Details of the Target

General Information of Target

Target ID LDTP02869
Target Name Stathmin (STMN1)
Gene Name STMN1
Gene ID 3925
Synonyms
C1orf215; LAP18; OP18; Stathmin; Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASSDIQVKELEKRASGQAFELILSPRSKESVPEFPLSPPKKKDLSLEEIQKKLEAAEER
RKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFSKMAEEKLTHKMEANKENREAQMAAKL
ERLREKDKHIEEVRKNKESKDPADETEAD
Target Type
Clinical trial
Target Bioclass
Other
Family
Stathmin family
Subcellular location
Cytoplasm, cytoskeleton
Function
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear.
TTD ID
T62739
Uniprot ID
P16949
DrugMap ID
TT369WU
Ensemble ID
ENST00000357865.6
HGNC ID
HGNC:6510
ChEMBL ID
CHEMBL3879843

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1B SNV: p.E145V .
HT115 SNV: p.E138Ter .
MOLT4 SNV: p.P36T .
RKO SNV: p.E10Ter .
SW403 SNV: p.E58Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.72  LDD0402  [1]
AZ-9
 Probe Info  		10.00  LDD0393  [2]
FBPP2
 Probe Info  		4.51  LDD0318  [3]
SAA-alkyne
 Probe Info  		1.08  LDD0252  [4]
C-Sul
 Probe Info  		16.62  LDD0066  [5]
ONAyne
 Probe Info  		K53(0.00); K119(0.00); K62(0.00); K104(0.00)  LDD0273  [6]
OPA-S-S-alkyne
 Probe Info  		K119(1.62); K53(1.68); K128(2.80); K126(2.80)  LDD3494  [7]
AMP probe
 Probe Info  		K53(0.00); K70(0.00)  LDD0200  [8]
ATP probe
 Probe Info  		K53(0.00); K70(0.00); K128(0.00); K119(0.00)  LDD0199  [8]
ATP probe
 Probe Info  		N.A.  LDD0035  [9]
NHS
 Probe Info  		K43(0.00); K85(0.00); K100(0.00); K41(0.00)  LDD0010  [10]
SF
 Probe Info  		K128(0.00); K53(0.00); K29(0.00); K119(0.00)  LDD0028  [11]
STPyne
 Probe Info  		K85(0.00); K70(0.00); K119(0.00); K80(0.00)  LDD0009  [10]
Acrolein
 Probe Info  		H78(0.00); H64(0.00); K128(0.00); H129(0.00)  LDD0217  [12]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [12]
Methacrolein
 Probe Info  		H129(0.00); H64(0.00)  LDD0218  [12]
AOyne
 Probe Info  		13.70  LDD0443  [13]
HHS-465
 Probe Info  		K100(0.00); K80(0.00)  LDD2240  [14]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		21.56  LDD1713  [15]
C052
 Probe Info  		8.17  LDD1750  [15]
C187
 Probe Info  		16.45  LDD1865  [15]
C252
 Probe Info  		9.65  LDD1925  [15]
C314
 Probe Info  		11.63  LDD1981  [15]
C354
 Probe Info  		7.62  LDD2015  [15]
C397
 Probe Info  		11.16  LDD2056  [15]
FFF probe12
 Probe Info  		16.04  LDD0473  [16]
FFF probe13
 Probe Info  		12.65  LDD0475  [16]
FFF probe3
 Probe Info  		20.00  LDD0464  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 12.48  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa H78(0.00); H129(0.00); H64(0.00)  LDD0222  [12]
 LDCM0107  IAA HeLa H64(0.00); H129(0.00); K128(0.00)  LDD0221  [12]
 LDCM0109  NEM HeLa H64(0.00); H129(0.00); H78(0.00); K128(0.00)  LDD0223  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase inhibitor 1B (CDKN1B) CDI family P46527
SEC14 domain and spectrin repeat-containing protein 1 (SESTD1) SOLO family Q86VW0

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pbi-shrna Stmn1 Short hairpin RNA DSE59Z

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 Chemoproteomics and Phosphoproteomics Profiling Reveals Salvianolic Acid A as a Covalent Inhibitor of mTORC1. J Proteome Res. 2023 Jul 7;22(7):2450-2459. doi: 10.1021/acs.jproteome.3c00188. Epub 2023 Jun 22.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.