardilysin (NRDC) 7.1
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 6.6
 LDTP06371  GTP-binding protein Rheb (RHEB) 6.6
 LDTP12851  UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1) 6.5
 LDTP03682  DNA replication licensing factor MCM7 (MCM7) 6.4
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 6.3
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 6.3
 LDTP15236  TRMT1-like protein (TRMT1L) 6.3
 LDTP10020  Ras-related protein Rab-24 (RAB24) 6.1
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 5.9
 LDTP03540  Heme oxygenase 2 (HMOX2) 5.8
 LDTP00988  Protein O-GlcNAcase (OGA) 5.7
 LDTP05193  ADP-ribosylation factor 5 (ARF5) 5.7
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 5.5
 LDTP09569  Ras-related protein Rab-2B (RAB2B) 5.5
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 5.4
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 5.4
 LDTP03592  Ribonucleoside-diphosphate reductase subunit M2 (RRM2) 5.2
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 5.1
 LDTP00890  S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) 5.0
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 5.0
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 4.9
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) 4.9
 LDTP04384  Cyclin-dependent kinase 9 (CDK9) 4.8
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 4.7
 LDTP15879  Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) 4.6
 LDTP09388  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (STT3B) 4.5
 LDTP12657  Nucleotide triphosphate diphosphatase NUDT15 (NUDT15) 4.5
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 4.4
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 4.4
 LDTP11819  STE20-like serine/threonine-protein kinase (SLK) 4.4
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 4.3
 LDTP02743  Insulin-degrading enzyme (IDE) 4.3
 LDTP03523  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) 4.0
 LDTP06903  Ubiquitin carboxyl-terminal hydrolase 39 (USP39) 4.0
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) 3.9
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2) 3.6
 LDTP01986  NADH-ubiquinone oxidoreductase chain 5 (MT-ND5) 3.5
 LDTP04542  Thimet oligopeptidase (THOP1) 3.4
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 3.4
 LDTP04962  26S proteasome regulatory subunit 4 (PSMC1) 3.2
 LDTP04963  26S proteasome regulatory subunit 8 (PSMC5) 3.0
Transporter and channel
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 11.7
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 11.2
 LDTP16190  Protein FAM8A1 (FAM8A1) 10.3
 LDTP00310  Syntenin-1 (SDCBP) 9.7
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 9.7
 LDTP11250  MICOS complex subunit MIC26 (APOO) 9.7
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 9.5
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 9.3
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 8.3
 LDTP03405  Calnexin (CANX) 7.8
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 7.8
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 7.0
 LDTP05938  Sorting nexin-1 (SNX1) 6.6
 LDTP09149  ATP-binding cassette sub-family F member 1 (ABCF1) 6.5
 LDTP01601  Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) 5.3
 LDTP04501  Importin subunit alpha-1 (KPNA2) 5.1
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 3.9
 LDTP09949  Transportin-1 (TNPO1) 3.1
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02870  Y-box-binding protein 3 (YBX3) 5.6
Other
Click to Show/Hide to Show 49 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05160  Nucleobindin-2 (NUCB2) 9.5
 LDTP05375  Nucleobindin-1 (NUCB1) 9.4
 LDTP08594  Negative elongation factor C/D (NELFCD) 9.0
 LDTP13086  Syntaxin-18 (STX18) 8.4
 LDTP08224  Protein LYRIC (MTDH) 7.8
 LDTP02756  Junction plakoglobin (JUP) 7.7
 LDTP15887  Lipase maturation factor 2 (LMF2) 7.7
 LDTP05922  Dynactin subunit 2 (DCTN2) 7.5
 LDTP12412  Reticulon-4 (RTN4) 7.4
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 7.2
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) 6.8
 LDTP14085  Protein PRRC2C (PRRC2C) 6.6
 LDTP06268  Condensin complex subunit 2 (NCAPH) 6.6
 LDTP16080  Protein FAM114A2 (FAM114A2) 6.5
 LDTP16006  Optic atrophy 3 protein (OPA3) 6.4
 LDTP00105  Protein unc-119 homolog B (UNC119B) 6.4
 LDTP13532  Malignant T-cell-amplified sequence 1 (MCTS1) 6.3
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 6.2
 LDTP05068  Tropomyosin alpha-4 chain (TPM4) 6.2
 LDTP04558  Arfaptin-1 (ARFIP1) 6.2
 LDTP13044  Ribosome-binding protein 1 (RRBP1) 6.2
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 6.2
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 6.1
 LDTP04570  Coatomer subunit beta (COPB1) 6.0
 LDTP13402  Dynactin subunit 4 (DCTN4) 6.0
 LDTP01522  Reticulon-3 (RTN3) 6.0
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 5.8
 LDTP04199  Protein PRRC2A (PRRC2A) 5.7
 LDTP00849  17S U2 SnRNP complex component HTATSF1 (HTATSF1) 5.6
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 5.6
 LDTP06515  Coiled-coil domain-containing protein 6 (CCDC6) 5.4
 LDTP00934  C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9) 5.0
 LDTP04078  Proliferation marker protein Ki-67 (MKI67) 4.7
 LDTP13908  AP-3 complex subunit mu-1 (AP3M1) 4.4
 LDTP04518  DNA mismatch repair protein Msh6 (MSH6) 4.4
 LDTP09878  Symplekin (SYMPK) 4.1
 LDTP06121  Caprin-1 (CAPRIN1) 4.0
 LDTP01456  Pre-mRNA-processing factor 6 (PRPF6) 4.0
 LDTP03030  Annexin A7 (ANXA7) 3.9
 LDTP13817  Nuclear migration protein nudC (NUDC) 3.8
 LDTP04853  Eukaryotic translation initiation factor 3 subunit E (EIF3E) 3.7
 LDTP13813  Eukaryotic translation initiation factor 3 subunit L (EIF3L) 3.7
 LDTP13467  RNA-binding protein Raly (RALY) 3.6
 LDTP06280  Squamous cell carcinoma antigen recognized by T-cells 3 (SART3) 3.6
 LDTP00223  26S proteasome non-ATPase regulatory subunit 11 (PSMD11) 3.4
 LDTP04917  Proteasome activator complex subunit 3 (PSME3) 3.3
 LDTP04092  Crk-like protein (CRKL) 3.2
 LDTP06301  Eukaryotic translation initiation factor 4H (EIF4H) 3.1
 LDTP05277  Protein SET (SET) 3.0

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.