Details of the Target

General Information of Target

Target ID LDTP13467
Target Name RNA-binding protein Raly (RALY)
Gene Name RALY
Gene ID 22913
Synonyms
HNRPCL2; P542; RNA-binding protein Raly; Autoantigen p542; Heterogeneous nuclear ribonucleoprotein C-like 2; hnRNP core protein C-like 2; hnRNP associated with lethal yellow protein homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAACEGRRSGALGSSQSDFLTPPVGGAPWAVATTVVMYPPPPPPPHRDFISVTLSFGENY
DNSKSWRRRSCWRKWKQLSRLQRNMILFLLAFLLFCGLLFYINLADHWKALAFRLEEEQK
MRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDG
TQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQ
GTPVHLNYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWI
LGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGN
RLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEA
VEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQE
TQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVYHG
LPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPET
VESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFF
LGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPIWTPA
Target Bioclass
Other
Family
RRM HNRPC family, RALY subfamily
Subcellular location
Nucleus
Function
RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis. May be a heterogeneous nuclear ribonucleoprotein (hnRNP).
Uniprot ID
Q9UKM9
Ensemble ID
ENST00000246194.8
HGNC ID
HGNC:15921

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.G82V .
JEKO1 Substitution: p.G251S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y57(16.35); Y62(8.98)  LDD0260  [1]
C-Sul
 Probe Info  		7.22  LDD0066  [2]
STPyne
 Probe Info  		K13(8.52); K146(7.03); K159(10.00); K165(10.00)  LDD0277  [3]
DBIA
 Probe Info  		C51(2.51)  LDD3333  [4]
BTD
 Probe Info  		C51(1.61)  LDD1700  [5]
Acrolein
 Probe Info  		N.A.  LDD0222  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
ATP probe
 Probe Info  		K159(0.00); K198(0.00); K94(0.00)  LDD0035  [10]
IPM
 Probe Info  		N.A.  LDD0025  [11]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
W1
 Probe Info  		N.A.  LDD0236  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		16.00  LDD1865  [15]
C191
 Probe Info  		11.47  LDD1868  [15]
FFF probe11
 Probe Info  		9.79  LDD0472  [16]
FFF probe13
 Probe Info  		20.00  LDD0475  [16]
FFF probe2
 Probe Info  		20.00  LDD0463  [16]
FFF probe3
 Probe Info  		10.93  LDD0464  [16]
VE-P
 Probe Info  		N.A.  LDD0396  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C51(0.69)  LDD2112  [5]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C51(1.30)  LDD2130  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C51(0.71)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C51(1.24)  LDD2152  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C51(1.26)  LDD2103  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C51(1.01)  LDD2132  [5]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C51(1.19)  LDD2131  [5]
 LDCM0214  AC1 HEK-293T C51(0.95)  LDD1507  [18]
 LDCM0226  AC11 HEK-293T C51(1.01)  LDD1509  [18]
 LDCM0237  AC12 HEK-293T C51(1.02)  LDD1510  [18]
 LDCM0259  AC14 HEK-293T C51(1.14)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C51(0.96)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C51(0.92)  LDD1515  [18]
 LDCM0278  AC19 HEK-293T C51(0.89)  LDD1517  [18]
 LDCM0280  AC20 HEK-293T C51(1.00)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C51(0.93)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C51(1.04)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C51(1.05)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C51(1.00)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C51(0.90)  LDD1524  [18]
 LDCM0287  AC27 HEK-293T C51(1.03)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C51(1.04)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C51(0.98)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C51(1.08)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C51(1.35)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C51(1.00)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C51(1.00)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C51(1.01)  LDD1533  [18]
 LDCM0296  AC35 HEK-293T C51(0.99)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C51(1.00)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C51(1.12)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C51(0.87)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C51(0.98)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C51(1.06)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C51(0.94)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C51(0.98)  LDD1542  [18]
 LDCM0305  AC43 HEK-293T C51(0.99)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C51(1.03)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C51(0.97)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C51(0.90)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C51(0.95)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C51(0.95)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C51(0.95)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C51(1.07)  LDD1551  [18]
 LDCM0314  AC51 HEK-293T C51(1.06)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C51(0.94)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C51(0.97)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C51(1.03)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C51(0.95)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C51(0.98)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C51(0.89)  LDD1559  [18]
 LDCM0322  AC59 HEK-293T C51(0.93)  LDD1561  [18]
 LDCM0323  AC6 HEK-293T C51(1.09)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C51(0.92)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C51(0.85)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C51(1.00)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C51(0.85)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C51(0.90)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C51(0.97)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C51(1.03)  LDD1569  [18]
 LDCM0545  Acetamide MDA-MB-231 C51(0.99)  LDD2138  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C51(0.85)  LDD2113  [5]
 LDCM0248  AKOS034007472 HEK-293T C51(1.01)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C51(1.01)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C51(0.97)  LDD1514  [18]
 LDCM0498  BS-3668 MDA-MB-231 C51(0.79)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 HEK-293T C51(0.82)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C51(1.00)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C51(0.92)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C51(0.87)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C51(1.18)  LDD1575  [18]
 LDCM0373  CL104 HEK-293T C51(0.99)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C51(0.90)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C51(0.87)  LDD1579  [18]
 LDCM0377  CL108 HEK-293T C51(0.95)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C51(0.90)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C51(1.02)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C51(1.00)  LDD1584  [18]
 LDCM0382  CL112 HEK-293T C51(0.99)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C51(0.91)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C51(1.03)  LDD1588  [18]
 LDCM0386  CL116 HEK-293T C51(1.04)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C51(0.90)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C51(1.02)  LDD1592  [18]
 LDCM0390  CL12 HEK-293T C51(0.86)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C51(0.95)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C51(0.87)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C51(1.12)  LDD1597  [18]
 LDCM0395  CL124 HEK-293T C51(0.88)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C51(0.80)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C51(0.71)  LDD1601  [18]
 LDCM0399  CL128 HEK-293T C51(0.80)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C51(0.75)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C51(0.94)  LDD1605  [18]
 LDCM0403  CL16 HEK-293T C51(0.86)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C51(0.86)  LDD1608  [18]
 LDCM0406  CL19 HEK-293T C51(1.14)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C51(0.89)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C51(1.03)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C51(0.96)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C51(1.13)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C51(1.14)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C51(0.93)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C51(0.81)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C51(0.99)  LDD1618  [18]
 LDCM0416  CL28 HEK-293T C51(0.91)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C51(0.98)  LDD1621  [18]
 LDCM0420  CL31 HEK-293T C51(1.02)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C51(1.03)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C51(0.89)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C51(1.16)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C51(1.18)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C51(1.06)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C51(0.89)  LDD1630  [18]
 LDCM0429  CL4 HEK-293T C51(0.76)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C51(0.93)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C51(0.97)  LDD1635  [18]
 LDCM0433  CL43 HEK-293T C51(1.20)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C51(1.08)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C51(0.88)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C51(1.35)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C51(1.01)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C51(0.97)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C51(0.91)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C51(0.92)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C51(1.24)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C51(0.99)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C51(0.99)  LDD1647  [18]
 LDCM0446  CL55 HEK-293T C51(1.19)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C51(1.06)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C51(0.93)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C51(0.96)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C51(1.04)  LDD1653  [18]
 LDCM0452  CL60 HEK-293T C51(0.90)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C51(0.86)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C51(0.95)  LDD1657  [18]
 LDCM0456  CL64 HEK-293T C51(0.92)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C51(0.99)  LDD1660  [18]
 LDCM0459  CL67 HEK-293T C51(1.17)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C51(0.99)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C51(0.97)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C51(1.05)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C51(1.19)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C51(0.98)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C51(0.99)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C51(0.90)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C51(0.81)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C51(0.90)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C51(0.96)  LDD1673  [18]
 LDCM0472  CL79 HEK-293T C51(1.10)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C51(0.71)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C51(1.07)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C51(0.97)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C51(1.13)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C51(1.03)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C51(0.91)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C51(0.73)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C51(0.72)  LDD1683  [18]
 LDCM0482  CL88 HEK-293T C51(0.75)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C51(0.92)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C51(0.97)  LDD1687  [18]
 LDCM0486  CL91 HEK-293T C51(0.95)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C51(0.86)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C51(0.89)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C51(1.06)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C51(0.74)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C51(0.77)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C51(0.87)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C51(0.98)  LDD1696  [18]
 LDCM0192  Compound 35 HEK-293T 3.63  LDD0509  [16]
 LDCM0625  F8 Ramos C51(0.57)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C51(0.62)  LDD2189  [19]
 LDCM0574  Fragment12 Ramos C51(0.65)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C51(0.88)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C51(0.73)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C51(0.49)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C51(0.86)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C51(0.93)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C51(0.91)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C51(0.64)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C51(1.23)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C51(1.03)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C51(0.77)  LDD2201  [19]
 LDCM0468  Fragment33 Ramos C51(1.16)  LDD2202  [19]
 LDCM0596  Fragment38 Ramos C51(0.85)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C51(0.67)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C51(1.05)  LDD1631  [18]
 LDCM0610  Fragment52 Ramos C51(1.36)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C51(1.90)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C51(0.57)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C51(0.41)  LDD2188  [19]
 LDCM0022  KB02 HEK-293T C51(1.01)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C51(0.99)  LDD1497  [18]
 LDCM0024  KB05 MOLM-13 C51(2.51)  LDD3333  [4]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C51(1.28)  LDD2102  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C51(1.22)  LDD2121  [5]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C51(0.53)  LDD2089  [5]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C51(1.02)  LDD2090  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C51(1.31)  LDD2092  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C51(0.88)  LDD2093  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C51(2.44)  LDD2094  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C51(0.11)  LDD2096  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C51(0.93)  LDD2097  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C51(0.94)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C51(1.28)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C51(1.22)  LDD2101  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C51(1.67)  LDD2105  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C51(0.49)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C51(0.89)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C51(0.44)  LDD2109  [5]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C51(1.23)  LDD2110  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C51(0.77)  LDD2111  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C51(1.00)  LDD2115  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C51(1.81)  LDD2116  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C51(2.06)  LDD2119  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C51(0.81)  LDD2120  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C51(0.59)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C51(0.09)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C51(0.57)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C51(0.33)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C51(0.72)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C51(0.99)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C51(1.09)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C51(0.62)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C51(1.18)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C51(1.33)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C51(0.92)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C51(0.83)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C51(1.61)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C51(0.51)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C51(0.80)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C51(1.01)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C51(2.68)  LDD2144  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C51(2.59)  LDD2145  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C51(0.80)  LDD2146  [5]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C51(3.03)  LDD2147  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C51(1.00)  LDD2148  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C51(1.32)  LDD2150  [5]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C51(0.11)  LDD2151  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C51(1.72)  LDD2153  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) RRM HNRPC family P07910
RNA-binding protein FUS (FUS) RRM TET family P35637

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578