Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C397  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 30 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13846  Nuclease EXOG, mitochondrial (EXOG) 56.5
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 26.9
 LDTP12679  Trimethyllysine dioxygenase, mitochondrial (TMLHE) 21.6
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 18.0
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 15.7
 LDTP04114  E3 ubiquitin-protein ligase NEDD4 (NEDD4) 15.3
 LDTP10020  Ras-related protein Rab-24 (RAB24) 14.2
 LDTP06427  Translin (TSN) 14.0
 LDTP00659  DNA-directed RNA polymerase II subunit RPB4 (POLR2D) 13.8
 LDTP01803  Adenosine deaminase (ADA) 13.5
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 13.4
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 12.8
 LDTP04552  Biliverdin reductase A (BLVRA) 12.2
 LDTP03540  Heme oxygenase 2 (HMOX2) 12.1
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 11.9
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 11.6
 LDTP00697  Cytochrome b5 type B (CYB5B) 10.8
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 10.5
 LDTP12315  RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (SSU72) 10.4
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 10.3
 LDTP09416  Alanine aminotransferase 2 (GPT2) 9.9
 LDTP17305  Glycosyltransferase 8 domain-containing protein 1 (GLT8D1) 9.9
 LDTP09074  UDP-glucuronic acid decarboxylase 1 (UXS1) 9.9
 LDTP05881  Rho-associated protein kinase 1 (ROCK1) 9.8
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 9.8
 LDTP02616  Creatine kinase B-type (CKB) 9.7
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 9.6
 LDTP02359  Heme oxygenase 1 (HMOX1) 9.5
 LDTP03813  Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (CPOX) 9.5
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 9.4
Transporter and channel
Click to Show/Hide to Show 17 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 69.1
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 22.9
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 19.8
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 17.3
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 16.9
 LDTP12383  Protein GPR108 (GPR108) 14.1
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 13.5
 LDTP11615  Protein tweety homolog 3 (TTYH3) 11.9
 LDTP15648  BRI3-binding protein (BRI3BP) 11.7
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 11.3
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 11.2
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 11.1
 LDTP05900  Metaxin-1 (MTX1) 10.7
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 10.3
 LDTP01051  Target of Myb1 membrane trafficking protein (TOM1) 10.2
 LDTP13256  SUN domain-containing protein 2 (SUN2) 10.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 9.9
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05235  Transcription factor A, mitochondrial (TFAM) 11.6
Other
Click to Show/Hide to Show 27 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01075  Protein CutA (CUTA) 24.9
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 15.5
 LDTP00986  Syntaxin-10 (STX10) 14.9
 LDTP13086  Syntaxin-18 (STX18) 14.2
 LDTP05160  Nucleobindin-2 (NUCB2) 13.7
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 13.4
 LDTP00887  Calumenin (CALU) 12.0
 LDTP10056  Protein FAM162A (FAM162A) 11.5
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 11.4
 LDTP02869  Stathmin (STMN1) 11.2
 LDTP02285  U2 small nuclear ribonucleoprotein B'' (SNRPB2) 10.7
 LDTP08594  Negative elongation factor C/D (NELFCD) 10.6
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 10.6
 LDTP06097  Reticulocalbin-2 (RCN2) 10.6
 LDTP00573  Prefoldin subunit 6 (PFDN6) 10.5
 LDTP11134  DNA replication complex GINS protein SLD5 (GINS4) 10.3
 LDTP09069  Kinetochore protein Spc24 (SPC24) 10.3
 LDTP16080  Protein FAM114A2 (FAM114A2) 10.3
 LDTP12094  Conserved oligomeric Golgi complex subunit 4 (COG4) 10.2
 LDTP10857  c-Myc-binding protein (MYCBP) 10.1
 LDTP09719  Progesterone-induced-blocking factor 1 (PIBF1) 10.1
 LDTP05763  Liprin-alpha-1 (PPFIA1) 9.9
 LDTP02297  Vimentin (VIM) 9.7
 LDTP04369  Peroxisomal targeting signal 1 receptor (PEX5) 9.6
 LDTP06879  Protein FAM98B (FAM98B) 9.6
 LDTP01358  Pre-mRNA-splicing factor SPF27 (BCAS2) 9.5
 LDTP02351  Tropomyosin alpha-1 chain (TPM1) 9.5

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587