Details of the Probe

General Information of Probe

Probe ID
LDPC0425
Probe Name
C187
Synonyms
Z3433405206
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 335.4
Lipid-water partition coefficient (xlogp) 2.5
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C18H17N5O2
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-5-phenoxypyrazine-2-carboxamide
Canonical SMILES
C#CCCC1(N=N1)CCNC(=O)C2=CN=C(C=N2)OC3=CC=CC=C3
InChI
InChI=1S/C18H17N5O2/c1-2-3-9-18(22-23-18)10-11-19-17(24)15-12-21-16(13-20-15)25-14-7-5-4-6-8-14/h1,4-8,12-13H,3,9-11H2,(H,19,24)
InChIKey
UUXWZPBGRWVQTA-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

135 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
14 kDa phosphohistidine phosphatase (PHPT1) LDTP12543 16.80  LDD1865 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 25.63  LDD1865 
7-dehydrocholesterol reductase (DHCR7) LDTP13131 16.11  LDD1865 
7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) LDTP10032 20.82  LDD1865 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 42.52  LDD1865 
Acid ceramidase (ASAH1) LDTP05905 69.07  LDD1865 
Acireductone dioxygenase (ADI1) LDTP11268 15.14  LDD1865 
Activin receptor type-1B (ACVR1B) LDTP03822 20.97  LDD1865 
Acyl-coenzyme A thioesterase 1 (ACOT1) LDTP08209 17.51  LDD1865 
Adenosine kinase (ADK) LDTP04689 20.11  LDD1865 
ADP-dependent glucokinase (ADPGK) LDTP11127 24.93  LDD1865 
ADP-ribosylation factor-like protein 10 (ARL10) LDTP19745 24.25  LDD1865 
AFG3-like protein 2 (AFG3L2) LDTP14075 15.67  LDD1865 
Alanine--tRNA ligase, mitochondrial (AARS2) LDTP07015 60.13  LDD1865 
Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) LDTP04437 25.11  LDD1865 
Alpha-galactosidase A (GLA) LDTP02141 21.41  LDD1865 
Amidophosphoribosyltransferase (PPAT) LDTP05480 17.75  LDD1865 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 19.70  LDD1865 
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) LDTP06618 22.16  LDD1865 
ATP-dependent translocase ABCB1 (ABCB1) LDTP02254 33.13  LDD1865 
Beta-galactosidase (GLB1) LDTP02837 22.78  LDD1865 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 15.56  LDD1865 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 33.13  LDD1865 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 25.81  LDD1865 
Carbohydrate sulfotransferase 14 (CHST14) LDTP09096 22.94  LDD1865 
Carboxymethylenebutenolidase homolog (CMBL) LDTP10215 41.07  LDD1865 
Ceramide glucosyltransferase (UGCG) LDTP06617 18.00  LDD1865 
Ceramide synthase 1 (CERS1) LDTP03394 50.91  LDD1865 
Ceramide synthase 2 (CERS2) LDTP10329 37.01  LDD1865 
Choline kinase alpha (CHKA) LDTP03787 16.11  LDD1865 
Choline-phosphate cytidylyltransferase A (PCYT1A) LDTP04261 16.56  LDD1865 
Copper-transporting ATPase 2 (ATP7B) LDTP03779 19.16  LDD1865 
Cytochrome b-c1 complex subunit 9 (UQCR10) LDTP13189 99.73  LDD1865 
Cytochrome b5 type B (CYB5B) LDTP00697 59.30  LDD1865 
Cytochrome c oxidase assembly factor 7 (COA7) LDTP10137 24.08  LDD1865 
Cytochrome c oxidase subunit 6C (COX6C) LDTP02367 17.88  LDD1865 
Cytochrome P450 20A1 (CYP20A1) LDTP17410 25.99  LDD1865 
DCN1-like protein 5 (DCUN1D5) LDTP11199 20.25  LDD1865 
Delta(24)-sterol reductase (DHCR24) LDTP06375 18.00  LDD1865 
Deoxyhypusine hydroxylase (DOHH) LDTP11225 16.68  LDD1865 
Dermatan-sulfate epimerase (DSE) LDTP13504 24.08  LDD1865 
Diacylglycerol lipase-beta (DAGLB) LDTP09095 15.56  LDD1865 
Dihydropteridine reductase (QDPR) LDTP02342 32.00  LDD1865 
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12) LDTP11259 20.11  LDD1865 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) LDTP04120 17.39  LDD1865 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (STT3B) LDTP09388 15.03  LDD1865 
Dolichyl-phosphate beta-glucosyltransferase (ALG5) LDTP14214 21.86  LDD1865 
E3 ubiquitin-protein ligase ARIH1 (ARIH1) LDTP14079 17.75  LDD1865 
E3 ubiquitin-protein ligase TRIM21 (TRIM21) LDTP03001 15.24  LDD1865 
Endonuclease domain-containing 1 protein (ENDOD1) LDTP01462 23.59  LDD1865 
Endoplasmic reticulum aminopeptidase 1 (ERAP1) LDTP12868 51.63  LDD1865 
Endoplasmic reticulum protein SC65 (P3H4) LDTP09874 20.11  LDD1865 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 28.25  LDD1865 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 19.70  LDD1865 
Epoxide hydrolase 1 (EPHX1) LDTP02175 23.43  LDD1865 
Ferrochelatase, mitochondrial (FECH) LDTP03198 18.00  LDD1865 
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) LDTP12253 32.22  LDD1865 
Glycogen synthase kinase-3 alpha (GSK3A) LDTP04318 21.41  LDD1865 
GPI ethanolamine phosphate transferase 2 (PIGG) LDTP06977 15.56  LDD1865 
GPI-anchor transamidase (PIGK) LDTP09835 16.56  LDD1865 
Heme oxygenase 1 (HMOX1) LDTP02359 36.00  LDD1865 
Heme oxygenase 2 (HMOX2) LDTP03540 28.25  LDD1865 
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) LDTP07990 19.56  LDD1865 
Histone-lysine N-methyltransferase 2A (KMT2A) LDTP05396 26.72  LDD1865 
Holocytochrome c-type synthase (HCCS) LDTP04581 29.86  LDD1865 
Hydroxysteroid dehydrogenase-like protein 2 (HSDL2) LDTP07762 18.90  LDD1865 
Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) LDTP06787 40.22  LDD1865 
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (IDH3A) LDTP04345 15.35  LDD1865 
Kinesin-like protein KIF20A (KIF20A) LDTP01535 18.77  LDD1865 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 37.27  LDD1865 
Lathosterol oxidase (SC5D) LDTP01329 20.68  LDD1865 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 19.56  LDD1865 
Leukotriene A-4 hydrolase (LTA4H) LDTP02385 19.70  LDD1865 
Lysocardiolipin acyltransferase 1 (LCLAT1) LDTP07679 20.82  LDD1865 
Lysophospholipid acyltransferase 7 (MBOAT7) LDTP10612 65.34  LDD1865 
Lysosomal acid glucosylceramidase (GBA1) LDTP02005 22.94  LDD1865 
Lysosomal protective protein (CTSA) LDTP02505 36.50  LDD1865 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 23.43  LDD1865 
Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) LDTP10177 15.35  LDD1865 
Methionine aminopeptidase 1 (METAP1) LDTP04565 99.73  LDD1865 
Methylsterol monooxygenase 1 (MSMO1) LDTP06477 36.50  LDD1865 
Minor histocompatibility antigen H13 (HM13) LDTP09396 19.56  LDD1865 
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) LDTP00837 36.25  LDD1865 
NAD(P) transhydrogenase, mitochondrial (NNT) LDTP05862 71.01  LDD1865 
NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) LDTP08385 15.67  LDD1865 
NADH-cytochrome b5 reductase 1 (CYB5R1) LDTP13303 16.45  LDD1865 
NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) LDTP01982 20.97  LDD1865 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 99.73  LDD1865 
Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) LDTP12628 27.28  LDD1865 
Phospholipase A2 group XV (PLA2G15) LDTP09088 17.27  LDD1865 
Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) LDTP05624 47.50  LDD1865 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 33.13  LDD1865 
Prenylcysteine oxidase-like (PCYOX1L) LDTP15480 17.75  LDD1865 
Presequence protease, mitochondrial (PITRM1) LDTP07003 24.25  LDD1865 
Prostaglandin reductase 3 (PTGR3) LDTP15422 22.47  LDD1865 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 21.86  LDD1865 
Proteasome subunit beta type-4 (PSMB4) LDTP03417 22.94  LDD1865 
Proteasome subunit beta type-5 (PSMB5) LDTP03419 42.22  LDD1865 
Protein disulfide-isomerase TMX3 (TMX3) LDTP10471 17.15  LDD1865 
Protein phosphatase 3 catalytic subunit alpha (PPP3CA) LDTP05549 17.63  LDD1865 
Protein SCO2 homolog, mitochondrial (SCO2) LDTP00877 24.25  LDD1865 
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) LDTP01039 31.12  LDD1865 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 22.32  LDD1865 
Putative peptidyl-tRNA hydrolase PTRHD1 (PTRHD1) LDTP19478 15.89  LDD1865 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 53.82  LDD1865 
Pyridoxine-5'-phosphate oxidase (PNPO) LDTP12691 37.79  LDD1865 
Ras-related protein Rab-11B (RAB11B) LDTP06501 15.35  LDD1865 
Ras-related protein Rab-1A (RAB1A) LDTP05006 99.73  LDD1865 
Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) LDTP09666 48.50  LDD1865 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) LDTP00907 15.78  LDD1865 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 38.32  LDD1865 
Ribonuclease T2 (RNASET2) LDTP00316 16.34  LDD1865 
RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) LDTP05588 17.15  LDD1865 
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) LDTP00890 15.24  LDD1865 
S-methyl-5'-thioadenosine phosphorylase (MTAP) LDTP05758 24.76  LDD1865 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 16.00  LDD1865 
Serine palmitoyltransferase 1 (SPTLC1) LDTP00597 19.70  LDD1865 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 17.15  LDD1865 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 42.22  LDD1865 
Signal peptidase complex subunit 2 (SPCS2) LDTP06270 20.68  LDD1865 
Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) LDTP02067 16.00  LDD1865 
Squalene synthase (FDFT1) LDTP03842 55.33  LDD1865 
SUMO-activating enzyme subunit 1 (SAE1) LDTP13107 15.24  LDD1865 
Telomerase RNA component interacting RNase (TRIR) LDTP11055 18.51  LDD1865 
Thioredoxin-related transmembrane protein 1 (TMX1) LDTP11874 21.26  LDD1865 
Thiosulfate sulfurtransferase (TST) LDTP06620 16.11  LDD1865 
TLC domain-containing protein 1 (TLCD1) LDTP10182 35.26  LDD1865 
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) LDTP03912 99.73  LDD1865 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 44.02  LDD1865 
Ubiquitin carboxyl-terminal hydrolase 14 (USP14) LDTP04618 37.53  LDD1865 
Ubiquitin-protein ligase E3A (UBE3A) LDTP05446 15.35  LDD1865 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 50.91  LDD1865 
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) LDTP12954 18.25  LDD1865 
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) LDTP08728 18.25  LDD1865 
Xaa-Arg dipeptidase (PM20D2) LDTP08666 15.45  LDD1865 
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⏷ Show the Full List of 135 Enzyme
80 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
45 kDa calcium-binding protein (SDF4) LDTP11116 20.39  LDD1865 
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) LDTP09328 16.80  LDD1865 
Anion exchange protein 2 (SLC4A2) LDTP02061 16.80  LDD1865 
Anoctamin-6 (ANO6) LDTP06855 22.47  LDD1865 
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) LDTP03284 32.45  LDD1865 
ATP synthase subunit g, mitochondrial (ATP5MG) LDTP14511 41.36  LDD1865 
Battenin (CLN3) LDTP05814 24.59  LDD1865 
Ceramide transfer protein (CERT1) LDTP14140 30.91  LDD1865 
Coiled-coil domain-containing protein 93 (CCDC93) LDTP06928 48.50  LDD1865 
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) LDTP02645 63.12  LDD1865 
Cytochrome c oxidase subunit 5A, mitochondrial (COX5A) LDTP03064 26.91  LDD1865 
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) LDTP02724 77.71  LDD1865 
Cytoskeleton-associated protein 4 (CKAP4) LDTP05511 38.05  LDD1865 
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) LDTP13393 15.56  LDD1865 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 40.50  LDD1865 
Exocyst complex component 8 (EXOC8) LDTP08651 16.00  LDD1865 
Golgi SNAP receptor complex member 1 (GOSR1) LDTP01542 16.56  LDD1865 
Golgin subfamily A member 5 (GOLGA5) LDTP09333 19.29  LDD1865 
H(+)/Cl(-) exchange transporter 3 (CLCN3) LDTP04459 16.91  LDD1865 
H(+)/Cl(-) exchange transporter 6 (CLCN6) LDTP04462 23.43  LDD1865 
Heme transporter FLVCR1 (FLVCR1) LDTP14178 26.91  LDD1865 
Importin-4 (IPO4) LDTP09515 15.56  LDD1865 
Importin-7 (IPO7) LDTP01574 17.03  LDD1865 
Lipid scramblase CLPTM1L (CLPTM1L) LDTP10499 23.26  LDD1865 
Lysosome membrane protein 2 (SCARB2) LDTP06034 45.25  LDD1865 
Magnesium transporter NIPA3 (NIPAL1) LDTP17362 25.11  LDD1865 
Magnesium transporter protein 1 (MAGT1) LDTP11732 15.78  LDD1865 
Melanoma inhibitory activity protein 2 (MIA2) LDTP10669 16.22  LDD1865 
Membrane-associated progesterone receptor component 1 (PGRMC1) LDTP00235 23.59  LDD1865 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 30.70  LDD1865 
Metaxin-1 (MTX1) LDTP05900 36.76  LDD1865 
Metaxin-2 (MTX2) LDTP01217 26.72  LDD1865 
MICOS complex subunit MIC60 (IMMT) LDTP06660 17.15  LDD1865 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 20.11  LDD1865 
Mitochondrial carrier homolog 1 (MTCH1) LDTP12909 22.01  LDD1865 
Mitochondrial dicarboxylate carrier (SLC25A10) LDTP13174 33.13  LDD1865 
Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) LDTP13983 19.29  LDD1865 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 99.73  LDD1865 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 99.73  LDD1865 
Mitochondrial inner membrane protein OXA1L (OXA1L) LDTP06308 34.78  LDD1865 
Mitochondrial proton/calcium exchanger protein (LETM1) LDTP01525 18.25  LDD1865 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 37.01  LDD1865 
Mpv17-like protein 2 (MPV17L2) LDTP14952 54.95  LDD1865 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 19.16  LDD1865 
Nucleoporin NDC1 (NDC1) LDTP11213 22.78  LDD1865 
PAT complex subunit CCDC47 (CCDC47) LDTP10059 16.11  LDD1865 
Peroxisomal biogenesis factor 19 (PEX19) LDTP03905 61.82  LDD1865 
Peroxisomal membrane protein 2 (PXMP2) LDTP16069 24.93  LDD1865 
Prosaposin (PSAP) LDTP02215 59.30  LDD1865 
Protein ERGIC-53 (LMAN1) LDTP04237 74.03  LDD1865 
Protein FAM8A1 (FAM8A1) LDTP16190 15.56  LDD1865 
Protein tweety homolog 3 (TTYH3) LDTP11615 99.73  LDD1865 
Protein wntless homolog (WLS) LDTP07156 17.03  LDD1865 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 49.52  LDD1865 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 20.82  LDD1865 
Secretory carrier-associated membrane protein 2 (SCAMP2) LDTP00547 65.34  LDD1865 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 22.01  LDD1865 
Sigma non-opioid intracellular receptor 1 (SIGMAR1) LDTP10958 30.06  LDD1865 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 53.82  LDD1865 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 15.78  LDD1865 
Sorting nexin-25 (SNX25) LDTP15987 48.17  LDD1865 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 45.89  LDD1865 
Stomatin (STOM) LDTP03380 30.91  LDD1865 
SUN domain-containing protein 1 (SUN1) LDTP01454 17.88  LDD1865 
Syntaxin-6 (STX6) LDTP00857 23.75  LDD1865 
Tetraspanin-10 (TSPAN10) LDTP15967 19.70  LDD1865 
Tetraspanin-3 (TSPAN3) LDTP16813 54.57  LDD1865 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 56.49  LDD1865 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 61.82  LDD1865 
Transmembrane emp24 domain-containing protein 7 (TMED7) LDTP13969 26.35  LDD1865 
Transmembrane protein 126A (TMEM126A) LDTP15948 33.13  LDD1865 
Transmembrane protein 160 (TMEM160) LDTP20002 19.84  LDD1865 
Transmembrane protein 205 (TMEM205) LDTP07667 99.73  LDD1865 
Transmembrane protein 230 (TMEM230) LDTP10065 18.77  LDD1865 
Transmembrane protein 70, mitochondrial (TMEM70) LDTP11229 17.51  LDD1865 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 38.85  LDD1865 
V-type proton ATPase subunit d 1 (ATP6V0D1) LDTP04924 15.03  LDD1865 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 58.89  LDD1865 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 60.97  LDD1865 
Voltage-dependent anion-selective channel protein 3 (VDAC3) LDTP13824 16.45  LDD1865 
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⏷ Show the Full List of 80 Transporter and channel
8 Transcription factor Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DnaJ homolog subfamily C member 1 (DNAJC1) LDTP10501 15.24  LDD1865 
High mobility group protein B1 (HMGB1) LDTP02343 21.71  LDD1865 
High mobility group protein B3 (HMGB3) LDTP00612 15.78  LDD1865 
NF-kappa-B-repressing factor (NKRF) LDTP00576 15.03  LDD1865 
Non-POU domain-containing octamer-binding protein (NONO) LDTP06341 30.27  LDD1865 
PHD finger-like domain-containing protein 5A (PHF5A) LDTP08006 51.98  LDD1865 
Transcription factor BTF3 (BTF3) LDTP03043 16.22  LDD1865 
Transcriptional repressor p66-alpha (GATAD2A) LDTP08409 21.86  LDD1865 
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⏷ Show the Full List of 8 Transcription factor
1 GPCR Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Membrane progestin receptor alpha (PAQR7) LDTP15303 64.00  LDD1865 
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1 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
HLA class I histocompatibility antigen, alpha chain E (HLA-E) LDTP02688 58.08  LDD1865 
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146 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
14-3-3 protein eta (YWHAH) LDTP05442 16.91  LDD1865 
17S U2 SnRNP complex component HTATSF1 (HTATSF1) LDTP00849 19.56  LDD1865 
ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) LDTP08950 18.51  LDD1865 
Alpha-2-macroglobulin receptor-associated protein (LRPAP1) LDTP03545 15.56  LDD1865 
Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) LDTP08364 39.40  LDD1865 
Apolipoprotein L2 (APOL2) LDTP11076 80.45  LDD1865 
Bcl-2-associated transcription factor 1 (BCLAF1) LDTP12826 15.56  LDD1865 
BUB3-interacting and GLEBS motif-containing protein ZNF207 (ZNF207) LDTP00830 18.25  LDD1865 
Calponin-3 (CNN3) LDTP06383 16.22  LDD1865 
Calumenin (CALU) LDTP00887 20.68  LDD1865 
Chromobox protein homolog 1 (CBX1) LDTP05189 19.84  LDD1865 
Clustered mitochondria protein homolog (CLUH) LDTP14486 27.28  LDD1865 
Collectin-12 (COLEC12) LDTP07031 27.10  LDD1865 
Coronin-1B (CORO1B) LDTP11101 34.06  LDD1865 
DBIRD complex subunit ZNF326 (ZNF326) LDTP06952 19.84  LDD1865 
DDB1- and CUL4-associated factor 13 (DCAF13) LDTP12652 19.43  LDD1865 
DET1- and DDB1-associated protein 1 (DDA1) LDTP11312 18.25  LDD1865 
Diablo IAP-binding mitochondrial protein (DIABLO) LDTP12468 71.51  LDD1865 
DNA polymerase epsilon subunit 3 (POLE3) LDTP12506 18.90  LDD1865 
DnaJ homolog subfamily C member 8 (DNAJC8) LDTP01361 15.03  LDD1865 
Dynein light chain 1, cytoplasmic (DYNLL1) LDTP05049 41.07  LDD1865 
Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) LDTP08689 27.28  LDD1865 
EF-hand calcium-binding domain-containing protein 14 (EFCAB14) LDTP19021 19.29  LDD1865 
Emerin (EMD) LDTP04356 26.17  LDD1865 
Endophilin-A3 (SH3GL3) LDTP11021 40.22  LDD1865 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 38.32  LDD1865 
ER lumen protein-retaining receptor 3 (KDELR3) LDTP00850 36.76  LDD1865 
Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2) LDTP03027 20.39  LDD1865 
Eukaryotic translation initiation factor 3 subunit H (EIF3H) LDTP00620 17.03  LDD1865 
Eukaryotic translation initiation factor 3 subunit I (EIF3I) LDTP05834 15.45  LDD1865 
Eukaryotic translation initiation factor 3 subunit J (EIF3J) LDTP01320 18.38  LDD1865 
Eukaryotic translation initiation factor 3 subunit M (EIF3M) LDTP07947 16.45  LDD1865 
Eukaryotic translation initiation factor 4H (EIF4H) LDTP06301 17.63  LDD1865 
Far upstream element-binding protein 2 (KHSRP) LDTP09938 20.82  LDD1865 
Ganglioside-induced differentiation-associated protein 1 (GDAP1) LDTP09324 19.84  LDD1865 
GH3 domain-containing protein (GHDC) LDTP08795 15.03  LDD1865 
Golgi apparatus protein 1 (GLG1) LDTP09920 27.10  LDD1865 
Golgi integral membrane protein 4 (GOLIM4) LDTP00281 89.88  LDD1865 
HAUS augmin-like complex subunit 3 (HAUS3) LDTP07318 19.56  LDD1865 
HAUS augmin-like complex subunit 5 (HAUS5) LDTP01466 16.11  LDD1865 
HCLS1-associated protein X-1 (HAX1) LDTP00199 20.11  LDD1865 
Heterogeneous nuclear ribonucleoprotein A0 (HNRNPA0) LDTP05768 21.41  LDD1865 
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) LDTP00500 15.14  LDD1865 
Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) LDTP03614 19.29  LDD1865 
Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) LDTP07891 72.00  LDD1865 
Jupiter microtubule associated homolog 2 (JPT2) LDTP12077 38.85  LDD1865 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 16.80  LDD1865 
Kinesin light chain 1 (KLC1) LDTP05533 16.68  LDD1865 
Kinetochore-associated protein 1 (KNTC1) LDTP04382 19.70  LDD1865 
Lamin-B1 (LMNB1) LDTP03065 15.03  LDD1865 
Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) LDTP03968 17.03  LDD1865 
Large proline-rich protein BAG6 (BAG6) LDTP04094 30.48  LDD1865 
Large ribosomal subunit protein bL27m (MRPL27) LDTP16162 19.97  LDD1865 
Large ribosomal subunit protein eL28 (RPL28) LDTP04108 20.11  LDD1865 
Large ribosomal subunit protein eL29 (RPL29) LDTP04140 17.75  LDD1865 
Large ribosomal subunit protein eL33 (RPL35A) LDTP02940 31.78  LDD1865 
Large ribosomal subunit protein eL43 (RPL37A) LDTP04926 30.27  LDD1865 
Large ribosomal subunit protein uL10m (MRPL10) LDTP08154 31.12  LDD1865 
Large ribosomal subunit protein uL24 (RPL26) LDTP04914 18.13  LDD1865 
LIM and SH3 domain protein 1 (LASP1) LDTP06220 15.03  LDD1865 
MICOS complex subunit MIC19 (CHCHD3) LDTP12764 18.64  LDD1865 
Mitochondrial calcium uniporter regulator 1 (MCUR1) LDTP10093 24.76  LDD1865 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 24.93  LDD1865 
Mitochondrial import receptor subunit TOM20 homolog (TOMM20) LDTP06373 17.39  LDD1865 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 85.04  LDD1865 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 99.73  LDD1865 
Myosin light chain 6B (MYL6B) LDTP02736 33.36  LDD1865 
Negative elongation factor C/D (NELFCD) LDTP08594 25.46  LDD1865 
Neurofilament medium polypeptide (NEFM) LDTP02181 20.39  LDD1865 
Nischarin (NISCH) LDTP13870 15.03  LDD1865 
Nonsense-mediated mRNA decay factor SMG8 (SMG8) LDTP09112 25.63  LDD1865 
Nuclear migration protein nudC (NUDC) LDTP13817 24.25  LDD1865 
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1) LDTP11764 19.03  LDD1865 
Nucleobindin-1 (NUCB1) LDTP05375 19.29  LDD1865 
Nucleobindin-2 (NUCB2) LDTP05160 47.84  LDD1865 
Nucleophosmin (NPM1) LDTP02164 20.25  LDD1865 
Nucleosome assembly protein 1-like 4 (NAP1L4) LDTP10965 18.25  LDD1865 
Optic atrophy 3 protein (OPA3) LDTP16006 20.39  LDD1865 
Oxysterol-binding protein-related protein 6 (OSBPL6) LDTP11533 25.63  LDD1865 
Periodic tryptophan protein 1 homolog (PWP1) LDTP05942 26.91  LDD1865 
PHD finger protein 6 (PHF6) LDTP08552 22.94  LDD1865 
Phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU) LDTP11906 20.11  LDD1865 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 17.15  LDD1865 
Prelamin-A/C (LMNA) LDTP01932 16.80  LDD1865 
Programmed cell death protein 5 (PDCD5) LDTP00417 34.30  LDD1865 
Proline-rich protein PRCC (PRCC) LDTP09850 18.64  LDD1865 
Protein CEBPZOS (CEBPZOS) LDTP18883 50.91  LDD1865 
Protein enabled homolog (ENAH) LDTP08984 18.51  LDD1865 
Protein FAM114A2 (FAM114A2) LDTP16080 19.70  LDD1865 
Protein FAM162A (FAM162A) LDTP10056 42.52  LDD1865 
Protein FAM98B (FAM98B) LDTP06879 17.88  LDD1865 
Protein LYRIC (MTDH) LDTP08224 20.25  LDD1865 
Protein SET (SET) LDTP05277 95.67  LDD1865 
Protein unc-119 homolog A (UNC119) LDTP05868 23.59  LDD1865 
Protein unc-119 homolog B (UNC119B) LDTP00105 54.57  LDD1865 
Putative RNA-binding protein Luc7-like 2 (LUC7L2) LDTP13956 21.71  LDD1865 
RAD50-interacting protein 1 (RINT1) LDTP07476 17.27  LDD1865 
Ran-specific GTPase-activating protein (RANBP1) LDTP04049 21.26  LDD1865 
Replication protein A 32 kDa subunit (RPA2) LDTP02816 31.34  LDD1865 
Reticulocalbin-2 (RCN2) LDTP06097 20.97  LDD1865 
Reticulon-3 (RTN3) LDTP01522 99.73  LDD1865 
Reticulon-4 (RTN4) LDTP12412 15.56  LDD1865 
Rho GTPase-activating protein 10 (ARHGAP10) LDTP00024 18.25  LDD1865 
RNA-binding protein 10 (RBM10) LDTP05224 18.38  LDD1865 
RNA-binding protein 12 (RBM12) LDTP16096 15.56  LDD1865 
RNA-binding protein 14 (RBM14) LDTP10684 25.99  LDD1865 
RNA-binding protein 3 (RBM3) LDTP05226 17.51  LDD1865 
RNA-binding protein FUS (FUS) LDTP03775 19.29  LDD1865 
RNA-binding protein Raly (RALY) LDTP13467 16.00  LDD1865 
Serine/arginine-rich splicing factor 7 (SRSF7) LDTP06583 15.45  LDD1865 
Signal recognition particle receptor subunit beta (SRPRB) LDTP16323 19.29  LDD1865 
Small ribosomal subunit protein bS16m (MRPS16) LDTP13981 34.06  LDD1865 
Small ubiquitin-related modifier 2 (SUMO2) LDTP04945 18.25  LDD1865 
Sorcin (SRI) LDTP03554 17.15  LDD1865 
Spartin (SPART) LDTP08735 17.39  LDD1865 
Src substrate cortactin (CTTN) LDTP06094 18.00  LDD1865 
Stathmin (STMN1) LDTP02869 16.45  LDD1865 
Survival motor neuron protein (SMN1; SMN2) LDTP06587 25.46  LDD1865 
Syntaxin-10 (STX10) LDTP00986 34.78  LDD1865 
Syntaxin-18 (STX18) LDTP13086 70.52  LDD1865 
Syntaxin-7 (STX7) LDTP00632 16.00  LDD1865 
Testis-expressed protein 264 (TEX264) LDTP14259 30.27  LDD1865 
Tetraspanin-6 (TSPAN6) LDTP14458 55.33  LDD1865 
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) LDTP07368 25.46  LDD1865 
Tetratricopeptide repeat protein 21B (TTC21B) LDTP08073 16.68  LDD1865 
Thioredoxin-related transmembrane protein 4 (TMX4) LDTP18373 22.32  LDD1865 
THUMP domain-containing protein 1 (THUMPD1) LDTP12780 34.06  LDD1865 
Thyroid hormone receptor-associated protein 3 (THRAP3) LDTP13919 18.90  LDD1865 
TraB domain-containing protein (TRABD) LDTP19963 16.56  LDD1865 
Translation initiation factor eIF2B subunit gamma (EIF2B3) LDTP12476 33.36  LDD1865 
Treacle protein (TCOF1) LDTP05867 16.22  LDD1865 
Trophoblast glycoprotein (TPBG) LDTP05960 16.80  LDD1865 
Tropomyosin alpha-3 chain (TPM3) LDTP02165 17.15  LDD1865 
Tropomyosin alpha-4 chain (TPM4) LDTP05068 25.46  LDD1865 
Tumor protein D54 (TPD52L2) LDTP00759 44.02  LDD1865 
U1 small nuclear ribonucleoprotein C (SNRPC) LDTP02335 21.56  LDD1865 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 56.89  LDD1865 
Ubiquitin-fold modifier-conjugating enzyme 1 (UFC1) LDTP13978 16.11  LDD1865 
UPF0488 protein C8orf33 (C8orf33) LDTP12025 53.82  LDD1865 
UV excision repair protein RAD23 homolog B (RAD23B) LDTP04627 19.29  LDD1865 
Vesicle transport protein SEC20 (BNIP1) LDTP05715 23.59  LDD1865 
Vesicle-trafficking protein SEC22b (SEC22B) LDTP01206 20.68  LDD1865 
Vimentin (VIM) LDTP02297 22.01  LDD1865 
YTH domain-containing family protein 3 (YTHDF3) LDTP08136 19.97  LDD1865 
Zinc finger CCCH domain-containing protein 18 (ZC3H18) LDTP08292 33.13  LDD1865 
Zinc finger RNA-binding protein (ZFR) LDTP15762 15.67  LDD1865 
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Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1865 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587